Clinical trials: Duration of Response
Sepsis, Prognostic Model
Artificial Intelligence Prognostic Model for Sepsis Based on Time Series Analysis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. It is one of the leading causes of death and disability worldwide, with an inpatient mortality rate of 10-20%.
- Conditions
- Sepsis, Prognostic Model, Artificial Intelligence, Individuality
- Trial name
- NCT06724120
- Testing
- No interventions
- Where
- China
- Volunteers
- 3,641 people
- Sponsor
- West China Hospital
Attention Deficit Hyperactivity Disorder
Effectiveness and Duration of Effect of Open Treatment in Attention Deficit Hyperactivity Disorder (ADHD) Patients Treated With Lisdexamfetamine Dimesylate(Vyvanse)
The purpose of this study is to examine the effectiveness and length of effect of Vyvanse on lessening Attention-Deficit/Hyperactivity Disorder symptoms in adults.
- Trial name
- NCT01070394
- Testing
- LDX Treatment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Alzheimer's Disease, Mild Cognitive Impairment
Investigating the Impact of Duration and Amount of Light on the Circadian System Response - Aim 3
Investigate the long-term impact of amount and duration of Tailored Lighting Intervention (TLI) obtained from Aims 1 and 2 on sleep, cognition, circadian marker, mood, and behavior in AD/ADRD patients.
- Trial name
- NCT06595030
- Testing
- Active Lighting Intervention, Control Lighting Intervention
- Where
- 2 sites in United States
- Volunteers
- 101 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cardiovascular Fitness
Physiological and Perceptual Responses During 4-Second Exercise
The purpose of this study is to investigate the acute effects of different intensities (i.e., 50, 75, and 100% of maximal anaerobic power) of 4-s sprint interval exercise on physiological responses.
- Trial name
- NCT06912932
- Testing
- Preventive
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Cardiopulmonary Arrest
Extension of Rapid Response Team Operation Time and Cardiopulmonary Resuscitation Incidence
Although early rapid response team was reported as a full-time operating system, similar efficacy of part-time rapid response team has been recently reported.
- Trial name
- NCT05712915
- Testing
- RRT operation
- Where
- South Korea
- Volunteers
- 142,088 people
- Sponsor
- Dong-A University Hospital
Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic
Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury
The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect…
- Conditions
- Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic, Cardiovascular, Transcutaneous Spinal Stimulation
- Trial name
- NCT06841198
- Testing
- spinal cord transcutaneous stimulation, Ice testing
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Obesity, Diabetes Mellitus, Type 2
This Study Assessed the Impact of Diet on Gastric Emptying Time and Metabolic Flexibility
Consumption of slowly digestible carbohydrates can elicit higher satiety feeling compared to rapidly digestible carbohydrates, however not all individuals respond the same.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Appetitive Behavior
- Trial name
- IODC (NCT03630263)
- Testing
- Raw Corn Starch, No Raw Corn Starch
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Purdue University
Infant, Newborn, Neonatal SEPSIS
7 Days Versus 14 Days of Antibiotics for Neonatal Sepsis
The optimum duration of intravenous antibiotic therapy for culture-proven neonatal bacterial sepsis is not known. Current practices, ranging from 7 days to 14 days of antibiotics, are not evidence-based.
- Conditions
- Infant, Newborn, Neonatal SEPSIS, Anti-bacterial Agents, Recurrence
- Trial name
- NCT03280147
- Testing
- 7-day course of antibiotics, 14-day course of antibiotics
- Where
- 7 sites in India
- Volunteers
- 261 people
- Sponsor
- Indian Council of Medical Research
Parkinson's Disease
A Study of Istradefylline (KW-6002) in Treating Patients With Parkinson's Disease on Levodopa
To establish the efficacy of 10, 20 and 40 mg/d dose of istradefylline for reducing the percentage of OFF time in patients with advanced Parkinson's disease (PD) treated with levodopa.
- Trial name
- NCT00199420
- Testing
- Istradefylline (KW-6002)
- Where
- 2 sites in United States
- Volunteers
- 580 people
- Sponsor
- Kyowa Kirin, Inc.
Prostate Cancer
Response of Patients on Surveillance for Prostate Cancer to Dutasteride
Hypothesis: That, in men on surveillance for favorable risk prostate cancer treated with dutasteride, prostate specific antigen (PSA) kinetics is of value in identifying those men who harbor occult high grade prostate cancer.
- Trial name
- NCT01525914
- Testing
- Dutasteride
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Sunnybrook Health Sciences Centre
Fasting, Feeding, Time Restricted
Anabolic Effects of Intraoperative Feeding in Reconstruction Surgery
Perioperative fasting remains a common clinical practice in surgical patients to prevent the development of postoperative anesthesia- and surgical-related complications.
- Conditions
- Fasting, Feeding, Time Restricted, Stress-related Problem, Head and Neck Neoplasms
- Trial name
- NCT04266015
- Testing
- Enteral nutrition formula
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- E-DA Hospital
Follicular Lymphoma
Study of Tazemetostat in Adults With Follicular Lymphoma Previously Treated With at Least Two Therapies
This study aims to evaluate how well the effectiveness of the medicine Tazemetostat works in adults with relapsed/refractory follicular lymphoma, a slow-growing type of blood cancer that affects a kind of white blood cell called…
- Trial name
- NCT07282548
- Sponsor
- Ipsen
Lactation
Influence of Unrestricted Introduction of Pacifiers on Breastfeeding Duration
We will enroll 1010 mother-infant dyads in a randomized trial exploring the effect of distribution of the pacifier during the first days of life on breastfeeding prevalence and duration. .
- Trial name
- NCT03981133
- Testing
- offer a pacifier, no pacifier
- Where
- 6 sites in Argentina
- Volunteers
- 1,010 people
- Sponsor
- Fundación para el Estudio y Prevención de la Muerte Infantil y Perinatal
Resectable Stage II-III Non-Small Cell Lung Cancer (NSCLC)
Effect of Infusion Timing on Pathologic Response to Neoadjuvant Immunotherapy in Resectable Non-Small Cell Lung Cancer
This prospective study aims to investigate whether the time of day when immune checkpoint inhibitors (ICIs) are administered affects the efficacy of neoadjuvant immunotherapy in patients with resectable stage II-III non-small…
- Trial name
- LungTime-C02 (NCT07251582)
- Testing
- Time of Day-based Assignment for Infusion of Immune Checkpoint Inhibitor (e.g., toripalimab, or pembrolizumab) + platinum-based chemotherapy
- Where
- 2 sites in China
- Volunteers
- 186 people
- Sponsor
- Hunan Province Tumor Hospital
Advanced Refractory Chronic Lymphocytic Leukemia
Combined Treatment With Fresh Frozen Plasma and Rituximab (Mabthera) in Patients With Advanced Refractory Chronic Lymphocytic Leukemia
Chronic lymphocytic leukemia (CLL), an indolent disease of mature-looking B lymphocytes, is the most common leukemia in Israel and the Western world.
- Trial name
- NCT00892827
- Testing
- Rituximab (Mabthera) , FFP (Fresh Frozen Plasma)
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Wolfson Medical Center
Breast Neoplasms
Tumor Response Time of Palbociclib in Combination With AI in Real-world Chinese Patients
The international treatment guidelines now include recommendations for the use of CDK 4/6 inhibitors in combination with hormone agents for the treatment of postmenopausal women with hormone-receptor-positive/HER2-negative ABC as…
- Trial name
- NCT04858997
- Testing
- Palbociclib, AI
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Zhejiang Cancer Hospital
Adhd
The Day-time Response Variation of (Lis)Dexamphetamine
In the Netherlands, two forms of amphetamines are available for the treatment of ADHD in adults; dexamfetamine (Tentin) and lisdexamfetamine (Elvanse) and both belong to regular and primary care pharmacotherapy.
- Trial name
- IDEAL (NCT04946461)
- Testing
- Dexamfetamine Sulfate 5 Mg Oral Tablet, Lisdexamfetamine Dimesylate, blood samples
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Amsterdam UMC, location VUmc
Septic Shock Point Prevalence, Sepsis
İntensive Care Sepsis Prevelance in Turkey (INSEP-TURK)
Sepsis is a life-threatening condition characterized by a dysregulated host response to infection, leading to tissue damage, multiple organ dysfunction (MODS), disseminated intravascular coagulation (DIC), and high mortality.
- Trial name
- INSEP-TURK (NCT07283588)
- Where
- Turkey (Türkiye)
- Volunteers
- 850 people
- Sponsor
- Gulhane Training and Research Hospital
Kidney Cancer
Pazopanib Versus Temsirolimus in Poor-Risk Clear-Cell Renal Cell Carcinoma (RCC)
The goal of this clinical research study is to compare pazopanib to temsirolimus in the treatment of advanced clear-cell renal cell carcinoma. The safety of each drug will also be studied.
- Trial name
- NCT01392183
- Testing
- Pazopanib, Temsirolimus, Quality of Life Assessment
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- M.D. Anderson Cancer Center
Stage III Fallopian Tube Cancer, Stage III Ovarian Cancer
IGFBP-2 Vaccine and Combination Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Undergoing Surgery
This phase II trial studies how well pUMVC3-IGFBP2 plasmid deoxyribonucleic acid (DNA) vaccine (IGFBP-2 vaccine) and combination chemotherapy work in treating patients with stage III-IV ovarian, fallopian tube, or primary…
- Conditions
- Stage III Fallopian Tube Cancer, Stage III Ovarian Cancer, Stage III Primary Peritoneal Cancer, Stage IIIA Fallopian Tube Cancer
- Trial name
- NCT03029611
- Testing
- Carboplatin, Gynecological Surgical Procedure, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Washington