Clinical trials: Dydrogesterone
IVF, Oocyte Maturation Defect 1
IVF Outcome Following Progestogen Ovarian Stimulation
The new strategy is by using the progestogen to block the luteinizing hormone(LH) surge either endogenous during luteal phase stimulation, or exogenous in the follicular phase i.e progestin primed ovarian stimulation (PPOS).
- Conditions
- IVF, Oocyte Maturation Defect 1, Clinical Pregnancy Rate, Ovarian Hyperstimulation
- Trial name
- NCT04175990
- Testing
- Dydrogesterone Pill
- Where
- Malaysia
- Volunteers
- 155 people
- Sponsor
- National University of Malaysia
Polycystic Ovary Syndrome (PCOS)
Efficacy of Oral Contraceptive, Progesterone, and Inositol on Menstrual Regulation in PCOS
This cross-sectional study aims to compare the effectiveness of oral contraceptives, oral progesterone (didrogesterone), and inositol in regulating menstrual cycles among women diagnosed with polycystic ovary syndrome (PCOS).
- Trial name
- NCT07242131
- Testing
- Combined Oral Contraceptive (Ethinylestradiol 0.03 mg + Drospirenone 3 mg), Inositol mid-level volume, Dydrogesterone Pill
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ege University
Irregular Menstrual Cycle
Duphaston in Cycle Regularization: A Post-marketing, Prospective, Multicenter, Observational Study
In India Duphaston is approved and widely used for the treatment of progesterone deficiencies such as for management of dysmenorrhea, endometriosis, secondary amenorrhea, irregular cycles, dysfunctional uterine bleeding…
- Trial name
- NCT01525563
- Where
- 32 sites in India
- Volunteers
- 1,000 people
- Sponsor
- Abbott
ART
Oral Dydrogesterone vs. Vaginal Micronized Progesterone for Luteal Phase Support in Frozen-thawed Embryo Transfer
The current trial is intended to assess the efficacy of oral versus vaginal progesterone for luteal support in frozen IVF cycles.
- Trial name
- NCT03832699
- Testing
- Dydrogesterone 10 MG, Endometrin 100Mg Vaginal Insert
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Female Infertility
A Multicenter Study Comparing the Efficacy, Safety and Tolerability of Oral Dydrogesterone 30 mg Daily Versus Intravaginal Micronized Progesterone Capsules 600 mg Daily for Luteal Support in In-Vitro Fertilization
Female inability to conceive a child. The purpose of this randomized, two-arm and double blind, double dummy study is to demonstrate that the treatment of a daily dose of 3x10mg dydrogesterone orally is as effective and safe as…
- Trial name
- Lotus I (NCT01850030)
- Testing
- Dydrogesterone 30 mg, Micronized Progesterone 600 mg
- Where
- 40 sites in Austria, Belgium and 5 more
- Volunteers
- 1,070 people
- Sponsor
- Abbott
Endometrial Hyperplasia Without Atypia
MPA Versus Dydrogesterone for Management of Endometrial Hyperplasia Without Atypia
To compare the efficacy of Medroxyprogesterone Acetate with dydrogesterone in patients having endometrial hyperplasia (EH) without atypia.
- Trial name
- NCT03675139
- Testing
- Medroxyprogesterone Acetate, Dydrogesterone 10 MG
- Where
- China
- Volunteers
- 471 people
- Sponsor
- Xiaojun Chen
Endometriosis, Sexual Dysfunction
The Effect of Dydrogesterone on Sexual Function in Women With Endometriosis
This study aimed to assess the effects of dydrogesterone on sexual function in women with endometriosis using Female Function Sexual Index (FSFI).
- Trial name
- NCT04287205
- Testing
- Dydrogesterone
- Where
- Turkey (Türkiye)
- Volunteers
- 79 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Frozen Embryo Transfer, Hormone Replacement Therapy
Oral Versus Vaginal Progesterone for Luteal Phase Supplementation in Frozen Embryo Transfer Cycles
To investigate the efficacy of dydrogesterone 30 mg compared to micronized vaginal progesterone 800 mg daily for luteal phase support in hormone replacement therapy frozen embryo transfer cycles, as confirmed by visualization of…
- Conditions
- Frozen Embryo Transfer, Hormone Replacement Therapy, Dydrogesterone, Infertility, Female
- Trial name
- REMODEL (NCT04758871)
- Testing
- Dydrogesterone 10 MG Oral Tablet, Micronized progesterone
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- CRG UZ Brussel
Menorrhagia, Metrorrhagia
Severity of Bleeding as a Predictor of Quality of Life (QoL) in Women With Heavy Menstrual Bleeding (HMB) Under Dydrogesterone Treatment
Dydrogesterone is a retroprogesterone with a molecular structure similar to natural progesterone. As a C-21 steroid, it has a high affinity for progesterone receptors, a low antigonadotropic activity and antiestrogenic activity…
- Trial name
- NCT01647360
- Where
- 20 sites in Pakistan
- Volunteers
- 210 people
- Sponsor
- Abbott
Female Infertility
A Study Comparing the Efficacy, Safety and Tolerability of Oral Dydrogesterone 30 mg Daily Versus Crinone 8% Intravaginal Progesterone Gel 90 mg Daily for Luteal Support in In-Vitro Fertilization (LOTUS II)
The purpose of this randomized, two-arm and open label study is to demonstrate that the treatment of a daily dose of 3x10mg dydrogesterone orally is as effective and safe as the daily dose Crinone 8% intravaginal progesterone gel…
- Trial name
- LOTUS II (NCT02491437)
- Testing
- Dydrogesterone 30 mg, intravaginal progesterone gel 90 mg
- Where
- 40 sites in Australia, Belgium and 8 more
- Volunteers
- 1,034 people
- Sponsor
- Abbott
Abnormal Uterine Bleeding
Evaluation of the Effects of Levonorgestrel-releasing Intrauterine Device and Dydrogestreone on Quality of Life and Sexual Life in Patients With Abnormal Uterine Bleeding.
This study was retrospectively collected from patients who were diagnosed with abnormal uterine bleeding and received oral dydrogesterone therapy for at least six months or who were administered an intrauterine device containing…
- Trial name
- NCT05474703
- Testing
- SF-36 Scores
- Where
- Turkey (Türkiye)
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Infertility
Efficacy and Safety of Crinone Versus Combination Medication (ACCESS)
The study to compare to the efficacy and safety of Crinone versus combination medication in infertile women receive frozen-thawed embryo transfer (FET) in artificial cycles (AC).
- Trial name
- NCT03858049
- Testing
- Crinone, Duphaston
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Endometriosis
A Survey on Efficacy and Safety in Patients With Endometriosis
This survey is intended to collect efficacy and safety data of Duphaston® Tablets in patients with endometriosis under actual condition of its use and to obtain data for effectively and safely utilizing this drug.
- Trial name
- NCT02921763
- Testing
- Dydrogesterone
- Where
- 15 sites in Japan
- Volunteers
- 60 people
- Sponsor
- Mylan Inc.
Abnormal Uterine Bleeding (AUB), Ovulation Dysfunction
Clinical Efficacy And Safety of Dydrogesterone In The Treatment Of Abnormal Uterine Bleeding During Puberty
This multicenter prospective cohort study evaluates the clinical efficacy and safety of dydrogesterone versus drospirenone and ethinylestradiol in adolescents aged 10-19 years with abnormal uterine bleeding-ovulatory dysfunction…
- Trial name
- NCT07703488
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Guangdong Women and Children Hospital