Clinical trials: Dysfunction; Endocrine
Hypertension, Obesity
Effect of EGCG on the Body's Response to Insulin
This study will examine whether epigallocatechin gallate (EGCG), a major component of green tea, affects how the body responds to insulin in healthy and obese people.
- Conditions
- Hypertension, Obesity, Type 2 Diabetes, Insulin Resistance
- Trial name
- NCT00434499
- Testing
- EGCG
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Irisin, Endothelial Dysfunction
The Relation Between Plasma Irisin Level and Endothelial Dysfunction in Type 2 Diabetes
Irisin is a signaling protein that is released into the blood from skeletal muscle after proteolysis of the membrane protein FNDC5 . FNDC5, encoded by the Fndc5 gene.
- Conditions
- Irisin, Endothelial Dysfunction, Type 2 Diabetes
- Trial name
- NCT01877603
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wuhan General Hospital of Guangzhou Military Command
Diabetes Mellitus, Steroid Diabetes
Sitagliptin Prophylaxis for Glucocorticoid-Induced Impairment of Glucose Metabolism in Males With the Metabolic Syndrome
The investigators will assess whether the DPP-inhibitor sitagliptin will ameliorate glucocorticoid-induced impairment of glucose metabolism and beta-cell dysfunction and thus could be used as a prophylaxis for…
- Conditions
- Diabetes Mellitus, Steroid Diabetes, Glucocorticoid-induced Diabetes, Beta-cell Function
- Trial name
- SPHINX (NCT00721552)
- Testing
- Sitagliptin 100 mg, Prednisolone 30 mg
- Where
- Netherlands
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Gestational Diabetes Mellitus
The Role of Pregnancy-induced Gallbladder Dysmotility in the Pathophysiology of Gestational Diabetes Mellitus
The primary aim of the study is to evaluate postprandial gallbladder emptying and plasma concentrations of the glucose-lowering and satiety-promoting gut hormone glucagon-like peptide 1 (GLP-1) during third trimester of pregnancy…
- Trial name
- NCT04108065
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Diabetes Mellitus, Cognitive Impairment
Relationship Between Diabetes and Cognitive Impairment Based on Olfactory Function Assessment and Functional MRI
The purpose of this study is to explore the relationship between diabetes and cognitive impairment by olfactory function assessment and functional MRI.
- Conditions
- Diabetes Mellitus, Cognitive Impairment, Obesity
- Trial name
- NCT02738671
- Testing
- Cognitive assessment, functional magnetic resonance imaging, olfactory function measurement
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese
From Skin Fibroblasts to Neural Stem Cells to Investigate in Vitro the Impact of Diabetes on Adult Neurogenesis
Obesity and glucose intolerance or overt diabetes are increasing at an alarming rate in the population, and are bound to become a public health issue and a major cause of disability, loss of independence and high social costs in…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese, Diabetes Mellitus Type 2 in Nonobese, Obesity
- Trial name
- NCT05755321
- Testing
- Skin biopsy
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Type 2 Diabetes, Healthy Aging
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction
The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: Does presence of Type 2 Diabetes reduce autophagy and impair…
- Trial name
- NCT05593549
- Testing
- Trehalose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Diabetes Mellitus, Type 2, Cognitive Dysfunction
Detection of Visual-Auditory Reaction Rates in Individuals With Type 2 Diabetes
Background: The primary purpose of our study was to understand the damage in the peripheral nerves of patients with diabetes and to determine the change in patients' reaction rates and perceptions by the age groups, duration of…
- Conditions
- Diabetes Mellitus, Type 2, Cognitive Dysfunction, Nerve Damage
- Trial name
- NCT05725889
- Testing
- recation time test
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Baskent University
Prediabetes
Training Induced Muscle-Adipose EV Communication
This study examines how muscle cells communicate with fat cells through tiny packages called extracellular vesicles (EV) during exercise.
- Trial name
- TIMER2 (NCT07106450)
- Testing
- Acute Resistance Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yuan Wen
Non-proliferative Diabetic Retinopathy, Diabetes Mellitus Type 2
Efficacy of Ubiquinone and Combined Antioxidant Therapy in Non-proliferative Diabetic Retinopathy
The purpose of this study is to evaluate the efficacy of ubiquinone and combined antioxidant therapy on progression, clinical regression, oxidative stress markers and mitochondrial dysfunction in non-proliferative diabetic…
- Trial name
- NCT02062034
- Testing
- Ubiquinone, Combined antioxidant therapy
- Where
- Mexico
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Erectile Dysfunction, Diabetes Mellitus
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction
Erectile dysfunction (ED) is defined as penile erection that is insufficient and unsustainable for a satisfactory sexual performance.
- Trial name
- NCT05884957
- Testing
- Nitric oxide synthase gene
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Egymedicalpedia
Opiate Dependence, Osteoporosis
Bone Density and Serum Testosterone in Male Methadone Maintained Patients
This is a pilot study designed to answer the question " Do men who are receiving methadone maintenance therapy have lower spinal bone densities compared with age-matched controls who are not receiving methadone therapy?" The…
- Conditions
- Opiate Dependence, Osteoporosis, Erectile Dysfunction, Hypogonadism
- Trial name
- NCT00170339
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hennepin Healthcare Research Institute
Spinal Cord Injuries (SCI), Prediabetes / Type 2 Diabetes
Neuromodulation for Metabolic Dysfunction
This study evaluates the use of noninvasive transcutaneous spinal cord stimulation (tSCS) to improve glucose regulation and metabolic function in individuals with and without spinal cord injury (SCI) across a spectrum of…
- Trial name
- NCT07597161
- Testing
- Transcutaneous Spinal Cord Stimulation (tSCS)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rahul Sachdeva
Diabetes Mellitus, Type 2, Erectile Dysfunction With Diabetes Mellitus
Evaluation of Drug Interactions of Saxagliptin With Sildenafil in Healthy Volunteers
Patients with diabetes are three times more likely to develop erectile dysfunction (ED), and longer duration of diabetes is strongly associated with ED.
- Conditions
- Diabetes Mellitus, Type 2, Erectile Dysfunction With Diabetes Mellitus, Drug Interaction
- Trial name
- NCT04170790
- Testing
- Saxagliptin 5mg, Sildenafil 50 mg
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Mild Cognitive Impairment, Prediabetes
Piedmont Aging, Cognition & Exercise Study-2
The purpose of this research study is to examine the effects of high and low intensity exercise for those with mild memory loss and pre-diabetes.
- Trial name
- PACE-2 (NCT02312843)
- Testing
- Exercise/Aerobic, Exercise/Stretching
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Breast Cancer, Fatigue
Thyroid Dysfunction in Women With Newly Diagnosed Breast Cancer Compared to Healthy Volunteers
RATIONALE: Learning about thyroid dysfunction in patients with breast cancer may help plan treatment and may help patients live more comfortably.
- Conditions
- Breast Cancer, Fatigue, Hypothyroidism
- Trial name
- NCT00336102
- Testing
- physiologic testing, fatigue assessment and management, management of therapy complications
- Where
- 41 sites in United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Type 1 Diabetes Mellitus
Doppler Ultrasound Investigation of Microcirculations
The investigators aim to show that quantitative analysis of doppler flow velocity waveforms i.e. ultrasound which is a non-invasive and very safe means of assessing blood flow; recorded in the proximity of terminal microvascular…
- Trial name
- NCT01045005
- Testing
- Administration ofOxygen and carbon dioxide, Administration of Oxygen and carbon dioxide
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Diabetes, Obesity
PGC-1 & Muscle Mitochondrial Dysfunction in Diabetes
The goal of this study is to understand how and why insulin resistant individuals respond differently to exercise as compared with insulin sensitive individuals at the skeletal muscle and gene expression level.
- Trial name
- PGC-1 (NCT02282423)
- Testing
- Pre-study dietary and exercise instruction., Screening examination and oral glucose tolerance test, Euglycemic clamp
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Polycystic Ovary Syndrome (PCOS)
Blood Vessel Function in Adolescents and Women With Polycystic Ovary Syndrome
The purpose of this study is to determine if changes in blood vessel health lead to the menstrual irregularities that women with PCOS experience.
- Trial name
- NCT01615562
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Dysfunction; Endocrine, Effects of Chemotherapy
Blood Spot Self-administered Test and Assay
The current study will compare hormone levels of AMH, FSH and inhibin B in blood specimens collected by venipuncture and fingerstick in a sample of pre-menopausal women ages 18-45 years with normal menstrual cycles.
- Conditions
- Dysfunction; Endocrine, Effects of Chemotherapy, Premature Ovarian Failure
- Trial name
- NCT03840824
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania