Clinical trials: Dysfunction; Endocrine
Diabetes Type 2, Diabetes Type 1
Disentangling the Effect of Brain Insulin Resistance on Brain Health
People with diabetes are at increased risk of developing dementia, including Alzheimer's disease and vascular dementia. In addition, persons with diabetes have more pronounced age-related brain atrophy and cognitive difficulties…
- Trial name
- BIR 1 (NCT07374705)
- Where
- 3 sites in Denmark, Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henrik Bo Wiberg Larsson
Precocious Puberty, Central, Executive Dysfunction
Hypiend - Multicomponent Behavioral Intervention in Pre-puberal Children (Hypiend-PPC)
This study is part of the European Hypiend project, which aims to explore the effects of co-exposure to endocrine-disrupting chemicals (EDCs) on the function and epigenetic programming of the hypothalamic-pituitary-adrenal (HPA)…
- Trial name
- Hypiend-PPC (NCT07411001)
- Testing
- Multi-Component Behavioral intervention, Information
- Where
- Belgium
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Sciensano
Thyroid; Functional Disturbance
Photodegraded Edible Food Dyes
Assess and contrast the effect of erythrosine and photodegraded erythrosine on thyroid function. Thyroid function will be evaluated as serum triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH), T3 resin…
- Trial name
- NCT04708704
- Testing
- Erythrosine, prepared in drinking water (0.69 mg/kg bw/day), SODIS-treated erythrosine, prepared in drinking water (0.69 mg/kg bw/day), Iodine, prepared in drinking water 0.075 mg/kg bw/day)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Stress, Job, PTSD
The Sequestration of Holistic Stress Management Techniques for Adults
This remote study is intended to assist the population with access to cost-effective pastoral counseling for stress management in the workplace and every day life.
- Conditions
- Stress, Job, PTSD, Hypervigilance, Hyperthyroidism
- Trial name
- NCT06098755
- Testing
- Holistic Medicine (HM)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Goddess Zena I. Jones
Diabetes Mellitus, Type 2, Hypoxia
Carotid Body Function in Type 2 Diabetes Mellitus
This trial will assess chemosensitivity differences of the carotid bodies in individuals with T2DM, compared to healthy controls. During baseline and hyperinsulinemia.
- Trial name
- CBHypoxia (NCT05237076)
- Testing
- Hyperinsulemic-Euglycemic Clamp & Hypoxic Ventilatory Response (HVR)
- Where
- Netherlands
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Type2 Diabetes, Type 2 Diabetes Mellitus in Obese
Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g.
- Conditions
- Type2 Diabetes, Type 2 Diabetes Mellitus in Obese, Dysglycemia, Microvascular Complications
- Trial name
- Metabrain (NCT05277558)
- Testing
- Observational
- Where
- 2 sites in United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Insulin Resistance, Type 2 Diabetes
Microvascular Dysfunction and the Development of Whole-body Insulin Resistance
This study aims to elucidate the role of the microcirculation in the development of whole body insulin resistance. The investigators hypothesize that impaired insulin signaling in the vasculature is an early phenomenon in the…
- Conditions
- Insulin Resistance, Type 2 Diabetes, Obesity
- Trial name
- DESIRE (NCT02628301)
- Testing
- Hypercaloric diet, Normocaloric diet
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Charcot Arthropathy, Type 2 Diabetes
Genetic Contribution to the Pathophysiology of the Charcot Foot in Qatari Patients With Diabetes
To assess the hypothesis that Charcot foot is associated with more vascular complications compared to matched diabetic patients without Charcot foot and to classify patients with Charcot foot according to the human genetic…
- Trial name
- NCT02316483
- Where
- Qatar
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Hypertension, Aging
Wild Blueberries and Cardiovascular Health in Middle-aged/Older Men and Postmenopausal Women
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Aging is the primary risk factor for CVD, in large part due to adverse modifications to the arteries.
- Conditions
- Hypertension, Aging, Endothelial Dysfunction, Men
- Trial name
- WB2020 (NCT04530916)
- Testing
- Blueberry Powder
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Diabetes Mellitus, Hypertension
Community-based E-Health Program for Older Adults Living With Chronic Diseases
With increased aging population, there is a higher rate of having chronic diseases and cognitive impairment. In order to achieve successful aging, it is important for community-dwelling older adults to perform better…
- Conditions
- Diabetes Mellitus, Hypertension, Hyperlipidemias
- Trial name
- CeHP (NCT04560296)
- Testing
- Community-based E-Health Program, usual self-management and follow up with doctors/nurse
- Where
- 9 sites in Singapore
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Diabetes, Obese
PGC-1 and Mitochondrial Dysfunction in Diabetes
The purpose of this study is determine if you have too much fat in your body that it will decrease the conversion of food energy into energy that your body can use.
- Trial name
- NCT01724515
- Testing
- Lipid infusion and muscle biopsies
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Sexual Dysfunction, Endothelial Dysfunction
Comparing Effects of Diet, With or Without Exercise, on Sexual, Urinary and Endothelial Function, Inflammatory Profile and Quality of Life in Obese Men
This study aims to compare the effects of 8 months of diet modification, with or without exercise, on weight loss, sexual, urinary and endothelial function, systemic inflammation and quality of life in obese men.
- Conditions
- Sexual Dysfunction, Endothelial Dysfunction, Quality of Life, Inflammation
- Trial name
- NCT01642576
- Testing
- weight loss counselling
- Where
- Singapore
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Changi General Hospital
Cushing Syndrome
Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome
This is a prospective, multi-center, case-control study where neurocognitive function will be evaluated in 36 patients with Cushing syndrome (CS) and 36 controls matched for age, gender and education.
- Trial name
- NCT03211624
- Where
- 3 sites in Netherlands, Spain and 1 more
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Type 1 Diabetes
Identification of β Cell Dysfunction in Relatives of Individuals With Type 1 Diabetes Mellitus
Despite the valuable information derived from older studies evaluating type 1 diabetes, the diabetes research community has, in large part, overlooked potential contributions of baseline abnormalities in β cell function to T1D…
- Trial name
- NCT04362917
- Testing
- There is no intervention
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Indiana University
Diabetic Foot Ulcer, Temporomandibular Disorder
Temporomandibular Dysfunction in Patients With Diabetic Foot Ulcers
The aim of this observational study is to investigate the effects of the type, area and duration of ulceration on jaw pain, mandibular function limitation, TMD and swallowing in individuals with diabetic foot ulcers.The main…
- Conditions
- Diabetic Foot Ulcer, Temporomandibular Disorder, Swallowing Disorder
- Trial name
- NCT06067022
- Testing
- observation
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Harran University
Diabetes, Proteinuria
The Effect of Renin Angiotensin System Blockage (RAS) Blockade On PTX3 Levels In Diabetic Patients With Proteinuria
Long pentraxin 3 (PTX3) is a recently discovered multimeric inflammatory mediator structurally linked to CRP and serum amyloid P-component.
- Conditions
- Diabetes, Proteinuria, Renin Angiotensin System
- Trial name
- NCT00674596
- Testing
- ramipril
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Diabetes Mellitus Type 2
Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery
The present protocol aims to understand and establish whether there is a causal link between adipose tissue metabolic remodeling and Type 2 Diabetes (T2D) remission after bariatric surgery.
- Trial name
- CB5 (NCT05934409)
- Testing
- Bariatric surgery, Nicotinic Acid
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Lipodystrophy
Study of Alpha-2 Adrenergic Receptor Dysfunction in Regional Lipoatrophy
OBJECTIVES: I. Determine the response in plasma norepinephrine concentration and plasma glycerol to the agonist (clonidine) and the antagonist (yohimbine) of the alpha-2 adrenergic receptor in 6 patients with regional lipoatrophy…
- Trial name
- NCT00004329
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Diabetic Autonomic Neuropathy Type 2, Perioperative Complication
Effect of Diabetes Mellitus on Cardiac Autonomic Function in Surgical Patients Undergoing General Anesthesia
Because autonomic neuropathy affects the constriction of thermoregulatory blood vessels, it is more difficult for diabetic patients to maintain their own body temperature in cold environments than normal people, and therefore it…
- Conditions
- Diabetic Autonomic Neuropathy Type 2, Perioperative Complication, Temperature Change, Body
- Trial name
- NCT06432270
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital