Clinical trials: Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia
LDL Cholesterol, Triglycerides
Safety and Efficacy of a Natural Health Product in Reducing Cholesterol and Triglyceride Levels.
The purpose of this study is to assess the safety and efficacy of a natural health product among participants with elevated LDL cholesterol and triglyceride levels.
- Trial name
- NCT01028274
- Testing
- Investigational Product 1, Investigational Product 2
- Where
- Canada
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Nordic Pharma, USA
Non-alcoholic Steatohepatitis, Hypertriglyceridemia
Open-Label Study To Evaluate MN-001 on HDL & Triglyceride in NASH & NAFLD Subjects
This is a multi-center, proof-of-principle, open-label study designed to evaluate the efficacy, safety, and tolerability of MN-001 in non-alcoholic steatohepatitis (NASH) and Non-Alcoholic Fatty Liver Disease (NAFLD) subjects…
- Conditions
- Non-alcoholic Steatohepatitis, Hypertriglyceridemia, Non-alcoholic Fatty Liver Disease, Hypercholesterolemia
- Trial name
- NCT02681055
- Testing
- MN-001
- Where
- 3 sites in United States
- Volunteers
- 19 people
- Sponsor
- MediciNova
Hypertension, Metabolic Syndrome
WB-EMS Effects on Cardiometabolic Risk Factors
From the age of 50 onwards, there is a disproportionate decline in muscle strength, mass and function, which can be prevented or at least delayed by physical training.
- Conditions
- Hypertension, Metabolic Syndrome, Hypercholesterolemia, Hypertriglyceridemia
- Trial name
- NCT07406191
- Testing
- WB-EMS, Control
- Where
- 2 sites in Germany
- Volunteers
- 28 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Dyslipidemia
A Study to Assess the Efficacy and Safety of ETC-1002 in Subjects With Elevated Blood Cholesterol and Either Normal or Elevated Triglycerides
This Phase 2 proof-of-concept study will assess the lipid regulating efficacy and safety of ETC-1002 in subjects with hypercholesterolemia and either normal or elevated triglycerides.
- Trial name
- NCT01262638
- Testing
- ETC-1002
- Where
- 11 sites in United States
- Volunteers
- 177 people
- Sponsor
- Esperion Therapeutics, Inc.
Dyslipidemia, Hypercholesterolemia
Pilot Study To Assess CAT-2003 in Patients With Hyperlipidemia
The purpose of this study is to determine the safety and efficacy of different doses of CAT-2003 in patients with hyperlipidemia when CAT-2003 is taken for 4 weeks.
- Conditions
- Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia
- Trial name
- PATHWAYS I (NCT01912560)
- Testing
- CAT-2003, Statin
- Where
- 14 sites in United States, Canada
- Volunteers
- 99 people
- Sponsor
- Catabasis Pharmaceuticals
Morbid Obesity, Obstructive Sleep Apnea
Laparoscopic Adjustable Gastric Banding With Truncal Vagotomy
Laparoscopic Adjustable Gastric Banding (LAGB) is a gold standard in the surgical treatment of morbid obesity. We hypothesize that the addition of truncal vagotomy (cutting of nerves to the stomach) will produce greater weight…
- Conditions
- Morbid Obesity, Obstructive Sleep Apnea, Hypertension, Urinary Incontinence
- Trial name
- NCT00329862
- Testing
- Laparoscopic Truncal Vagotomy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Central Carolina Surgery, PA
Pediatric Homozygous Familial Hypercholesterolemia (HoFH), Severe Hypertriglyceridemia (HTG)
Compassionate Use of Evinacumab
Provide compassionate use of evinacumab
- Conditions
- Pediatric Homozygous Familial Hypercholesterolemia (HoFH), Severe Hypertriglyceridemia (HTG), Dysbetalipoproteinemia (DBL)
- Trial name
- NCT06500598
- Testing
- Evinacumab
- Sponsor
- Regeneron Pharmaceuticals
Overweight and Obesity, Hypercholesterolemia
Effect of Silibinin(A) as a Potential Anti-obesity Agent
Our preliminary reports have found in silico and in vitro that the milk thistle derivative Silibinin(A) is able to inhibit pancreatic lipase, in a similar way that the classical anti-obesity drug orlistat.
- Conditions
- Overweight and Obesity, Hypercholesterolemia, Hypertriglyceridemia
- Trial name
- NCT05069298
- Testing
- Silibinin A
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
HIV Infections, Hypercholesterolemia
Garlic in Hyperlipidemia Caused by HAART
The purpose of this study is to test the effectiveness and tolerability of garlic pills in lowering cholesterol and triglycerides in hyperlipidemic HIV-infected individuals who are being treated with highly active antiretroviral…
- Conditions
- HIV Infections, Hypercholesterolemia, Hypertriglyceridemia, Hyperglycemia
- Trial name
- NCT00029250
- Testing
- Garlic powder standardized to allicin
- Where
- 2 sites in United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Dyslipidemias, Hypertriglyceridemia
Effects of Phytoestrogen From Pueraria Mirifica in Improvement of Serum Lipid Parameters in Postmenopausal Women
The goal of this clinical trial is to learn about the effects of phytoestrogen from Pueraria Mirifica in improvement of serum lipid parameters.
- Conditions
- Dyslipidemias, Hypertriglyceridemia, Hypercholesterolemia, Hyper-LDL-cholesterolemia
- Trial name
- NCT06220266
- Testing
- Phytoestrogen, Diet control & life style modification
- Where
- Thailand
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Dhurakij Pundit University
Hypercholesterolemia, Hypertriglyceridemia
Beef in an Optimal Lean Diet (BOLD) Effects on Cardiovascular Disease (CVD) Risk
The study is designed to assess the effects of a heart-healthy diet that includes lean beef as the primary source of high quality protein on risk factors for cardiovascular disease.
- Trial name
- BOLD (NCT00937898)
- Testing
- BOLD+ Diet, BOLD diet
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Penn State University
Hypercholesterolemia
LDL-Cholesterol Lowering Effect of KB2115 as Add on to Ezetimibe
Eprotirome (KB2115) is a liver selective thyroid hormone that can induce hyperthyroidism in the liver, while an euthyroid state is preserved in the extrahepatic tissue.
- Trial name
- NCT00677248
- Testing
- Eprotirome and ezetimibe
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Karo Bio AB
Primary Hypercholesterolemia, Mixed Hyperlipemia
Study of SHR-1209 in the Treatment of Hypercholesterolemia and Hyperlipidemia Ⅲ Stage
The study is ongoing to evaluate the efficacy and safety of SHR-1209 in patients with hypercholesterolemia and hyperlipemia.
- Trial name
- NCT04849000
- Testing
- SHR-1209
- Where
- China
- Volunteers
- 709 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Hyperlipidemias
Effect of Lapaquistat Acetate Combined With Fenofibrate on Blood Cholesterol Levels
The purpose of this study is to compare changes in cholesterol levels in patients with elevated blood cholesterol with administration of lapaquistat acetate, once daily (QD), and fenofibrate.
- Trial name
- NCT00813527
- Testing
- Lapaquistat acetate and fenofibrate, Fenofibrate
- Where
- 36 sites in United States, Canada
- Volunteers
- 213 people
- Sponsor
- Takeda
Hypercholesterolemia, Hypertriglyceridemia
Study of Ezetimibe and Fenofibrate in Patients With Mixed Hyperlipidemia (0653-036)(COMPLETED)
The purpose of this study is to assess the cholesterol lowering safety and effectiveness of two investigational drugs in patients with mixed hyperlipidemia (high cholesterol and high triglycerides).
- Trial name
- NCT00092573
- Testing
- MK0653, ezetimibe, Comparator: fenofibrate monotherapy
- Volunteers
- 576 people
- Sponsor
- Organon and Co
Hypercholesterolemia
Long-term Comparison of Pitavastatin/Ezetimibe and Pitavastatin in Patients With Hypercholesterolemia and Elevated Triglycerides
A multicenter, randomized, double-blind, phase Ⅳ study to evaluate the long-term efficacy and safety of Pitavastatin/Ezetimibe and Pitavastatin in patients with hypercholesterolemia with elevated triglycerides
- Trial name
- NCT07442630
- Testing
- Pitavastatin 4mg, Ezetimibe 10 mg
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- JW Pharmaceutical
Gut Microbiota, Hyperglycemia
Sustainable-psycho-nutritional Intervention Program and Its Effects on Health Outcomes and the Environment
Mexico is going through a major environmental and nutritional crisis, which is related to unsustainable dietary behaviors. Sustainable diets could solve both problems together.
- Conditions
- Gut Microbiota, Hyperglycemia, Hypercholesterolemia, HDLC
- Trial name
- NCT05457439
- Testing
- Sustainable diet promotion through behavioral change intervention
- Where
- Mexico
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Metabolic Syndrome, Hypercholesterolemia
Crocus Sativus (Saffron) and Berberis Vulgaris (Barberry Fruit) in Metabolic Syndrome
The metabolic syndrome is associated with increased risk of cardiovascular disease and diabetes mellitus. The age-adjusted prevalence of the metabolic syndrome in the United States is 34% for men and 35% for women.
- Conditions
- Metabolic Syndrome, Hypercholesterolemia, Hypertriglyceridemia, Hyperglycemia
- Trial name
- NCT01625442
- Testing
- Saffron tablet, Barberry tablet
- Where
- Iran
- Volunteers
- 732 people
- Sponsor
- Birjand University of Medical Sciences
Hypercholesterolemia, Hypertriglyceridemia
Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia
VT-20101 is an Open-label, Phase 1b, Single-ascending dose study that will evaluate the safety of VERVE-201 administered to patients with Refractory Hyperlipidemia.
- Conditions
- Hypercholesterolemia, Hypertriglyceridemia, Refractory Hyperlipidemia
- Trial name
- NCT06451770
- Testing
- VERVE-201
- Where
- 18 sites in United States, Australia and 4 more
- Volunteers
- 132 people
- Sponsor
- Verve Therapeutics, Inc.
Dyslipidemias, Familial Hypercholesterolemia
Study of ARO-ANG3 in Healthy Volunteers and in Dyslipidemic Patients
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetcs and pharmacodynamics of single- and multiple doses of ARO-ANG3 in healthy adult volunteers and in dyslipidemic patients including familial…
- Conditions
- Dyslipidemias, Familial Hypercholesterolemia, Hypertriglyceridemia
- Trial name
- NCT03747224
- Testing
- ARO-ANG3, sterile normal saline (0.9% NaCl)
- Where
- 6 sites in Australia, New Zealand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Arrowhead Pharmaceuticals