Clinical trials: Dyslipidemia
Hypercholesterolemia
Screening for Hypercholesterolemia in Children Using Dried Blood Spot
Purpose: Heterozygous Familial Hypercholesterolemia (HeFH) is a common genetic disease responsible for premature atherosclerosis.
- Trial name
- CHOLESPOT (NCT05191355)
- Testing
- blood test
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Overweight and Obesity, Prediabetes
Effects of Biofunctional Orange Juice on Cardiometabolic Risk Markers
The effects of orange juice enriched with vitamin D3 and encapsulated probiotics (Lacticaseibacillus casei Shirota and Lacticaseibacillus rhamnosus GG) compared to conventional orange juice on several cardiometabolic and…
- Conditions
- Overweight and Obesity, Prediabetes, Hypertension, Dyslipidemias
- Trial name
- NCT06114576
- Testing
- Orange juice enriched with vitamin D3 and encapsulated probiotics, Conventional orange juice
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Agricultural University of Athens
Hyperlipidemia, Diabetes
Tele-Pharmacy Intervention to Improve Treatment Adherence
The purpose of this cluster randomized controlled trial is to evaluate whether a novel tele-pharmacist-based intervention for patients with hyperlipidemia, hypertension, and diabetes improves medication adherence, disease…
- Conditions
- Hyperlipidemia, Diabetes, Hypertension
- Trial name
- STIC2IT (NCT02512276)
- Testing
- Telepharmacist intervention
- Where
- United States
- Volunteers
- 4,078 people
- Sponsor
- Brigham and Women's Hospital
Postprandial Hyperglycemia, Lipidemia
Black Rice Anthocyanin in Mixed Meals: Influence on Postprandial Glycaemic and Lipid Responses Among Healthy Individuals
The diabetes epidemic is a pertinent concern globally. The prevalence of this metabolic disease among adults had been disclosed by the World health Organisation (WHO), reporting a total of 422 million diabetic adults and 3.7…
- Trial name
- NCT04063137
- Testing
- Anthocyanin fortified bread with beef patty (35% fat)
- Where
- Singapore
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Lipoprotein Lipase Deficiency
Lipoprotein Lipase Enzyme Activity Assay Validation and Clinical Assessment
This study plans to learn more about measuring Lipoprotein lipase (LPL) activity in humans. LPL is an enzyme in the breakdown of certain types of fats into smaller parts.
- Trial name
- NCT02656095
- Testing
- Heparin
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
HIV Seropositivity, Dyslipidemias
COPANA - A09 PCSK 9 Substudy: Impact of Protease Inhibitors on PCSK9 Levels in Naive HIV-Infected Patients
Evaluation of the impact of initiation of protease inhibitor/ritonavir on PCSK9 levels in HIV-infected antiretroviral-naïve patients from the ANRS C09 COPANA cohort.
- Conditions
- HIV Seropositivity, Dyslipidemias, PCSK9
- Trial name
- COPANA (NCT03139630)
- Where
- France
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Franck Boccara
End Stage Renal Disease, Chronic Kidney Disease
Palm Tocotrienols in Chronic Hemodialysis (USA)
Patients undergoing chronic hemodialysis are at increased risk for cardiovascular disease, attributed in part to increased oxidative stress, inflammation and dyslipidemia.
- Trial name
- PATCH (NCT02358967)
- Testing
- TRF (Tocotrienol-rich-fraction)
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Wayne State University
Hypercholesterolemia, Diabetes Insipidus
Effect of Statin Treatment on Urinary AQP2 (uAQP2/01)
The purpose of this study is to test the hypothesis that the function and/or regulation of urinary aquaporin 2 in hypercholesterolemic humans is affected by standard statin therapy, as compared with diet alone
- Trial name
- uAQP2/01 (NCT02523001)
- Where
- Italy
- Volunteers
- 37 people
- Sponsor
- University of Bari
Hyperprolactinemia, Weight Gain
Reversal of Antipsychotic-Induced Hyperprolactinemia, Weight Gain, Hyperglycemia and Dyslipidemia
This is a prospective, open-label study to evaluate the efficacy and safety in reducing antipsychotic-induced hyperprolactinemia, weight gain, and dyslipidemia by aripiprazole.
- Conditions
- Hyperprolactinemia, Weight Gain, Dyslipidemia
- Trial name
- NCT00541554
- Testing
- Abilify (aripiprazole)
- Sponsor
- Genovate Biotechnology Co., Ltd.,
Hypercholesterolemia, Familial
Is Family Screening Improved by Genetic Testing of Familial Hypercholesterolemia
To test the hypothesis that in patients with a clinical diagnosis of familial hypercholesterolemia (FH), genetic testing and identification of a causative mutation might enhance the success of family-based cascade screening.
- Trial name
- IFIGhTFH (NCT04526457)
- Testing
- Standard of Care, Genetic Testing
- Volunteers
- 240 people
- Sponsor
- University of Pennsylvania
Lipid Disorders
Lipoprotein Interactions and Platelet Function in Healthy Individuals and Those With Lipid Disorders
This study looks at how lipoproteins, which are particles in the blood that transport cholesterol, influence heart and blood vessel health.
- Trial name
- NCT06747000
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Cardiovascular Diseases, Heart Diseases
Pharmacogenetics of Hypertriglyceridemia in Hispanics
To study the effect of genes on lipid-lowering drug treatment in hypertriglyceridemia.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertriglyceridemia
- Trial name
- NCT00086437
- Volunteers
- 274 people
- Sponsor
- University of California, Los Angeles
Hypercholesterolemia
A Study to Evaluate the Effects of Ezetimibe (MK-0653) on the Postprandial (Following a Meal) Lipoprotein Response in Participants With Primary Hypercholesterolemia (High Cholesterol) (MK-0653-072)(COMPLETED)
A study to evaluate the cholesterol-lowering effects of ezetimibe in participants with primary hypercholesterolemia (high cholesterol) after eating a meal that is high in cholesterol.
- Trial name
- NCT00101439
- Testing
- ezetimibe
- Volunteers
- 58 people
- Sponsor
- Organon and Co
Hyperlipidemias
Centralized Prescribing for Statins
This pilot study consists of a pair of pragmatic clinical trials that will evaluate two separate methods for optimizing referral of eligible patients to a centralized pharmacy service for statin management: 1) A stepped wedge…
- Trial name
- NCT05537064
- Testing
- Non-visit Based Intervention, Visit-Based Intervention
- Where
- United States
- Volunteers
- 1,950 people
- Sponsor
- University of Pennsylvania
Waist, Hypertriglyceridemic
Dietary Incorporation of Lentils to Improve Metabolic Health
Approximately 40% of Americans are pre-diabetic or diabetic, mostly in the form of type 2 diabetes (T2D), which is heavily influenced by diet.
- Trial name
- NCT04448067
- Testing
- Dietary Lentil Intake, No Dietary Lentil CONTROL
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Montana State University
Tumors of the Central Nervous System, Childhood Cancer Survivors
Cardiovascular Disorders and Risk Factors in Childhood Cranial and Craniospinal Tumors Survivors
The purpose of research is to study to adverse cardiovascular disorder and risks factors in childhood cranial and craniospinal tumors survivors.
- Trial name
- NCT05641636
- Testing
- 12-lead ECG, hormone and lipid blood tests, echocardiography (Echo-CG), cardiopulmonary exercise testing (CPET) and pulse wave analysis
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Hypercholesterolemia, Dyslipidaemia
Rosuvastatin Versus Atorvastatin in the Treatment of Hypercholesterolaemia in African American Subjects(ARIES)
The purpose of this study is to compare the effect of 6 weeks of treatment with Rosuvastatin with 6 weeks of treatment with Atorvastatin in African American subjects with hypercholesterolemia.
- Trial name
- ARIES (NCT00653744)
- Testing
- Rosuvastatin, Atorvastatin
- Volunteers
- 1,700 people
- Sponsor
- AstraZeneca
Familial Hypercholesterolemia
Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Patients With Familial Hypercholesterolemia
The main objective of this pilot study is to evaluate the effects of the Brazilian Cardioprotective Diet (DICA Br) supplemented or not with phytosterols and/or krill oil in patients with a probable or definitive diagnosis of…
- Trial name
- DICA-HF (NCT05695937)
- Testing
- phytosterol, krill oil
- Where
- 9 sites in Brazil
- Volunteers
- 58 people
- Sponsor
- Hospital do Coracao
Atherosclerosis, Cardiovascular Diseases
Cholesterol Reduction in Seniors Program (CRISP)
To conduct a pilot study to determine whether lowering elevated serum cholesterol levels with 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG CoA) reductase inhibitors reduced mortality due to the sequelae of atherosclerotic…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Coronary Disease, Heart Diseases
- Trial name
- NCT00000477
- Testing
- lovastatin
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypercholesterolemia
Study of Efficacy and Safety of Inclisiran in Asian Participants With Atherosclerotic Cardiovascular Disease (ASCVD) or ASCVD High Risk and Elevated Low Density Lipoprotein Cholesterol (LDL-C)
A multicenter study to evaluate safety and efficacy of inclisiran in Asian patients with ASCVD or ASCVD high risk and elevated LDL-C
- Trial name
- NCT04765657
- Testing
- inclisiran sodium
- Where
- 45 sites in China, Singapore and 2 more
- Volunteers
- 345 people
- Sponsor
- Novartis Pharmaceuticals