Clinical trials: Dysphoria
Gender Dysphoria, Emotion Regulation
Internet-delivered Treatment for Transgender Individuals With Co-occurring Mental Health Problems
This project aims to develop and evaluate if an internet delivered psychological intervention for transgender individuals undergoing assessment for gender dysphoria and a support person, is feasible, acceptable and effective in…
- Conditions
- Gender Dysphoria, Emotion Regulation, Internet Delivered Treatment
- Trial name
- IERGD (NCT05534763)
- Testing
- IERGD, IER SUPPORT
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Karolinska Institutet
Gender Incongruence, Cardiovascular Disease (CVD) Risk Factors
Cardiomodulatory Effects of Gender-Affirming Hormone Therapy
Gender-affirming hormone therapy is today a well-established treatment for individuals experiencing gender-incongruence. However, little is known about the long-term effects of gender-affirming hormone therapy on the…
- Trial name
- CARMEN (NCT07128771)
- Where
- Norway
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Gender Dysphoria
Evaluation of the Effectiveness of Hormonal Treatment in Adolescents Suffering From Gender Dysphoria
Gender dysphoria (GD) is a significant suffering lasting more than 6 months in a subject, with regard to the discrepancy felt between his or her gender identity and his or her birth sex.
- Trial name
- TRANSADO (NCT06351501)
- Testing
- hormonal treatment with cross sex hormones (testosterone or oestrogenes) started at 14 years old +/- 6 months, Cross sex hormones ( œstrogenes or testosterone) started at 15.5 years old +/- 6 months
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gender Dysphoria
Gender Dysphoria Among Adolescents (Norwegian Title: Kjønnsdysfori Blant Ungdom)
The aim of this study is to explore how gender dysphoria is experienced among adolescents aged 13 - 18 from a clinical population. The method is qualitative, with a phenomenological approach.
- Trial name
- NCT03643120
- Testing
- Qualitative interview
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Gender Dysphoria
Trans Care: An Online Intervention to Reduce Symptoms of Gender Dysphoria
The current project aims to improve the well-being of trans and nonbinary (TNB) individuals through an online intervention (Trans Care) targeting the reduction of symptoms of gender dysphoria.
- Trial name
- NCT05903911
- Testing
- Trans Care Web App
- Where
- United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Gender Dysphoria
Acoustic and Perceptual Effects of Intonation Training in Gender Diverse People
The aim of this project is to investigate the short- and the longer-term effect of intonation training on vocal characteristics, listener perceptions and patient related outcome measures (PROMS) in gender diverse people using a…
- Trial name
- B6702021001262 (NCT05204732)
- Testing
- Intonation training
- Where
- Belgium
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University Ghent
Postoperative Bleeding, Gender Dysphoria
Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy
The purpose of this study is to determine if applying a single dose of topical estrogen cream in the operating room at the end of your hysterectomy (removal of uterus and cervix) improves the postoperative experience with…
- Conditions
- Postoperative Bleeding, Gender Dysphoria, Hysterectomy
- Trial name
- NCT06969326
- Testing
- Use of topical estradiol, No intervention
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Gender Dysphoria
Patient Reported Outcome on Genital Sensitivity and Sexual Function After Genital Gender Affirming Surgery
For genital gender affirming surgery, it remains unclear to what extent genital sensitivity might be expected and what the impact of this might be on sexual functioning.
- Trial name
- PROGAS (NCT04993469)
- Testing
- Semmes-Weinstein monofilament testing and questionnaires
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- University Hospital, Ghent
Dysphoria
Neuromodulation for Dysphoria
This is an open label prospective pilot study of two neuromodulation interventions for patients suffering from dysphoria. Dysphoria is a transdiagnostic symptom of unease or dissatisfaction experienced across a range of…
- Trial name
- NCT05061745
- Testing
- Guided Meditation VR for Wellness, Accelerated Transcranial Magnetic Stimulation: MagVenture Transcranial Magnetic Stimulation (Treatment Coil Cool B70 AP), Accelerated Transcranial Magnetic Stimulation: MagVenture Transcranial Magnetic Stimulation (Cool D-B80 AP)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Florida State University
Rokitansky Kuster Hauser Syndrome, Vaginal Neoplasms
Peritoneum Vaginoplasty; Implementation According to IDEAL Framework
This study aims to assess if a single flap peritoneum vaginoplasty is safe and feasible.The IDEAL framework for evaluation and implementation of surgical techniques will be used.
- Conditions
- Rokitansky Kuster Hauser Syndrome, Vaginal Neoplasms, Gender Incongruence, Vaginal Obstruction
- Trial name
- PeriVaS (NCT05925361)
- Testing
- Laparoscopic pedicled single flap peritoneum vaginoplasty
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- Amsterdam UMC, location VUmc
Dysphoric Mood
Components of Placebo Effects in Sadness
Research has shown that placebo effects contribute substantially to clinical outcomes. Recent evidence suggests that placebos remain effective even if they are openly described as placebos (so-called Open-Label Placebos).
- Trial name
- COPES (NCT03507959)
- Testing
- OLP scientifically-objective, OLP personally-affective, DP scientifically-objective
- Where
- Germany
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Gender Dysphoria
Effect of Nitropaste in Chest Masculinizing Surgery
Nitropaste is a topical agent that contains 2% nitroglycerin. It is an effective vascular smooth dilator, with more powerful effect on venous vasculature than arterial vasculature.
- Trial name
- NCT06428669
- Testing
- Nitro-Bid 2 % Topical Ointment
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- University of Virginia
Gender Identity, Gender Dysphoria
Pubertal Blockade and Hormone Therapy in Transgender Youth
This study will enroll female-to-male transgender youth who are and are not on a puberty blocker (gonadotropin-releasing hormone analogue) at baseline and 1 and 12 months after starting testosterone.
- Conditions
- Gender Identity, Gender Dysphoria, Gender Identity Disorder in Adolescence and Adulthood
- Trial name
- PUBErTY (NCT03557268)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Colorado, Denver
Transgender, Gender Incongruence
China Gender-affirming Hormone Therapy Study
Data about transgender medical care, especially the gender-affirming hormone therapy (GAHT) is extremely insufficient in China. Few evidence exists in the physical and psychological effects of the hormonal treatment in Chinese…
- Trial name
- CGAHT (NCT05318755)
- Testing
- GAHT for transgender men, GAHT for transgender women
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Gender Dysphoria
Development of Effective, Opioid Sparing Techniques for Peri-operative Pain Management of Transgender Patients Undergoing Gender Affirming Surgeries
This study will compare the current standard-of-care pain treatment regimen options that are available to patients who undergo gender-affirming surgery.
- Trial name
- NCT04979338
- Testing
- Ultrasound guided Continuous Infraclavicular Brachial Plexus Block, Ultrasound guided Continuous Femoral Nerve Block, Ultrasound guided Pudendal Nerve Block
- Where
- United States
- Volunteers
- 640 people
- Sponsor
- Cedars-Sinai Medical Center
Gender Dysphoria, Adolescent
Psychological Vulnerabilities and Transgender Adolescents: A Descriptive Epidemiology Study
The number of adolescents engaging in a transidentity journey has been increasing rapidly over the last decade. However, the knowledge of the medical world concerning the specificities of these adolescents is still too little in…
- Trial name
- VATED (NCT05126134)
- Testing
- KSADS (Kiddie Schedule for Affective Disorders and Schizophrenia)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Toulouse
Stigma, Social, Gays
An LGBT-Competency Program for Mental Health Professionals in Romania
Lesbian, gay, bisexual and transgender individuals (LGBTI) present increased morbidity compared to the general population, which is attributed to healthcare discrimination and lack of LGBT-specific expertise, especially in…
- Conditions
- Stigma, Social, Gays, Lesbians, Bisexuals
- Trial name
- NCT03602222
- Testing
- Mobile web training LGBT mental health, In-person training LGBT mental health
- Where
- Romania
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Testicular Cancer, Testicular Torsion
Prospective Observational Study on SEBBIN Silicone Gel-filled Testicular Implants
To analyze the short and long term postoperative clinical outcome and patient satisfaction of silicone gel-filled testicular implants.
- Conditions
- Testicular Cancer, Testicular Torsion, Gender Dysphoria, Undescended Testes
- Trial name
- NCT05097820
- Testing
- Placement of testicular prosthesis
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Gender Dysphoria Vaginoplasty Sexuality
Sexual Function of Trans Women After Vaginoplasty
Genital feminine affirming surgery may be an important step for transgender women. Vaginoplasty consists in the creation of external female genitalia and an operational vaginal cavity, and thus responds to major functional and…
- Trial name
- GGAS-SEX (NCT05292820)
- Testing
- Validated and non-validated questionnaire for exploration of sexuality and satisfaction after surgical procedure
- Where
- 3 sites in France
- Volunteers
- 158 people
- Sponsor
- Hospices Civils de Lyon
Fertility Preservation, Parenting
Fertility Desires and Reproductive Needs of Transgender People
Majority of transgender and gender nonconforming people seeking medical care are in pubertal and reproductive age. Cross-sex hormones may compromise fertility especially when preceded by puberty blocking regimen.
- Conditions
- Fertility Preservation, Parenting, Gender Dysphoria
- Trial name
- PaFer (NCT03836027)
- Testing
- No intervention
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France