Clinical trials: Dyspnoea
Dyspnea
Effect of Non Invasive Brain Stimulation on Experimentally Induced Dyspnea (Breathlessness)
Dyspnea is a frequent, mostly unpleasant and long-lasting, but also often undertreated symptom. Transcranial direct current stimulation (tDCS), a new non invasive method to modify brain activation has shown good efficacy in the…
- Trial name
- tDCS-Dyspnea (NCT01892553)
- Testing
- tDCS
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Shortness of Breath
Effect of Senobi Versus Buteyko Technique on Functional Performance of Chronic Obstructive Pulmonary Disease Patient.
Effect of Senobi breathing exercise versus Buteyko breathing technique on functional performance among chronic obstructive pulmonary patient.
- Trial name
- NCT06196957
- Testing
- pursed lip breathing
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Chronic Obstructive Pulmonary Disease (COPD), Heart Failure
Breathlessness Patterns in Patients With Cancer, COPD and Heart Failure: an fMRI Feasibility Study
Dyspnea that persists despite optimal pathophysiological treatment is defined as persistent dyspnea. Currently all brain functional magnetic resonance imaging (fMRI) studies conducted to evaluate breathlessness have done so using…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Heart Failure, Cancer, Volunteers
- Trial name
- BREACH-fMRI (NCT07319039)
- Testing
- Cerebral fMRI, Immersive virtual reality
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Dyspnea
Trial of a Breathlessness Intervention Service for Intractable Breathlessness
The aim of this study is to evaluate the impact of a Breathlessness Intervention Service (BIS) on the quality of life of patients and families affected by intractable breathlessness.
- Trial name
- NCT00678405
- Testing
- Breathlessness Intervention Service, Best supportive care (Standard Care)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
COPD, Dyspnea
Ventilation Imbalances in Mild to Moderate Chronic Obstructive Pulmonary Disease
The Investigators plan a single center study to get preliminary data to answer a number of fundamental questions directly related to management of COPD.
- Conditions
- COPD, Dyspnea, Respiratory Disease, Lung Diseases
- Trial name
- VAPOR (NCT04880551)
- Testing
- Fluoroscopy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University
Acute Viral Bronchiolitis
Slow Expiratory Technique to Improve Alimentation in Children With Bronchiolitis
The purpose of this study is to determine wether a single chest physiotherapy session with slow expiratory technique (SET) improves infants with viral bronchiolitis quality of life (food intake and sleep) on the next 24 hours.
- Trial name
- BRONCHIOL-EAT (NCT03738501)
- Testing
- Chest physiotherapy with SET, Standard Treatment
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Groupe Hospitalier du Havre
Lung Cancer
Maximal Exercise Capacity and Extra-pulmonary Characteristics in Patients With Lung Cancer With Complete Remission .
While lung cancer are rare disease in the early 20th century, its incidence increased in parallel with the increase in smoking habits. It is the most common type of cancer in the world.
- Trial name
- NCT03838757
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Heart Failure, Congestive, Dyspnea
The DIAMOND Study: Distensibility Improvement And Remodeling in Diastolic Heart Failure
The purpose of this study is to test the hypothesis that treatment with oral ALT-711 twice daily for 16 weeks will improve aortic distensibility, exercise tolerance, and quality of life in elderly patients with isolated diastolic…
- Conditions
- Heart Failure, Congestive, Dyspnea, Pulmonary Edema
- Trial name
- NCT00043836
- Testing
- ALT-711
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Synvista Therapeutics, Inc
COPD (Chronic Obstructive Pulmonary Disease)
RESP-FIT: A Respiratory Muscle Strength Training Intervention for COPD
Individuals with chronic obstructive pulmonary disease (COPD) often experience dyspnea, low physical activity, and reduced quality of life.
- Trial name
- NCT07811219
- Testing
- RESPFIT Intervention
- Volunteers
- 288 people
- Sponsor
- Medical University of South Carolina
End of Life, Pain
Virtual Reality at End-of-life
The purpose of this research is to determine the effect that repeated, personalized virtual reality experiences have on symptom severity, comparing self-reported symptom severity both pre and post each session, and overtime…
- Conditions
- End of Life, Pain, Nausea, Fatigue
- Trial name
- NCT06149429
- Testing
- Personalized virtual reality experience
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- State University of New York at Buffalo
VATS, Kinesiophobia
Comparison of Early Postoperative Functional Capacity and Kinesiophobia in Patients Undergoing Thoracic Surgery Via Thoracotomy or VATS
This observational cross-sectional study aims to compare early postoperative functional capacity and kinesiophobia in patients undergoing thoracic surgery via thoracotomy or video-assisted thoracic surgery (VATS).
- Conditions
- VATS, Kinesiophobia, Thoracotomy, Thoracic Surgery
- Trial name
- NCT07647822
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people
- Sponsor
- Hacettepe University
Interstitial Lung Disease
Nebulized Fentanyl in Patients With Mild to Moderate Interstitial Lung Disease and Chronic Dyspnea
Patients with interstitial lung disease (ILD) experience distressing activity-related respiratory discomfort which is challenging to manage therapeutically.
- Trial name
- NCT03018756
- Testing
- Fentanyl Citrate
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Dr. Denis O'Donnell
Asthma, Bronchospasm
Epinephrine Inhalation Aerosol USP, a HFA-MDI Study for Assessment of Pharmacokinetics
This study examines the pharmacokinetic profile of Armstrong's proposed Epinephrine Inhalation Aerosol USP, an HFA-MDI (E004), using a stable isotope deuterium-labeled epinephrine (epinephrine-d3) to differentiate the…
- Conditions
- Asthma, Bronchospasm, Wheezing, Shortness of Breath
- Trial name
- NCT01188577
- Testing
- Epinephrine Inhalation Aerosol, HFA, Epinephrine Inhalation Aerosol
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Amphastar Pharmaceuticals, Inc.
COPD, Dyspnea
Vitabreath Pilot in Chronic Obstructive Pulmonary Disease (COPD) Patients
Dyspnea is the most common symptom limiting the ability of COPD patients to perform activities of daily living. Although there has been research involving the benefit of providing Non Invasive Ventilation (NIV) during exercise to…
- Trial name
- NCT03349437
- Testing
- Vitabreath Device, Pursed Lip Breathing
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Philips Respironics
Heart Failure, Dyspnea; Cardiac
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure
Autophagy is considered an important component of Heart failure progression. Deubiquitination enzymes play an important role in autophagy. An important regulatory process within the autophagy pathway is ubiquitination.
- Trial name
- NCT04999995
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
COPD, Emphysema
Feasibility of a Multi Component Intervention in Patients With Severe Dyspnea and Obesity
Researchers are trying to test the effectiveness and feasibility of a multicomponent lifestyle intervention to support weight loss decreases dyspnea in obese people with chronic lung disease and clinically significant…
- Conditions
- COPD, Emphysema, Lung Diseases
- Trial name
- NCT03836547
- Testing
- Coaching and Weight Loss for patients with dyspnea, Active Control
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Mayo Clinic
Cancer, COPD
SELF-BREATHE RCT for Chronic Breathlessness
A feasibility RCT comprising two groups: 1. Intervention (SELF-BREATHE in addition to standard NHS care) 2. Control group (standard / currently available NHS care)
- Conditions
- Cancer, COPD, Asthma, Bronchiectasis Adult
- Trial name
- NCT04574050
- Testing
- SELF-BREATHE
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- King's College Hospital NHS Trust
Coronary Artery Disease, Chest Pain
Arterial Stiffness for Improved Prediction of Coronary Artery Disease by Coronary CT Angiography
This study will evaluate the ability of device-estimated pulse wave velocity and machine learning methods to improve the prediction of potential symptomatic coronary artery disease
- Conditions
- Coronary Artery Disease, Chest Pain, Dyspnea, Arterial Stiffness
- Trial name
- NCT06734247
- Testing
- Coronary computer tomography angiography (CCTA), Photoplethysmography (PPG) and single-lead ECG, Brachial single cuff-based arterial stiffness
- Where
- Sweden
- Volunteers
- 156 people
- Sponsor
- Danderyd Hospital
Dyspnea, Emergencies
European Dyspnoea Survey in the EMergency Departments
Braunwald defines dyspnoea as an abnormally uncomfortable awareness of breathing. Breathing discomfort, and its varying degrees of severity, is the one of the most disturbing symptoms patients can experience; and it is one of the…
- Trial name
- EuroDEM (NCT02060799)
- Where
- 10 sites in Belgium, Finland and 8 more
- Volunteers
- 2,156 people
- Sponsor
- Hopital Lariboisière
Lung Disease, Lung Ultrasound
Point of Care Lung Ultrasound Examination in Patients With Shortness of Breath
This is a prospective, non-randomized clinical validation research study. Subjects will consent and have two ultrasounds as part of the study.
- Trial name
- NCT07046234
- Testing
- Lung ultrasound
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- GE Healthcare
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