Clinical trials: Dyspnoea
Childhood Cancer, Cancer Survivors
Diaphragm Structure and Function in Childhood Cancer Survivors
The purpose of this research is to study the feasibility of a specific training program for the breathing muscles (inspiratory muscle training) and the effects on how breathing is regulated during exercise in childhood cancer…
- Trial name
- NCT06205251
- Testing
- POWERbreathe Plus IMT
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Maryland, Baltimore
Breathlessness, COPD
Sentinel - Triaging Acute Breathlessness Using Multi-Modal Biomarkers
The Sentinel-001 study aims to identify a combination of biomarkers suitable for triage of breathlessness.
- Conditions
- Breathlessness, COPD, Asthma, Asthma Chronic
- Trial name
- NCT05304494
- Testing
- Biomarker tests for participant profiling
- Sponsor
- Sanome
Heart Failure, Congestive, Heart Decompensation
A Study of Two Doses of Intravenous NATRECOR hBNP (Nesiritide) in Patients With Worsening Congestive Heart Failure Who Have Difficulty Breathing at Rest
The purpose of this study is to assess the safety and efficacy of two doses of intravenous NATRECOR® hBNP (a recombinant form of the natural human peptide normally secreted by the heart) versus placebo in the treatment of…
- Trial name
- NCT00288730
- Testing
- nesiritide
- Volunteers
- 127 people
- Sponsor
- Scios, Inc.
Lung Diseases, Rare Non-Neoplastic Disorder
Palliative Care Coaching for Families With Rare Advanced Lung Diseases
With one of the highest incidences of lung disease deaths in the nation, there is great need for home end-of-life palliative care in the rural, disadvantaged communities of West Virginia.
- Trial name
- NCT03813667
- Testing
- Intervention FamPALcare
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- West Virginia University
COVID-19, Respiratory Disease
Radiofrequency in Patients Post Covid 19 With Respiratory Sequelae.
The sequelae that occur in post-COVID-19 patients are multiple and, at a therapeutic level, these represent a new challenge within the general context of the pandemic that the world is suffering.
- Conditions
- COVID-19, Respiratory Disease, Dyspnea, Cough
- Trial name
- NCT07184372
- Testing
- Radiofrequency and manual tecniques, Manual tecniques
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Clinica Gema Leon
SARS-CoV2 Infection, Covid19
S-Nitrosylation Therapy of COVID-19
The primary objective of this study is to provide expanded access of S-nitrosylation therapy for the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV2) infection.
- Trial name
- NCT04528771
- Testing
- SNO, Nitrogen gas
- Where
- United States
- Sponsor
- James Reynolds
Respiratory Distress of Newborn, Preterm Birth
Antenatal Dexamethasone for Late Preterm Deliveries
The goal of this clinical trial is to compare dexamethasone in late preterm deliveries. The main questions it aims to answer are: Does antenatal dexamethasone reduce the need for respiratory support in late preterm infants? Does…
- Trial name
- NCT05841121
- Testing
- Dexamethasone
- Where
- Vietnam
- Volunteers
- 294 people
- Sponsor
- Chulalongkorn University
Respiratory Muscle Weakness, Quality of Lifte
Effects of a Pulmonary and Cardiovascular Rehabilitation Program
Non-communicable chronic diseases (NCDs) affect approximately 30% of the adult global population, significantly impacting respiratory function and quality of life.
- Conditions
- Respiratory Muscle Weakness, Quality of Lifte, Dyspnea; Asthmatic, Dyspnea; Cardiac
- Trial name
- NCT06772922
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- University of Campinas, Brazil
Long COVID, Breathlessness
Long COVID and Post-exertional Pulmonary Diffusion
Aim of investigators was to study whether abnormalities of lung diffusing capacity for nitric oxide (DLNO) and carbon monoxide (DLCO) in long COVID may have a clinical impact in relation to exercise intolerance.
- Conditions
- Long COVID, Breathlessness, Exercise Intolerance, Alveolar Lung Disease
- Trial name
- Long_COVID_Ex (NCT05430503)
- Testing
- Lung volumes, spirometry and standard single-breath DLCO were measured at rest while combined DLNO and DLCO were measured at rest and post-exercise
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Copd, Fatigue
The Effect of Education and Reminder Messages on the Fatigue Level of Individuals With COPD
COPD is an important respiratory system disease that progresses with damage to the airways.Increased mucus secretion and thickening in the airways causes obstruction.This obstruction causes symptoms such as shortness of breath…
- Trial name
- NCT06286072
- Testing
- Education and message
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Pulmonary Disease, Chronic Obstructive, Chronic Bronchitis
Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients
The primary objective is to comparatively evaluate the isolated effects of a long-acting beta2-adrenergic (formoterol fumarate 12µg b.i.d.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Chronic Bronchitis, Pulmonary Emphysema
- Trial name
- NCT00680056
- Testing
- Formoterol plus Tiotropium
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Federal University of São Paulo
Lung Diseases, Cystic Fibrosis
CF Bronchodilation
It is estimated that one in every 3,600 children in Canada has cystic fibrosis (CF). CF is a genetic disease that affects the glands that produce mucus and sweat.
- Trial name
- NCT03522831
- Testing
- Salbutamol
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
ARDS
MultiStem Administration for COVID-19 Induced ARDS (MACoVIA)
Multicenter investigation featuring an open-label lead-in followed by a double blinded, randomized, placebo-controlled Phase 2/3 part to evaluate the safety and efficacy of MultiStem therapy in subjects with moderate to severe…
- Trial name
- MACoVIA (NCT04367077)
- Testing
- MultiStem
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- Healios K.K.
Exercise-Induced Laryngeal Obstruction, Dyspnea During Activity
Effect of Ipratropium Bromide on EILO
The investigators propose a study that compares breathlessness and airway obstruction during intense exercise in 34 children and adolescents with Exercise-Induced Laryngeal Obstruction after breathing in ipratropium bromide or…
- Trial name
- NCT07394036
- Testing
- Ipratropium Bromide
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Cook Children's Health Care System
Acute Dyspnea, Acute Heart Failure
Multimarker Approach for Acute Dyspnea in Elderly Patients Admitted in the Emergency Department
Elderly people constitute the largest proportion of emergency department (ED) patients, representing 12% of all ED admissions. The need for diagnostic tests or therapeutic interventions is much greater in this patient population.
- Trial name
- READ-MA (NCT04240067)
- Testing
- READ-MA Multimarker Approach
- Where
- France
- Volunteers
- 238 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Breathlessness, Dyspnea
Improving Management of Breathlessness in Patients With Lung Cancer
Many individuals with lung cancer experience debilitating breathlessness at some point during the course of their illness. Unfortunately, few interventions exist to treat this distressing symptom of cancer.
- Conditions
- Breathlessness, Dyspnea, Lung Cancer
- Trial name
- NCT01937637
- Testing
- Cognitive Behavioral Intervention for Breathlessness
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Massachusetts General Hospital
Dyspnea, Healthy Volunteers
Effects on Experimental Dyspnea of High Flow Nasal Cannula
To develop an experimental model of dyspnea by external thoraco-abdominal elastic strapping at rest in order to study the mechanisms involved in the relief of dyspnea by the administration of high flow by nasal cannula (HFNC).
- Trial name
- EDEN (NCT03469037)
- Testing
- Optiflow with an inspired fraction of oxygen of 100%, Optiflow with an inspired fraction of oxygen of 21%
- Where
- 2 sites in France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Prematurity, Mechanical Ventilation
The Effect of Breast Milk Odor and Swaddling on Physiological Parameters and Stress Levels in Premature Infants Receiving Ventilator Support
It will be done to shorten the hospital stay of the newborn and increase the quality of care by proving the positive effect of the safe wrapping method and the smell of breast milk on the physiological parameters and stress level…
- Trial name
- NCT07681934
- Testing
- Breast Milk Smell, Arson, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- KTO Karatay University
Diabetes Mellitus, Type 2, Congestive Heart Failure
Improving Patient Prioritization During Hospital-homecare Transition
This research work is focused on building and evaluating one of the first evidence-based clinical decision support tools for homecare in the United States.
- Conditions
- Diabetes Mellitus, Type 2, Congestive Heart Failure, Obstructive Pulmonary Disease, Dyspnea
- Trial name
- PREVENT (NCT04136951)
- Testing
- PREVENT clinical decision support
- Where
- 2 sites in United States
- Volunteers
- 1,915 people
- Sponsor
- Columbia University
COPD (Chronic Obstructive Pulmonary Disease)
Multidimensional Study of Dyspnea at Rest, During Exertion, Self-induced Through a Virtual Reality Scenario, and Its Placebo Effect in Patients With COPD and Control Subjects.
This quasi-experimental laboratory study aims to describe and compare the multidimensional experience of dyspnea at rest and during exertion in patients with chronic obstructive pulmonary disease (COPD) and healthy controls.
- Trial name
- DisVir (NCT07568379)
- Testing
- Induced Dyspnea via Inspiratory Muscle Loading, Virtual Reality Sensory Immersion
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Deusto
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