Clinical trials: Dyspnoea
Advanced Lung Cancer, Dyspnea
Multi-site Trial of a Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer
Dyspnea, or breathlessness, is one of the most common and distressing symptoms experienced by patients with advanced lung cancer.
- Trial name
- BREEZE+ (NCT06791057)
- Testing
- Dyspnea Intervention, Enhanced Usual Care
- Where
- 2 sites in United States
- Volunteers
- 420 people
- Sponsor
- Massachusetts General Hospital
Scleroderma, Interstitial Lung Disease
Comparison of Therapeutic Regimens for Scleroderma Interstitial Lung Disease (The Scleroderma Lung Study II)
Scleroderma is a rare, long-term autoimmune disease in which normal tissue is replaced with dense, thick fibrous tissue. Normally, the immune system helps defend the body against disease and infection.
- Trial name
- SLSII (NCT00883129)
- Testing
- Mycophenolate mofetil, Cyclophosphamide
- Where
- 14 sites in United States
- Volunteers
- 142 people
- Sponsor
- Michael Roth
Acute Dyspnoea
Comparison of CXR and MnDCT
A comparison of chest x-ray (CXR) and Minimum dose CT (MnDCT) in the acutely ill patient. The hypothesis is that MnDCT is more sensitive than CXR in the detection of acute findings in the acutely ill patient.
- Trial name
- NCT00188435
- Testing
- Minimum Dose CT
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Pneumonia, Pulmonary Edema
Prehospital Use of Ultrasound in Undifferentiated Shortness of Breath
This is a pilot observational feasibility study of the ability of paramedics to assess thoracic ultrasound findings in the prehospital environment.
- Conditions
- Pneumonia, Pulmonary Edema, Dyspnea
- Trial name
- NCT02638649
- Testing
- Lung ultrasound, ultrasound
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Yale University
Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia
Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs
Pulmonary arteriovenous malformations (PAVMs) are a rare vascular condition affecting the lungs. PAVMs lead to low blood oxygen levels, yet are very well tolerated by patients.
- Trial name
- NCT02436213
- Testing
- Cardiopulmonary exercise test, Blood test
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Respiratory Distress Syndrome, Newborn, Transient Tachypnea of the Newborn
Efficacy of Antenatal Steroids in Reducing Respiratory Morbidities in Late Preterm Infants
The hypothesis of the study is that administration of antenatal steroid to women at high risk of preterm birth after 34 weeks of gestation would reduce the risk of respiratory complications, specifically Respiratory Distress…
- Trial name
- NCT01206946
- Testing
- Betamethasone, Normal Saline
- Where
- 5 sites in Lebanon
- Volunteers
- 700 people
- Sponsor
- American University of Beirut Medical Center
Asthma (Diagnosis)
Predictive Factors for a Positive Exercise Bronchial Hyperresponsiveness Test
Exertional dyspnea has a significant impact on a child's daily life. Current guidelines recommend performing an exercise challenge test to confirm or rule out exercise-induced bronchoconstriction (EIB).
- Trial name
- PredEIB (NCT07766460)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
COPD, Dyspnea
Ventilation Imbalances in Mild to Moderate Chronic Obstructive Pulmonary Disease
The Investigators plan a single center study to get preliminary data to answer a number of fundamental questions directly related to management of COPD.
- Conditions
- COPD, Dyspnea, Respiratory Disease, Lung Diseases
- Trial name
- VAPOR (NCT04880551)
- Testing
- Fluoroscopy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University
Prematurity, Oxidative Injury
Comparison of Different Oxygen Delivery Strategies During Resuscitation of Babies
Preterm infants are born with immature lungs and often require help with breathing shortly after birth. This currently involves administering 100% oxygen.
- Conditions
- Prematurity, Oxidative Injury, Respiratory Distress
- Trial name
- NCT00356902
- Testing
- titration of oxygen during resuscitation
- Where
- Canada
- Volunteers
- 215 people
- Sponsor
- University of Calgary
Chronic Obstructive Pulmonary Disease
Internet-Based and Established Dyspnea Self-Management Programs in Chronic Obstructive Pulmonary Disease (COPD) Patients
The overall goal of this study is to compare the impact of a new Internet Dyspnea Self-Management Program (eDSMP) with an established face-to-face Dyspnea Self-Management Program (DSMP) in patients with COPD.
- Trial name
- NCT00102401
- Testing
- Internet-based Dyspnea Self-Management Program, Face-to-face Dyspnea Self-Management Program
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Robert Wood Johnson Foundation
Heart Failure, Dyspnea
NT-proBNP in Acute Dyspnea: Effects on Treatment, Hospitalisation and Costs
Diagnostic uncertainty in patients with complaints of shortness of breath presenting to the Emergency Department of a hospital may delay treatment and proper care.
- Trial name
- NCT00410293
- Testing
- NT-proBNP testing
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Erasmus Medical Center
Dyspnea, Coma
The Use of a Point-of-care Thoracic Ultrasound Protocol for Hospital Medical Emergency Teams
Study to assess the possible effects of the use of a point-of-care thoracic ultrasound protocol for hospital medical emergency teams (MET)
- Conditions
- Dyspnea, Coma, Hypotension and Shock
- Trial name
- METUS (NCT03214809)
- Testing
- ultrasound protocol
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Rijnstate Hospital
Chronic Obstructive Pulmonary Disease, Arthritis
Modifying Exercise for the COPD Patient
This study will test whether using the Biodex BioStep Semi Recumbent Elliptical for the chronic obstructive pulmonary disease (COPD) patient with arthritic limitations will improve participation in a pulmonary rehab program…
- Conditions
- Chronic Obstructive Pulmonary Disease, Arthritis, Pain
- Trial name
- NCT02143206
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Angela N Fellner PhD CCRP
Heart Failure
Myocardial Performance at Rest and During Exercise in Heart Failure With Preserved Ejection Fraction
This study is being done to study how well the heart contracts and relaxes during exercise. In addition to traditional measures of heart function, we will use a new computer program that may improve understanding of why people…
- Trial name
- X-HF-SPECKLE (NCT01747785)
- Testing
- Cardiac rehabilitation, Myocardial deformation imaging, Cardiopulmonary exercise test
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Dyspnea
Value of Transthoracic Ultrasonography (TTU) for Etiological Diagnosis of Acute Dyspnea: Cross Sectional Study
Evaluating the capability and efficiency of transthoracic ultrasound in attempting to identify the etiology of acute dyspnea.
- Trial name
- NCT05647655
- Testing
- Ultrasonography
- Where
- Egypt
- Volunteers
- 143 people
- Sponsor
- Assiut University
COPD, Dyspnea
The Effect of Transcranial Direct Current Stimulation (tDCS) on Dyspnoea Perception, Pulmonary Function and Functional Level During COPD Exacerbation
Chronic obstructive pulmonary disease (COPD) is a treatable disease characterized by irreversible and progressive airflow limitation, which is a cause of high morbidity and mortality.
- Conditions
- COPD, Dyspnea, tDCS
- Trial name
- NCT06944626
- Testing
- tDCS, Conventional physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Okan University
Diaphragmatic Paralysis, Pain, Chest
Phrenic Nerve Reconstruction for the Treatment of Diaphragmatic Paralysis: Patient Experiences and Reported Outcomes.
This study utilizes a grounded theory methodology to explore patient experiences of phrenic nerve reconstructive surgery as a treatment for diaphragmatic paralysis.
- Conditions
- Diaphragmatic Paralysis, Pain, Chest, Breath Shortness
- Trial name
- NCT06243718
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Advanced Reconstructive Surgery Alliance
Covid19
Respiratory Muscle Function, Dyspnea, Exercise Capacity and Quality of Life in Severe COVID19 Patients
Further knowledge regarding sequelae in severe COVID-19 patients who have required ICU admission for invasive mechanical ventilation is still needed.
- Trial name
- NCT04853940
- Testing
- Data collection and clinical testing of subjects
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Respiratory Distress
Efficacy and Safety of Gastric Suctioning During Neonatal Resuscitation
The stomach of the newborn baby is often emptied soon after birth to prevent breathing problems (respiratory distress). Babies born with meconium-stained amniotic fluid and those with increased secretions associated with birth by…
- Trial name
- NCT00729989
- Testing
- Gastric suctioning
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Benjamin T. Stevens
Asthma, Pneumonia
PECO Air Purification in Hospital Rooms to Improve Health Outcomes for Pediatric Respiratory Distress
This study will investigate the efficacy of a novel air purification technology, Photo Electrochemical Oxidation (PECO), has on pediatric patients hospitalized for respiratory distress.
- Conditions
- Asthma, Pneumonia, Respiratory Distress Syndrome
- Trial name
- NCT03647397
- Testing
- Photo Electrochemical Oxidation (PECO) for Air Purification
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Molekule
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