Clinical trials: Dyspnoea
COPD
Continuous Chest Wall Vibration in COPD Rehabilitation
Dyspnea, the sensation of breathing discomfort or shortness of breath, is one of the main symptoms for patients affected by Chronic Obstructive Pulmonary Disease (COPD), particularly during exercise.
- Trial name
- NCT03644888
- Testing
- Cycle ergometer training, Airway clearance program, Vibration therapy
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease
Morphine to Maximize the Benefits of Exercise Training in COPD or ILD and Persistent Breathlessness
The purpose of this study is to explore the role of low-dose immediate-release oral morphine as a novel adjunct pharmacotherapy to enable symptomatic adults with advanced chronic obstructive pulmonary disease (COPD) or…
- Trial name
- MorEx (NCT03824834)
- Testing
- Exercise training with morphine
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Dennis Jensen, Ph.D.
Dyspnea, Muscle Strain
Muscle Reflex Inhibition in Hypoxic Exercise
The goal of this interventional study is to compare muscle reflex function under settings of normoxia (normal oxygen level), acute hypoxia (brief oxygen-lack) and chronic hypoxia (long-duration exposure to oxygen-lack).
- Trial name
- NCT05619887
- Testing
- Fentanyl, Saline
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Dyspnea During Mechanical Ventilation
Automatic Detection of Dyspnea in Mechanically Ventilated, Critically Ill Patients
The investigators will conduct a prospective, observational, two-center ICU study of 60 subjects on mechanical ventilation with respiratory failure of any cause.
- Trial name
- NCT07205952
- Where
- Argentina
- Volunteers
- 60 people
- Sponsor
- Hospital de Clinicas José de San Martín
Wheezing, Dyspnea
Effectiveness of Inhaled Corticosteroids in Preschool Children With Acute Dyspnea and Wheeze
The aim of the study is to investigate whether inhaled corticosteroids after a first hospital admission for acute dyspnea and wheeze is effective in reducing subsequent episodes of these complaints in children aged 1 to 4 years.
- Trial name
- ICS@ADP (NCT00962299)
- Testing
- Beclomethasone
- Where
- Netherlands
- Volunteers
- 7 people
- Sponsor
- Princess Amalia Children's Clinic
Cancer
Non-invasive Ventilation in Terminally Ill Cancer Patients
The occurrence of acute respiratory failure (ARF) is often seen by oncologists as a terminal phase of the disease, this view being based on studies reporting limited survival at considerable costs in such patients.
- Trial name
- NCT00533143
- Testing
- non invasive ventilation (NIV)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Dyspnea, Heart Failure
Systolic Time Intervals a Prognostic Tool of Heart Failure in Emergency Departement (STI/AHF)
The performance of STIs and clinical scores alone and their combination to predict short term prognosis of acute decompensated heart failure.
- Trial name
- NCT03831204
- Testing
- biopac, prognostic scores
- Where
- Tunisia
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Healthy Volunteers
Biomarkers in Dyspnea
To explore biological mechanisms in human model of induced dyspnea, in order to remove the source of dyspnoea, to modify cerebral impact and to allow the development of targeted therapies.
- Trial name
- BIODYSPNEE (NCT03056547)
- Testing
- Induced dyspnea
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Cancer, COPD
SELF-BREATHE RCT for Chronic Breathlessness
A feasibility RCT comprising two groups: 1. Intervention (SELF-BREATHE in addition to standard NHS care) 2. Control group (standard / currently available NHS care)
- Conditions
- Cancer, COPD, Asthma, Bronchiectasis Adult
- Trial name
- NCT04574050
- Testing
- SELF-BREATHE
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- King's College Hospital NHS Trust
Chronic Obstructive Pulmonary Disease
Impact of Hypnosis Intervention on the Emotional Dimension of Dyspnea in Patients With COPD.
The purpose of the clinical study is to compare the effect of hypnosis intervention on the emotional dimension of the dyspnea during a pulmonary rehabilitation program to the pulmonary rehabilitation program alone.
- Trial name
- NCT04010825
- Testing
- Hypnosis intervention focused on the emotional dimension of the dyspnea
- Where
- 2 sites in France
- Volunteers
- 106 people
- Sponsor
- 5 Santé
Quality of Life
Effect of Breathıng Exercıse Applıed to Indıvıduals Wıth Copd on Respıratory Functıon, Dyspnea and Qualıty of Lıfe
Purpose of the research This research was designed to determine the effect of breathing exercise applied to individuals diagnosed with COPD on respiratory function, dyspnea and quality of life.
- Trial name
- NCT06706297
- Testing
- pranayama breathing exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ondokuz Mayıs University
Chronic Obstructive Pulmonary Disease
The Effect of Pursed Lip Breathing Exercise and Laughter Therapy Individuals With The COPD
Chronic Obstructive Pulmonary Disease is a chronic disease with increasing mortality, morbidity and prevalence in the world and in our country, and in which serious symptoms, especially dyspnea, develop.
- Trial name
- NCT05997550
- Testing
- Pursed Lip Breathing Exercise, Laughter Therapy, the control group.
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Yuksek Ihtisas University
Longitudinal Observational Study With 6 Months Follow-up
Longitudinal Observational Study for mIddle Term Follow-up Patients Admitted for Acute Dyspnea in TunIsia
The purpose of the SIDI study is to follow, few months after discharge from the hospital, the patients admitted to the 3 emergency departments in Tunisia for acute dyspnea and to determine the proportion and the factors favoring…
- Trial name
- SIDI (NCT04947358)
- Where
- Tunisia
- Volunteers
- 180 people
- Sponsor
- S Form Pharma
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Fentanyl Buccal Tablet or Morphine for Exertional Dyspnea in Cancer Patients
This phase II trial studies fentanyl buccal tablet or morphine to see how well it works compared to a placebo in controlling shortness of breath during or after physical activity in cancer patients.
- Trial name
- NCT04188418
- Testing
- Fentanyl Citrate Buccal Tablet, Morphine, Physical Performance Testing
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- M.D. Anderson Cancer Center
Idiopathic Pulmonary Fibrosis, Cough
Does CBT Improve the Perception/Impact of Cough and Breathlessness in IPF Patients
Idiopathic Pulmonary Fibrosis (IPF) is a chronic progressive lung disease of unknown cause for which there is no effective medical treatment.
- Conditions
- Idiopathic Pulmonary Fibrosis, Cough, Breathlessness
- Trial name
- NCT01738711
- Testing
- Cognitive behavioural therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Victoria Infirmary
Hypertension
Finding Early Predictors of Myocardial Dysfunction in Patients With Hypertension
Finding early predictors of myocardial in patients with hypertension 1. Scientific objective The study objective is to clarify the grounds of heart exertional dyspnoea stenocardial pain in patients with well-controlled stage I or…
- Trial name
- dysh (NCT01455714)
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Interstitial Lung Disease
Effects of Incentive Spirometry With and Without Aerobic Exercises in Interstitial Lung Disease
Effects of Incentive spirometry with and without Aerobic exercises on dyspnea, exercise capacity and quality of life in interstitial lung disease
- Trial name
- NCT06133998
- Testing
- incentive spirometer with aerobic exercises, incentive spirometry without aerobic exercises
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Smoking
Effect of Lower Limb Resistance Versus Endurance Training in Smokers
Patients was selected based on inclusion and exclusion criteria. Experimental group was treated with Resistance training while control group received endurance training.
- Trial name
- NCT06674174
- Testing
- lower limb strength training, endurance training
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Dyspnea, Pulmonary Disease
Prevalence and Characterization of Persistent Dyspnea After Hospitalization
The investigators aim to make an overview of persistent dyspnea at the end of an hospitalization for a respiratory disease using an actual tool, the Multidisciplinary Dyspnea Profile questionnaire.
- Trial name
- DyHP (NCT03798158)
- Testing
- Multidisciplinary Dyspnea Profile questionnaire
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Dyspnea
Emergency Classification According to Fingertip Circulation
Dyspnea is one of the most common reasons for admission to the emergency department[1]. Oxygen saturation has great importance in determining the triage status of patients admitted to the hospital with dyspnea and planning the…
- Trial name
- NCT05742113
- Testing
- Masimo Radical-7
- Where
- Turkey (Türkiye)
- Volunteers
- 1,490 people
- Sponsor
- Manisa Celal Bayar University
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