Clinical trials: Dyspnoea
Interstitial Lung Disease, Dyspnea
Palliation of Dyspnea With Morphine in Patients With Interstitial Lung Disease
36 patients with interstitial lung disease will be randomized to 1 weeks treatment with morphine hydrochloride as oral linctus 5 mg, four times a day, and 5 mg as needed up to 4 times a day, or corresponding doses of placebo.
- Conditions
- Interstitial Lung Disease, Dyspnea, Morphine
- Trial name
- MORPHILD (NCT02622022)
- Testing
- Morphine hydrochloride
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- University of Aarhus
Dyspnea
Specificity of Dyspnoea Relief With Inhaled Furosemide
This study evaluates the effect of inhaled furosemide on different types of breathlessness relief in healthy volunteers. Each volunteer inhaled mists of either furosemide or a control substance on 3 occasions per day on 2…
- Trial name
- FurosAH (NCT02881866)
- Testing
- Furosemide, Saline
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Asthma
Triple vs High Dose Inhaled CORticosteroids
Increase in inhaled corticosteroid dose vs triple therapy in T2-high asthma patients who remain uncontrolled with medium dose inhaled corticosteroids/long-acting β2 adrenergic combination: a real-life study.
- Trial name
- TRICORDA (NCT05919394)
- Testing
- To compare in both treatment arms the percentage of patients controlled at week 52.
- Where
- 17 sites in Spain
- Sponsor
- Galaxia Empírica
Pediatric Acute Respiratory Distress Syndrome (PARDS)
Role of Dyspnea in the Progression of Pediatric Acute Respiratory Distress Syndrome
Pediatric acute respiratory distress syndrome (ARDS) is a life-threatening clinical syndrome, and dyspnea is its key symptom. Strenuous respiratory effort is a "second hit" for ARDS lungs, inducing changes in regional lung…
- Trial name
- NCT07750288
- Testing
- Noninvasive respiratory support, Transition from controlled to assisted mechanical ventilation, Weaning from mechanical ventilation
- Where
- Chile
- Volunteers
- 68 people
- Sponsor
- Universidad Nacional Andres Bello
Idiopathic Pulmonary Fibrosis
Pulmonary Rehabilitation for Idiopathic Pulmonary Fibrosis
The purpose of this study is to determine the effects of Pulmonary Rehabilitation (PR) on shortness of breath, exercise capacity, symptom control, mental health, cognitive function, and quality of life in patients with Idiopathic…
- Trial name
- NCT00692796
- Testing
- Pulmonary rehabilitation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Jewish Health
Acute Heart Failure
Renal Optimization Strategies Evaluation in Acute Heart Failure and Reliable Evaluation of Dyspnea in the Heart Failure Network (ROSE) Study
The purpose of this study is to determine the benefits and safety of intravenous administration of low dose nesiritide or low dose dopamine in patients with congestive heart failure and kidney dysfunction.
- Trial name
- ROSE/RED ROSE (NCT01132846)
- Testing
- Nesiritide, Dopamine
- Where
- 8 sites in United States, Canada
- Volunteers
- 360 people
- Sponsor
- Duke University
Pulmonary Complications, Quality of Life
Theophylline in Treating Cancer Patients With Shortness of Breath
RATIONALE: Theophylline may help to relieve shortness of breath in patients who have cancer. It is not yet known whether theophylline is more effective than no further treatment for shortness of breath.
- Conditions
- Pulmonary Complications, Quality of Life, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00003684
- Testing
- theophylline, quality-of-life assessment
- Where
- 4 sites in Canada
- Volunteers
- 3 people
- Sponsor
- NCIC Clinical Trials Group
Dyspnea, Heart Failure
Registry of Patients With Acute Dyspnea in the Emergency Department
This is a prospective registry of patients presenting with acute dyspnea to the emergency department of the city hospital in Nuremberg.
- Conditions
- Dyspnea, Heart Failure, COPD
- Trial name
- NCT01910233
- Where
- Germany
- Volunteers
- 947 people
- Sponsor
- Klinikum Nürnberg
Coronavirus Infections, Pneumonia, Viral
Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID19 Infection
The scientific community is in search for novel therapies that can help to face the ongoing epidemics of novel Coronavirus (COVID-19) originated in China in December 2019.
- Conditions
- Coronavirus Infections, Pneumonia, Viral, Dyspnea
- Trial name
- NoCovid (NCT04290858)
- Testing
- Nitric Oxide
- Sponsor
- Xijing Hospital
Pneumonia in Children
Effects of Balloon Blowing Therapy and Bubble PEP on Oxygen Saturation, Dyspnea, and Enjoyment in Pediatric Pneumonia
Pneumonia is a major cause of illness and death in children, leading to breathing difficulties and reduced oxygen levels due to impaired gas exchange.
- Trial name
- NCT07578870
- Testing
- Balloon Blowing Therapy, Bubble PEP
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Respiratory Distress, Pain
Management of Pain Respiratory Distress at the End of Life in Newborn Palliative Care in the Delivery Room
The newborn feels pain and the newborn at the end of life, in the delivery room, is potentially exposed to pain and respiratory distress.
- Trial name
- PALLI-ACC (NCT05220644)
- Testing
- Protocols for the management of end-of-life symptoms
- Where
- 4 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Early Stage Breast Carcinoma, Dyspnea
Inspiratory Muscle Training for Breast Cancer Patients on Chemotherapy
This clinical trial studies whether breathing exercises for the muscles that help with breathing air in, inspiratory muscle training (IMT), works to improve breathing muscle strength, shortness of breath, and physical activity…
- Trial name
- IMACT (NCT07386444)
- Testing
- Inspiratory muscle training
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Acute Respiratory Failure, Respiratory Insufficiency
HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport
The HERMES Phase III study is an international, multicenter, prospective observational investigation designed to characterize the quality and safety of patient transport during advanced respiratory support.
- Conditions
- Acute Respiratory Failure, Respiratory Insufficiency, Respiratory Distress, Critical Illness
- Trial name
- HERMES (NCT07805603)
- Testing
- Advanced Respiratory Support During Patient Transport
- Where
- 4 sites in Colombia, Egypt and 2 more
- Volunteers
- 565 people
- Sponsor
- Medipol University
Asthma, Dyspnea
SU JOK THERAPY TO IMPROVE DYSPNEA AND INSOMNIA IN ASTHMA
Asthma is a long-term lung disease that can make breathing difficult and can also affect sleep. Even with regular medical treatment, many people with asthma continue to experience shortness of breath and insomnia.
- Conditions
- Asthma, Dyspnea, Insomnia
- Trial name
- SUJOK-ASTHMA (NCT07746570)
- Testing
- su jok therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Erzincan Binali Yildirim Universitesi
Pulmonary Disease, Chronic Obstructive
Does Pulmonary Rehabilitation Improve Breathing of COPD Patients
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death world-wide. Dyspnea (i.e., sensations of breathlessness) is the hallmark symptom of patients with this disease.
- Trial name
- PR-COPD (NCT01815970)
- Testing
- Pulmonary Rehabilitation
- Where
- Canada
- Sponsor
- University of British Columbia
Phrenic Nerve Injury
Modified Diaphragmatic Plication Rectifies Dyspnea
Traditional diaphragmatic plication (DP) surgery is employed to ameliorate respiratory function in patients with diaphragmatic paralysis, which is rather complicated. This study introduces a modified method of DP.
- Trial name
- NCT06775873
- Testing
- Modified diaphragmatic plication
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tongji University
Dyspnea
The Impact of Inhaled Furosemide and Perorally Administered Levodropropizine on Dyspnea in Patients With Respiratory Diseases
The goal of this monocentric double blinded cross over trial is to evaluate safety and tolerability of inhaled furosemide in patients with pulmonary diseases and dyspnea.
- Trial name
- INFURO (NCT06252454)
- Testing
- Furosemide 40 mg, Levodropropizine
- Where
- Czechia
- Volunteers
- 102 people
- Sponsor
- University Hospital Hradec Kralove
Occupational Therapy, Cancer
Study of an Integral Respiratory Rehabilitation Program in Oncological Patient With Disney
Hypothesis: Oncological patients presenting with respiratory problems will benefit both at a functional level and at a level of quality of life from the inclusion of a program of integral respiratory rehabilitation from the…
- Conditions
- Occupational Therapy, Cancer, Dyspnea, Rehabilitation
- Trial name
- NCT04186754
- Testing
- Comprehensive functional care plan, Traditional intervention without rehabilitation
- Where
- Spain
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Acute Heart Failure
Dynamic Variation of Impedance Cardiography(DYVIC) as a Diagnostic Tool of Acute Heart Failure (AHF)
Dynamic variations of bio-impedance measured cardiac output using non pharmacologic intervention (sitting position, passive leg rising and valsalva maneuver) could be used to detect acute heart failure in patients admitted to the…
- Trial name
- DYVIC (NCT03241069)
- Testing
- Reference position, sitting position, Valsalva maneuver
- Where
- Tunisia
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Acute Dyspnea
Evaluation of Rapid Emergency Echography for Acute Dyspnoea
Elderly people constitute the largest proportion of emergency room patients, representing 12% of all emergency room admissions. The need for diagnostic tests or therapeutic interventions is much greater in this patient…
- Trial name
- READ (NCT02531542)
- Testing
- Echocardiography according to the READ method.
- Where
- 5 sites in France
- Volunteers
- 461 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
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