Clinical trials: Dyspnoea
Chronic Obstructive Pulmonary Disease (COPD)
129-Xe MRI Study of Single Triple Therapy Inhaler Effects in COPD Patients With Moderate-severe Dyspnea and/or Poor Health Status With High or Low Risk of Exacerbation
The goal of this study is to study how 12-weeks daily (and optional 48-weeks) single inhaler triple therapy (fluticasone furoate (FF)-an inhaled corticosteroid; umeclidinium (UMEC)-a long-acting muscarinic antagonist; vilanterol…
- Trial name
- MUST (NCT07192016)
- Testing
- fluticasone furoate(FF)/umeclidinium (UMEC)/vilanterol(VI) (100/62.5/25) mcg
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Western University, Canada
Bronchiectasis Post-Tuberculosis Lung Disease
Respiratory Muscle Stretching for Improving Chest Expansion and Dyspnea in Post-Tuberculosis Bronchiectasis
This study intends to examine the effectiveness of adding RMS to a traditional program of pulmonary rehabilitation regarding chest expansion, dyspnea, and cough symptoms in bronchiectasis post-tuberculosis patients.
- Trial name
- NCT06597409
- Testing
- Standard PR, Standard PR plus Respiratory Muscle Stretching (RMS)
- Where
- Indonesia
- Volunteers
- 48 people
- Sponsor
- Universitas Padjadjaran
Healthy, Dyspnea
Aerosol Inhalation Treatment for Dyspnea
The purpose of this protocol is to develop and test optimal delivery of aerosol furosemide, a treatment that has the potential to significantly improve symptom management and enhance the quality of care for patients with…
- Trial name
- NCT01440764
- Testing
- Furosemide, Saline
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
COPD
Morphine or Fentanyl for Refractory Dyspnea in COPD
Rationale: The most important complaint in severe COPD is dyspnea which is associated with a diminished exercise tolerance, reduced quality of life and can lead to anxiety and depression.
- Trial name
- MoreFoRCOPD (NCT03834363)
- Testing
- Fentanyl, Morphine Retard
- Where
- 10 sites in Netherlands
- Volunteers
- 59 people
- Sponsor
- Huib A.M. Kerstjens
Chronic Obstructive Pulmonary Disease, Dyspnea
Abdominal Binding in Chronic Obstructive Pulmonary Disease
Conventional approaches to relieve dyspnea (respiratory discomfort) in chronic obstructive pulmonary disease (COPD) have focused on improving respiratory motor drive (e.g., hyperoxia) and/or dynamic respiratory mechanics (e.g.…
- Trial name
- NCT01852006
- Testing
- Abdominal Binder
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University
Dyspnea
Pilot Randomized Controlled Trial of a Breathlessness Intervention Service for Chronic Obstructive Pulmonary Disease
The aim of this study is to test the feasibility of conducting a pragmatic fast track Randomized Controlled Trial (RCT) of the Breathlessness Intervention Service (BIS) versus standard care for patients with COPD and their…
- Trial name
- BIS-PhIInm (NCT00711438)
- Testing
- Breathlessness Intervention Service (BIS), Best supportive care (Standard care)
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Dyspnea, Well Being
Combined Use of Respiratory Devices After Thoracic Surgery
In a rehabilitation setting, respiratory muscle training with re-expansion techniques in patients following cardio-thoracic surgery represents a consolidated intervention.
- Trial name
- NCT01510275
- Testing
- Combined use of RESPIVOL® and RESPILIFT®
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Villa Pineta Hospital
Dyspnea, Pulmonary Embolism
Inhaled Nitric Oxide (iNO) in Post-Pulmonary Embolism (Post-PE)
Following acute pulmonary embolism (PE), up to a third of patients develop post-PE syndrome described as having persistent breathlessness (dyspnea), impaired exercise capacity, and a reduced quality of life.
- Trial name
- NCT04920695
- Testing
- Nitric Oxide
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Dr. Denis O'Donnell
Venous Thromboembolism (VTE), Exercise Therapy
Early Exercise-Based Rehabilitation in Patients Hospitalized for Acute Pulmonary Embolism
Up to half of patients with pulmonary embolism (PE) suffer from impaired quality of life, reduced physical capacity, and symptoms like shortness of breath even three months after diagnosis, despite standard treatment with…
- Conditions
- Venous Thromboembolism (VTE), Exercise Therapy, Quality of Life (QOL), Anxiety Depression
- Trial name
- RehabPE (NCT07143539)
- Testing
- Exercise-based rehabilitation program
- Where
- 6 sites in Switzerland
- Volunteers
- 160 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hypertension, Stage II Hypertension
Mat Pilates With Paced Breathing Versus Diaphragmatic Breathing in Stage II Hypertension
This randomized controlled trial aims to compare the effects of mat Pilates combined with paced breathing versus mat Pilates combined with diaphragmatic breathing on stress, anxiety, cardiopulmonary endurance, dyspnea, and…
- Conditions
- Hypertension, Stage II Hypertension, Essential Hypertension
- Trial name
- NCT07433790
- Testing
- Mat Pilates, Paced Breathing
- Where
- Pakistan
- Volunteers
- 63 people
- Sponsor
- University of Lahore
Chronic Obstructive Pulmonary Disease
Nurse Managed Sequential Strength Training and Bicycle Training in Chronic Obstructive Pulmonary Disease (COPD)
This is a 16 week exercise training program for people with severe to very severe chronic obstructive pulmonary disease (COPD). The purpose of this study is to find out if performing strength training prior to initiating exercise…
- Trial name
- NCT01058213
- Testing
- Resistance training, Aerobic training
- Where
- United States
- Volunteers
- 354 people
- Sponsor
- University of Illinois Chicago
Esophageal Perforation
A 75 Year Old With Dyspnea a Case Report.Observational Study
Clinical Case report Of spontaneous esophageal perforation in a 75 year old man. He prsented with breathlessness and on investigation found to have esophageal perforation
- Trial name
- NCT00422760
- Volunteers
- 1 people
- Sponsor
- Stanley Medical College
Healthy Adults
Effects of Isocapnic Respiratory Muscle Endurance Training in Healthy Adults
Respiratory muscle training (RMT) strengthens breathing muscles and may improve exercise performance and reduce breathlessness. However, different training methods and devices create controversy in the field.
- Trial name
- NCT07103291
- Testing
- Respiratory muscle endurance training
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Chronic Obstructive Pulmonary Disease
Effects of Diaphragm and Abdominal Muscle Training on PFT and Dyspnea Among COPD Obstructive Pulmonary Disease Patients.
It will be a randomized control trial at Services Hospital Lahore through convenience sampling technique which will be allocated through simple random sampling through sealed opaque enveloped in to Group A and Group B .
- Trial name
- NCT05587829
- Testing
- • Diaphragmatic breathing technique, basic breathing technique
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Heart Failure, Dyspnea
Study of Electrical Bioimpedance in Heart Failure.
The purpose of this study is to determine how electrical impedance is modified in relation to extracellular space body fluid retention detected by an electrical bioimpedance method in patients with heart failure.
- Trial name
- BELIC (NCT00843245)
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Shortness of Breath
Effect of Senobi Versus Buteyko Technique on Functional Performance of Chronic Obstructive Pulmonary Disease Patient.
Effect of Senobi breathing exercise versus Buteyko breathing technique on functional performance among chronic obstructive pulmonary patient.
- Trial name
- NCT06196957
- Testing
- pursed lip breathing
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
COVID-19
Pulmonary Vascular Dysfunction as a Cause of Persistent Exertional Dyspnea After Coronavirus Disease (COVID-19)
To identify pulmonary vascular disease in post/long-COVID-19 patients as a cause of dyspnea/exercise limitation and to differentiate it from other causes of dyspnea
- Trial name
- PulmVasC (NCT05374577)
- Testing
- pulmonary vascular dysfunction, pulmonary vascular function
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Giessen
Pulmonary Disease, Chronic Obstructive (COPD)
Comparative Effects of Coherent Breathing and Regular Paced Breathing on Dyspnea and Pulmonary Function in Patients With Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory condition of airways characterized by recurrent episodes of coughing, respiratory muscle weakness, lung hyperinflation and air trapping which ultimately leads to…
- Trial name
- NCT07875036
- Testing
- Coherent Breathing Group A, Regular Paced Breathing Group B
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Foundation University Islamabad
Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Family Palliative and End-of-Life Care for Advanced Heart Failure
Overall objective is to test whether the 5-weekly family home palliative and end-of-life care (FamPALcare) intervention educational and supportive sessions will improve rural home end-of-life and palliative care (EOLPC) for…
- Trial name
- NCT04153890
- Testing
- FamPALcare
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- West Virginia University
Pulmonary Complication
Respiratory Exercise Diary in Major Abdominal Surgery
Postoperative pulmonary complications are common and lead to increased morbidity and mortality in patients. These complications are observed especially after major surgical interventions.
- Trial name
- NCT06078644
- Testing
- respiratory exercise diary
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
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