Clinical trials: Dyspnoea
Apnea, Sleep Disorders
A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Do Not Use a Breathing Machine (PAP) (VESPER-OSA 2)
This study is being done to learn about the safety and effects of a study medicine called berobenatide (bear-oh-BEN-uh-tide). The study will see if berobenatide can help adults with breathing problems during sleep (obstructive…
- Conditions
- Apnea, Sleep Disorders, Overweight and/or Obesity
- Trial name
- VESPER-OSA 2 (NCT07881757)
- Testing
- Berobenatide
- Where
- 2 sites in United States
- Volunteers
- 258 people
- Sponsor
- Pfizer
Parkinson Disease
DBS and Respiration
Patients referred to neurosurgery routinely and safely undergo deep brain stimulation (DBS) for treatment of neurological conditions, most commonly Parkinson's disease.
- Trial name
- NCT04058457
- Testing
- DBS
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Chronic Obstructive Pulmonary Disease, Dyspnea
Muscle Training Effectiveness in the Degree of Dyspnea and Aerobic Capacity in COPD
Objective: To estimate the effectiveness of muscle training, the degree of dyspnea and aerobic capacity in patients over 50 with COPD, in a health care institution provider in Antioquia.
- Trial name
- NCT01452932
- Testing
- Physiotherapy, Yoga
- Volunteers
- 44 people
- Sponsor
- CES University
Chronic Obstructive Pulmonary Disease
The Effect of Inhaled Nitric Oxide on Deadspace in COPD
Chronic obstructive pulmonary disease (COPD) is a progressive disease of the respiratory system that generally develops as a result of smoking.
- Trial name
- NCT04069052
- Testing
- Nitric Oxide
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Dr. Denis O'Donnell
Chronic Obstructive Pulmonary Disease (COPD), Airway Clearance
Oscillating Positive Expiratory Pressure Therapy Versus Autogenic Drainage in Patients With COPD
Chronic Obstructive Pulmonary Disease (COPD) is a long-term lung condition that causes breathing difficulty, cough, and sputum production.
- Trial name
- OPEP-AD-COPD (NCT07402850)
- Testing
- Oscillating Positive Expiratory Pressure Therapy, Autogenic Drainage
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Adnan Hashim
Dyspnea, COPD
Validity and Reliability of The Turkish Version of Breathlessness Beliefs Questionnaire
In our study, we aimed to evaluate the validity and reliability of the Turkish version of the Breathlessness Beliefs Questionnaire-BBQ in our study.
- Trial name
- NCT03517826
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Bezmialem Vakif University
Pleural Effusion
Effect of Bubble Positive Expiratory Pressure and Segmental Breathing Versus Incentive Spirometry in Pleural Effusion
Conducted as a randomized clinical trial, this study will include 40 pediatric participants aged 5-16, recruited from Gulab Devi Chest Hospital and Children's Hospital, Lahore.
- Trial name
- NCT07248774
- Testing
- Bubble PEP, Incentive Spirometery
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Heart Failure, Congestive, Cardiomyopathy
Impact of Nesiritide Infusion for Decompensated Heart Failure in the Emergency Department
The purpose of this study is to determine if an 8hr infusion of nesiritide in the emergency department in the Acutely decompensated heart failure patients will decrease 30 day recidivism.
- Trial name
- NCT00559338
- Testing
- recombinant B-type, natriuretic peptide
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Obstructive Pulmonary Disease
Pennsylvania Study Of Chronic Obstructive Pulmonary Exacerbations
The overall purpose of PA-SCOPE is to determine why black and rural residents of Pennsylvania might be at higher risk for deadly, debilitating, and costly hospitalizations for chronic obstructive pulmonary disease (COPD)- and…
- Trial name
- PA-SCOPE (NCT00774176)
- Where
- 3 sites in United States
- Volunteers
- 1,066 people, healthy volunteers welcome
- Sponsor
- Temple University
Congestive Heart Failure, Cardiomyopathy
FAST (Fluid Accumulation Status Trial)
Heart failure is a progressive disease that decreases the pumping action of the heart. This may cause a backup of fluid in the heart and may result in heart beat changes.
- Conditions
- Congestive Heart Failure, Cardiomyopathy, Dyspnea, Pulmonary Edema
- Trial name
- NCT00289276
- Testing
- Fluid Status Monitoring (OptiVol™)
- Where
- 16 sites in United States, Canada and 1 more
- Volunteers
- 156 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Decompensation
A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure
The purpose of this study is to find out if nesiritide (a human B-type natriuretic peptide/hBNP) as compared to placebo, plus the usual treatment for acute decompensated heart failure, helps to improve breathing difficulties…
- Trial name
- NCT00475852
- Testing
- Nesiritide
- Where
- 328 sites in United States, Argentina and 26 more
- Volunteers
- 7,141 people
- Sponsor
- Scios, Inc.
Quality of Life
Effect of Breathıng Exercıse Applıed to Indıvıduals Wıth Copd on Respıratory Functıon, Dyspnea and Qualıty of Lıfe
Purpose of the research This research was designed to determine the effect of breathing exercise applied to individuals diagnosed with COPD on respiratory function, dyspnea and quality of life.
- Trial name
- NCT06706297
- Testing
- pranayama breathing exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ondokuz Mayıs University
COPD
Harmonica Playing Improves Quality of Life in Patients With COPD
15 patients who have completed the Baylor Martha Foster Lung Center Pulmonary Rehabilitation Program at least six months ago will be selected to participate in a 12 week training program with six months of follow up.
- Trial name
- NCT03442140
- Testing
- Harmonica playing
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Baylor Research Institute
Asthma
A Study of Omalizumab (Xolair) in Subjects With Moderate to Severe Persistent Asthma (EXTRA)
This is a multicenter, randomized, double-blind, placebo-controlled study of the efficacy, safety, and tolerability of subcutaneously administered Xolair as add-on therapy for the treatment of subjects aged 12-75 years old…
- Trial name
- NCT00314574
- Testing
- omalizumab (Xolair), corticosteroids, long-acting beta-agonists
- Volunteers
- 850 people
- Sponsor
- Genentech, Inc.
Dyspnea, Emergencies
Blue Protocol Assessment
Acute dyspnea is a common disease in emergency medicine. Mortality remains high is estimated at 15%. One third of initial diagnoses before paraclinical examination are estimated to be inaccurate.
- Trial name
- Blue P (NCT04223297)
- Testing
- lung ultrasound
- Where
- France
- Volunteers
- 115 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Shortness of Breath, Asthma in Children
The Effect of Nebulized Epinephrine in Asthma Exacerbation in Pediatric Age Group With the Standard Treatment Compared to Standard Treatment Using Improvement PRAM Score as a Primary Outcome
Our study aiming to look in improvement of Pediatric Respiratory Assessment Measure (PRAM) score as a primary outcome. The secondary outcomes involving the need for second step management, need for admission and possible side…
- Conditions
- Shortness of Breath, Asthma in Children, Epinephrine Causing Adverse Effects in Therapeutic Use, Salbutamol Adverse Reaction
- Trial name
- NCT05667727
- Testing
- nebulized epinephrine, Salbutamol
- Where
- Oman
- Volunteers
- 30 people
- Sponsor
- Oman Medical Speciality Board
Mild Respiratory Distress
A Dose Escalation Study of NanO2 in Patients With Mild Respiratory Distress
EXTEND is a dose escalation study of NanO2™ in patients with mild respiratory distress who are at risk for mechanical ventilation. The study will establish dosing guidelines for a Phase 2 study.
- Trial name
- EXTEND-1b (NCT06658535)
- Testing
- dodecafluoropentane (0.025 mL/kg), dodecafluoropentane (0.032 mL/kg), dodecafluoropentane (0.050 mL/kg)
- Where
- 2 sites in Canada
- Volunteers
- 18 people
- Sponsor
- NuvOx LLC
COVID-19
Functional Capacity in Patients Post Mild COVID-19
Patients recovered from mild coronavirus 2019 (COVID-19) disease without pulmonary involvement may experience long-term physical impairment and dyspnea.
- Trial name
- NCT05323760
- Testing
- Cardiopulmonary exercise test (CPET)
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
Asthma, Asthma (Diagnosis)
Intercostal and Thoracic Cage Stretching on Chest Expansion , Dyspnea ,Oxygen Saturation in Asthma
The rationale of this study is to clarify distinct role of these two stretching techniques in pulmonary rehabilitation. Insight gained from this research could provide evidence based recommendations for implementing these…
- Trial name
- NCT07331662
- Testing
- thoracic cage stretching, intercostal stretching
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Riphah International University
Cardiomyopathies, Heart Failure, Congestive
A Study of Short-Term Outcomes and Economic Impact For Patients With Worsening Congestive Heart Failure When Natrecor (Nesiritide) is Added to Standard-Care Therapy, Compared to Administration of Placebo With Standard-Care Therapy
The purpose of this pilot study is to compare the clinical effects, safety profile, and economic impact of standard therapy plus Natrecor® (nesiritide, a recombinant form of the natural human peptide normally secreted by the…
- Conditions
- Cardiomyopathies, Heart Failure, Congestive, Dyspnea, Paroxysma
- Trial name
- NCT00270387
- Testing
- Natrecor (nesiritide)
- Volunteers
- 250 people
- Sponsor
- Scios, Inc.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.