Clinical trials: Dyssomnias
Myalgia, Apnea, Obstructive Sleep
Temporomandibular Disorder (TMD) Pain in Response to Jaw Advancement in People With TMD and Obstructive Sleep Apnea
The purpose of this study is to characterize the course of temporomandibular disorder (TMD) pain in adults with TMD and obstructive sleep apnea (OSA), all of whom are being treated with mandibular advancement splint (MAS)…
- Trial name
- NCT02685202
- Testing
- Mandibular advancement splint
- Volunteers
- 9 people
- Sponsor
- University of North Carolina, Chapel Hill
Sleep Disorders, Circadian Rhythm
Efficacy of Ramelteon on Speeding Up Sleep in Subjects With Delayed Sleep Phase Syndrome
The purpose of this study is to evaluate the ability of ramelteon, once daily (QD), to advance the timing of sleep in individuals with delayed sleep phase syndrome.
- Trial name
- NCT00593736
- Testing
- Ramelteon
- Where
- 42 sites in United States
- Volunteers
- 132 people
- Sponsor
- Takeda
Insomnia, Nicotine Dependence
Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban
Objectives: The primary objective of this study is to determine the efficacy of eszopiclone at treating sleep problems related to withdrawal from nicotine in healthy smokers attempting smoking cessation.
- Trial name
- NCT00511134
- Testing
- Eszopiclone, Bupropion
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Yale University
Sleep Disordered Breathing
Oxygen Monitoring of Patients After Surgery on the Hospital General Care Floor
The pain medication given after major surgery may cause some patients to stop breathing for periods of time especially at night time. An oxygen monitor may reflect this abnormal breathing pattern.
- Trial name
- NCT01082575
- Testing
- Oxygen Monitoring
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Medtronic - MITG
Obstructive Sleep Apnea, Nocturia
Mandibular Advancement Device and Changes in Nocturia
The main purpose of this study is to test is mandibular advancement device (MAD) use is associated with reductions in nocturia.
- Conditions
- Obstructive Sleep Apnea, Nocturia, OSA
- Trial name
- MAD (NCT05562388)
- Testing
- Somnodent Classic
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Isabel Moreno Hay
Spinal Cord Injury, Sleep-disordered Breathing
Treatment of Sleep-disordered Breathing in Patients With SCI
Sleep-disordered breathing (SDB) remains under-treated in individuals living with spinal cord injuries and disorders (SCI/D). The investigators' aim is to test a program that addresses challenges and barriers to positive airway…
- Conditions
- Spinal Cord Injury, Sleep-disordered Breathing, Spinal Cord Disease, Multiple Sclerosis
- Trial name
- NCT02830074
- Testing
- Best practices PAP + patient Education +ongoing Support and Training, Sleep Education
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- VA Office of Research and Development
Myotonic Dystrophy, Type 1 (DM1), Myotonic Dystrophy
Safety, Tolerability and Pharmacokinetics of ERX-963 in Adults With Myotonic Dystrophy Type 1
Participants in this study will receive two treatments, placebo and ERX-963, on different days in a randomized fashion. The primary purpose of this study is to investigate the safety and tolerability of ERX-963 in participants…
- Trial name
- NCT03959189
- Testing
- ERX-963
- Where
- 4 sites in United States
- Volunteers
- 12 people
- Sponsor
- Expansion Therapeutics, Inc.
Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection, COVID-19
A Phase 2 Study to Evaluate the Efficacy and Safety of TNX-102 SL in Patients With Multi-Site Pain Associated With Post-Acute Sequelae of SARS-CoV-2 Infection
This is a Phase 2, randomized, parallel-group, double-blind, placebo-controlled, 14-week study designed to evaluate the efficacy and safety of TNX-102 SL 5.6 mg (2 x 2.8 mg tablets) taken once daily at bedtime for the management…
- Conditions
- Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection, COVID-19, Long COVID, Long Haul COVID
- Trial name
- PREVAIL (NCT05472090)
- Testing
- TNX-102 SL
- Where
- 29 sites in United States
- Volunteers
- 63 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Obstructive Sleep Apnea
The Effect of Eszopiclone on the Arousal Threshold in Sleep Apnea Syndrome
The purpose of this study is to find out whether taking eszopiclone (Lunesta) changes the breathing effort required to briefly wake people with obstructive sleep apnea from sleep (respiratory arousal threshold).
- Trial name
- NCT01102270
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Brigham and Women's Hospital
Primary Snoring, Obstructive Sleep Apnea
Analysis of Snore Sound Following Minimal Invasive Surgery in Sleep-disordered Breathing Patients
1. Background：The methods of anti-snore (treatment of snoring ) can be divided into conservative, invasive and minimal invasive treatment.
- Trial name
- NCT01955083
- Testing
- Pillar implant, Radiofrequency
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Insomnia
Improving Sleep Using Mentored Behavioral and Environmental Restructuring
The goal of this study is to test potential functional/psychosocial benefits of improved sleep using a program designed to teach nursing facility staff to improve sleep promoting strategies and environment for nursing home…
- Trial name
- SLUMBER (NCT03327324)
- Testing
- Sleep Using Mentored Behavioral and Environmental Restructuring
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Hypersomnia, Idiopathic Hypersomnia
Clarithromycin for the Treatment of Hypersomnia
The term 'hypersomnia' describes a group of symptoms that includes severe daytime sleepiness and sleeping long periods of time (more than 10 hours per night).
- Conditions
- Hypersomnia, Idiopathic Hypersomnia, Narcolepsy
- Trial name
- NCT01146600
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Lynn Marie Trotti
Benzodiazepine Dependence, Anxiety Disorders
Anxiety Lowering and Deprescribing Through Emotion Regulation
The goal of this clinical trial is to test ALDER (Anxiety Lowering and Deprescribing through Emotion Regulation), an online self-guided positive emotion intervention, in patients over the age of 65 who are candidates for…
- Conditions
- Benzodiazepine Dependence, Anxiety Disorders, Sleep Disturbance
- Trial name
- ALDER (NCT06359314)
- Testing
- ALDER
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Obstructive Sleep Apnea
Effect of Montelukast Therapy in Obstructive Sleep Apnea(OSA) Children
The investigators leading hypotheses are: Oral therapy with montelukast may lead to improved sleep study findings in children with mild to moderate Obstructive Sleep Apnea Syndrome (OSAS) who require surgical removal of adenoids…
- Trial name
- 32543 (NCT01027806)
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Chicago
Obstructive Sleep Apnea, Sleep Apnea
Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism
Obstructive sleep apnea affects approximately 2-4% of middle-aged adults in the general population and is associated with several medical conditions including hypertension and coronary artery.
- Conditions
- Obstructive Sleep Apnea, Sleep Apnea, Sleep-disordered Breathing
- Trial name
- SOMNOS (NCT01503164)
- Testing
- Positive Pressure Therapy (PAP), LifeStyle Counseling
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Johns Hopkins University
Sleep Apnea Syndromes
Amara View Benchmark Study
This randomized crossover, benchmark clinical trial aims to compare the Philips Amara View and ResMed AirFit F40 minimal contact full face masks on patient preference of mask attributes and usage parameters.
- Trial name
- NCT06535932
- Testing
- Amara View Minimal Contact Full Face Mask, F40 Minimal Contact Full Face Mask
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Philips Clinical & Medical Affairs Global
Obstructive Sleep Apnea
The Effectiveness of SensAwake™ for Continue Positive Airway Pressure Treatment of Obstructive Sleep Apnea Patients
This study will investigate Obstructive Sleep Apnea (OSA) and an automatically Adjusting Positive Airway Pressure (APAP) device with new technology called SensAwake™.
- Trial name
- NCT03294629
- Testing
- SensAwake™ modification
- Volunteers
- 35 people
- Sponsor
- Chang Gung Memorial Hospital
Obstructive Sleep Apnea
Sleep Schedules Modifications in Sleep Apnea Patients Treated by nCPAP
In Obstructive sleep apnea (OSA) patients, sleep is disrupted and sleep quality is very poor. The investigators can suppose that with continuous positive airway pressure (CPAP) therapy, there is an improvement in sleep quality…
- Trial name
- NCT01355419
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Menopause
Menopausal Sleep Fragmentation and Body Fat Gain
This study aims to investigate the impact of menopause-related sleep fragmentation on metabolic biomarkers of body fat gain. The investigators hypothesize that experimental sleep fragmentation will result in an adverse leptin…
- Trial name
- NCT03047330
- Testing
- Estradiol withdrawal, Fragmented sleep
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Restless Legs Syndrome
Long-term Efficacy, Safety and Tolerability of Pramipexole in Patients With Idiopathic Moderate to Severe Restless Legs Syndrome (RLS)
The primary objective of the current study will be the evaluation of long-term efficacy of a 26-weeks treatment with pramipexole in patients with idiopathic moderate to severe Restless Legs Syndrome (RLS) in comparison to…
- Trial name
- NCT00472199
- Testing
- Pramipexole
- Where
- 42 sites in Austria, Belgium and 7 more
- Volunteers
- 331 people
- Sponsor
- Boehringer Ingelheim