Clinical trials: Dystonia
Dyskinesia, Cerebral Palsy
Study to Assess the Efficacy, Safety, and Tolerability of Valbenazine for the Treatment of Dyskinesia Due to Cerebral Palsy
The primary objective of this study is to evaluate the efficacy of valbenazine versus placebo on improving chorea in pediatric and adult participants who have dyskinesia due to cerebral palsy (DCP) with choreiform movements.
- Trial name
- NCT05206513
- Testing
- Valbenazine
- Where
- 38 sites in United States, Argentina and 8 more
- Volunteers
- 86 people
- Sponsor
- Neurocrine Biosciences
Movement Disorders, Parkinson Disease
A Post-Market Study Evaluating the Safety of Infinity DBS System With MR Conditional Labeling
The Infinity MRI PMCF was conducted as an international, multicenter, observational, prospective, single-arm, post-market clinical follow-up (PMCF) study.
- Conditions
- Movement Disorders, Parkinson Disease, Essential Tremor, Tremor
- Trial name
- NCT03884231
- Testing
- Infinity DBS System with MR Conditional labelling
- Where
- 16 sites in United States, France and 3 more
- Volunteers
- 74 people
- Sponsor
- Abbott Medical Devices
Dystonia
A Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia
Stride Dystonia is a randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, and tolerability of VIM0423 in individuals with isolated dystonia.
- Trial name
- NCT07304089
- Testing
- VIM0423
- Where
- 45 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Vima Therapeutics
Cervical Dystonia
A Study of IPN10200 for the Treatment of Cervical Dystonia in Adults
The purpose of this study is to evaluate the efficacy and safety of the study drug, Corabotase (also known as IPN10200), and to assess how well it works when compared with placebo in treating Cervical Dystonia (CD) in adults.
- Trial name
- CATALPA (NCT06937931)
- Testing
- Corabotase
- Where
- 45 sites in United States, Czechia and 6 more
- Volunteers
- 132 people
- Sponsor
- Ipsen
Cervical Dystonia
Randomized, Placebo-Controlled Study of AbobotulinumtoxinA (Dysport®) for the Treatment of Cervical Dystonia
The aim of this study is to demonstrate the effectiveness and safety of 500 units of Dysport manufactured at a new manufacturing facility in Europe.
- Trial name
- NCT00257660
- Testing
- Botulinum toxin type A
- Where
- 22 sites in United States, Russia
- Volunteers
- 116 people
- Sponsor
- Ipsen
Cervical Dystonia
Daily Dystonia Practice - A Trial to Investigate NT 201, the Duration of Treatment Effect After One Injection Session and in Long-term Treatment in Cervical Dystonia
The aim of this study is to confirm efficacy and safety of NT 201 (Xeomin®, also known as IncobotulinumtoxinA) after one injection session and to determine the efficacy and safety profile and the duration of treatment effect of…
- Trial name
- NCT00541905
- Testing
- NT 201
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- Merz Pharmaceuticals GmbH
Cervical Dystonia
Study of the Oral Treatment MTR-601 in Cervical Dystonia
Study MTR-601-201 is an 8-week, randomized, placebo-controlled study to examine the safety, tolerability, and efficacy of MTR-601 in participants with cervical dystonia.
- Trial name
- NCT06830642
- Testing
- MTR-601
- Where
- 17 sites in United States
- Volunteers
- 38 people
- Sponsor
- Motric Bio
Spasmodic Torticollis
An Electrophysiological Study Of E2014 In Healthy Adult Male Japanese And Caucasian Subjects
To evaluate inter-ethnic similarity in pharmacodynamics between Japanese and Caucasian healthy adult male subjects by comparing electrophysiological reactions after administering E2014 to extensor digitorum brevis muscle (EDB).
- Trial name
- NCT00280384
- Testing
- E2014 (Botulinum toxin type B)
- Where
- Japan
- Volunteers
- 48 people
- Sponsor
- Eisai Limited
Cervical Dystonia
Open-label Extension Study of AbobotulinumtoxinA (Dysport®) for the Treatment of Cervical Dystonia
The aim of this study is to assess longer term safety and effectiveness of Dysport®.
- Trial name
- NCT00288509
- Testing
- Botulinum toxin type A
- Where
- 18 sites in United States, Russia
- Volunteers
- 108 people
- Sponsor
- Ipsen
Cervical Dystonia
Extension Study of ABP-19000 to Evaluate Safety and Efficacy of Repeat Treatments of ABP-450 in Cervical Dystonia
This Open-label Extension trial will evaluate the safety and efficacy of ABP-450 for the treatment of cervical dystonia in adults.
- Trial name
- NCT04871451
- Testing
- ABP-450
- Where
- 20 sites in United States
- Volunteers
- 51 people
- Sponsor
- AEON Biopharma, Inc.
Cervical Dystonia
Assessment of Long-term Clinical Response to BoNT in Cervical Dystonia
The goal of this retrospective, international, multi-center chart abstraction is to learn about the long-term impact of product-specific immunogenicity-related factors in different botulinum neurotoxin type A formulations in…
- Trial name
- RELY-CD (NCT05884528)
- Testing
- CC BoNT/A, CF BoNT/A, CF to CC BoNT/A
- Where
- Germany
- Volunteers
- 270 people
- Sponsor
- Merz Therapeutics GmbH
Cervical Dystonia
A Phase 2 Study to Evaluate the Safety and Efficacy of ABP-450 in the Treatment of Cervical Dystonia
This Phase 2 trial will evaluate the safety and efficacy of ABP-450 for the treatment of cervical dystonia in adults. The study will enroll 60 patients across approximately 30 sites in the United States.
- Trial name
- NCT04849988
- Testing
- ABP-450
- Where
- 21 sites in United States
- Volunteers
- 61 people
- Sponsor
- AEON Biopharma, Inc.
Blepharospasm, Hemifacial Spasm
Post Marketing Surveillance Study of Dysport
The purpose of this study is to provide further information regarding the risks and benefits of Dysport in marketed indications.
- Conditions
- Blepharospasm, Hemifacial Spasm, Cervical Dystonia, Spasmodic Torticollis
- Trial name
- NCT00210431
- Where
- 36 sites in France, Germany and 1 more
- Volunteers
- 783 people
- Sponsor
- Ipsen
Dystonia, Dystonic Disorder
Meditoxin® Treatment in Patients With Cervical Dystonia
To determine the efficacy and safety of Meditoxin in subjects with cervical dystonia compared with placebo (normal saline)
- Trial name
- NCT03232320
- Testing
- Meditoxin
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Medy-Tox
Cervical Dystonia, Blepharospasm
A Retrospective Chart Review of BOTOX® and Xeomin® for the Management of Cervical Dystonia and Blepharospasm
This study is a retrospective chart review to evaluate the doses of botulinum Type A toxins BOTOX® (onabotulinumtoxinA) and Xeomin® (incobotulinumtoxinA) used for the treatment of Cervical Dystonia and Blepharospasm in clinical…
- Trial name
- NCT02245958
- Testing
- No Intervention
- Where
- 2 sites in Mexico, United Kingdom
- Volunteers
- 44 people
- Sponsor
- Allergan
Cervical Dystonia, Spasmodic Torticollis
Randomized, Double-Blind, Placebo-Controlled, Parallel, Group Dose-Response, Study of E2014 in Patients WIth Spasmodic Torticollis
To evaluate efficacy and safety of E2014 (2500U, 5000U, 10000U, placebo) in a multicenter, randomized, double-blind, parallel group comparative study by intramuscularly administering to patients with spasmodic torticollis.
- Trial name
- NCT00165776
- Testing
- BOTULINUM TOXIN TYPE B
- Where
- 21 sites in Japan
- Volunteers
- 133 people
- Sponsor
- Eisai Co., Ltd.
Cervical Dystonia, Blepharospasm
A Retrospective Chart Review of BOTOX® and Xeomin® for the Treatment of Cervical Dystonia and Blepharospasm
This study is a retrospective chart review to evaluate the doses of botulinum Type A toxins BOTOX® (onabotulinumtoxinA) and Xeomin® (incobotulinumtoxinA) used for the treatment of Cervical Dystonia and Blepharospasm in clinical…
- Trial name
- NCT01814774
- Testing
- No Intervention
- Where
- 2 sites in Norway, United Kingdom
- Volunteers
- 48 people
- Sponsor
- Allergan
Spinal Cord Stimulation, Deep Brain Stimulation
Implantable Systems Performance Registry
The Implantable Systems Performance Registry (ISPR) was developed to evaluate the long-term reliability and performance of market-released Medtronic Neuromodulation infusion and stimulation products.
- Conditions
- Spinal Cord Stimulation, Deep Brain Stimulation, Drug Infusion (Implantable Pumps), Sacral Neuromodulation
- Trial name
- ISPR (NCT00959296)
- Testing
- Various
- Where
- 50 sites in United States, Austria and 5 more
- Volunteers
- 10,981 people
- Sponsor
- MedtronicNeuro
Movement Disorders, Parkinson Disease
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling…
- Conditions
- Movement Disorders, Parkinson Disease, Essential Tremor, Tremor
- Trial name
- ADROIT (NCT04071847)
- Testing
- Deep Brain Stimulation (DBS)
- Where
- 48 sites in United States, Australia and 7 more
- Volunteers
- 1,000 people
- Sponsor
- Abbott Medical Devices
Cervical Dystonia
Single Treatment of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-1)
This is a randomized, double-blind, placebo-controlled, parallel group, multi-center trial of two doses of daxibotulinumtoxinA (DAXI) for injection (high-dose; low-dose in adult subjects with isolated (primary) cervical dystonia…
- Trial name
- ASPEN-1 (NCT03608397)
- Testing
- DaxibotulinumtoxinA for injection
- Where
- 75 sites in United States, Austria and 7 more
- Volunteers
- 301 people
- Sponsor
- Revance Therapeutics, Inc.