Clinical trials: Dystonic Disorder
Movement Disorders, Parkinson Disease
Sedation During Microelectrode Recordings Before Deep Brain Stimulation for Movement Disorders.
The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to sedation during deep brain stimulation surgery.
- Conditions
- Movement Disorders, Parkinson Disease, Parkinsonian Disorders, Dystonia
- Trial name
- NCT00355927
- Testing
- Sedation with IV propofol
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Dystonia, Deep Brain Stimulation
Dystonia Image-based Programming of Stimulation: A Prospective, Randomized, Double-blind Crossover Trial
The primary objective of this exploratory study is to prospectively evaluate the feasibility of image-guided programming of pallidal deep brain stimulation (DBS) for dystonia.
- Trial name
- DIPS (NCT05097001)
- Testing
- DBS programming
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Wuerzburg University Hospital
Spasticity, Focal Dystonia
Compare Two Guidance Techniques for Botulinum Toxin Injections for the Treatment of Limb Spasticity and Focal Dystonia
This study seeks to compare the use of ultrasound and electrophysiologic techniques to target muscles for the treatment of spasticity and focal dystonia of the limbs.
- Conditions
- Spasticity, Focal Dystonia, Tremor, Limb
- Trial name
- NCT02334683
- Testing
- Electrical stimulation, Ultrasound
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Dystonia
Interactions Between Striatum and Cerebellum in ADCY5 and PRRT2 Dystonias
The investigators will study the relationship between the basal ganglia and the cerebellum in dystonia by associating cerebellar stimulations with functional magnetic resonance imaging analysis.
- Trial name
- AMEDYST (NCT03481491)
- Testing
- transcranial magnetic stimulation of the cerebellum
- Where
- France
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Dystonia
Multimodal Investigation of Cortico-Basal Ganglia-Thalamo-Cortical Network Dynamics in Dystonic Patients With Deep Brain Stimulation
The goal of this prospective open label study is to elucidate the pathophysiology of dystonia and to understand how deep brain stimulation (DBS) influences brain networks.
- Trial name
- DYScover (NCT06716983)
- Testing
- fMRI, EEG-MEG, registration of local field potentials
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Parkinson's Disease, Dystonia
Perceptual Decision Making Under Conditions of Visual Uncertainty
In this proposal the investigators have three Specific Aims using human patient populations as model systems; 1) identify a role for the Basal Ganglia (BG) in perceptual decision making; 2) determine whether the Basal Ganglia…
- Conditions
- Parkinson's Disease, Dystonia, Ataxia
- Trial name
- NCT01845883
- Testing
- Deep Brain Stimulation (DBS)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Focal Dystonia
fMRI Studies of Task Specificity in Focal Hand Dystonia
This study will examine how the brain makes involuntary spasms and contractions in patients with focal hand dystonia (FHD). Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or…
- Trial name
- NCT00310414
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Occupational; Cramp(s)
Study of Arm and Putter Movement in Golfers With Golfer's Cramp
The investigators will investigate golfers with visual evidence of an involuntary movement while putting before and after treatment with a low dose of propranolol.
- Trial name
- NCT02032758
- Testing
- Propranolol, Opal Device, Science and Motion PuttLab (SAM)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Focal Hand Dystonia, Musician's Dystonia
Somatosensory Processing in Focal Hand Dystonia
Patients with focal dystonia experience uncontrollable movements of the hand during certain types of skilled movements. Though the origin of the disorder is not fully understood, it is thought that brain areas involved in moving…
- Conditions
- Focal Hand Dystonia, Musician's Dystonia, Writer's Cramp, Dystonic Cramp
- Trial name
- NCT00579033
- Testing
- Tactile training + rTMS
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University Health Network, Toronto
Cervical Dystonia
DYSPORT™ Clinical & Health Economics Outcomes Registry in Cervical Dystonia
The purpose of the protocol is to determine typical patient response to Dysport in the treatment of adult cervical dystonia (CD).
- Trial name
- ANCHOR-CD (NCT01314365)
- Where
- 45 sites in United States
- Volunteers
- 350 people
- Sponsor
- Ipsen
Focal Dystonia
Amlodipine Plus Botulinum Toxin for Focal Dystonia
Objective: To determine if the calcium channel blockers, amlodipine can augment the effect of botulinum toxin injections in the treatment of focal dystonia.
- Trial name
- NCT00015457
- Testing
- Amlodipine plus Botulinum toxin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Isolated Cervical Dystonia
Accelerating TMS for Cervical Dystonia
This study aims to investigate the impact of accelerated transcranial magnetic stimulation (TMS) on brain function and behavior in patients with focal cervical dystonia.
- Trial name
- NCT06328114
- Testing
- Transcranial Magnetic Stimulation (TMS), trihexyphenidyl 10mg
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Cervical Dystonia
Plasticity in Cervical Dystonia
This study will identify changes that occur in the part of the brain that controls hand movements in patients with cervical (neck) dystonia.
- Trial name
- NCT00323765
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cervical Dystonia, Primary
The Effects of Waning of Botulinum Toxin in the Treatment of Cervical Dystonia
The main treatment for cervical dystonia is botulinum toxin injections. However, some patients receiving this treatment after many years tend to experience short duration of benefit.
- Trial name
- NCT06886750
- Testing
- Botulinum toxin type A injection
- Volunteers
- 45 people
- Sponsor
- Western University, Canada
Cervical Dystonia
Long-term Outcome of DBS Versus Botulinum Toxin Treatment in Cervical Dystonia
Cervical dystonia (CD) is the most common isolated dystonia in adults. Cervical dystonia symptoms can in most patients be managed well by botulinum toxin (BTX) injections, and supporting treatment measures.
- Trial name
- NCT04432285
- Testing
- DBS-device, implanted in GPi bilaterally, Botulinum toxin
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital