Clinical trials: Dystonic Disorder
Cervical Dystonia
Safety and Effectiveness of Valbenazine as Adjunct Therapy to Botulinum Toxin Injections in Cervical Dystonia
The most common form of idiopathic dystonia is adult-onset cervical dystonia (CD), a focal form of dystonia affecting the muscles of the neck.
- Trial name
- NCT06771323
- Testing
- Valbenazine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Blepharospasm of Both Eyelids, Blepharospasm of Left Eyelid
DaxibotulinumtoxinA for Blepharospasm
This study aims to provide real-world information about the duration, safety, and overall benefit of DaxibotulinumtoxinA (also called DAXI) treatment for adults living with blepharospasm (BSP), a condition that causes…
- Conditions
- Blepharospasm of Both Eyelids, Blepharospasm of Left Eyelid, Blepharospasm of Right Eyelid, Blepharospasm, Benign Essential
- Trial name
- BLEXI (NCT07489430)
- Testing
- Botulinum Neurotoxin Type A
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Primary Cervical Dystonia
Segmental Muscle Vibration on Pain in Patients With Primary Cervical Dystonia
This pilot study aims to evaluate the effectiveness of Vibration Muscle Stimulation (VMS) in reducing pain and improving quality of life in patients with primary cervical dystonia (CD), a focal dystonia characterized by…
- Trial name
- VIBRA-DYSTONIA (NCT06748846)
- Testing
- Physiotherapy + Occupational therapy + Focal Muscle Vibration
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Dystonia, Cervical
Exercise Program for Patients With Cervical Dystonia Who Are Treated With Botulinum Toxin Type A
Dystonia is involuntary movements characterized by posture abnormalities or repetitive movements as a result of continuous or intermittent simultaneous contraction of opposing muscle groups.
- Trial name
- NCT05502718
- Testing
- Stretching and Strengthening Exercises, Breathing and Rhythmic Coordination Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Prof. Dr. Şehim Kutlay
Cervical Dystonia
Daily Dystonia Practice - A Trial to Investigate NT 201, the Duration of Treatment Effect After One Injection Session and in Long-term Treatment in Cervical Dystonia
The aim of this study is to confirm efficacy and safety of NT 201 (Xeomin®, also known as IncobotulinumtoxinA) after one injection session and to determine the efficacy and safety profile and the duration of treatment effect of…
- Trial name
- NCT00541905
- Testing
- NT 201
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- Merz Pharmaceuticals GmbH
GLUT1 Deficiency Syndrome, GLUT1DS1
Sodium Lactate Infusion in GLUT1DS Patients
This study investigates the effect of lactate infusion on epileptic discharges on EEG and seizure frequency in glucose transporter 1 deficiency syndrome (GLUT1DS) patients.
- Conditions
- GLUT1 Deficiency Syndrome, GLUT1DS1, GLUT1DS2, Epilepsy
- Trial name
- NCT04112862
- Testing
- sodiumlactate
- Where
- Netherlands
- Volunteers
- 2 people
- Sponsor
- Radboud University Medical Center
Laryngeal Dystonia, Spasmodic Dysphonia
Cortical Silent Period in Laryngeal Dystonia
The goal of this observational study is to evaluate the cortical silent period (cSP) in cricothyroid muscle (CT) in laryngeal dystonia and control healthy subjects.
- Trial name
- cSPDystonia (NCT05580302)
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- Croatia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Focal Dystonia
Motor Training to Treat Hand Dystonia
This study will evaluate the effect of motor training on focal hand dystonia in people with writer's cramp and will examine whether this training affects excitability of the motor cortex of the brain.
- Trial name
- NCT00021853
- Testing
- constraint-induced movement therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Essential Tremor, Cervical Dystonia
Neurophysiologic Study of Patient With Essential Tremor and Dystonic Tremor
Background: Essential tremor is when a person has tremor, but no other neurological symptoms. Dystonic tremor is when a person also has dystonia. Dystonia is a condition in which muscle contraction causes changes in posture.
- Conditions
- Essential Tremor, Cervical Dystonia, Focal Dystonia
- Trial name
- NCT03041714
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonia Disorder
İnvestigating Dysphagia in Pediatric Dystonia
Dystonia is a movement disorder involving involuntary, sustained, or intermittent muscle contractions that cause abnormal postures and repetitive movements, worsened by voluntary actions or stress.
- Trial name
- NCT06815757
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Gazi University
Dystonic Disorders
Brain Inhibition of Muscle Movement in Normal Volunteers
This study will use transcranial magnetic stimulation, or TMS (described below), to examine how the brain controls muscle movement to prevent unwanted movements in surrounding muscles.
- Trial name
- NCT00047957
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease, Isolated Dystonia
Chronic Effects of DBS in Parkinson's Disease and Dystonia
The purpose of this study is to use an investigational device to record brain activity for 12-24 months following surgical implantation of deep brain stimulation (DBS) systems.
- Trial name
- Activa PC+S (NCT01934296)
- Testing
- Activa PC+S
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of California, San Francisco
X-Linked Dystonia Parkinsonism
MINGO Supplemental Trial in X-linked Dystonia-Parkinsonism Patients
To see whether MINGO, a food supplement, will be able to lessen the drastic weight loss seen among X-linked Dystonia Parkinsonism patients.
- Trial name
- MINGO (NCT03019458)
- Testing
- MINGO
- Where
- Philippines
- Volunteers
- 50 people
- Sponsor
- Sunshine Care Foundation
Cervical Dystonia
Efficacy and Safety of MEDITOXIN® in Cervical Dystonia
The purpose of this study is to test the hypothesis that the efficacy and safety of Meditoxin® are not inferior to Botox®'s in the treatment of Cervical Dystonia.
- Trial name
- CD Phase III (NCT03905304)
- Testing
- Medytoxin, Botox
- Volunteers
- 152 people
- Sponsor
- Medy-Tox
Functional Movement Disorder, Parkinson Disease
Movement Disorders and Early Maladaptive Schemas
Functional neurological disorders (FND) are neurological symptoms that cannot be explained by a lesion or related to an identified dysfunction of the central nervous system.
- Conditions
- Functional Movement Disorder, Parkinson Disease, Dystonic Disorders
- Trial name
- SCHEMAF (NCT03717376)
- Testing
- Self-questionnaire YSQ-S3 (Young Schema Questionnaire)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dystonia
Brain Function in Focal Dystonia
Objectives The main objectives of this proposal are (1) to characterize motor learning abnormalities in patients with focal dystonia; (2) to show, using transcranial magnetic stimulation, that this abnormal motor learning went…
- Trial name
- NCT00102999
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cervical Dystonia Adults ,, Abnormal Head Position and Neck Pain for These 7 Muscle Groups: Splenius,Scalene,Sterno-cleido-mastoid,Levator Scapulae,Semispinalis,Trapezius,and Longissimus.
ASIS for Botox in Cervical Dystonia
Botox acts on nerve endings, yet there are no nerve endings inside the muscle, where they are typically injected. All nerves terminate on the fascia, where ASIS device can precisely deliver Botox by creating that subdermal…
- Trial name
- ASISinCD (NCT02074293)
- Testing
- Gadolinium, Efficacy of Botox intramuscularly at Week 6, Efficacy of Botox intramuscularly at Week 12
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- li nguyen
Spasmodic Dysphonia, Laryngeal Dystonia
Examining the Spasmodic Dysphonia Diagnosis and Assessment Procedure (SD-DAP) for Measuring Symptom Change
This is a study of patients with spasmodic dysphonia to determine how best to measure the severity of the disorder in patients. It addresses which characteristics of speech are the best indicator of whether or not a particular…
- Trial name
- NCT02061943
- Where
- 2 sites in United States
- Sponsor
- Emory University
Cervical Dystonia
Zinc as an Adjunctive Therapy for Cervical Dystonia
The goal of this clinical trial is to evaluate if supplemental zinc can prolong the duration of benefit of botulinum toxin injections in cervical dystonia patients receiving care at the University of Florida.
- Trial name
- NCT07140874
- Testing
- Zinc citrate
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Cervical Dystonia
CD-PROBE: Cervical Dystonia Patient Registry for the Observation of onabotulinumtoxinA Efficacy
This study is an observational trial which will measure the efficacy of onabotulinumtoxinA in treating Cervical Dystonia.
- Trial name
- NCT00836017
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 1,046 people
- Sponsor
- Allergan