Clinical trials: Dystonic Disorders
Laryngeal Dystonia, Spasmodic Dysphonia
Characterization of Clinical Phenotypes of Laryngeal Dystonia and Voice Tremor
The researchers will systematically evaluate current and novel clinical voice assessment tools and measures to elucidate distinct clinical phenotypes of those with laryngeal dystonia and voice tremor.
- Conditions
- Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
- Trial name
- NCT05150106
- Testing
- Clinical assessments of laryngeal function
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Dystonia, Neurologic Disorder
Study of Behavioral Dysfunctions and Related Neuronal Correlates in Patients With Dystonia
Dystonias represent hyperkinetic movement disorders characterized by protracted muscle contractions, such as to cause torsional movements and anomalous postures in different parts of the body.
- Conditions
- Dystonia, Neurologic Disorder, NEUROSCIENCE
- Trial name
- D-DIST (NCT06264063)
- Testing
- control group, experimental group, EEG power in alpha band
- Where
- Italy
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Focal Dystonia, Healthy Volunteers
Depotentiation in People With Focal Hand Dystonia
Background: Focal hand dystonia (FHD) causes muscles to contract, leading to abnormal movements or postures. Musicians, writers, and athletes often get it.
- Trial name
- NCT02106936
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonia, Tremor
Repetitive Transcranial Magnetic Stimulation (rTMS) for Dystonia and Tremor
The study will include subjects diagnosed with Dystonic Tremor (DT), Essential Tremor (ET), and healthy controls in the age range of 21-80 years. Electroencephalography (EEG) will be used as the primary outcome measure.
- Trial name
- NCT04299087
- Testing
- repetitive Transcranial Magnetic Stimulation (rTMS), Control group
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Florida
Healthy, Focal Dystonias
Role of Dopamine Receptors in Primary Focal Dystonias
Dystonia is a disabling movement disorder characterized by repetitive patterned or sustained muscle contractions causing twisting or abnormal postures that may afflict 250,000 people in the U.S.
- Trial name
- NCT01373840
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Deformational Plagiocephaly, Deformational Posterior Plagiocephaly
Effectiveness of Repositioning and Cranial Remolding in Infants With Cranial Deformation
This study will examine how effective caregiver's repositioning strategies are in correcting an infant's deformational cranial shape, as well as the effectiveness of the use of a custom cranial remolding orthosis for treatment of…
- Conditions
- Deformational Plagiocephaly, Deformational Posterior Plagiocephaly, Brachycephaly, Torticollis
- Trial name
- NCT05917678
- Testing
- Repositioning Therapy, Cranial Remolding Orthosis
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Torticollis Congenital, Motor Development
Development in Children Diagnosed With Congenital Muscular Torticollis
It has been thought that head position may affect the shoulder, rib cage and abdominal muscles, which may have a negative effect on posture control and movement development, sensory-motor coordination and cause retardation in…
- Conditions
- Torticollis Congenital, Motor Development, Sensory Integration Dysfunction
- Trial name
- NCT06879314
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Dystonia, Drug Induced Dystonia
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia
This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.
- Conditions
- Dystonia, Drug Induced Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- NCT05317390
- Testing
- DystoniaNet-based diagnosis of isolated dystonia
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Laryngeal Dystonia, Spasmodic Dysphonia
Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor
The researchers will examine functional neural correlates that differentiate between laryngeal dystonia and voice tremor and contribute to disorder-specific pathophysiology using a cross-disciplinary approach of multimodal brain…
- Conditions
- Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
- Trial name
- NCT05216770
- Testing
- Brain imaging, Laryngeal sensory block with topical bupivacaine
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Focal Dystonia
Electrophysiological and Neuroimaging Correlates of the Effect of Zolpidem in Patients With Focal Dystonia
To study electrophysiological and imaging correlations of the clinical effectiveness of zolpidem in task-specific dystonia and to elucidate mechanisms underlying its therapeutic effects, patients with focal dystonia will be…
- Trial name
- NCT04692285
- Testing
- Zolpidem
- Where
- 2 sites in Serbia, Slovenia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Cervical Dystonia, Primary, Blepharospasm
Analysis of Gait Before and After Botulinum Toxin Treatment in Patients With Focal Dystonia
Efficient gait requires effective postural control, both static and dynamic. Hence, postural disorders may affect gait. Yet, very little is known about the specific effects of focal postural disorders such as cervical dystonia…
- Trial name
- GAIT-TOX (NCT03938363)
- Testing
- Treadmill, Botulinum Toxin injection, Severity scale of the disease
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
GLUT1DS1, Dystonia
Harmonic Ratio in Patients With GLUT1 Deficiency Syndrome
Glucose transporter deficiency syndrome type 1 (GLUT1DS) is a rare, genetically determined, neurometabolic disorder . It is estimated that about 90% of affected patients present various pathological gait patterns.
- Conditions
- GLUT1DS1, Dystonia, Gait Disorders, Neurologic, Gait Ataxia
- Trial name
- NCT05887739
- Testing
- Inertial gait analysis
- Where
- 2 sites in Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Cervical Dystonia
Specialized Physiotherapy Program for Cervical Dystonia
The investigators wish to establish on a small scale the effectiveness of adding the physiotherapy programme developed by Jean-Pierre Bleton to the present standard treatment for cervical dystonia with a view to undertaking a…
- Trial name
- NCT00703287
- Testing
- Physiotherapy
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Dr Donald Grosset
Spasmodic Dysphonia
Laryngeal Vibration for Spasmodic Dysphonia
The general aim of the research is to provide scientific evidence that vibro-tactile stimulation (VTS) represents a non-invasive form of neuromodulation that can induce measurable improvements in the speech of people with…
- Trial name
- SD-VTS (NCT03746509)
- Testing
- Laryngeal Vibration (Treatment), Laryngeal Vibration (Comparator)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cervical Dystonia
Effect of Vibro-tactile Stimulation Intensity on Head Posture in Cervical Dystonia
The primary goal of this clinical trial is to examine the effects of cervical vibrotactile stimulation intensity on abnormal head posture in people with cervical dystonia.
- Trial name
- (CD-VTS) (NCT07245615)
- Testing
- cervical vibrotactile stimulation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cerebral Palsy, Muscle Hypertonia
Hypertonia in Patients With Cerebral Palsy
This study will classify types of hypertonia in patients with cerebral palsy and determine if the classifications are reasonable in relation to the functional task of walking. Hypertonia is an abnormal increase in muscle tension.
- Trial name
- NCT00123708
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Dystonic Disorder, Healthy
Transcranial Magnetic Stimulation (TMS) Studies of Dystonia
This study will use transcranial magnetic stimulation to examine how the brain controls muscle movement in focal and generalized types of dystonia.
- Trial name
- NCT00017875
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cervical Dystonia
Neubotulinum Toxin Injection in Cerivical Dystonia
24-Week Prospective, Double-Blinded, Randomized, Cross-over design in Multicenter Study of 50 unit of Neubotulinum Toxin Type A (Neuronox) and 100 unit of Neubotulinum Toxin Type A (Neuronox) injection for Cervical Dystonia in…
- Trial name
- NTCD (NCT04582929)
- Testing
- Neuronox ® Injection
- Where
- 4 sites in Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Cervical Dystonia
Assessment of Brain Activities in Cervical Dystonia
To address joint position sense in cervical dystonia patients and how it affects the brain activity.
- Trial name
- NCT02959645
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Plagiocephaly
Newborn Head Molding and Later Asymmetries
Prospective randomized clinical interventional trial after birth in maternity ward, and follow up to 8-9 years of age. Hypothesis: Preventive handling and caring advices to parents of newborns decrease craniofacial asymmetries…
- Trial name
- NCT02283229
- Testing
- Newborns with preventive caring advices, Newborns with normal caring advices
- Where
- Finland
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Oulu