Clinical trials: E-Cig Use
Smoking, Cigarette, Electronic Cigarette Use
Dual Use of ENDS and Combustible Cigarettes
This study investigates the degree to which shared behavioral processes underlie combustible cigarette (CC) and electronic nicotine delivery system (ENDS) use in young adult dual users of these products in both the laboratory and…
- Trial name
- DUET (NCT05280535)
- Testing
- Cue Reactivity Task, Computerized Visual Dot Probe, Choice Task
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Brown University
E Cigarette Use
Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers
This is a longitudinal study of the long-term health impact of e-cigarette smoking on the lungs. Participants will be followed over a period of 5 years, and impacts of e-cigarette smoking on the lungs will be measured with…
- Trial name
- NCT04616313
- Testing
- Hyperpolarized Xenon-129 MRI of the lungs, Computed Tomography (CT), Pulmonary Function Tests (PFT)
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Tobacco Use
Baby Albert: Electronic Cigarette Pharmacokinetics (PK) and Abuse Liability
The overall aim of the current research is to understand purchasing and product choice behaviors of tobacco/nicotine users if banning the sale of fully nicotinized cigarettes were to go into effect.
- Trial name
- NCT03637452
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Nicotine Dependence
The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users
This study will help determine if menthol administered by inhalation via electronic cigarettes (e-cigarette) changes the reinforcing effects of pure nicotine administered intravenously in cigarette smokers who smoke mentholated…
- Trial name
- NCT02102100
- Testing
- nicotine, menthol
- Where
- 2 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Yale University
Small Airways Diseases, Vaping
The Canadian Lung Outcomes in Users of Vaping Devices Study
Vaping is increasingly popular with both adolescent and adult Canadians, but the long-term health impacts remain unknown. We believe that the tools we currently have to detect lung disease in people who vape may be insufficient…
- Conditions
- Small Airways Diseases, Vaping, Vaping Related Disorder, Vaping Teens
- Trial name
- CLOUD (NCT06819969)
- Where
- 8 sites in Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cigarette Smoking-Related Carcinoma
PK/PD of Vaping THC-containing Liquids vs. Smoked Cannabis
We will conduct a randomized, within-subjects clinical study to compare short-term pharmacokinetic (PK) and pharmacodynamic (PD) effects of Δ9-tetrahydrocannabinol (THC) vaping liquids vs.
- Trial name
- NCT06055231
- Testing
- Vape device, Joint, Marijuana via vape device
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Nicotine Dependence
E-cigarettes and Blood Vessel Function
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on endothelial function and markers of oxidative stress.
- Trial name
- NCT02740595
- Testing
- one time exposure to e-cig with nicotine, one time exposure to e-cig without nicotine, one time exposure to empty e-cig
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cigarette Smoking Toxicity, Nicotine
The Acute Cardiovascular Effects of Nicotine in E-cigarettes (ACE) Study
The goal of this project is to evaluate the nicotine induced acute cardiovascular changes in E-Cigarette users and also study the mechanism involved particularly with vascular impairment.
- Conditions
- Cigarette Smoking Toxicity, Nicotine, Acute Cardiovascular Disease
- Trial name
- ACE (NCT03010995)
- Testing
- Prazosin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Louisville
Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma
Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers
This trial studies what would happen if the nicotine levels in cigarettes are greatly reduced, but electronic cigarettes containing different amount of nicotine are available.
- Trial name
- NCT02964182
- Testing
- Cigarette, Nicotine Replacement, Questionnaire Administration
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Electronic Cigarette Related Lung Damage
Dissolved Phase HXe-129 MRI: A Novel Biomarker to Quantify Pulmonary Pathology
A two-center, longitudinal assessment of 40 electronic cigarette users and 40 healthy controls at the initial visit and a follow-up visit 12 months later.
- Trial name
- ECig (NCT06856525)
- Testing
- Hyperpolarized xenon 129, Cardiopulmonary Stress Test, Pulmonary Function Test
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Y. Michael Shim, MD
Current Smoker, Never Smoker
Effects of Electronic Cigarette Use on the Lungs
This randomized pilot clinical trial studies the effects of electronic cigarettes on the lungs. Studying the effects of electronic cigarettes on the lungs may provide the Food and Drug Administration (FDA) and other government…
- Conditions
- Current Smoker, Never Smoker, Tobacco Use Disorder, Former Smoker
- Trial name
- NCT02596685
- Testing
- Bronchoscopy, Electronic Cigarette, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tobacco Use
Responses to Regulated E-Cigarette Advertisements
While conventional cigarette use continues to decline among youth and young adults, e-cigarette (EC) use is on the rise. Specifically, the investigators will conduct a randomized control trial (RCT) where young adults are…
- Trial name
- NCT05207033
- Testing
- Regulated ad condition, Unregulated ad condition
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Acute Lung Injury
The Study of ELEctronic Cigarette Toxicity in a Human Model in Vivo Model of Inflammation and Vascular Dysfunction
To carry out a prospective cohort study of healthy volunteers, assessing differences between baseline pulmonary inflammation, response to LPS inhalation and endothelial function, as measured by flow mediated dilation between…
- Trial name
- SELECT (NCT02739438)
- Testing
- Electronic cigarette use, Cigarette use, Control group
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Cigarette Addiction
The Effects of Electronic Cigarette and Traditional Cigarette
The aim of the study is to investigate and compare the effects of traditional cigarette and e-cigarette consumption habits on sleep quality, fatigue, mental health and quality of life.
- Trial name
- NCT07131891
- Testing
- Fatigue Severity Scale, Depression, Anxiety and Stress Scale-21, Jenkins Sleep Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Atılım University
Smoking Cessation
Enhanced E-cigarette Coaching Intervention for Dual Users of Cigarettes and E-cigarettes
The purpose of this study is to develop and pilot test an enhanced behavioral coaching intervention for dual users of cigarettes and electronic nicotine delivery systems (ENDS) who call tobacco quitlines for help quitting smoking.
- Trial name
- NCT03575468
- Testing
- Enhanced E-cigarette Coaching, Quitline treatment as usual
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Consumer Wellness Solutions
Smoking Cessation; Tobacco Dependence, E-Cig Use
BREATHE Free Curriculum
The purpose of this study is to evaluate whether BREATHE Free, an in-person faith-based smoking cessation program, can help people quit using tobacco products, including cigarettes, cigars, cigarillos, and e-cigarettes/vapes.
- Conditions
- Smoking Cessation; Tobacco Dependence, E-Cig Use, Nicotine Dependence, Other Tobacco Product
- Trial name
- NCT06862050
- Testing
- BREATHE Free Curriculum
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Augusta University
Smoking, Cigarette Smoking
e-Cigarette - DNA Adducts
This study will examine the level of toxicity of e-cigarette use compared to smokers and nonsmokers including inflammation markers, toxicant and carcinogen exposure.
- Conditions
- Smoking, Cigarette Smoking, Electronic Cigarettes
- Trial name
- NCT03284632
- Where
- United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Tobacco Dependence
European Regulatory Science on Tobacco: Policy Implementation to Reduce Lung Diseases (EUREST-PLUS)
The main objective of EUREST-PLUS is to monitor and evaluate the impact of the Tobacco Products Directive (TPD) within the context of FCTC ratification at an EU level.
- Trial name
- EUREST-PLUS (NCT02773836)
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 6,036 people, healthy volunteers welcome
- Sponsor
- European Network For Smoking and Tobacco Prevention
E-cigarette Use, Cigarette Smoking
BIDI Stick ENDS Abuse Liability and Puffing Topography Assessment
This study assessed the abuse liability (measured by assessing how much nicotine enters the body when the BIDI Stick is used, and how this makes users feel) and puffing topography (puff characteristics like volume and duration)…
- Trial name
- NCT05072925
- Testing
- Tobacco products
- Where
- Poland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- BIDI Vapor
Tobacco Use Disorder
Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes
Cigarette smoking remains the leading cause of preventable morbidity and mortality in the US. Use of multiple tobacco products is becoming increasingly prevalent, with dual use of e-cigarettes and cigarettes representing the most…
- Trial name
- RDEC (NCT06614504)
- Testing
- Varying the nicotine content of cigarettes, Varying the nicotine content of e-cigarettes
- Where
- 2 sites in United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University of Vermont