Clinical trials: E-cigarette
Smoking Cessation, Harm Reduction
Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes
This study will evaluate a reward devaluation strategy in which smokers use the JUUL e-cigarette immediately before any combustible cigarettes (CCs) are smoked.
- Conditions
- Smoking Cessation, Harm Reduction, E-Cig Use, Cigarette Smoking
- Trial name
- RECON (NCT04188197)
- Testing
- JUUL
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Tobacco Use Disorder
Menthol Flavored E-cigarette Use During a Simulated Ban of Menthol Cigarettes
The purpose of this formative study is to provide preliminary data regarding how the availability of menthol flavored e-cigarettes affects tobacco use behavior in the context of a ban on menthol flavored cigarettes
- Trial name
- NCT03164668
- Testing
- menthol flavored e-cigarette, tobacco flavored e-cigarette
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Energy Intake, Food Intake
The Acute Effect of Vaping on Food Intake
This study assesses the acute effects of a standardized 20-minute vaping episode compared to a non-vaping control condition on ad libitum food intake during a 30-minute buffet meal, occurring approximately 45 minutes after the…
- Conditions
- Energy Intake, Food Intake, E-Cig Use, Appetite
- Trial name
- NCT04219189
- Testing
- Vaping condition, Control condition
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Tobacco Dependence
Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers
The overall goal of this project is to understand the likely health effects of cigarette smokers switching to a Standardized Research Electronic Cigarette (SREC) and to assess the role of nicotine delivery on switching and…
- Trial name
- NCT03625986
- Testing
- Nicotine-Containing Electronic Cigarette, Non-Nicotine Electronic Cigarette
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
E-cigarette Use
Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth
This clinical trial examines the influence of nicotine form, concentration, and e-liquid flavor on youth vaping behavior, as well as the heart and lung effects associated with this behavior.
- Trial name
- NCT05458895
- Testing
- ECIG lab session 1, ECIG lab session 2, ECIG lab session 3
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Health Behavior
Effects of Electronic Cigarettes on Nicotine Concentrations
This study will examine whether nicotine levels increase with electronic cigarettes. It will also examine whether electronic cigarettes alter lung function tests.
- Trial name
- ECIG (NCT01775787)
- Testing
- Nicotine with Tobacco Flavor and Tobacco & Menthol Flavor
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- UConn Health
Toxicant Exposure
Effects Among Smokers Who Use and Do Not Use E-Cigarettes
This study compares effects among Latino and African American cigarette smokers who use e-cigarettes with those who continue smoking as usual.
- Trial name
- NCT03511001
- Testing
- E-Cigarette Vs. Smoking as Usual
- Where
- 2 sites in United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- California State University, San Marcos
Electronic Cigarette Use
Assessing the Effect of Nicotine Reduction on ENDS User's Addiction and Exposures
The rapid increase of electronic nicotine delivery systems (ENDS) use by young people in the US and their potential to harm health, cause addiction, and serve as a risk for cigarette smoking or dual-use is alarming.
- Trial name
- NCT05205382
- Testing
- 5% nicotine (Partial Nicotine Reduction), 3% or 2.4% nicotine (Partial Nicotine Reduction), 5% nicotine (Total Nicotine Reduction)
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Florida International University
Tobacco Dependence
Low Nicotine Cigarettes Plus Electronic Cigarettes
This study aims to determine the health effects of very low nicotine content in cigarettes, in conjunction with the availability of nicotine-containing electronic cigarettes (e-cigs) among smokers with mental health conditions…
- Trial name
- NCT04058717
- Testing
- Normal Nicotine Content research cigarettes, High Nicotine e-cigarette, Very Low Nicotine Content research cigarettes
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Electronic Cigarette Use
Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC
The goal of this study is to conduct a pilot randomized waitlist-controlled trial to assess the feasibility, acceptability, and preliminary effects of substituting the NIDA standardized research e-cigarette (SREC) for combusted…
- Trial name
- SWITCHED (NCT05881304)
- Testing
- Standardized research e-cigarette (SREC)
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Tobacco Use Disorder
Effect of Banning Menthol Flavorant on Cigarette and E-Cigarette Use
In this pilot study, menthol cigarette smokers will be randomized to one of three experimental marketplaces: 1) a condition simulating a ban on menthol cigarettes but not menthol e-cigarettes (condition A); 2) a condition…
- Trial name
- NCT03402243
- Testing
- Menthol ban on cigarettes, Menthol ban on cigarettes and e-cigarettes, No menthol ban
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Vaping Behavior
High Impact E-cigarette Advertisement Features
This randomized controlled trial aims to examine the effects of high-impact e-cigarette advertisement features among young adults of various tobacco-use statuses.
- Trial name
- NCT06704295
- Testing
- Control ad with dark gray product with tobacco flavor name, Dark gray product with strawberry flavor name, Colorful (strawberry color) product with strawberry flavor name
- Where
- United States
- Volunteers
- 3,083 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Cigarette Smoking Behavior
Effects of Cigarette and E-cigarette Flavors on Substitutability in the ETM
In 2009, the FDA banned all flavored conventional cigarettes except menthol. While no such ban exists for e-cigarettes, proposals have emerged in several regions.
- Trial name
- NCT06910202
- Testing
- Manipulation of nicotine/tobacco product price and availability
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Virginia Polytechnic Institute and State University
Smoking
Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors
Project 2 will evaluate the impact of very low nicotine content cigarettes, e-cigarette nicotine content, and e-cigarette flavoring on cigarettes smoked per day, nicotine exposure, puff topography, discomfort/dysfunction, other…
- Trial name
- NCT03185546
- Testing
- NNC Spectrum Cigarette, VLNC Spectrum Cigarette, Moderate nicotine level e-liquid
- Where
- 2 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
E Cig Use
Young Adult EC Use and Respiratory Outcomes
E-cigarette (EC) use continues to increase among youth, and EC may be detrimental to youth respiratory health. Public health officials and the Food and Drug Administration (FDA) can now regulate ECs.
- Trial name
- NCT04395274
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Smoking, Tobacco Use
Clinical Outcomes of a Nationwide, Naturalistic E-Cig Trial (CONNECT)
The purpose of this study is to measure changes in smoking behavior during and following sampling of an e-cigarette product. E-cigarettes are classified by the US Food and Drug Administration (FDA) as a tobacco product, though…
- Trial name
- CONNECT (NCT03453385)
- Testing
- Electronic Cigarette
- Where
- United States
- Volunteers
- 638 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Electronic Cigarette Use
Assessing Electronic Cigarette Nicotine Flux
The purpose of this study is to determine differences in nicotine delivery, use behavior, carbon monoxide delivery, subjective effects, and physiological effects, when cigarette smokers use an electronic cigarette with constant…
- Trial name
- NCT04378907
- Testing
- Cigarette Smoker/ECIG users: 0 mg/ml nicotine concentration, Cigarette Smokers/ECIG users: 6 mg/ml nicotine concentration, Cigarette Smokers/ECIG users: 15 mg/ml nicotine concentration
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Nicotine Dependence
Clinical Pharmacology of Electronic Cigarettes
The purpose of this study is to learn more about nicotine exposure and the safety of electronic cigarettes (EC). It will focus on the areas that are thought to most closely relate to the addictive potential of EC, namely: (1) EC…
- Trial name
- NCT02470754
- Testing
- Tobacco Cigarette, Electronic Cigarette
- Where
- 2 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Smoking, Cigarette, Electronic Cigarettes
Evaluating New Nicotine Standards for Cigarettes - Project 3
This study is designed to examine how the nicotine content of cigarettes and the nicotine concentration and flavors in e-liquids influence responses to and use of these products in adolescent smokers.
- Trial name
- CENIC2-P3 (NCT03194256)
- Testing
- Spectrum Research Cigarettes
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Brown University
Nicotine Vaping, Nicotine
Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes
This is a single-center, randomized, controlled, open-label, cross-over study with healthy adult smokers. The study will investigate the nicotine pharmacokinetic (PK) profiles of two e-liquid variants used with the P4M3 Gen 2.0…
- Conditions
- Nicotine Vaping, Nicotine, Vaping
- Trial name
- NCT05383508
- Testing
- CA35, CM35, Cig
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.