Clinical trials: E-cigarette Use
Electronic Cigarette Use, Tobacco Smoking
Characterize the Nicotine Uptake and Subjective Effects With Use of JUUL Electronic Nicotine Delivery Systems
The purpose of this study is to estimate nicotine uptake and assess subjective effects during ad libitum use sessions of 4 flavors of JUUL ENDS (also referred to as nicotine salt pod system; NSPS) products (i.e., Virginia…
- Trial name
- NCT04123041
- Testing
- JUUL ENDS, Combustible cigarette, comparator e-cigarette, Nicorette gum
- Where
- 2 sites in United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Smoking Cessation
Exploratory Study of Switching From Combustible Cigarettes to the BIDI E-cigarette
The aim of this study is to shed light on the importance of nicotine pharmacokinetics in switching to a reduced-harm product by fully matching the nicotine pharmacokinetics of smokers' usual brands of cigarettes.
- Trial name
- NCT05855343
- Testing
- BIDI Stick e-cigarette
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Tobacco Use
Biomarkers of Exposure and Biomarkers of Potential Harm in Adult Smokers Who Completely Switch to E-vapor Products
The purpose of this study was to estimate changes in biomarkers of exposure (BoE) and biomarkers of potential harm (BoPH) in adult cigarette smokers (AS) who switched to using an e-vapor product (EVP) relative to adult smokers…
- Trial name
- NCT04800211
- Testing
- Experimental: Test Product 1, Experimental: Test Product 2
- Where
- 10 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Altria Client Services LLC
Smoking, Smoking Behaviors
CSD201201: Study to Assess Elements of Abuse Liability for Electronic Nicotine Delivery System P12
This is a randomized, open-label, 6-way crossover, multi-site study designed to evaluate elements of abuse liability (AL) including subjective effects and physiological measures (pharmacodynamics [PD]), and nicotine uptake…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT05210699
- Testing
- Product A, Product B, Product C
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Nicotine Vaping, Nicotine
Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes
This is a single-center, randomized, controlled, open-label, cross-over study with healthy adult smokers. The study will investigate the nicotine pharmacokinetic (PK) profiles of two e-liquid variants used with the P4M3 Gen 2.0…
- Conditions
- Nicotine Vaping, Nicotine, Vaping
- Trial name
- NCT05383508
- Testing
- CA35, CM35, Cig
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Nicotine Dependence, Nicotine Dependence, Cigarettes
Clinical Study Comparing 7 ENDS Products and 1 Combustible Cigarette Using 2 Delivery Methods.
A Randomized Study Comparing Nicotine Pharmacokinetics of Seven Electronic Cigarette Products and One Traditional Cigarette Across Two Delivery (10 puff and ad- libitum) Conditions, in Healthy Adult Smokers
- Conditions
- Nicotine Dependence, Nicotine Dependence, Cigarettes, Tobacco Use, Tobacco Smoking
- Trial name
- NCT03700112
- Testing
- JUUL Virginia Tobacco flavored 5.0% ENDS, PMI iQOS Heat sticks, Reynolds VUSE Solo ENDS - Original
- Where
- New Zealand
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Electronic Cigarette Use
Use Behavior, Nicotine Uptake, and Subjective Effects Comparison of Tobacco and Menthol e-Liquids by ENDS Consumers
This study is being conducted to evaluate the impact of within-flavor category (tobacco and menthol) differences in e-liquid flavors on product use behaviors, nicotine uptake, and subjective effects by current ENDS consumers when…
- Trial name
- NCT05134415
- Testing
- RELX ENDS Tobacco Flavor 1, RELX ENDS Tobacco Flavor 2, RELX ENDS Menthol Flavor 1
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cheerain HK Limited
Healthy Volunteers
Pharmacokinetic Study Comparing Nicotine Delivery From E-cigarettes and a Conventional Cigarette in Healthy Subjects
This study will compare nicotine delivery, heart rate, puffing parameters and product satisfaction in healthy subjects either using several different types of electronic cigarettes or smoking a conventional cigarette.
- Trial name
- NCT02474849
- Testing
- Use electronic cigarette or smoke conventional cigarette
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- British American Tobacco (Investments) Limited
Healthy Volunteers, Smoking
E-cigarette Nicotine Pharmacokinetic Study
This study will compare nicotine delivery and product satisfaction in healthy subjects either using several different types of electronic cigarettes or smoking a conventional cigarette.
- Trial name
- NCT03178981
- Testing
- Use electronic cigarette or smoke conventional cigarette
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- British American Tobacco (Investments) Limited
Electronic Cigarette Use, Cigarette Use, Electronic
Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to JUUL ENDS
A Randomized, Open Label, Parallel Group Study in Adult Smokers to Evaluate Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to using JUUL Electronic Nicotine Delivery Systems With…
- Conditions
- Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
- Trial name
- NCT04107779
- Testing
- Switch from UB of Combustible Cigarette to JUUL 5% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Mint ENDS
- Where
- 5 sites in United States
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Smoking
Characterization of Nicotine Exposure and Urge-to-Smoke Following Use of Electronic and Conventional Cigarettes
This trial was the initial characterization of the blu™ products being studied, with the purpose of gaining an understanding of the exposure to nicotine and craving reduction attained following use of blu™ e-cigarettes by adult…
- Trial name
- NCT02210754
- Testing
- blu™ Classic Tobacco rechargeable (2.4% nicotine, glycerin vehicle), blu™ Classic Tobacco rechargeable (2.4% nicotine, glycerin/PG vehicle), blu™ Magnificent Menthol rechargeable (2.4% nicotine, glycerin vehicle)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Lorillard Tobacco Company
Smoking Cessation, Harm Reduction
Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes
This study will evaluate a reward devaluation strategy in which smokers use the JUUL e-cigarette immediately before any combustible cigarettes (CCs) are smoked.
- Conditions
- Smoking Cessation, Harm Reduction, E-Cig Use, Cigarette Smoking
- Trial name
- RECON (NCT04188197)
- Testing
- JUUL
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Nicotine Replacement Therapy
A Study of Blood Levels of Nicotine Following an Electronic Cigarette
The purpose of this study is to assess the amount of nicotine that is absorbed into the blood stream following the use of a new Electronic Cigarette device called the CN electronic cigarette.
- Trial name
- NCT02794220
- Testing
- CN electronic cigarette 10 mg, CN electronic cigarette 15 mg, Nicorette Inhalator 15 mg
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Simbec Research
Cigarette Smoking
Characterization of Biomarkers of Tobacco Exposure, Urge-to-Smoke Following Exclusive and Dual Ad Lib Use of Electronic Cigarettes
This is a randomized, open-label, forced-switch, parallel, proof-of-concept study to assess exposure to biomarkers of tobacco exposure following short-term ad lib use of three blu e-cigarette products.
- Trial name
- NCT02385227
- Testing
- Exclusive blu™ e-cigarette A1, Exclusive blu™ e-cigarette A2, Exclusive blu™ e-cigarette A3
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Lorillard Tobacco Company
Electronic Cigarette Use
Characterization of Product Use in Smokers Switching From Cigarettes to a RELX Electronic Nicotine Delivery System
The study will assess product use behaviors, biomarkers of exposure, subjective effects, and safety in smokers who switch to a RELX ENDS over 8-weeks.
- Trial name
- NCT04708106
- Testing
- RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, RELX ENDS Tobacco and Menthol Flavors
- Where
- 5 sites in United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Cheerain HK Limited
Tobacco Use
Expanding the Click City Tobacco Prevention Program to Include E-cigarettes and Other Novel Tobacco Products
The goal of this study is to modify a smoking prevention program for 5th and 6th grade students to also target vaping e-cigarettes.
- Trial name
- NCT03682900
- Testing
- Click City®: Tobacco, Usual Tobacco Curriculum
- Where
- United States
- Volunteers
- 2,673 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Smoking
Assess Biomarkers of Tobacco Exposure and Nicotine Pharmacokinetics in Smokers After a 5-Day In-Clinic Confinement Switch to an Electronic Cigarette or Nicotine Gum
A single-center, randomized, controlled, switching, open-label, parallel cohort study. Smoking subjects will be confined to a clinic for 9 days.
- Trial name
- NCT02323438
- Testing
- Usual Brand Cigarette, Electronic Cigarette #1, Electronic Cigarette #2
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- R.J. Reynolds Vapor Company
Nicotine Addiction, Cigarette Smoking
Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use
Three hundred-twenty (320) adult smokers of menthol or non-menthol combustible cigarettes will be recruited and randomly assigned to one of five groups (n=64/group), who will be asked to switch for 12 weeks to ad libitum use of…
- Trial name
- DUAL (NCT02870218)
- Testing
- Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Electronic Cigarette Use, Cigarette Use, Electronic
Evaluating Selected Constituents in the Exhaled Breath Samples
An Open-Label, Multi-Center Study to Evaluate Selected Constituents in the Exhaled Breath Samples From the Use of JUUL Nicotine Salt Pod System Product (5% and 3% Virginia Tobacco, Mint, Mango, Menthol) Users and Conventional…
- Conditions
- Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
- Trial name
- NCT04143256
- Testing
- JUUL ENDS 5% Virginia Tobacco, JUUL 3% Virginia Tobacco ENDS, JUUL 5% Mint ENDS
- Where
- 3 sites in United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Vaping Cessation
Pilot Study of a Smartphone-Based Vaping Cessation Program
Prospective, open label, single center clinical study enrolling up to 100 participants to evaluate the effect of the Pivot vaping cessation program.
- Trial name
- NCT05642598
- Testing
- Pivot for Vape
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Pivot Health Technologies Inc.