Clinical trials: ED
Clinical Decision Support, Buprenorphine
Clinical Decision Support to Implement ED-initiated Buprenorphine for OUD
Emergency Departments (EDs) frequently care for individuals with Opioid Use Disorder (OUD). Buprenorphine (BUP) is an effective treatment option for patients with OUD that can safely be initiated in the ED.
- Conditions
- Clinical Decision Support, Buprenorphine, Opioid-use Disorder
- Trial name
- EMBED (NCT03658642)
- Testing
- Clinical Decision Support (CDS)
- Where
- 22 sites in United States
- Volunteers
- 5,047 people
- Sponsor
- Yale University
Scabies
National Study on the Epidemiology and Effectiveness of Therapies in the Treatment of Scabies
Multicentre retrospective, prospective, non-profit, national observational study
- Trial name
- SCAB-net (NCT07305961)
- Testing
- data collection
- Where
- 23 sites in Italy
- Volunteers
- 1,332 people
- Sponsor
- Societa Italiana di Dermatologia Medica, Chirurgica, Estetica e di Malattie Sessualmente Trasmesse
Gout
Improving Gout Care After an ED Visit
The prevalence of gout has been steadily increasing over several decades and is correlated with the rising burden of obesity, chronic cardiac and renal disease; all conditions overrepresented in the Southeastern U.S.
- Trial name
- CARE-Gout (NCT06534554)
- Testing
- Patient Navigation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Alabama at Birmingham
Erectile Dysfunction
Vardenafil Orodispersible Tablet (ODT) Versus Placebo in Males With Erectile Dysfunction, 50% of Whom Are to be 65 Years or Older.
This study investigates the safety and efficacy of a new dosage form of Vardenafil, an orodispersible tablet (ODT), and compares it to the safety and efficacy of a placebo (inactive) tablet in the treatment of erectile…
- Trial name
- NCT00655629
- Testing
- Vardenafil ODT (STAXYN, BAY38-9456)
- Where
- 40 sites in United States, Australia and 2 more
- Volunteers
- 339 people
- Sponsor
- Bayer
Psychomotor Agitation, Behavioral Disorder
ED-TREAT (Early Detection and Treatment to Reduce Events With Agitation Tool) Compared to Usual Care
The purpose of this study is to conduct a a pilot trial that tests the acceptability, fidelity, and feasibility of ED-TREAT.
- Trial name
- NCT04959279
- Testing
- ED-TREAT
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Yale University
Extensive Stage Lung Small Cell Carcinoma, Recurrent Lung Small Cell Carcinoma
Cisplatin/Carboplatin and Etoposide With or Without Nivolumab in Treating Patients With Extensive Stage Small Cell Lung Cancer
This randomized phase II clinical trial studies whether the addition of nivolumab to cisplatin (or carboplatin) and etoposide will improve outcomes when treating patients with extensive stage small cell lung cancer.
- Trial name
- NCT03382561
- Testing
- Carboplatin, Cisplatin, Etoposide
- Where
- 779 sites in United States
- Volunteers
- 160 people
- Sponsor
- National Cancer Institute (NCI)
Homosexuality, Gender Identity
Patient Centered Methods to Collect Sexual Orientation and Gender Identity Status in the ED
This trial is the final phase of a three phase PCORI-funded study to develop and test patient-centered approaches to collect sexual orientation and gender identity (SO/GI) information in the ED.
- Trial name
- EQUALITY (NCT02701049)
- Testing
- Methods to collect SO/GI information in the ED
- Volunteers
- 749 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Food Insecurity, Food Security
The Indiana SNAP-Ed Long-term Study
The goal of the study is to determine the immediate and long-term effects of SNAP-Ed on the food insecurity of the entire household, household adults, and household children.
- Conditions
- Food Insecurity, Food Security, Education
- Trial name
- NCT03436589
- Testing
- Indiana SNAP-Ed
- Where
- United States
- Volunteers
- 575 people, healthy volunteers welcome
- Sponsor
- Purdue University
Radical Prostatectomy, Erectile Dysfunction Following Radical Prostatectomy
EVERiST: Impact of Image Detected Accessory Pudendal Artery on Erection Recovery After Nerve Sparing Prostatectomy
Prostate cancer is the most common cancer amongst men in the United Kingdom, and two common curative treatments are surgery to remove the prostate (radical prostatectomy) or radiotherapy.
- Conditions
- Radical Prostatectomy, Erectile Dysfunction Following Radical Prostatectomy, Erectile Dysfunction Due to Arterial Insufficiency, Robotic Radical Prostatectomy
- Trial name
- EVERiST (NCT07597798)
- Testing
- Robotic Radical Prostatectomy, Penile doppler ultrasound
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University College, London
All Eligible ED Patients (Not Limited to a Particular Condition)
Juice Preference in the Emergency Department
ED patients who are able to drink juice will be approached and asked their beverage preference.
- Trial name
- JUICED (NCT02506478)
- Testing
- Beverage procurement
- Where
- United States
- Volunteers
- 385 people
- Sponsor
- Hennepin Healthcare Research Institute
Intentional Self-Harm, Suicide
The BEACON Study: Smartphone-Assisted Problem-Solving Therapy in Men Presenting to the ED With Self-Harm (Protocol A)
This study evaluates the effectiveness of a smartphone-assisted problem-solving therapy (PST) service across Emergency Departments in Ontario.
- Trial name
- NCT03489382
- Testing
- Smartphone Assisted PST
- Where
- Canada
- Sponsor
- University of Ottawa
Sepsis
Prospective Observational Study to Compare REMS vs NEWS2 for Patients Presenting to the ED With Sepsis
Prospective observational study to determine the utility of Rapid Emergency Medicine Score (REMS) in comparison to National Early Warning Score2 (NEWS2) for predicting morbidity and mortality among patients presenting to the…
- Trial name
- NCT07171918
- Testing
- Antibiotics, Vasopressors
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Pain
An Efficacy and Safety of Proprietary Formulations of Oral Ketamine + Aspirin in Treatment of Acute Headache
Headaches affect over 50% of patients annually, with close to 4% of ED visits for headache. Most headaches managed in the ED are benign, with 90% of these headaches classified as tension, migraine, or cluster.
- Trial name
- NCT04860713
- Testing
- aspirin and ketamine, Nurtec (Rimegepant)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Antonios Likourezos
Smoking
Survey of Smokers Treated in the Emergency Department (ED) on Ownership and Usage of Cell Phones
To study ownership and use of cell phones in low-income smokers. This may help us better understand the impact of cell phone ownership plans on low income smokers' access to quitlines.
- Trial name
- NCT01820533
- Testing
- Cell Phone Survey
- Where
- United States
- Volunteers
- 775 people
- Sponsor
- Yale University
Erectile Dysfunction
Efficacy of Intracavernosal as add-on Therapy to Sildenafil 100 mg on Demand Compared to Sildenafil 100 mg on Demand for the Treatment of Erectile Dysfunction (ED) Not Sufficiently Responsive to Standard Therapy With Phosphodiesterase Type 5 Inhibitors
The primary objective of this study is to investigate the efficacy of intracavernosal (Xeomin®) (100U) as add-on therapy to sildenafil 100 mg on demand in men with ED and insufficient response to standard therapy with 100 mg…
- Trial name
- MENOX (NCT05196308)
- Testing
- Investigational product administration Xeomin® (MERZ PHARMACEUTICALS GMBH)
- Where
- France
- Volunteers
- 226 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Head and Neck Neoplasms, Emergency Department Presentation
Access to Care Pilot for ED-Presenting Head and Neck Cancer Patients (ENRICH-HNC)
Patients diagnosed with head and neck cancer (HNC) after presenting to an emergency department (ED) often face significant delays in diagnosis and treatment.
- Conditions
- Head and Neck Neoplasms, Emergency Department Presentation, Head and Neck Cancer (H&N)
- Trial name
- ENRICH-HNC (NCT07225725)
- Testing
- Community Health Support Specialist (CHSS) Navigation
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Tennessee
Abdominal Pain
Morphine in Acute Abdominal Pain
The investigators primary outcome measure was the clinically important change in diagnostic accuracy and physical examination in the morphine vs. placebo group.
- Trial name
- NCT01112540
- Testing
- Morphine
- Where
- Turkey (Türkiye)
- Sponsor
- Akdeniz University
Respiratory Tract Infections, Influenza, Human
Rapid Diagnostics for Upper Respiratory Infections in the Emergency Department
This is a randomized clinical trial to assess the effect of rapid, near point-of-care testing for multiple common respiratory viruses and bacteria on antibiotic and anti-influenza medication use in emergency department (ED)…
- Conditions
- Respiratory Tract Infections, Influenza, Human, Common Cold
- Trial name
- URIDxED (NCT02957136)
- Testing
- Rapid respiratory pathogen nucleic acid amplification test
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- University of California, Davis
Awareness, Mechanical Ventilation
The ED-AWARENESS-2 Trial
The investigators will screen all mechanically ventilated ED patients for study eligibility and will enroll all consecutive patients satisfying inclusion and exclusion criteria.
- Conditions
- Awareness, Mechanical Ventilation, Intubation Complication, PTSD
- Trial name
- ED-AWARENES II (NCT05534243)
- Testing
- Standard neuromuscular blocker practices, Education
- Where
- 4 sites in United States
- Volunteers
- 3,212 people
- Sponsor
- Washington University School of Medicine
Pain
Intravenous Lidocaine Versus Morphine for Severe Pain in the ED
Objective: Evaluate the analgesic efficacy of intravenous (IV) lidocaine versus provider chosen dose of IV morphine for the treatment of severe pain in the emergency department.
- Trial name
- NCT02912195
- Testing
- Intravenous lidocaine, Intravenous morphine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Alameda Health System