Clinical trials: EDS
Ehlers-Danlos Syndrome
Origins and Impact of EDS in Connective Tissues and Skin
Ehlers-Danlos Syndrome (EDS) is an inherited disease of collagen, found in connective tissues, such as skin. EDS patients suffer from joint and skin problems (skin hyperextensibility, joint hypermobility) along with a large range…
- Trial name
- NCT02721797
- Testing
- Orthopaedic & Gynaecology surgery
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- University College, London
Myocarditis, Cardiomyopathies
JOint Use of Database to Identify Risk Factors of CARDio-vascular Toxicity Induced by Immune Checkpoint Inhibitors
Immune checkpoint inhibitors (ICIs) might induce high grade immune-related adverse events (irAEs) involving the cardio-vascular system.
- Conditions
- Myocarditis, Cardiomyopathies, Heart Diseases, Cardiovascular Diseases
- Trial name
- JOCARDITE (NCT04294771)
- Testing
- ICI
- Where
- France
- Volunteers
- 500,000 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Stroke, Ischemic, Stroke Hemorrhagic
Exploring Accessible Beauty for Individuals With Upper Extremity Deficits
The purpose of this study is to investigate the accessibility of beauty products for individuals with upper extremity disabilities.
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Stroke (CVA) or TIA, Stroke, Acute
- Trial name
- NCT05945784
- Testing
- Use of Rare Beauty makeup products
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Language Discordance
Cost Effectiveness of Language Services in Hospital Emergency Departments (EDs)
Numerous studies suggest that the use of in-person, professionally trained medical interpreters can reduce health care costs associated with diagnosing and treating patients with limited English proficiency.
- Trial name
- NCT01041014
- Testing
- Professional medical interpreter
- Where
- 2 sites in United States
- Volunteers
- 447 people
- Sponsor
- Mathematica Policy Research, Inc.
Ehlers-Danlos Syndrome, Craniocervical Syndrome
Opioid-Free Anesthesia for Patients With Joint Hypermobility Syndrome Undergoing Craneo-Cervical Fixation: A Case-series
Cranio-cervical instability (CCI) has been well identified in diseases regarding connective tissue, such as Ehlers-Danlos Syndrome/Hipermobility Type (EDS-HT).
- Trial name
- NCT04437589
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Servei Central d'Anestesiologia
Cardiovascular Risk
Clinical Trial on the Effects of Caffeine and Taurine From Energy Drinks (EDs) to Parameters of the Cardiovascular System in Humans
The aim of this study is to examine the safety and the effects of EDs at high doses, either alone or in combination with other risk factors such as alcohol intake, physical exercise and sleep deprivation, on cardiovascular…
- Trial name
- NCT01421979
- Testing
- Energy Drink, Taurine, Caffeine
- Where
- Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Dehydration, Gastroenteritis
Ondansetron Administration to Children With Gastroenteritis, Vomiting and SOME Dehydration in EDs in Pakistan
The primary objective is to determine if the administration of a single dose of oral ondansetron (an anti-vomiting medication), compared to placebo, results in a reduction in intravenous (IV) rehydration therapy in children…
- Conditions
- Dehydration, Gastroenteritis, Vomiting, Diarrhea
- Trial name
- OSEP (NCT01870648)
- Testing
- Ondansetron
- Where
- 2 sites in Pakistan
- Volunteers
- 918 people
- Sponsor
- Dr. Stephen Freedman
Ehlers-Danlos Syndrome, Classical Ehlers-Danlos Syndrome
Ultrastructural Collagen Markers in Ehlers Danlos Syndromes
Establishing the diagnosis of Ehlers Danlos Syndromes (EDS)/generalized hypermobility spectrum disorders (G-HSD) is often problematic for patients.
- Conditions
- Ehlers-Danlos Syndrome, Classical Ehlers-Danlos Syndrome, Hypermobile EDS (hEDS)
- Trial name
- NCT05429996
- Testing
- Skin Biopsy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Ehlers-Danlos Syndrome
Vision-based Assessment of Joint Extensibility in Ehlers Danlos Syndrome
Ehlers Danlos Syndrome (EDS) is a heterogenous group of genetic disorders with 13 identified subtypes. Hypermobile EDS (hEDS), although the most common subtype of EDS, does not yet have an identified genetic mutation for…
- Trial name
- NCT05366114
- Testing
- No intervention, additional video data collection only
- Where
- Canada
- Volunteers
- 225 people
- Sponsor
- University Health Network, Toronto
Students, Spinal Cord Injury
Group Coaching Study for Life Goals
This study plans to implement's group coaching with neurodivergent STEM undergraduate students, individuals with spinal cord injuries and their caregivers, and individuals with Ehler's Danlos Syndrome.
- Conditions
- Students, Spinal Cord Injury, Ehlers Danlos Syndrome, Care Givers
- Trial name
- NCT07083713
- Testing
- Group Coaching
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University
Family-centered Care in Pediatric Resuscitation
Evaluation of Online Training Tools in Pediatric Resuscitation
The primary objective is to conduct a randomized controlled trial (RCT) to assess the impact of an online skills training module on 1) individual providers' self-rated confidence and comfort with and current practice of family…
- Trial name
- NCT03640520
- Testing
- FACETS: Pediatric Resuscitation, Control
- Where
- 2 sites in United States
- Volunteers
- 547 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Ehlers-Danlos Syndrome
Evaluation of a Cohort of Patients With Ehlers-Danlos Syndrome Treated With Orthopedic Surgery (SED-eval)
The aim of this study is to assess the joint involvement (shoulder - ankle - knee - elbow - wrist) in patients with Ehlers-Danlos Syndrome and treated by surgery.
- Trial name
- SED-eval (NCT05137379)
- Testing
- A joint functional score based on the affected joint
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Dry Eye Disease, Dry Eye
Neurological Dry Eye Study Stimulating Both Lacrimal and Vagus Nerves
This is a study on neurological dry eye disease, focusing on a patented over-the-counter supplement supporting tear production neurologically, including the lacrimal and vagus nerves.
- Trial name
- NCT06271005
- Testing
- NeuroTears
- Volunteers
- 75 people
- Sponsor
- Genetic Disease Investigators
Coronary Artery Disease, Platelet Aggregation Inhibitors
Plavix, Prasugrel and Drug Eluting Stents Pilot Trial
The purpose of this study is to determine the level of inhibition of platelet activation of an approved thienopyridine(clopidogrel or prasugrel) and aspirin regimen in the setting of drug eluting coronary stent implantation.
- Conditions
- Coronary Artery Disease, Platelet Aggregation Inhibitors, PCI- Percutaneous Coronary Intervention
- Trial name
- PPD (NCT01103843)
- Testing
- Loading Dose Arm, Maintenance Dose Arm
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- St. Francis Hospital, New York
Ehlers-Danlos Syndrome Hypermobility Type (hEDS)
Validity of Somatosensori Remediation for Postural Control in the Treatment of Ehlers-Danlos Syndrome Hypermobility Type (hEDS)
In the absence of a medical consensus, the current management of Ehlers-Danlos Syndrome hypermobility type (hEDS) remains very speculative That's why investigators want in this study to demonstrate the beneficial contribution of…
- Trial name
- VITALISED (NCT04020107)
- Testing
- Compressive garment and Somatosensori Remediation
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Alpha-Thalassemia, Beta-Thalassemia
FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases
FLOWER is a completely virtual, nationwide, real-world observational study to collect, annotate, standardize, and report clinical data for rare diseases.
- Conditions
- Alpha-Thalassemia, Beta-Thalassemia, Amyloidosis, Amyotrophic Lateral Sclerosis
- Trial name
- NCT06539169
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- xCures
Connective Tissue Disease, Dissecting Aneurysm
Study of Heritable Connective Tissue Disorders
The purposes of this study are to identify the genes responsible for inherited connective tissue disorders and learn about the range of medical problems they cause.
- Conditions
- Connective Tissue Disease, Dissecting Aneurysm, Ehlers Danlos Syndrome, Marfan Syndrome
- Trial name
- NCT00001641
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Marfan Syndrome, Loeys-Dietz Syndrome
Micro RNAs as a Marker of Aortic Aneurysm in Hereditary Aortopathy Syndromes
The primary objective of this study is to determine whether specific patterns of circulating micro-ribonucleic acids (miRNAs) are associated with aortic aneurysm and dissection in patients with hereditary aortopathy syndromes.
- Conditions
- Marfan Syndrome, Loeys-Dietz Syndrome, Thoracic Aortic Aneurysm and Dissection Syndromes, Ehlers-Danlos Type IV Syndrome
- Trial name
- NCT02213484
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Narcolepsy With Cataplexy, Excessive Daytime Sleepiness
Pitolisant to Assess Weekly Frequency of Cataplexy Attacks and EDS in Narcoleptic Patients (HARMONY CTP)
Double blind, randomized, parallel groups study of Pitolisant versus placebo, in narcoleptic patients experiencing EDS, and cataplexy (minimum of 3 complete or partial cataplexy attacks per week).
- Trial name
- NCT01800045
- Testing
- Pitolisant
- Where
- Hungary
- Volunteers
- 103 people
- Sponsor
- Bioprojet
Obstructive Sleep Apnea, Excessive Daytime Sleepiness
BF2.649 in Patients With OSA, Still Complaining of EDS and Refusing to be Treated by CPAP.
Multicenter randomized double blind study versus placebo during 12 weeks with at first, an escalating dose period followed by stable dose period at the selected dose.
- Trial name
- HAROSA2 (NCT01072968)
- Testing
- BF2.649
- Where
- France
- Volunteers
- 268 people
- Sponsor
- Bioprojet