Clinical trials: EMBRYO IMPLANTATION
Aortic Valve Disease Mixed, Transcatheter Aortic Valve Replacement
Feasibility of Valve-in-Root Transcatheter Aortic Valve Implantation in 363 Patients After Aortic Root Replacement and Repair
Biological replacement of the aortic valve in the sense of a complete root replacement is the therapy for a dilatation or aneurysm of the ascending aorta, which also involves the aortic valve.
- Trial name
- Valve in Root (NCT06697249)
- Testing
- Analysis of postoperative CT scans checking for the feasibility of transcatheter valve-in-root implantation
- Where
- Germany
- Volunteers
- 760 people
- Sponsor
- Alicja Zientara
Coronary Artery Bypass Grafting, Heart Valve Replacement
A Prehabilitation Program for Frail Patients Undergoing Cardiac Surgeries/Procedures
The purpose of this study is to develop and evaluate a frailty-specific prehabilitation program for patients awaiting cardiac surgeries/procedures.
- Conditions
- Coronary Artery Bypass Grafting, Heart Valve Replacement, Transcatheter Aortic Valve Implantation, Frailty
- Trial name
- PREHAB (NCT06323317)
- Testing
- Multi-component exercise programme, Structured preoperative education, Nutritional optimization
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Hearing Loss, Sensorineural
Intracochlear Platelet-rich Fibrin Application in Cochlear Implantation
Fibrosis due to surgical trauma is a common problem with cochlear implants. Fibrosis limits the effectiveness of implant and increases the power consumption.
- Trial name
- NCT05215197
- Testing
- intracochlear platelet rich fibrin administration
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Pamukkale University
Acute Kidney Injury
Remote Ischemic Preconditioning and Risk of Contrast-Induced Acute Kidney Injury in Patients Undergoing Coronary Stent Implantation
This single-center, randomized controlled trial is to investigate the impact of remote ischemic preconditioning (RIPC) on the risk contrast-induced acute kidney injury and its long-term impact on renal function for patients with…
- Trial name
- REPAIR (NCT01827891)
- Testing
- remote ischemic preconditioning (RIPC)
- Where
- China
- Volunteers
- 310 people
- Sponsor
- Beijing Anzhen Hospital
Cataract
Visual Performance With a Hydrophobic Aspheric Monofocal IOL
Artificial lenses, otherwise known as intraocular lenses (IOLs), are used to replace the natural crystalline lens within the eye during cataract or refractive lens surgery.
- Trial name
- NCT03819582
- Testing
- EyeCee One intraocular lens
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Plymouth
Coronary Artery Disease
A Randomized Controlled Comparison Between One Versus More Than Six Months of Dual Antiplatelet Therapy After Biolimus A9-eluting Stent Implantation
DES are preferred over BMS for most patients, however prolonged dual antiplatelet therapy is required for patients treated with DES for prevention of late or very late stent thrombosis. which increases a risk of major bleeding.
- Trial name
- NCT02513810
- Testing
- BioFreedom with 1 month DAPT, BioMatrix or Ultimaster with 6 to 12 months DAPT
- Where
- South Korea
- Volunteers
- 3,020 people
- Sponsor
- Yonsei University
Critical Limb Ischemia
Safety and Effect of Adipose Tissue Derived Mesenchymal Stem Cells Implantation in Patients With Critical Limb Ischemia
The purpose of this study is to investigate the efficacy and safety of autologous transplantation of Adipose Tissue derived Mesenchymal stem cells (MSCs) in patient with critical limb ischemia
- Trial name
- NCT01663376
- Testing
- Autologous Adipose Tissue derived MSCs Transplantation
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- R-Bio
Pacing Leads Implantation
An Observational Study on the Sorin Group New Brady Leads XFine and Beflex
This observational study is a non-interventional multi-centre, prospective study. The aim of the study is to evaluate the Sorin Group new passive- and active- fixation pacing leads.
- Trial name
- XFine & Beflex (NCT01168518)
- Where
- France
- Volunteers
- 2,254 people
- Sponsor
- LivaNova
Valve Stenoses, Aortic
Secondary Access - FEmoral or Radial in Transcatheter Aortic Valve Implantation?
Transcatheter aortic valve implantation (TAVI) is a well-known safe and effective treatment for anatomically suitable patients with severe aortic stenosis (AS).
- Trial name
- SAFER-TAVI (NCT06284837)
- Testing
- Access site
- Where
- 3 sites in Australia
- Volunteers
- 542 people
- Sponsor
- The Alfred
Spinal Cord Injuries, Acute Traumatic Spinal Cord Injury
Spinal Decompression Plus Nerve Graft Implantation Following TSCI
This is a single-blinded (with outcome assessors blinded to treatment allocation), 12-month pilot study to evaluate of the safety, feasibility, and preliminary efficacy of dorsal myelotomy and expansive duraplasty performed…
- Trial name
- NCT06243211
- Testing
- DMED, ANGI
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Francis Farhadi
Sudden Cardiac Death, Myocardial Infarction
Prevention Of Sudden Cardiac Death After Myocardial Infarction by Defibrillator Implantation
Patients who have survived a myocardial infarction (MI) are at increased risk for sudden cardiac death (SCD) caused by ventricular tachycardia and ventricular fibrillation.
- Trial name
- PROFID EHRA (NCT05665608)
- Testing
- Implantable cardioverter-defibrillator (ICD), Optimal Medical Therapy (OMT)
- Where
- 86 sites in Austria, Belgium and 11 more
- Volunteers
- 3,595 people
- Sponsor
- Charite University, Berlin, Germany
Ischaemic Heart Disease
Sirolimus Eluting Stents in Complex Coronary Lesions (SCANDSTENT)
The purpose of this study is to evaluate the clinical and angiographic outcome of implantation of stents eluting or not eluting Sirolimus in patients with complex coronary artery lesions suitable for percutaneous coronary…
- Trial name
- NCT00151658
- Testing
- Coronary Drug Eluting Stents for PCI
- Where
- Denmark
- Volunteers
- 322 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Endometriosis
Biomarkers in the Endometrial Fluid, Tissue, and Follicular Fluid of Moderate/Severe Endometriosis Patients
This study aims to explore biomarkers in the endometrial fluid and tissue of women with moderate to severe endometriosis, with a specific focus on those involved in pre-receptive endometrium and embryo implantation.
- Trial name
- NCT07182643
- Testing
- Endometrial fluid, Endometrial biopsy, Follicular fluid
- Where
- Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Aortic Stenosis
SecOnd-generation seLf-expandable Versus Balloon-expandable Valves and gEneral Versus Local Anesthesia in TAVI
Aim of the study is to demonstrate equivalence of second-generation self-expandable valves (CoreValve Evolut R) in comparison to second-generation balloon-expandable valves (Edwards Sapien 3) and of local anesthesia with…
- Trial name
- SOLVE-TAVI (NCT02737150)
- Testing
- CoreValve Evolut R, Edwards Sapien 3, Local anesthesia with conscious sedation
- Where
- Germany
- Volunteers
- 444 people
- Sponsor
- Helios Health Institute GmbH
Infertility, Low Molecular Weight Heparin
Weight Adjusted Low Molecular Weight Heparin in Recurrent Implantation Failure: a Randomized Open Labeled Trial
Prospective randomized study of patients with infertility candidates to Assisted ReproductiveTechniques (ART), screened for all inclusion and exclusion criteria, submitted to ART cycle with or without low molecular weight heparin…
- Trial name
- NCT02991950
- Testing
- Parnaparin Sodium
- Volunteers
- 271 people
- Sponsor
- Istituto Clinico Humanitas
Glaucoma
Alcon Hydrus Stent Implantation - Long Term Follow up After 8 Years
The purpose of this study is to evaluate the long-term effectiveness and safety of the Hydrus implant combined with concomitant phacoemulsification for lowering intraocular pressure (IOP).Glaucoma patients often have high…
- Trial name
- NCT07460791
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Johannes Gutenberg University Mainz
Refractive Assessment
Visual Outcomes After Vivity Toric IOL Implantation
The purpose of this study is to evaluate patient satisfaction after bilateral implantation of Vivity Toric Extended Vision Intraocular lens and visual outcomes.
- Trial name
- NCT04675489
- Testing
- Procedure: Vivity Toric IOL
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- EVP Eye Care
Heart Failure
Prevention of Hemorrhage After Implantation of Mechanical Circulatory Support
Main objective of the study is to demonstrate that a prophylactic treatment with VWF factor concentrate after implantation of continuous-flow left ventricular assist device (CF-LVAD) reduces the frequency of clinically…
- Trial name
- PHAM (NCT02488525)
- Testing
- Prophylactic treatment with Wilfactin
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Lille
Cataract Surgery, Intraocular Lens Position
The Effect of Capsulotomy Size on Effective Lens Position in Robotic Laser Cataract Surgery
The goal of this clinical trial is to learn whether the size of the opening made during laser-assisted cataract surgery affects where the artificial lens sits in the eye and the glasses prescription after surgery.
- Conditions
- Cataract Surgery, Intraocular Lens Position, Refractive Outcomes After Cataract Surgery, Cataract
- Trial name
- PRECISE (NCT07856849)
- Testing
- Femtosecond Laser Capsulotomy - Small Size (4.6 mm), Femtosecond Laser Capsulotomy - Large Size (5.6 mm)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Twin Cities Eye Consultants
Aortic Stenosis, Gender
TAVI and Gender Outcomes Aortic Stenosis Undergoing Transfemoral Transcatheter Aortic Valve Implantation.
Severe aortic stenosis (AS) is the commonest form of valvular abnormality in the developed world and transcatheter aortic valve implantation (TAVI) is now widely practiced as in many cases is the preferred treatment option over…
- Conditions
- Aortic Stenosis, Gender, Surgery
- Trial name
- NCT04915976
- Volunteers
- 14,086 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
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