Clinical trials: ENT Disorder
ENT Disorder, Nasal Procedures
Pharmacokinetics, Safety, and Tolerability Study of GOPRELTO® Nasal Solution and NUMBRINO™ Nasal Solution
The purpose of this study is to assess the pharmacokinetic (PK) properties, safety and tolerability following a single dose administration of GOPRELTO® or NUMBRINO™ as an anesthetic for diagnostic procedures and surgeries on or…
- Conditions
- ENT Disorder, Nasal Procedures, Nasal Anesthesia, Nasal Mucosa Surgery
- Trial name
- NCT04792034
- Testing
- Cocaine Hydrochloride Nasal Solution
- Where
- 6 sites in United States
- Volunteers
- 40 people
- Sponsor
- LXO Ireland
Reflux Disease, Reflux, Gastroesophageal
One-stop-shop Endoscopy in Reflux-patients: Evaluation of ENT and GI Features
Patients suffering from gastroesophageal reflux may suffer from both esophageal and laryngeal irritations. The investigators developed an endoscopic technique called functional endoscopy to evaluate alterations in the larynx and…
- Conditions
- Reflux Disease, Reflux, Gastroesophageal, Reflux, Laryngopharyngeal
- Trial name
- ENTGI-reflux (NCT05634187)
- Testing
- Functional endoscopy
- Where
- Germany
- Volunteers
- 190 people
- Sponsor
- University Hospital Muenster
Non Small Cell Lung Cancer, Bladder Cancer
Prospective Study to Evaluate the Blood Kinetics of Immune Cells and Immunosuppressive Cytokines After Exposure to an Immunity Checkpoint Inhibitor (ICI): Study of the Impact of Chemotherapy
Non-small cell lung cancer (NSCLC) is the most common histological form, accounting for 85% of all bronchopulmonary cancers (PBC).
- Conditions
- Non Small Cell Lung Cancer, Bladder Cancer, ENT Cancer
- Trial name
- CINECI (NCT04487457)
- Testing
- Blood samples
- Where
- 2 sites in France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Tours
General Anesthesia
Multimodal Monitoring During General Anesthesia in ENT Surgery
This study evaluated whether using several monitoring methods together during general anesthesia could improve patient safety and help anesthesiologists adjust medication doses in adults undergoing ear, nose, and throat (ENT)…
- Trial name
- NCT07895836
- Testing
- Multimodal Anesthesia Monitoring (BIS, SPI, TOF), Standard Anesthesia Monitoring
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Barbara Verro
Laryngeal Diseases, Pharyngeal Diseases
ENT FiberLase CO2 Study
This study is intended to collect data regarding treatment with a new flexible fiber used to transmit laser emitted from a Carbon dioxide (CO2) laser to the transoral region.
- Trial name
- NCT01276418
- Testing
- CO2 laser
- Where
- 2 sites in Belgium, Italy
- Volunteers
- 49 people
- Sponsor
- Lumenis Be Ltd.
Apnea, Obstructive, Tonsillitis
Evaluation of the Functional Impact of Adenotonsilectomy
Spirometric assessment of respiratory function before and after adenotonsillectomy surgery
- Conditions
- Apnea, Obstructive, Tonsillitis, Tonsillar Hypertrophy, Respiratory Function Impaired
- Trial name
- NCT05532228
- Testing
- Adenotonsillectomy
- Where
- Portugal
- Volunteers
- 78 people
- Sponsor
- Instituto de Ciências Biomédicas Abel Salazar
Chronic Rhinitis, Inflammation of the Nasal Mucosa
Surgical Reduction of the Inferior Turbinates for Nasal Obstruction
The primary goal of this post-marketing surveillance study is to assess whether surgical turbinate reduction performed using a Coblation® device is associated with reduced nasal obstruction symptoms.
- Conditions
- Chronic Rhinitis, Inflammation of the Nasal Mucosa, Inflammation of Nasal Tissue
- Trial name
- NCT00737906
- Testing
- Surgical turbinate reduction procedure
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- ArthroCare Corporation
Human Papillomavirus
Multi-site HPV Screening by High-throughput Sequencing in Patients With Chronic HPV-HR Infection Followed by Gynecology
The main risk of developing cervical cancer is the persistence of an High risk human papillomavirus (HPV-HR) infection, the mechanisms of which are still not understood.
- Trial name
- DEP-HPV (NCT04901351)
- Testing
- Smear
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Sensorineural Hearing Loss, Bilateral Hearing Loss
Comparative Analysis of Hearing Outcomes: Robotic vs. Manual Insertion of Cochlear Implants
This research study is evaluating two different methods of cochlear implant (CI) insertion - robotic-assisted insertion and manual insertion - to better understand how they affect hearing outcomes.
- Conditions
- Sensorineural Hearing Loss, Bilateral Hearing Loss, Cochlear Implantation, Hearing Disorders
- Trial name
- NCT07081542
- Testing
- IotaSoft Robotic Insertion System, Manual Cochlear Implant Insertion
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- AdventHealth
Cancer, Sarcoma Metastatic
Benefits of Early Collaboration Between Oncologists and Palliative Care Physicians in Cases of Unplanned Hospitalization for Patients With Metastatic Cancer
This is a multicenter, national, interventional, cluster-randomized study, "stepped wedge" design. This study includes patients with metastatic or locally advanced digestive, gynecological, ENT, or sarcoma cancer, currently…
- Conditions
- Cancer, Sarcoma Metastatic, Gynaecologic Cancer, Digestive Cancers
- Trial name
- SPPC (NCT07490106)
- Testing
- Early integrated palliative care, Usual oncological care
- Where
- France
- Volunteers
- 493 people
- Sponsor
- Centre Oscar Lambret
Oxygen Deficiency, Desaturation of Blood
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Use in Pediatric Procedures
THRIVE (Transnasal Humidified Rapid-Insufflation Ventilatory Exchange) refers to the use of high-flow nasal cannula to augment the ability to oxygenate and ventilate a patient under general anesthesia.
- Conditions
- Oxygen Deficiency, Desaturation of Blood, Hypoventilation, Anesthesia; Adverse Effect
- Trial name
- NCT03430206
- Testing
- High-flow nasal cannula
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Stanford University
Mouth Breathing
Posture and Pulmonary Function of Mouth-breathing Children
The purpose of this study is to characterize the posture and respiratory function of mouth-breathing children.
- Trial name
- NCT01019525
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Hypotension, ENT Disease
Influence of the "Hypotension Probability Index" on Intraoperative and Postoperative Hypotension in ENT- and OM-Surgery
The aim of the project is to investigate whether the use of the HPI can reduce the number and duration of intra- and postoperative hypotension in ventilated patients during and two hours after extensive surgery in the head and…
- Conditions
- Hypotension, ENT Disease, Acute Kidney Injury, Anesthesia
- Trial name
- NCT04151264
- Testing
- Hypotension probability index (HPI)
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- University of Giessen
Xerostomia
Interest of the Sialendoscopy Associated With a Local Injection of Corticosteroids in the Treatment of Radio-induced Xerostomia in Comparison With the Hygiene Rules
Xerostomia is defined as the subjective sensation of dry mouth, and may be associated with a reduction in saliva secretion and composition.
- Trial name
- SIALORAD (NCT04584164)
- Testing
- sialendoscopy
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Otorhinolaryngologic Neoplasms
Support Pathway for ENT Cancer Patients in a Support Care Day Hospital
Cancers of the upper respiratory / digestive tract are a major public health problem, ranking 5th among the most common cancers. Surgery plays a central role in the recommended treatments for this type of pathology.
- Trial name
- PAKO-HDJ (NCT06512662)
- Testing
- Consultations with paramedics
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Clinique Pasteur Lanroze
Cerebrospinal Fluid Leak
Perioperative CSF Leak Management - an Opinion Study
Cerebrospinal fluid (CSF) leak is a rare condition. When it involves the ventral skull base, a surgical closure may be achieved using endoscopic skull base surgery techniques.
- Trial name
- NCT04124523
- Where
- France
- Volunteers
- 153 people
- Sponsor
- University Hospital, Montpellier
Anesthesia
Prediction of Hemodynamic Reactivity During General Anesthesia Using Analgesia/Nociception Index (ANI)
The aim of this study is to evaluate the performance of Analgesia/Nociception Index for the prediction of hemodynamic reactivity in adult patients undergoing ear-nose-throat or lower limb orthopedic surgery on…
- Trial name
- NCT01839513
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hôpital Edouard Herriot
Tinnitus
Oto Smartphone App in Treating Tinnitus Amongst Adult Patients Compared with Standard Talking Therapies
A study that looks at treating tinnitus and its associated burden, insomnia and quality of life effects with a smartphone app when compared with the talking therapies already offered on the national health service.
- Trial name
- NCT06623123
- Testing
- Oto Smartphone Application (Oto Health Ltd), Tinnitus Retraining Therapy (TRT)
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- East and North Hertfordshire NHS Trust
Sinus Disease, Rhinitis
Virtual Reality Induced Analgesia for Nasal Procedures
In-office nasal procedures can cause pain and discomfort to otolaryngology patients. While local anesthesia is the mainstay choice for main management, patients may have allergies or contraindications to the anesthetic agents…
- Conditions
- Sinus Disease, Rhinitis, Turbinate; Hypertrophy Mucous Membrane, Deviated Nasal Septum Acquired
- Trial name
- NCT06812676
- Testing
- Virtual Reality Goggles
- Where
- Saudi Arabia
- Volunteers
- 64 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Mucopolysaccharidosis (MPS)
Mucopolysaccharidosis (MPS) I, II, and VI Screening in a High-Risk Population With Previous Surgical Repair or Presence of Inguinal and/or Umbilical Hernia in Combination With Pediatric ENT Surgery (The HATT Project)
Mucopolysaccharidosis (MPS) type II (MPS II; Hunter syndrome) is a rare, X-linked disease caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase (I2S) and occurs almost exclusively in boys, with an incidence of…
- Trial name
- NCT02095015
- Where
- 14 sites in United States, Canada and 5 more
- Volunteers
- 159 people
- Sponsor
- Shire