Clinical trials: EOS, open to volunteers
Chronic Obstructive Pulmonary Disease
Molecular Signatures Associated With Response to ICS Treatment in Patients With COPD Stratified by Eosinophil Levels
The 3TR-ICS COPD study is an international, multicentre, randomized, parallel, controlled study that will recruit clinically stable former smokers COPD patients (with no exacerbations in the previous 8 weeks) on treatment with…
- Trial name
- 3TR-ICS-COPD (NCT06334575)
- Testing
- Budesonide
- Where
- 6 sites in Germany, Netherlands and 2 more
- Volunteers
- 135 people
- Sponsor
- Maria Joyera Rodríguez
Eosinophilic Asthma, Eosinophilic Granulomatosis With Polyangiitis (EGPA)
Eosinophil Subpopulations in Eosinophilic-associated Diseases
This single-center, non-commercial study will involve 160 participants (80 with eosinophilic asthma (EA), 30 with eosinophilic granulomatosis with polyangiitis (EGPA), 25 with hypereosinophilic syndrome (HES), and 25 healthy…
- Conditions
- Eosinophilic Asthma, Eosinophilic Granulomatosis With Polyangiitis (EGPA), Hypereosinophilic Syndrome (HES)
- Trial name
- IREOS (NCT06911775)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Florence
Eosinophilic Gastritis, Gastroparesis
Study of Gastric Motility in Eosinophilic Gastritis
Purpose: The study is a cross-sectional observational study designed to determine if eosinophilic gastritis (EG) results in gastric motility impairment.
- Conditions
- Eosinophilic Gastritis, Gastroparesis, Gastric Motility Disorder
- Trial name
- OAT-FEED (NCT05229432)
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Asthma Exacerbations, Biomarkers / Blood
Blood Eosinophil Guided Versus Usual Care In The Management Of Mild To Moderate Asthma at Primary Care (BEAM)
The aim of this study is to evaluate usual care versus biomarker-directed care (using blood eosinophil counts) for the management of asthma patients in primary care setting.
- Conditions
- Asthma Exacerbations, Biomarkers / Blood, Eosinophil Blood Count
- Trial name
- BEAM (NCT07486401)
- Testing
- Biomarker-directed treatment for asthma management, Usual Care
- Where
- Singapore
- Volunteers
- 240 people
- Sponsor
- National Healthcare Group Polyclinics
Hypereosinophilic Syndrome
Dupilumab as Add-On Therapy for Hypereosinophilic Syndrome With Partial Clinical Response to Eosinophil-Depleting Biologic Agents
Background: Hypereosinophilic syndrome (HES) is a blood disorder that causes high levels of white blood cells called eosinophils. HES can damage the lungs and airways, intestines, skin, and other organs.
- Trial name
- NCT06477653
- Testing
- dupilumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Early Onset Scoliosis (EOS)
Safety and Efficacy Evaluation of Insight GS Growing System
Premarket, interventional, single-arm clinical study, to evaluate the safety and efficacy of Insight GS Growing System in the surgical treatment of Early Onset Scoliosis (EOS).
- Trial name
- NCT06301984
- Testing
- Insight GS
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- EVEREST PESQUISA E DESENVOLVIMENTO LTDA
EGPA - Eosinophilic Granulomatosis With Polyangiitis, Severe Asthma
Beyond EOsinophils: proteoMICS to Identify Potential Biomarker of Organ Damage and Response to MEPOLIZUMAB in EGPA
Aim of the study is to identify potential biomarkers, through a proteomic approach, which could be used to evaluate organ damage and predict the response to mepolizumab in a cohort of patients affected by EGPA.
- Conditions
- EGPA - Eosinophilic Granulomatosis With Polyangiitis, Severe Asthma, Eosinophilic Asthma
- Trial name
- BEOMICS (NCT07343661)
- Testing
- Mepolizumab 100 MG Injection [Nucala], Mepolizumab 300 mg
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Azienda Ospedaliero Universitaria di Cagliari
Asthma, Mild-to-moderate Asthma
Remission in Adults With Mild-to-moderate Asthma in Thailand
The goal of this observational study is to determine the prevalence of remission among adults with mild-to-moderate asthma, as well as the factors associated with remission in Thailand.
- Conditions
- Asthma, Mild-to-moderate Asthma, Asthma Control Level
- Trial name
- NCT07351916
- Testing
- Global Initiative for Asthma (GINA) and Asthma Control Test (ACT) questionnaires, Spirometry, Fractional exhaled nitric oxide (FeNO) test
- Where
- 2 sites in Thailand
- Volunteers
- 289 people
- Sponsor
- Thammasat University
Asthma Control
A Study Assessing the Effect of Dupilumab on Inducing Clinical Remission in Asthma
This study tests whether an asthma medication called dupilumab can help people achieve complete asthma control (called "remission") when given earlier in their disease, before asthma becomes severe.
- Trial name
- HOTHOT (NCT07309614)
- Testing
- Dupilumab Prefilled Syringe
- Where
- 5 sites in Australia, Canada and 1 more
- Volunteers
- 150 people
- Sponsor
- Université de Sherbrooke
Chronic Obstructive Pulmonary Disease, COPD
Do Blood Tests Help to Decide Which Patients With Flares of Chronic Obstructive Pulmonary Disease (COPD) Need Antibiotics and Steroids?
The goal of this clinical trial is to see if the use of two simple blood tests: C reactive protein and eosinophils, can reduce the use of steroids and antibiotics in patients with flares of chronic obstructive pulmonary disease…
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD, Exacerbation of COPD, AECOPD
- Trial name
- Bidex (NCT06929767)
- Testing
- biomarker-guided decision making, GOLD recommendations
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Ottawa Hospital Research Institute
Spinal Deformity
Multimodal Bio-mechanical Analysis of Adult Spinal Deformity With Sagittal Plane Misalignment
A good understanding of the principles of balance is vital to achieve optimal outcomes when treating spinal disorders. A complex interaction of the neuromotor system and muscular recruitment is necessary for ergonomic balance and…
- Trial name
- ASD (NCT04812730)
- Testing
- 2D versus 3D analysis of EOS stereo radiographic analysis, Static versus dynamic analysis, Pre- versus postoperative analysis
- Where
- Belgium
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Severe Asthma, Asthma Control Level
Remission in Adults With Severe Asthma in Thailand
The goal of this observational study is to determine the prevalence of remission among adults with severe asthma, as well as the factors associated with remission in Thailand.
- Trial name
- NCT07328035
- Testing
- Global Initiative for Asthma (GINA) and Asthma Control Test (ACT) questionnaires, Spirometry, Fractional exhaled nitric oxide (FeNO) test
- Where
- Thailand
- Volunteers
- 230 people
- Sponsor
- Thammasat University
Hematologic Diseases, Neoplasms
IL-5 CAR-T Cell Therapy for Refractory/Relapsed Eosinophilic Leukemia
This is an open-label, single-arm clinical study designed to evaluate the efficacy and safety of IL-5 CAR-T cell therapy in the treatment of patients with CD125-positive eosinophilic leukemia.
- Trial name
- NCT07257640
- Testing
- IL-5 CAR-T cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhejiang University
Chronic Obstructive Pulmonary Disease (COPD), Eosinophilic COPD
Prevalence and Clinical Outcome of Eosinophilic COPD
Chronic Obstructive Pulmonary Disease (COPD) is a lung condition characterized by chronic breathing symptoms and progressive airflow blockages.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Eosinophilic COPD, Acute Exacerbation of Chronic Obstructive Pulmonary Disease
- Trial name
- NCT07734883
- Volunteers
- 70 people
- Sponsor
- Assiut University
Asthma, Inflammation
PROPULSION SANTE: Inflammometry to Improve the Diagnostic Trajectory in Situations of Suspected Asthma in Children and Adults
The objective of this observational study is to assess the relevance of inflammometry (based on the measurement of fractional exhaled nitric oxide (FeNO) and blood eosinophil count (BEC)) as a tool for prioritizing respiratory…
- Conditions
- Asthma, Inflammation, Asthma in Children
- Trial name
- PROPULSION (NCT06981169)
- Testing
- FeNO, blood sample
- Where
- 3 sites in Canada
- Volunteers
- 1,500 people
- Sponsor
- Université de Sherbrooke
Early-Onset Neonatal Sepsis
Population Pharmacokinetic of Piperacillin/Tazobactam in Maternal and Neonatal Populations
The purpose of this study is to describe the population pharmacokinetic characteristics of piperacillin/tazobactam after intravenous administration in pregnant women during pregnancy and delivery, and to evaluate pharmacodynamic…
- Trial name
- NCT06076200
- Testing
- Piperacillin Sodium and Tazobactam Sodium for Injection
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shandong University
COPD
Biannual Review of Exhaled Air and Trends in Health Evaluation in COPD
This study aims to evaluate how airway inflammation, lung function, and symptoms change over time in people with chronic obstructive pulmonary disease (COPD).
- Trial name
- BREATHE-COPD (NCT07045948)
- Testing
- Blood eosinophil Count
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Eosinophil Subtype, Eosinophilic Pulmonary Diseases
The Study of Differences in Eosinophil Function and Subsets in Patients With Eosinophilic Pulmonary Diseases
The study subjects of this research are patients with eosinophil-associated pulmonary diseases, including eosinophilic granulomatosis with polyangiitis, idiopathic hypereosinophilic syndrome, idiopathic acute eosinophilic…
- Trial name
- NCT06944418
- Testing
- observation
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Eosinophilia, Hypereosinophilic Syndrome
A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression
Eosinophils are a type of white blood cell. Elevated eosinophil levels can damage the heart, nerves, and other organs, in the syndrome known as hypereosinophilic syndrome (HES).
- Trial name
- NCT00091871
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Functional Dyspepsia
Budesonide as a Treatment for Functional Dyspepsia
This clinical study is being conducted to evaluate the investigational drug, Budesonide, for the treatment of functional dyspepsia.
- Trial name
- BuDy (NCT06841406)
- Testing
- budesonide, Mannitol
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven