Clinical trials: EUS
Pancreatic Disease
EUS Ductal Evaluation in One Endoscopic Session for the Diagnosis of Exocrine Pancreas Disease
The purpose of this study is, to develop a standard of care protocol using the combination of EUS, ePFT, and sEUS during one endoscopic session (instead of the three separate endoscopic sessions).
- Trial name
- NCT01997476
- Testing
- Combined EUS, e-PFT and sEUS Testing
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pancreatic Cyst
Accuracy of Dilution of EUS-FNA Pancreatic Cyst Fluid for Carcinoembryonic Antigen (CEA) Measurement
The purpose of this research project is to determine if pancreatic cyst fluid can be diluted and provide an accurate Carcinoembryonic Antigen (CEA) level.
- Trial name
- NCT01494077
- Testing
- Laboratory processing for results
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, Irvine
Nasopharyngeal Carcinoma
EUS-FNA for Retropharyngeal Lymph Node (RPLN) in Recurrent Nasopharyngeal Carcinoma (NPC) Patients
EUS-FNA for RPLN in NPC
- Trial name
- NCT03006588
- Testing
- EUS-FNA for RPLN in NPC patients
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-sen University
Biliary Drainage, Endoscopic Ultrasound-Guided Drainage
Real-world Evaluation of Different Endoscopic Biliary Drainage Techniques in Patients With Jaundice of Biliopancreatic Malignant Origin
The incidence of pancreatic cancer is rising. Tumor-induced obstruction of the distal bile duct is a common complication, occurring during the course of nearly 80% of pancreatic tumors.
- Conditions
- Biliary Drainage, Endoscopic Ultrasound-Guided Drainage, Pancreatic Cancer
- Trial name
- PROBILEUS (NCT07817602)
- Testing
- Endoscopic drainage
- Where
- 6 sites in France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Chronic Pancreatitis
Endoscopic Ultrasound (EUS) Features of Chronic Pancreatitis
The purpose of this study is to correlate Endoscopic Ultrasound (EUS) criteria for chronic pancreatitis with surgical pathology.
- Trial name
- NCT01442454
- Testing
- chronic pancreatitis
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pancreatic Neoplasm
Endoscopic Ultrasound Radiofrequency Ablation, Database Repository
The purpose of having this database is to collect data related to endoscopic ultrasound RFA procedures performed by Indiana University EUS physicians for the treatment of tumors or adenopathy.
- Trial name
- EUS-RFA (NCT04693754)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Indiana University
Biliary Stricture
FISH in Diagnosis of Biliary Stricture
The management of biliary strictures depends on their correct pre-operative evaluation which remains challenging. Despite the emerging multitudes of new diagnostic opportunities- modalities we have today, there is still a large…
- Trial name
- NCT04391153
- Testing
- ERCP with tissue sampling
- Where
- Czechia
- Volunteers
- 96 people
- Sponsor
- University Hospital Olomouc
Liver Biopsy
Liver Biopsy Using a 19 Gauge Fine Needle Biopsy Needle
A 19 gauge FNB needle, using same technique as with 22 gauge needle, to obtain liver histological specimen in regards to core length and the number of Complete Portal Triads.
- Trial name
- NCT03910790
- Testing
- 19 gauge needle liver biopsy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- AdventHealth
Malignant Biliary Obstruction
Percutaneous Transhepatic Cholangiography Versus Endoscopic Ultrasound Guided Biliary Drainage
Patients with obstructive jaundice due to locally advanced/metastatic malignancy with dilated intrahepatic bile ducts will be recruited from the department of Gastroenterology and Hepatology at the University Hospital of Leuven.
- Trial name
- PETRUS (NCT01686425)
- Testing
- Percutaneous transhepatic cholangiography vs. endoscopic biliary drainage
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Endoscopic Ultrasonography, Liver Biopsy
19G FNB Needle vs 22G FNB Needle for EUS-Guided Liver Biopsy
EUS-guided liver biopsy (EUS-LB) is increasingly used to diagnose patients with liver disease, especially in anxious patients who need sedation. There is an ongoing debate about the optimal needle size for EUS-LB.
- Trial name
- NCT06643520
- Testing
- 19-gauge, 22-gauge
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Duzce University
CTCs, Pancreatic Cancer
EUS-guided CTCs + Multi-omics: Predicting Pancreatic Cancer Recurrence and Metastases
The investigators conduct a single-center, prospective, observational study to explore the value of EUS-guided portal vein circulating tumor cells (PV-CTCs) and their subtypes combined with multi-omics tests in the early warning…
- Conditions
- CTCs, Pancreatic Cancer, Liver Metastases, Relapse
- Trial name
- NCT07448376
- Testing
- CTC
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Huazhong University of Science and Technology
Abdominal Pain
Endosonography For Right Side Acute Intestinal Mal-Symptoms (EFRAIM- Study)
Hypothesis: Endosonography (EUS) in a single setting is equivalent to the standard algorithm combining abdominal sonography, gastroscopy, endosonography in patients with acute right side abdominal pain.
- Trial name
- EFRAIM (NCT01080690)
- Testing
- EGD, EUS
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- Technical University of Munich
Walled Off Necrosis, Pancreatitis
Encapsulation-oriented vs. Timing-oriented Strategies for Necrotizing Pancreatitis
This multicenter, randomized controlled trial (WONDER-03 study) investigates the optimal timing for endoscopic ultrasound (EUS)-guided drainage in patients with necrotizing pancreatitis.
- Conditions
- Walled Off Necrosis, Pancreatitis, Acute Necrotic Collection, Necrotizing Pancreatitis
- Trial name
- WONDER-03 (NCT07106346)
- Testing
- The timing of endoscopic intervention for necrotizing pancreatitis is determined based on the degree of encapsulation, EUS-guided drainage based on the interval from the onset of acute pancreatitis
- Where
- 36 sites in Japan
- Volunteers
- 224 people
- Sponsor
- Tokyo University
PDAC - Pancreatic Ductal Adenocarcinoma
Functional, Personalised and Integrated Profiling of Biopsied Pancreatic Tumours (CancerProfile by FNB)
Pancreatic ductal adenocarcinoma (PDAC) has the poorest prognosis of all digestive cancers due to lack of early diagnosis and limited response to treatment.
- Trial name
- NCT06666803
- Testing
- FNB sampling, blood sampling
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- IHU Strasbourg
Malignant Distal Biliary Obstruction
EUS-Guided Biliary Drainage in Patients With Inoperable Malignant Distal Biliary Obstruction and Failed ERCP: a Prospective Feasibility Multicenter Trial
This research is being done to study the safety and feasibility of recruiting patients eligible for EUS-guided biliary drainage (EGBD). Our goal is to prospectively study safety and effectiveness of this procedure.
- Trial name
- NCT01889953
- Testing
- EUS-guided biliary drainage
- Where
- 13 sites in United States, India and 3 more
- Volunteers
- 96 people
- Sponsor
- Johns Hopkins University
Gastric Outlet Obstruction, Gastric Cancer
Nasobiliary Drain Assisted EUS-guided Gastroenterostomies in Unresectable Malignant Gastric Outlet Obstruction
Gastric outlet obstruction in malignant disease appears when the tumor affects the gastroduodenal area, precluding the passage of food into the small bowel. This condition severely affects the quality of life.
- Conditions
- Gastric Outlet Obstruction, Gastric Cancer, Pancreatic Cancer
- Trial name
- PENGUIN (NCT04660695)
- Testing
- EUS-guided gastroenterostomy
- Where
- 5 sites in India, Spain
- Volunteers
- 66 people
- Sponsor
- Hospital del Rio Hortega
Pancreatic Disease
First-in-human Navigation Endoscopic Ultrasound (EUS) System Clinical Study
The implementation of Echo-endoscopy (or EUS for: Endoscopic UltraSound) is limited by the difficulty of obtaining quality EUS procedures, since the accuracy of the method relies on the endoscopist's abilities.
- Trial name
- APEUS-Nav1 (NCT05515705)
- Testing
- EUS navigation system
- Where
- France
- Volunteers
- 21 people
- Sponsor
- IHU Strasbourg
Bronchogenic Carcinoma
A New Pathway With BronchOscopic or Oesophageal Ultrasound for Lung Cancer Diagnosis and STaging (BOOST)
In the UK, staging of lung cancer is time consuming (taking on average more than 3 weeks), costly and inaccurate in up to 20% of cases.
- Trial name
- BOOST (NCT00652769)
- Testing
- Endobronchial or Endoscopic Ultrasound, Bronchoscopy, CT-guided biopsy, PET scan, Mediastinoscopy
- Where
- 4 sites in United Kingdom
- Volunteers
- 168 people
- Sponsor
- University College London Hospitals
Non Small Cell Lung
Clinical Impact of EUS in Staging NSCLC
The goal of this prospective study is to determine the clinical and economic impact of endoscopic ultrasound (EUS) in staging NSCLC.
- Trial name
- NCT00577746
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Indiana University
Pancreatic Adenocarcinoma, Chronic Pancreatitis
Endoscopic Ultrasound Elastography in Pancreatic Masses
The aim of the study is to assess elastography during EUS examinations of focal pancreatic masses, and to consequently differentiate benign versus malignant pancreatic masses in a prospective multi-center design.
- Trial name
- EUS-EG (NCT00909103)
- Where
- 18 sites in Belgium, Denmark and 8 more
- Volunteers
- 285 people
- Sponsor
- University of Medicine and Pharmacy Craiova