Clinical trials: Early Acute Respiratory Failure
COVID-19, Acute Hypoxemic Respiratory Failure
Early Versus Delayed Intubation of Patients With COVID-19
Although management of acute hypoxemic respiratory failure associated with coronavirus disease 2019 (COVID-19) often includes mechanical ventilation, the optimal timing of initiation of invasive mechanical ventilation remains…
- Trial name
- EUDOCO (NCT04632043)
- Testing
- Endotracheal intubation
- Where
- Greece
- Volunteers
- 2 people
- Sponsor
- Evangelismos Hospital
Acute Hypoxemic Respiratory Failure, Mechanical Ventilation
Early Switch From Controlled to Assisted Ventilation
The goal of this physiological intervention study is to unravel the (patho)physiological mechanisms and potential clinical benefits of a pre-specified early switch from controlled to assisted ventilation in mechanically…
- Trial name
- SWITCH-SAFE (NCT06438198)
- Testing
- Pre-specified switch from controlled to assisted ventilation when PaO2/FiO2-ratio > 200 mmHg
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Erasmus Medical Center
Covid19, Acute Respiratory Distress Syndrome
The MEseNchymal coviD-19 Trial: MSCs in Adults With Respiratory Failure Due to COVID-19 or Another Underlying Cause
This is a pilot, multi-centre, open-label randomised controlled study to assess the early efficacy of intravenous (IV) administration of CYP-001 in adults admitted to an intensive care unit (ICU) with respiratory failure
- Trial name
- MEND (NCT04537351)
- Testing
- CYP-001
- Where
- 5 sites in Australia
- Volunteers
- 14 people
- Sponsor
- Cynata Therapeutics Limited
Acute Lung Injury, ALI
A Study of RLS-0071 in Patients With Acute Lung Injury Due to COVID-19 Pneumonia in Early Respiratory Failure
The aim of this study will test the safety, tolerability, and efficacy of RLS-0071 for approximately 28 days in comparison to a placebo control in patients with acute lung injury due to COVID-19 pneumonia in early respiratory…
- Conditions
- Acute Lung Injury, ALI, COVID-19
- Trial name
- NCT04574869
- Testing
- RLS-0071 10 mg/kg, RLS-0071 40 mg/kg
- Where
- United States
- Sponsor
- ReAlta Life Sciences, Inc.
Patients at Risk of Acute Respiratory Failure
Early Detection of Acute Respiratory Failure Using an Intelligent Respiratory Monitoring System
Introduction: The monitoring of respiratory patterns is crucial in the management of respiratory diseases, but in many cases, it still relies on subjective and visual assessment.
- Trial name
- NCT07164586
- Testing
- Respiratory Pattern Monitoring, Diaphragmatic Excursion, Respiratory muscle electrical activity
- Where
- 3 sites in Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
COVID-19
Early Versus Late Use of Hi-VNI in Covid-19
This study evaluate early administration of high-velocity nasal insufflation in COVID-19 patients presented with acute respiratory failure after failure of conventional low flow nasal cannula bypassing the escalating step of Non…
- Trial name
- NCT05663138
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Acute Respiratory Failure, Shock
Impact of Early Enteral vs. Parenteral Nutrition on Risk of Gastric-Content Aspiration in Patients Requiring Mechanical Ventilation and Catecholamines
To evaluate the impact of enteral nutrition on microaspiration of gastric content and pharyngeal secretions
- Trial name
- NCT03411447
- Testing
- Parenteral nutrition, Enteral nutrition
- Where
- 6 sites in France
- Volunteers
- 139 people
- Sponsor
- Centre Hospitalier Departemental Vendee
COPD, Non Invasive Ventilation (NIV)
Value of Volume Oxygenation Index to Detect Early Failure of Non-invasive Ventilation in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Non-invasive ventilation (NIV) is an evidence-based treatment for patients with acute respiratory failure due to an exacerbation of Chronic Obstructive Pulmonary Disease (COPD).
- Conditions
- COPD, Non Invasive Ventilation (NIV), VOX Index
- Trial name
- NCT07074210
- Testing
- non invasive ventilation
- Volunteers
- 190 people
- Sponsor
- Assiut University
Acute Heart Failure
Early and Comprehensive Care Bundle in Elderly for Acute Heart Failure: a Stepped Wedge Cluster Randomized Trial
This is a prospective multicentre (N=15), stepped-wedge randomized trial that aims to evaluate the benefit of a protocolised comprehensive care bundle for early management of acute heart failure in the ED.
- Trial name
- ELISABETH (NCT03683212)
- Testing
- Early intensive care bundle
- Where
- France
- Volunteers
- 503 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Obstructive Pulmonary Disease, Acute Respiratory Failure
Early Rehabilitation of COPD Patients in ICU
Twenty per cent of the intensive care patients mechanically ventilated suffer from chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00628992
- Testing
- No specific intervention, standard therapy serving as a control group, passive mobilization of the legs, Electrical stimulation of the thigh, Cycloergometer training
- Where
- 4 sites in France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Strasbourg, France
Coronavirus Infection, Acute Respiratory Failure
Early Prone Position on Coronavirus Disease 2019 Pneumonia
the purpose of this study to evaluate the effect of early awake PP (prone position)application on oxygenation and intubation requirement in patients with acute respiratory failure due to coronavirus disease 2019 pneumonia.
- Trial name
- Prone Position (NCT04427969)
- Testing
- prone position
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Critical Illness, Acute Respiratory Failure
Study of Therapeutic Exercise in Acute Respiratory Failure to Improve Neuromuscular Disability Trial
This is a stepped-wedge, cluster randomized, trial evaluating the effect of an early goal-directed mobilization intervention for ICU patients with acute respiratory failure within 12 medical and surgical ICUs across 4 hospitals…
- Trial name
- STAND (NCT03863470)
- Testing
- Early mobilization intervention
- Where
- 4 sites in United States
- Volunteers
- 1,917 people
- Sponsor
- University of Pennsylvania
Acute Respiratory Distress Syndrome (ARDS), Hypoxemia
Early Prone Positioning and Clinical Outcomes in Non-Intubated Acute Respiratory Distress Syndrome (ARDS) Patients
This study aimed to evaluate the effectiveness of early prone positioning in improving clinical outcomes among non-intubated patients with Acute Respiratory Distress Syndrome (ARDS).
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Hypoxemia, Respiratory Failure, Non-Intubated Patients
- Trial name
- EPP-ARDS (NCT07133022)
- Testing
- Early Prone Positioning Protocol, Standard ICU Care
- Where
- Palestinian Territories
- Volunteers
- 100 people
- Sponsor
- Loai Muawiah Zabin
Cardiac Surgical Patients (CABG,Mammary Coronary Bypass Surgery,Plastic and Replacement of Valves, Atrial Septal Defect,Ventricular Septal Defect)
Evaluation of the Effectiveness and Safety of Vibro-acoustic Pulmonary Therapy (VAPT) in Complex Therapy for Acute Respiratory Failure of Mixed Type I-II Stages in Comparison With Percussion Massage in Cardiac Surgical Patients in the Early Postoperative Period
The goal of this observational study is to evaluate the effectiveness and safety of vibro-acoustic pulmonary therapy (VAPT) in complex therapy for the acute respiratory failure of mixed type I-II stages in comparison with…
- Trial name
- NCT06320483
- Testing
- Vibroacoustic device BARK VibroLUNG
- Where
- 5 sites in Kazakhstan
- Volunteers
- 310 people
- Sponsor
- Bark Technology LLP
Chronic Heart Failure, Heart Decompensation
Early-start Exercise Training in Subacute Heart Failure
The purpose of this study is to evaluate the feasibility and the short-term effects of an early-start aerobic exercise training program on functional capacity, symptoms and neurohormonal activation in chronic heart failure…
- Trial name
- RE-START (NCT02051985)
- Testing
- Aerobic exercise training, Standard physical therapy
- Where
- 9 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione Salvatore Maugeri
Chronic Respiratory Failure With Acute Decompensation Requiring Mechanical Ventilation for More Than 48 Hours
Early Chair Sitting Exercise in Mechanically Ventilated Critically Ill Patients
The occurrence of an acute respiratory failure necessitates mostly admission to ICU and mechanical ventilation (MV). Rapid and safe discontinuation of MV should be the objective for the majority of patients.
- Trial name
- RehabVent (NCT02021227)
- Testing
- Early chair sitting exercise
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Montpellier
Acute Respiratory Failure
Standardized Rehabilitation for Intensive Care Unit (ICU) Patients With Acute Respiratory Failure
Acute Respiratory Failure (ARF) requiring mechanical ventilation affects 1.1 million of the 4.4 million people admitted to United States Intensive Care Units (ICU) every year.
- Trial name
- NCT00976833
- Testing
- Standardized Rehabilitation, Usual Care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Wake Forest University
Acute Respiratory Failure
Early Initiation of High-flow Nasal Cannula Oxygen Therapy in Patients With Acute Respiratory Failure in the Emergency Department: A Before-after Study
The aim of the study is to compare the efficiency on respiratory failure regression of high-flow nasal oxygen therapy versus standard oxygen in patients admitted to the ED for de novo acute respiratory failure.
- Trial name
- NCT03447457
- Testing
- High-flow oxygen, Standard oxygen
- Where
- 2 sites in France
- Volunteers
- 102 people
- Sponsor
- Poitiers University Hospital
COVID-19, Acute Respiratory Failure
Lung Ultrasound for COVID-19 Initial Triage and Monitoring
The QUICK study main aim is to assess the predictive value at Day 1, of a model built on lung ultrasound (LUS) and clinical data, both recorded at hospital admission of COVID-19 patients.
- Conditions
- COVID-19, Acute Respiratory Failure, Triage, Lung Ultrasound
- Trial name
- QUICK (NCT04474236)
- Testing
- thoracic lung ultrasound
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Toulouse
Non Invasive Ventilation, Acute Respiratory Failure
Prevalence of an Early Success of Non-invasive Ventilation in the Emergency Departement.
Non-invasive ventilation is a mechanical ventilation who provides ventilatory support through a facemask, and without the need for tracheal intubation.
- Trial name
- VENTIRU (NCT06213623)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Poitiers University Hospital