Clinical trials: Early Acute Respiratory Failure, open to volunteers
Mechanical Ventilation Complication, Hypoxemia
Trial of Venovenous ECMO to De-Sedate, Extubate and Mobilise in Hypoxic Respiratory Failure
To determine whether a strategy of adding venovenous ECMO to mechanical ventilation, as compared to mechanical ventilation alone, increases the number of intensive care free days at day 60, in patients with moderate to severe…
- Conditions
- Mechanical Ventilation Complication, Hypoxemia, Acute Respiratory Distress Syndrome Due to COVID-19, COVID-19 Respiratory Infection
- Trial name
- REDEEM (NCT05562505)
- Testing
- Venovenous ECMO
- Where
- 7 sites in Australia, Germany
- Volunteers
- 140 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Chronic Obstructive Pulmonary Disease
Efficacy of Morphine in Reducing the Rate of Early Non-Invasive Ventilation Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Phase I/IIa
Acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD) are a major source of morbidity and mortality for patients and cost to the society.
- Trial name
- MORPHEUS I/IIa (NCT04427826)
- Testing
- Morphine hydrochloride
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Grenoble
Acute Respiratory Failure, Community-Acquired Pneumonia
Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced by Community-Acquired Pneumonia
This is a prospective, multicenter, interventional cohort study aimed at constructing a high-quality, dynamic multimodal database for patients with acute respiratory failure caused by community-acquired pneumonia (CAP-ARF).
- Trial name
- NCT07357935
- Testing
- Methylprednisolone
- Volunteers
- 500 people
- Sponsor
- Qingyuan Zhan
Acute Hypoxemic Respiratory Failure, Sepsis
EARLY-SARDS: Early AlveolaR Lung biologY Underling Sepsis-Associated ARDS
Sepsis-associated acute respiratory distress syndrome (ARDS) remains a major cause of respiratory failure and mortality in critically ill patients.
- Conditions
- Acute Hypoxemic Respiratory Failure, Sepsis, ARDS (Acute Respiratory Distress Syndrome)
- Trial name
- EARLY-SARDS (NCT07281911)
- Testing
- Serial bronchoalveolar lavage and biological-physiological assessment
- Where
- Spain
- Volunteers
- 145 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
COPD, Non Invasive Ventilation (NIV)
Value of Volume Oxygenation Index to Detect Early Failure of Non-invasive Ventilation in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Non-invasive ventilation (NIV) is an evidence-based treatment for patients with acute respiratory failure due to an exacerbation of Chronic Obstructive Pulmonary Disease (COPD).
- Conditions
- COPD, Non Invasive Ventilation (NIV), VOX Index
- Trial name
- NCT07074210
- Testing
- non invasive ventilation
- Volunteers
- 190 people
- Sponsor
- Assiut University
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis
Nasal High Flow Versus Non-invasive Ventilation for Early Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis
The purpose of this study is to determine whether nasal high flow is non inferior to non invasive ventilation (NIV) in the early treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and…
- Conditions
- Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis, Respiratory Failure With Hypercapnia
- Trial name
- HiCOPD (NCT06114667)
- Testing
- Ventilatory support via nasal high flow, Ventilatory support via NIV
- Where
- 3 sites in France
- Volunteers
- 174 people
- Sponsor
- University Hospital, Montpellier
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Respiratory Insufficiency
Early Sedation With Dexmedetomidine vs. Placebo in Older Ventilated Critically Ill Patients
Sedation remains a ubiquitous and crucial component of intensive care treatments in critically ill mechanically ventilated patients.
- Trial name
- SPICEIV (NCT06251375)
- Testing
- Dexmedetomidine
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- St. Joseph's Healthcare Hamilton