Clinical trials: Early Breast Cancer
Early Primary Breast Cancer
KVUS at Neoadjuvant CTx of Breast Cancer
Effect of the contrast-enhanced diagnostic ultrasound during neoadjuvant chemotherapy of breast cancer on the achieved tumor size reduction and tolerability of chemotherapy
- Trial name
- NCT03385200
- Testing
- SonoVue
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Early Stage Breast Carcinoma
Observational Trial on the Impact of Hypnose Used as a Sedation in Oncology Surgery in Breast Cancer
The investigators will compare the operated patients for a beginning breast cancer in the Hypnose arm and the patient in the classical general anesthesia arm.
- Trial name
- NCT03003611
- Testing
- hypnose sedation, general anesthesia
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Breast Cancer, Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Pilot Study to Determine Radioiodide Accumulation and Dosimetry in Breast Cancers Using 124I PET/CT
This is a pilot imaging study for women whose tumors express NIS [Na+I- symporter, sodium iodide symporter]. Eligibility is limited to the presence of strong (3+) and/or plasma membrane staining in > 20% of cells as determined by…
- Conditions
- Breast Cancer, Breast Cancer Early Stage Breast Cancer (Stage 1-3), Breast Cancer Metastatic Breast Cancer
- Trial name
- NCT00725946
- Testing
- Iodine-124, PET/CT with Iodine-124
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Stanford University
Early Stage Breast Cancer
A Multi Centre Study to Determine the Feasibility of Using an Integrated Consent Model to Compare Standard of Care Administration Schedules of G-CSF (Filgrastim) for Primary Prophylaxis of Chemotherapy-Induced Febrile Neutropenia in Early Stage Breast Cancer (React-G Study)
In patients with early-stage breast cancer, chemotherapy has substantially improved survival rates for breast cancer patients. Improvements in outcomes, however, are compromised by the considerable toxicities associated with…
- Trial name
- React-G (NCT02428114)
- Where
- 2 sites in Canada
- Volunteers
- 142 people
- Sponsor
- Ottawa Hospital Research Institute
ER-positive Her2-negative Early Breast Cancer
Assessment of Genomic Test Impact on Shared Decision of Adjuvant Chemotherapy in ER-positive, Her2-negative Early Breast Cancer
The need/benefit of adjuvant chemotherapy could be negligible for a certain category of patient with newly diagnosed unilateral non metastatic breast cancer.
- Trial name
- OPTIGEN (NCT03080428)
- Testing
- Genomic test
- Sponsor
- UNICANCER
Early Stage Breast Cancer
Anti-proliferative Effects of Vitamin D and Melatonin in Breast Cancer
Investigators plan to carry out a study to investigate two different pills, Vitamin D and melatonin, and whether they can reduce the spread of cancer cells in the tumors of women with breast cancer.
- Trial name
- MELO-D (NCT01965522)
- Testing
- Melatonin, Vitamin D
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Juravinski Cancer Center
Early-Stage Breast Cancer
Tangential Radiation Therapy Without Axillary Dissection in Breast Cancer
The purpose of this study is to evaluate whether treatment to the axilla (area under the arm) can be safely minimized by omitting axillary surgery and full axillary radiation therapy and replacing it with radiation therapy to the…
- Trial name
- NCT00165243
- Testing
- Tangential radiation
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Dana-Farber Cancer Institute
Early-Stage Breast Carcinoma
PICTURE Breast XS: Patient Information Combined for Local Therapy oUtcome Assessment in bREast Cancer - Cross-sectional
This project which is fully funded by the European Union FP7 Program is designed to pull together all the information we obtain from scans and x-rays to design a personalised 3-D digital model of each patient, their anatomy and…
- Trial name
- PICTURE XS (NCT02310984)
- Where
- 3 sites in Netherlands, Portugal and 1 more
- Volunteers
- 222 people
- Sponsor
- University College, London
Breast Cancer Female, Early-Stage Breast Cancer
Methylene Blue Intradermal Injection for Sentinel Lymph Node Biopsy for Breast Cancer Patients
This study is designed to compare the effectiveness of intradermal injection and subcutaneous injection with methylene blue for early-stage breast cancer patients who need sentinel lymph node biopsy.
- Conditions
- Breast Cancer Female, Early-Stage Breast Cancer, Sentinel Lymph Node
- Trial name
- NCT02982148
- Testing
- methylene blue intradermal injection, methylene blue subcutaneous injection
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Early-stage Breast Cancer, Breast Conserving Surgery
Shandong Cancer Hospital Affiliated to Shandong University
In this study,the eligible breast cancer patients will be randomized divided into two groups. the study group receive the accelerated hypo-fractioned whole breast irradiation with a concurrent boost to the tumor bed (WBI 2.5Gy…
- Trial name
- NCT02958033
- Testing
- Whole Breast irradiation Plus simultaneous tumor bed Boost
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shandong Cancer Hospital and Institute
Breast Cancer, Early Breast Cancer
A Study to Determine the Safety and Tolerability of Herceptin as an Adjuvant Therapy of Early Breast Cancer
This was an open-labeled, multi-center, prospective, non-comparative study of the safety of Herceptin (trastuzumab) used as an adjuvant therapy in patients with early breast cancer who had previously received antracycline therapy…
- Trial name
- NCT02443467
- Testing
- No intervention
- Where
- Serbia
- Volunteers
- 211 people
- Sponsor
- Hoffmann-La Roche
Early-Stage Breast Cancer
A Couples Approach to Enhance Breast Cancer Survivorship
The purpose of the proposed study is to evaluate the efficacy of a new couple-based intervention for women with recently diagnosed, early stage breast cancer and their spouses or male partners.
- Trial name
- CanThrive (NCT00665899)
- Testing
- Cancer-Focused Relationship Enhancement, Couple's Cancer Education
- Where
- 2 sites in United States
- Volunteers
- 163 people
- Sponsor
- University of North Carolina, Chapel Hill
Lymphedema, Breast Cancer Stage II
Study the Usefulness of Bio-impedance Spectroscopy in the Early Assessment of Breast Cancer Related Lymphoedema
The goal of the study is to investigate the use of bio-impedance spectroscopy in the assessment of breast cancer related lymphoedema in patients operated with lumpectomy or mastectomy, axillary lymph node dissection and…
- Conditions
- Lymphedema, Breast Cancer Stage II, Early Disease Onset
- Trial name
- NCT01599039
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Nij Smellinghe Hosptial
Untreated Operable Early Breast Cancer
Randomized Phase II Study to Assess PD 0332991 in Breast Cancer
This is a Phase II study trying to identify whether short term treatment with PD0332991 yields anti-proliferative response -defined by a low level of Ki67 expression (IHC) at surgery- or induces senescence as determined by SABG…
- Trial name
- POP (NCT02008734)
- Testing
- PD0332991
- Where
- France
- Volunteers
- 132 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Breast Cancer, Early Stage Estrogen Receptor (ER) Positive Breast Cancer
Assessment of the Decision-making Impact of the Breast Cancer Index in Recommending Extended Adjuvant Endocrine Therapy for Patients With Early Stage ER-positive Breast Cancer
Investigators will examine the impact of the Breast Cancer Index (BCI) result on patients' anxiety / fear of recurrence and satisfaction with decisions regarding endocrine therapy.
- Trial name
- NCT02057029
- Testing
- BCI Assay Results
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Yale University
Early Breast Cancer
A Pharmacodynamics Pre-surgical Study of LEE011 in Early Breast Cancer Patients (MONALEESA-1)
This is a multi-center, open-label Phase II randomized pre-surgical pharmacodynamics study.
- Trial name
- MONALEESA-1 (NCT01919229)
- Testing
- LEE011 (ribociclib), letrozole
- Where
- 7 sites in United States, Singapore and 1 more
- Volunteers
- 14 people
- Sponsor
- Novartis Pharmaceuticals
Early-Stage Breast Cancer
Trial to Evaluate Genomic Expression Profiles to Direct Preoperative Chemotherapy in Early Stage Breast Cancer
This multi-center randomized Phase II study assigned HER2-negative early-stage breast cancer patients to receive preoperative systemic chemotherapy in either a "genomic-guided" arm or a "non-guided arm." The "genomic-guided"…
- Trial name
- NCT00636441
- Testing
- Doxorubicin/Cyclophosphamide (AC) or Docetaxel/Cyclophosphamide (TC)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Duke University
Early Triple Negative Breast Cancer
BRCA1-associated DNA Repair Dysfunction in Patients With Early Triple Negative Breast Cancer Treated With Neoadjuvant Platinum-based Chemotherapy
The purpose of this study is to assess efficacy of platinum-based neoadjuvant chemotherapy in correlation with BRCA1-associated DNA repair dysfunction in patients with early triple negative breast cancer.
- Trial name
- NCT01672671
- Testing
- Doxorubicin, Paclitaxel, Cisplatin
- Where
- Russia
- Volunteers
- 41 people
- Sponsor
- Russian Academy of Medical Sciences
Early Stage Breast Cancer
Impact of Breast Magnetic Resonance Imaging (MRI) on Mastectomy Rates
The primary goal of this study is to determine if preoperative breast MRI findings resulted in more extensive surgery, i.e., mastectomy than breast conserving surgery, i.e., lumpectomy in early stage breast cancers at Summa Akron…
- Trial name
- NCT01166581
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Summa Health System
Early Breast Cancer (Phase 2), Advanced Breast Cancer (Phase 1b)
Pre-Operative Study of PF-4691502 With Letrozole Compared To Letrozole Alone In Patients With Early Breast Cancer
PF-04691502 is an inhibitor of PI3K and mTOR kinase. Published data support the hypothesis that a PI3K/mTOR antagonist in combination with letrozole might mitigate the intrinsic or acquired resistance to hormonal therapy and…
- Trial name
- NCT01430585
- Testing
- PF-04691502, PF-04691502 in combination with Letrozole, Letrozole
- Where
- 5 sites in Belgium, Italy and 2 more
- Volunteers
- 14 people
- Sponsor
- Pfizer