Clinical trials: Early Cancer Detection
Colorectal Cancer
Increasing Colorectal Cancer Screening in Urban African American Communities Via Churches
This is an intervention study to increase colorectal cancer screening and physical activity in members of African-American churches who are 50 years old and older.
- Trial name
- ACTS (NCT01139242)
- Testing
- Body & Soul nutritional intervention, Experimental: newsletters and peer counseling
- Volunteers
- 955 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Movement Disorders
Effects of Exercise-Based Interventions on Symmio Self-Movement Screen
Musculoskeletal screening for physical risk factors requires equipment and a trained healthcare or fitness professional to perform and interpret the scoring so that appropriate exercise interventions can be prescribed.
- Trial name
- NCT06268366
- Testing
- Exercise
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Evansville
Lung Cancer Screening
LUNG-07: Advancing Precision-Based Lung Cancer Screening: Implementation, AI-Guided Risk Stratification, and Biomarker Integration (CREST AI)
This research study aims to investigate methods for enhancing lung cancer screening. The study will investigate whether an artificial intelligence (AI) tool, known as Sybil, can aid in predicting the risk of lung cancer.
- Trial name
- NCT07408531
- Testing
- Sybil Artificial Intelligence (AI) screening
- Where
- 2 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Time Face to Face With Friends, Screen Media Use
Screen Free Time With Friends: a Cluster-randomized Controlled Trial
The Screen Free Time with Friends study is a cluster-randomized controlled trial aiming to promote more time face-to-face with friends and reduce recreational screen media use after school and during weekends among children aged…
- Trial name
- NCT06163495
- Testing
- Screen Free Time with Friends intervention
- Where
- 18 sites in Denmark
- Volunteers
- 685 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Prostate Cancer, Hereditary Prostate Cancer
Targeted Prostate Cancer Screening in Men With BRCA1/2 Mutations
This interventional study is a follow-up component of the IMPACT project, which aims to identify men at increased hereditary risk of prostate cancer.
- Trial name
- IMPACT (NCT07416812)
- Testing
- Targeted Prostate Cancer Screening, Telephone Follow-Up Interview
- Where
- Slovenia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Institute of Oncology Ljubljana
Cancer
a PROspective Case Control Study to Develop and Validate a Blood Test FOr mUlti-caNcers Early Detection（PROFOUND）
This study is a multi-center, case-control study aiming at developing and blinded testing machine learning-based multiple cancers early detection model by prospectively collecting blood samples from newly diagnosed cancer…
- Trial name
- PROFOUND (NCT06217900)
- Where
- 8 sites in China
- Volunteers
- 16,666 people, healthy volunteers welcome
- Sponsor
- Shanghai Weihe Medical Laboratory Co., Ltd.
Lung Cancer
Circulating and Imaging Biomarkers to Improve Lung Cancer Management and Early Detection
Validation of biomolecular markers in the circulation and radiomic features are the focus of this project.The aim is to assess the role of molecular and cellular biomarkers (exosomes antigens, Circulating tumor cells - CTCs…
- Trial name
- SMAC-2 (NCT04315753)
- Testing
- LDCT (Low Dose CT)
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Cervical Cancer
Cervical Cancer Screening Project Part C
This proposal has been developed through collaboration between the University of Minnesota and New American Community Services (NACS), and the research design is based on a needs assessment conducted by the community partner.
- Trial name
- NCT01575444
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cancer
Development and Validation of Harbinger Health Test for Early Cancer Detection
This is a prospective, multi-center, observational study with a collection of biospecimens and clinical data from approximately 10,000 participants from up to 125 clinical network sites and locations in the United States.
- Trial name
- CORE-HH (NCT05435066)
- Testing
- Harbinger Health Test
- Where
- 128 sites in United States
- Volunteers
- 8,038 people, healthy volunteers welcome
- Sponsor
- Harbinger Health
Prostate Cancer Screening
Screening for Prostate Cancer Using High Resolution Micro-ultrasound Versus Multiparametric Magnetic Resonance Imaging.
The purpose of this study is to compare whether the FDA and Health Canada approved microUS is as effective as the currently used option (MRI) for imaging the prostate gland.
- Trial name
- MUSIC-Screen (NCT06626022)
- Testing
- MRI, ExactVu
- Where
- 9 sites in United States, Canada and 3 more
- Volunteers
- 1,284 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Breast Cancer
Digital Education for Breast Cancer Screening Beliefs and Prevention Behaviors
This randomized study compared three ways of delivering standardized digital education about breast cancer and early detection among adult women.
- Trial name
- NCT07820124
- Testing
- Instagram-Based Breast Cancer Education, Website-Based Breast Cancer Education, E-Brochure Breast Cancer Education
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Gümüşhane Universıty
Lung Cancer
Validation of Multiparametric Models and Circulating and Imaging Biomarkers to Improve Lung Cancer EARLY Detection.
CLEARLY will focus on validation of a multifactorial "bio-radiomic" protocol for early diagnosis of lung cancer that combines circulating biomarkers and radiomic analysis.
- Trial name
- CLEARLY (NCT04323579)
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Human Papillomavirus-Related Cervical Carcinoma
Self-Collection for Cervical Cancer Screening and HPV Vaccination for Cancer Prevention Among Women in Emergency Care in Northeast Florida
Human Papilloma Virus (HPV) is a cause of cervical cancer in women. This study is being done to identify sites for cervical cancer screening and education regarding HPV vaccination outside of the traditional settings of primary…
- Trial name
- NCT06607874
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Smoking
Low Dose Computed Tomography for Lung Cancer Screening
This study will evaluate the impact of a proactive, EHR-supported enrollment strategy that links LDCT-eligible smokers with an evidence-based intervention comprised of a web-based program and integrated text messaging.
- Trial name
- LDCT (NCT03084835)
- Testing
- Usual Care, WEB+TXT, WEB+TXT+TTS
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Oral Squamous Cell Carcinoma (OSCC), Periodontal Disease
Discovery and Validation of Biomarkers for Periodontitis, Dental Caries and Oral Squamous Cell Carcinoma
The goal of this observational study is to develop better ways to detect and predict major oral diseases, including oral cancer, gum disease, and tooth decay.
- Conditions
- Oral Squamous Cell Carcinoma (OSCC), Periodontal Disease, Dental Caries
- Trial name
- NCT07745803
- Testing
- Step 1 and 2 periodontal therapy according to the EFP clinical practice guidelines, Dental filling with or without root canal treatment, Oral cancer surgical resection including extension, dissection and reconstruction with adjunctive radiation, chemotherapy and/or biological treatments per international guidelines,
- Where
- China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
HR-HPV Testing
Expanding Access to Cervical Cancer Screening Through Primary HR-HPV Testing and Self-sampling: a Multicomponent Intervention for Safety Net Health Systems
To learn about the attitudes toward implementing self-collection among healthcare providers and staff, participants, and other stakeholders; and to inform the development of patient education and provider training materials to…
- Trial name
- NCT06843720
- Testing
- HR-HPV Testing
- Where
- United States
- Volunteers
- 7,100 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Study of Dual-energy (DE) Contrast-enhanced (CE) Digital Mammography
This is a feasibility study to evaluate dual-energy (DE) contrast-enhanced (CE) digital mammography to detect breast cancer in patients with increased breast density (BI-RADS category c or d).
- Trial name
- NCT02995980
- Testing
- Dual-Energy Contrast-Enhanced (DECE) mammography, digital mammography
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Breast Cancer
Evaluation the Diagnostic Ability of the Cancer Detection Technology (CDT) to Detect Breast Cancer Among Women Population Over Age 40
This study aimed to validate the diagnostic ability of the CDT (cancer detection technology) software to detect breast cancer among women population.
- Trial name
- NCT01043055
- Where
- Israel
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Polyp Resection Adequacy
Colorectal Polyp Resection Adequacy
The purpose of this study is to determine the best way to ensure that polyps are completely removed by evaluating the borders of the removed polyp.
- Trial name
- NCT02217085
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Stress, Burnout, Caregiver
Reducing Work-related Screen Time in Health Care Workers During Leisure Time
The purpose of this study is to determine the effect that uninstalling work email applications from mobile devices during leisure time has on health care worker stress levels.
- Trial name
- REDUCE-SCREEN (NCT05106647)
- Testing
- Reduce screen time
- Where
- United States
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
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