Clinical trials: Early Cancer Detection
Human African Trypanosomiasis
Prospective Evaluation of an RDT to Screen for Gambiense HAT and Diagnose P. Falciparum Malaria
A prototype rapid diagnostic test (RDT) to simultaneously screen for gambiense human African trypanosomiasis (HAT) and diagnose P. falciparum malaria (the "HAT/malaria combo") has recently been developed.
- Trial name
- NCT03394976
- Testing
- No intervention
- Volunteers
- healthy volunteers welcome
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Lung Cancer
Iraqi Trial for Lung Cancer Screening
Lung cancer is a global problem. Worldwide, 1.2 million people die of lung cancer each year. In Iraq, lung cancer is the most common malignancy after breast cancer and the leading cause of cancer-related death.
- Trial name
- ITLUCAS (NCT04366661)
- Testing
- low dose CT
- Where
- Iraq
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Oncology Teaching Hospital, Baghdad
Colorectal Cancer
The Effectiveness of Personalized Colorectal Cancer Screening Based on Fecal Hemoglobin Concentration
We aim to improve the yield and effectiveness of the Dutch colorectal cancer screening program by using a personalized screening strategy based on fecal Hemoglobin concentration in previous screening round for participants with a…
- Trial name
- PERFECT-FIT (NCT05423886)
- Testing
- Personalized screening invitation interval
- Where
- Netherlands
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Esther Toes-Zoutendijk
Breast Neoplasms
Australian Screening Mammography Decision Aid Trial (ASMDAT)
The purpose of the study is to develop and evaluate a decision aid to assist women aged 70 years and over to make an informed choice about whether to continue screening mammography.
- Trial name
- NCT00247442
- Testing
- Decision aid
- Where
- Australia
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Cancer
AssesSment of Early-deteCtion basEd oN liquiD Biopsy in PANCEATIC Cancer (ASCEND-PANCREATIC)
ASCEND-PANCREATIC is a prospective, multi-omics, observational study aimed at early detecting pancreatic cancer by combined assays for biomarkers of cfDNA methylation, circulating tumor DNA (ctDNA) mutation, serum protein markers…
- Trial name
- NCT05556603
- Where
- 3 sites in China
- Volunteers
- 7,062 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Uterine Cervical Neoplasms
Economic Evaluation of Three Populational Screening Strategies for Cervical Cancer
The aim of this study was to compare the effectiveness and the costs of three types of population interventions to increase the number of female participants in the screening programmes for cancer of the cervix carried out by…
- Trial name
- CRICERVA (NCT01373723)
- Testing
- Different alternatives to improve the coverage of the populational screening programmes of cervical cancer
- Where
- Spain
- Volunteers
- 20,994 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Adenomatous Polyps
Does Cap Assisted Colonoscopy Improve Detection of Adenomatous Polyps? (CAP Trial)
Effectiveness of screening colonoscopy in cancer prevention relies on the detection and removal of adenomatous polyps. However, a substantial rate of adenomas is missed during a colonoscopy.
- Trial name
- CAP (NCT01935180)
- Testing
- Colonoscopy Cap
- Where
- 2 sites in United States
- Volunteers
- 1,148 people, healthy volunteers welcome
- Sponsor
- White River Junction Veterans Affairs Medical Center
Breast Cancer, Breast Cancer Female
Detection of Breast Cancer With Non-invasive Method Based on DNA Methylation of Circulated Tumor DNA, PBMC
A central challenge in the fight against breast cancer is how to detect disease in a noninvasive manner before it is detectable by imaging methods.
- Trial name
- NCT03480659
- Where
- Kazakhstan
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- HKGepitherapeutics
Cervical Cancer, Cancer
The Association Between Cervical Cancer Screening and Cancer Occurrence
To investigate the protective effect of cervical cancer incidence and mortality by screening attending frequency or screening pattern, and to evaluate the possible risk of developing malignancies among women with cervical…
- Trial name
- NCT01015079
- Where
- Taiwan
- Volunteers
- 6,000,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Human Papilloma Virus, Cervical Cancer
The Selfie Study- Assessing Novel Markers for Cervical Cancer Screening From Self-collected Samples
Cervical cancer is primarily caused by Human Papillomaviruses (HPV). Testing for HPV in cervical samples is now an option for cervical cancer screening.
- Conditions
- Human Papilloma Virus, Cervical Cancer, CIN 2/3
- Trial name
- SELFIE (NCT04423679)
- Testing
- Evalyn Brush
- Where
- United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- George Washington University
Breast Carcinoma
Mammography, Early Detection Biomarkers, Risk Assessment, and Imaging Technologies, MERIT Study
This study collects mammogram images, blood samples, and clinical information from women undergoing routine screening mammograms.
- Trial name
- NCT03408353
- Testing
- Biospecimen Collection, Mammography, Questionnaire Administration
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Prostate Cancer
Prostate Cancer Screening With Abbreviated MRI Protocol
Prostate cancer is one of the most common malignancies in the male population with incidence and mortality rates comparable to breast cancer in women, but in contrast, a population screening program that would fulfill all the…
- Trial name
- ProstaPilot (NCT05603351)
- Testing
- magnetic resonance, serum PSA examination, Biopsy
- Where
- Czechia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Masaryk Memorial Cancer Institute
Colorectal Cancer
Social Media and Cancer Screening Information
NORC/AmeriSpeak will recruit participants who meet the study criteria and invite them to complete a 15-minute survey. Participants will be randomly assigned to one of five conditions, with approximately 400 people in each…
- Trial name
- NCT06712901
- Testing
- Median Ranked Cancer Screening Messaging, Overall Preferred Cancer Screening Messaging, Black American Preferred Cancer Screening Messaging
- Where
- United States
- Volunteers
- 2,030 people, healthy volunteers welcome
- Sponsor
- University of Utah
Cervical Cancer Screening
Effectiveness of an eHealth Intervention for Uptake of Cervical Cancer Screening in Hispanic Women
This study will test the effectiveness of an eHealth promotora (lay health advisor) outreach strategy to increase cervical cancer screening in Hispanic women.
- Trial name
- NCT06741241
- Testing
- eHealth Promotora, eHealth Healthy Nutrition
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Florida A&M University
Human Papilloma Virus, Human Papilloma Virus Related Cervical Carcinoma
Validation of Vaginal Self-Sampling With the Abbott Multi-Collect Swab for HPV Screening in Women Aged 30 to 64 Years
This study evaluates the performance of HPV testing on vaginal self-collected samples obtained with the Abbott Multi-Collect device.
- Conditions
- Human Papilloma Virus, Human Papilloma Virus Related Cervical Carcinoma, Cervical Carcinoma
- Trial name
- VALMUDES (NCT07768787)
- Testing
- Abbott Multi-Collect Specimen Collection Swab
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- AML
Lung Cancer
Adaptation and Pilot Testing of a Lung Cancer Screening Decision Aid for Patients From a Safety-Net Healthcare System
The goal of the study is to adapt and test a participant decision aid about lung cancer screening for use with patients in theHarris Health System (HHS).
- Trial name
- NCT07382557
- Testing
- Surveys, Focus groups, Cognitive Interviews
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Effect of Health Education Regarding Screening Tools of Breast Cancer
Effect of Health Education on Female Teachers' Knowledge and Practices Regarding Early Breast Cancer Detection and Screening in the Jazan Area: A Quasi-Experimental Study
The purpose of this study is to assess the effectiveness of health education in improving the knowledge and practices of female teachers regarding screening tools and the early detection of breast cancer.
- Trial name
- NCT03398057
- Testing
- Health education, Control group
- Where
- Saudi Arabia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Anwar Ali Ahmad Alameer
Cervical Cancer Screening Methods
Project CONTINUITY: Promoting Evidence-Based Cancer Screening Among Underserved Women
Project CONTINUITY (Connecting You to Care in the Community) was developed to increase adherence to cervical cancer screening regimens from initial screening to needed follow-up care by (1) providing personalized approaches to…
- Trial name
- NCT05390567
- Testing
- Participant Choice of HPV Self-Test, Survey: Participant cancer history and cervical cancer prevention/screening knowledge, Participant Choice of Standard of Care in-clinic Pap-test
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cancer Education, Health Equity
BINGO: Bridging Knowledge, Increasing Awareness
The U.S. population is becoming more diverse, but minority groups are still significantly underrepresented in cancer clinical trials. This disparity limits our understanding of how treatments work across different populations.
- Trial name
- NCT06504407
- Testing
- Bingo Educational Game
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Oropharyngeal Cancers, Biomarker in Early Diagnosis
Active MMP-8 in Oral Fluid for the Detection of Oral and Oropharyngeal Cancer
The goal of this observational study is to evaluate whether the active-matrix metalloproteinase-8 (aMMP-8) mouth-rinse test can help detect oral and oropharyngeal cancers.
- Conditions
- Oropharyngeal Cancers, Biomarker in Early Diagnosis, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Periodontal Diseases
- Trial name
- NCT06701058
- Where
- Finland
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
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