Clinical trials: Early Cancer Detection
Cancer
Pilot Study With the Aim to Quantify a Stress Protein in the Blood and in the Urine for the Monitoring and Early Diagnosis of Malignant Solid Tumors
Recent studies shows that extracellular vesicles (named "exosomes") released by cancer cells exhibit at their membrane the stress protein HSP70, contrary to exosomes released by normal cells.
- Trial name
- EXODIAG (NCT02662621)
- Testing
- blood samples, Urine samples
- Where
- France
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Centre Georges Francois Leclerc
Colorectal Neoplasms
FIT Mailing Protocol-For Cancer Screening Navigation
We plan to study whether the impact of offering the choice of a pre-colonoscopy physician visit or direct referral to colonoscopy will increase adherence to colonoscopy relative to usual care in a large fecal immunochemical test…
- Trial name
- NCT02934958
- Testing
- Colon Cancer Screening Navigation, Standard of Care
- Where
- United States
- Volunteers
- 13,392 people, healthy volunteers welcome
- Sponsor
- Renown Regional Medical Center
Colon Adenoma, Colorectal Cancer
Clinical Efficacy Evaluation of a Computer-aided Colonoscopy as Compared With the Standard Colonoscopy.
Colonoscopy is clinically used as the gold standard for detection of colorectal cancer (CRC) and removal of adenomatous polyps of the colon and rectum.
- Trial name
- NCT05240625
- Testing
- "aetherAI" Computer-aided Polyp Detection (CADe) Systems for Colonoscopy, Standard colonoscopy
- Where
- Taiwan
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Chronic Disease, Diabetes Mellitus
Social Risk Score, Clinical Decision Support Tool and Closed Loop Referral for Social Risk Screen and Referral
The overarching goal of this project is to leverage health information technology (HIT) to integrate available digital information on social needs to improve care for racial and ethnic minorities and socially disadvantaged…
- Conditions
- Chronic Disease, Diabetes Mellitus, Hypertension, Congestive Heart Failure
- Trial name
- NCT05574699
- Testing
- Social Risk Score and CDS Tool, Standard of Care
- Where
- 5 sites in United States
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Gastric Cancer
Use of a Liquid Biopsy Signature to Detect Early-onset Gastric Cancer
Early-onset gastric cancer (EOGC) is a lethal malignancy with a poor prognosis. It differs from late-onset gastric cancer (LOGC) in clinical and molecular characteristics.
- Trial name
- NCT06023121
- Testing
- Measurement of levels of an exosome-based liquid biopsy signature
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Healthcare Worker, Covid19
A Research Platform to Screen Healthcare Workers- Coordinated Approach to Pandemic Trials of COVID-19
Recent studies have shown that some individuals may be asymptomatic but continue to shed the COVID-19 virus. These individuals may represent a population that can unknowingly transmit the virus.
- Trial name
- RESPECT (NCT04574765)
- Testing
- Nasopharyngeal swab, Questionnaire collection (CITF), Optional blood collection
- Where
- Canada
- Volunteers
- 7,373 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Cervical Cancer Screening
Introducing a Telemedicine Strategy to Deliver Cervical Cancer Screening Results in El Salvador
Telemedicine, the use of telecommunication technologies to provide healthcare services remotely, has grown exponentially in the last decade.
- Trial name
- Telemedine (NCT07482306)
- Testing
- Telemedicine
- Where
- El Salvador
- Volunteers
- 1,103 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Cervical Carcinoma
Barriers to Cervical Cancer Screening
This study evaluates barriers to cervical cancer screening among non-compliant women.
- Trial name
- NCT06284447
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 2,216 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy, Breast Cancer
Validation of a Tear-based Screening Assay for Breast Cancer
This study will explore and better understand the value, usage, and benefits of a tear-based screening test for breast cancer as a supplemental tool for screening mammograms.
- Conditions
- Healthy, Breast Cancer, Breast Cancer Female, Health Care Utilization
- Trial name
- NCT04928014
- Testing
- Schirmer Strip
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Namida Lab
Colon Cancer Screening
A Study of Using Social Networks to Encourage Three Peers to Complete Screening for Colorectal Cancer
The Black community has higher rates of colorectal cancer and lower rates of colorectal cancer screenings than whites. Getting screened through FIT testing may help catch colorectal cancer earlier, when it is easier to treat.
- Trial name
- NCT05793593
- Testing
- FITx3 intervention and CRC education, Colorectal Cancer (CRC) education alone
- Where
- 7 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer Screening
Web-Based Interactive Nurse Support Program for Cancer Screening
This randomized controlled trial was conducted to evaluate the effect of a web-based interactive nurse support program based on Pender's Health Promotion Model on knowledge, attitudes, and behaviors regarding cancer screening…
- Trial name
- NCT07648004
- Testing
- Participants received a web-based interactive nurse support program based on the Health Promotion Model. The intervention included educational videos, interactive nurse support, and evidence-based inf
- Where
- Turkey (Türkiye)
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Breast Cancer
Clinical Breast Examination and Patient Navigation Intervention in Sub-Saharan Africa
Brief summery Prolonged presentation, along with diagnostic and treatment delays, remain significant problems for breast cancer care in sub-Saharan Africa , primarily due to low health-seeking behaviour, lack of access, long…
- Trial name
- NCT07023198
- Testing
- Clinical breast examination and Navigation
- Where
- Ethiopia
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Addis Ababa University
Colorectal Cancer
Early Detection and Risk Stratification of Colorectal Cancer Based on miRNA Platform
This is a prospective, observational cohort study to establish the minimal residual disease (MRD) model for predicting relapse risk and identifying disease recurrence in patients with colorectal adenocarcinoma based on the miRNA…
- Trial name
- NCT06351384
- Testing
- miRNA detection test
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Prostate Cancer, Prostate Biopsy
The PROFILE Study: Germline Genetic Profiling: Correlation With Targeted Prostate Cancer Screening and Treatment
Prostate cancer is now the most common cancer in men in the Western world. In the United Kingdom (UK), there were over 52,000 new cases diagnosed in 2016-2018 and a lifetime risk of 1 in 8.
- Conditions
- Prostate Cancer, Prostate Biopsy, Genetic Counselling, Genetic Markers
- Trial name
- PROFILE (NCT02543905)
- Testing
- Prostate MRI and Biopsy
- Where
- United Kingdom
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Institute of Cancer Research, United Kingdom
Bowel Cancer, Colon Cancer
Serial SMS Reminders and an Opt-out Mailed FIT Kits to Improve Colorectal Screening Participation: A Single Center RCT
This pilot study is a 2-armed randomized controlled trial assessing the impact of a multimodal approach on colorectal cancer screening participation rates in a Federally Qualified Health Center.
- Trial name
- NCT03479645
- Testing
- Serial text messages and mailed FIT kit
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Liver Cancer, Biliary Tract Cancer
Early-stage Detection of LIver, Biliary TRAct and PancReatic Cancers
LIBRARY is a prospective, multi-center, observational study aimed at detecting early liver, biliary tract, and pancreatic cancers by combining assays of cell-free DNA (cfDNA) methylation, serum protein, and microRNA.
- Conditions
- Liver Cancer, Biliary Tract Cancer, Pancreatic Cancer
- Trial name
- NCT06139042
- Testing
- Blood drawing
- Where
- China
- Volunteers
- 1,608 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Colorectal Cancer
Computer-Based Tailored or Standard Information for Colorectal Cancer Screening
RATIONALE: A computer program that provides information on colorectal cancer screening based on a patient's test preferences may be more effective than a computer program that gives standard information in helping patients get…
- Trial name
- NCT00955188
- Testing
- computer-assisted intervention, educational intervention, medical chart review
- Where
- 3 sites in United States
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- University of Michigan Rogel Cancer Center
Attendance, Breast Cancer Screening
The Effect on Attendance of an SMS Notification Prior to a Scheduled Screening Appointment in BreastScreen Norway
This study has been designed as a randomized controlled trial including women invited to a national screening program for breast cancer in Norway, BreastScreen Norway in 2025.
- Trial name
- NCT07355569
- Testing
- SMS notification
- Where
- Norway
- Volunteers
- 133,770 people, healthy volunteers welcome
- Sponsor
- Norwegian Institute of Public Health
Breastcancer, Breast Diseases
Empowering Latinas to Obtain Breast Cancer Screenings
The participatory-based project will quantify the 'added benefit' of an empowerment intervention relative to an education intervention for 150 Latinas on the following outcomes: women's adherence to breast cancer screening…
- Trial name
- NCT02964234
- Testing
- Empowerment, Education
- Where
- 3 sites in United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Health Behavior, Breast Cancer Screening
Improving Breast Cancer Screening Uptake Through Tailored Reminder Letters
The goal of this trial is to learn whether a culturally and linguistically tailored reminder letter can increase participation in the Flemish Breast Cancer Screening Program among women who previously did not attend screening.
- Conditions
- Health Behavior, Breast Cancer Screening, Mammography
- Trial name
- ENTER (NCT07472036)
- Testing
- Tailored reminder letter
- Where
- 2 sites in Belgium
- Volunteers
- 7,947 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
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