Clinical trials: Early Cancer Detection
Neoplasms, Solid Tumor
Methylation Profile Test (Methylscape) in Body Fluids for Multi-Cancer Detection and Monitoring in Colombia
DNA methylation changes occur early and broadly during carcinogenesis. Methylscape is a rapid assay that detects global DNA methylation patterns in body fluids (blood, urine, and saliva) and may detect a cancer signal and predict…
- Conditions
- Neoplasms, Solid Tumor, Breast Neoplasms, Lung Neoplasms
- Trial name
- METHYLSCAPE-CO (NCT07741435)
- Testing
- Methylscape DNA methylation assay
- Where
- Colombia
- Volunteers
- 3,250 people, healthy volunteers welcome
- Sponsor
- Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo
Breast Cancer, Breast Cancer Screening
Breast Cancer AI Imaging Study
This study aims to develop a social health platform called MammoChat (https://MammoChat.com) that allows patients to share their real-world patient data to a trusted network for development of clinical intelligence to improve…
- Trial name
- NCT06604078
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Pancreatic Cancer
Early Detection of Pancreatic Cancer
The purpose of this study is to enable non-invasive early detection of pancreatic cancer in high-risk populations through the establishment of a machine learning model using plasma cell-free DNA fragmentomics.
- Trial name
- NCT05596435
- Testing
- No intervention
- Where
- China
- Volunteers
- 496 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Breast Cancer
Effect of Lifestyle Factors and Hormone Function on Breast Density in Healthy Hispanic Women Who Are Undergoing Mammography for Breast Cancer Screening
RATIONALE: Lifestyle factors, such as physical activity, diet, and obesity, and hormone function may affect breast density. Screening tests, such as mammography, may help doctors find tumor cells early and plan better treatment…
- Trial name
- NCT00131950
- Testing
- physiologic testing, study of socioeconomic and demographic variables, breast imaging study
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Cervical Cancer, Cervical Dysplasia
Acceptability and Efficacy of Self-sampling for Cervical Cancer Screening: A Pilot Study
In Singapore, the current cervical cancer screening uptake among women in Singapore has remained at low 50% since its introduction in 2004.
- Conditions
- Cervical Cancer, Cervical Dysplasia, Human Papillomavirus Infection
- Trial name
- NCT03813576
- Testing
- Self-collected HPV vaginal swab
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Athletic Injuries, Soccer Injury
FIFA 11+ Warm-Up and Injury Risk Classification in Youth Amateur Soccer Players
This randomized controlled trial evaluated whether an eight-week, supervised FIFA 11+ neuromuscular warm-up program improves multifactorial injury risk classification, functional performance, and time-loss injury incidence in…
- Conditions
- Athletic Injuries, Soccer Injury, Lower Extremity Injury, Sprains and Strains
- Trial name
- NCT07713004
- Testing
- FIFA 11+ Neuromuscular Warm-Up Program, Routine Warm-Up
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Cervical Cancer
Optimizing Cervical Cancer Screening Modalities
This project aims to optimize cervical cancer screening adherence comparing Arm A (VIA) and Arm B self-sampled Human Papilloma Virus (HPV) testing and determine the molecular epidemiology of HPV, persistence level and identify…
- Trial name
- NCT03281135
- Testing
- HPV testing
- Volunteers
- 1,760 people, healthy volunteers welcome
- Sponsor
- Addis Ababa University
Healthy Adults
Study of the Safety of KSP Heptapeptide (KSP-910638G)
The purpose of this study is to evaluate the safety of orally administered KSP-910638G, a topically administered li-cor IRDye800CW labeled heptapeptide specific for human epithelial growth factor receptor 2 (HER2).
- Trial name
- NCT03161418
- Testing
- KSP-910638G, 0.4 mg, KSP-910638G, 1.2 mg
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Colorectal Cancer, Colorectal Adenoma
Protocol to Validate the Performance of the LifeKit® Prevent Colorectal Neoplasia Test for CRC Screening
The purpose of this study is to determine the sensitivity and specificity for LifeKit Prevent Colorectal Neoplasia Test for colorectal cancer (CRC) and for adenoma, including advanced adenoma.
- Trial name
- PREVENT (NCT04693546)
- Testing
- LifeKit Prevent Colorectal Neoplasia Test, FIT Test
- Where
- United States
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Metabiomics Corp
Colorectal Cancer
Polyprev: Study to Compare Fecal Immunochemical Test With Endoscopic Surveillance After Advanced Adenoma Resection in Fecal Immunochemical Test Colorectal Cancer Screening Programs.
Colorectal cancer (CRC) screening programs have been implemented to reduce the burden of the disease. When an advanced colonic lesions is detected, it is recommended to perform endoscopic surveillance with different intervals…
- Trial name
- NCT04967183
- Testing
- Annual FIT, Endoscopic surveillance.
- Where
- Spain
- Volunteers
- 3,788 people, healthy volunteers welcome
- Sponsor
- Fundacin Biomedica Galicia Sur
Colorectal Cancer Screening
Comparison of Transparent Retractable Extension Device and Narrow Band Imaging on Colorectal Adenoma Detection
The investigators previously reported that colonoscopy with a transparent retractable extension (TRE) device improved the adenoma detection rate without affecting intubation and withdrawal times.
- Trial name
- NCT00765180
- Testing
- TRE vs. NBI
- Where
- Japan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Showa Inan General Hospital
Lung Cancer, Lung Cancer, Nonsmall Cell
Lung Cancer Screening Using DNA Methylation Changes in Circulated Tumor and PBMC DNA
A central challenge in the fight against lung cancers is how to detect disease in a noninvasive manner before it is detectable by imaging methods.
- Conditions
- Lung Cancer, Lung Cancer, Nonsmall Cell, Lung Cancer, Small Cell
- Trial name
- NCT03499678
- Where
- Kazakhstan
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- HKGepitherapeutics
Colorectal Cancer
Colorectal Cancer Screening in Chinese Rural Communities
Colorectal cancer (CRC) is one of the most common malignant neoplasms significantly impacting population health and longevity. With the transformation of lifestyle and dietary patterns among Chinese residents, coupled with an…
- Trial name
- SMART-CRC (NCT07180303)
- Testing
- Remote training courses covering the latest CRC screening guidelines, identification of high-risk individuals and their standard of care, and dietary intervention strategies. Ongoing support services,, Continuation of routine healthcare services without any additional training interventions.
- Where
- China
- Volunteers
- 20,026 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Prostate Cancer
Improving Engagement From Underserved Communities With Prostate Cancer Genetics Services
Earlier work explored barriers and facilitators to accessing prostate cancer screening, particularly in underserved communities, and provided valuable insights to build upon.
- Trial name
- INCLUDE PC (NCT07407686)
- Testing
- Surveys, Semi-structured interviews and focus groups
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Colorectal Cancer
Veteran Primers for CRC Screening
This is a prospective, randomized controlled trial that will evaluate the effectiveness of primer postcards sent two weeks prior to the mailing of a FIT kit in improving adherence to annual CRC screening.
- Trial name
- NCT04923646
- Testing
- Primer
- Where
- United States
- Volunteers
- 2,404 people, healthy volunteers welcome
- Sponsor
- VA Puget Sound Health Care System
Cervical Precancer
Cervical Cancer Screening in Madagascar Using Smartphone Photos and Mobile Telemedicine
The purpose of this study is to determine whether smartphone photos may assist health-care worker (on-site) and to evaluate the diagnostic reliability and accuracy of cervical examination with smartphone photos of VIA (D-VIA)…
- Trial name
- NCT02693379
- Testing
- D-VIA
- Where
- Madagascar
- Volunteers
- 1,041 people, healthy volunteers welcome
- Sponsor
- Prof. Patrick Petignat
Breast Neoplasm, Neoplastic Cells, Circulating
Circulating Tumor Cells Screen for Breast Cancer
A prospective study was used to collect patients considering breast cancer admitted to our general surgery department from 2019-6 to 2023-8, to identify the case group (breast cancer) and the control group (non-breast cancer), to…
- Trial name
- CTCSFBC (NCT05633680)
- Testing
- Peripheral blood sampling for circulating tumor cells
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Handan First Hospital
Colorectal Cancer
Screening TO Prevent ColoRectal Cancer (STOP CRC) Among At-Risk Chinese and Korean American Primary Care Patients
The objective of the study is to conduct a randomized controlled trial to determine the impact of a multi-level culturally-sensitive decision support intervention on colorectal cancer screening adherence among 400 Chinese and…
- Trial name
- NCT03481296
- Testing
- Advanced Control, Culturally-Adapted Decision Support Navigation Intervention
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Breast Cancer, Cervical Cancer
CROSSROAD II: Activating Rural Clinics and Women With Disabilities to Improve Cancer Screening
The goal of this project is to develop and pilot test an innovative approach for overcoming barriers to cancer screening among women with physical disabilities (WWD) in rural Oregon.
- Conditions
- Breast Cancer, Cervical Cancer, Colorectal Cancer
- Trial name
- NCT01773980
- Testing
- Clinic Intervention, Patient Intervention
- Where
- United States
- Volunteers
- 1,570 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Colorectal Cancer
Trial of a Multilevel Intervention to Increase Colorectal Cancer Screening
This study will assess the effectiveness of a culturally-responsive intervention to increase colorectal cancer (CRC) screening among Latino immigrants in a primary care clinic setting of a large municipal Hospital in New York…
- Trial name
- NCT00836303
- Testing
- Colorecatal Cancer Screening Activation
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
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