Clinical trials: Early Cancer Detection
Cervical Cancer
Pap Smear Research Study
The principal hypothesis of this study is that HPV testing and/or p16 testing, either alone or in combination or associated with a Pap smear, will demonstrate greater specificity for clinically significant precancerous disease…
- Trial name
- NCT00743626
- Testing
- Diagnostic cervical cancer screening tests (Pap smear, HPV and/or p16)
- Where
- Canada
- Volunteers
- 1,712 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Oropharyngeal Cancer, HPV-Related Carcinoma
Biomarker Approach to Screening for the Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC)
Investigators seek to determine the sensitivity and specificity of a combined HPV 16 DNA and host gene methylation oral biomarker panel to distinguish early Oropharyngeal Cancer (OPC) cases from controls among 100 early and 100…
- Trial name
- BASH OPC (NCT06305676)
- Testing
- combined HPV 16 DNA and host gene methylation oral biomarker panel
- Where
- 3 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Lung Cancer
Sputum Labeling Utilizing Synthetic Meso-Tetra (4-Carboxyphenyl) Porphine (TCPP) for Detection of Lung Cancer
This is a single center study to assess the efficacy of CyPath® Early Detection Lung Cancer Assay to detect lung cancer cells from deep lung sputum.
- Trial name
- NCT02388074
- Testing
- CyPath®
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- bioAffinity Technologies Inc.
Cancer Diagnosis
Evaluation of Multi-Cancer Early Detection Testing in a High-Risk Military Population: The Sentinel Study
The purpose of this research study is to evaluate the possible benefits of an investigational, but commercially available Galleri multi-cancer early detection (MCED) blood test which is designed to detect many types of cancer…
- Trial name
- NCT06523868
- Testing
- GRAIL Galleri
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer
A Randomized Cluster Trial to Evaluate a Mobile Mammography Unit in Breast Cancer Screening in France (Mammobile)
Organized breast cancer screening (OBCS) has been implemented nationwide since 2004 inFrance, but the participation rate remains low (51%) and inequities in participation were reported.
- Trial name
- Mammobile (NCT05164874)
- Testing
- Mobile Mammography Unit
- Where
- France
- Volunteers
- 91,982 people, healthy volunteers welcome
- Sponsor
- Université de Caen Normandie
Cervical Cancer
Increasing Participation in Cervical Cancer Screening and Risk for Beliefs/Attitudes Among Women at Risk
In order to evaluate the effectiveness of nursing interventions aimed at the early detection of cervical cancer, health belief and participation in the screening of women aged 40-55 at risk for the purpose of cervical cancer…
- Trial name
- NCT03076879
- Testing
- Promoting participation in cervical cancer screening
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Cognitive Decline, Mild
Predict Early Cognitive Changes in a Healthy Elderly Population by Passively Recording Sensor Data From Mobile Devices
The study will recruit 100 participants aged 65+ residing in assisted living facilities. Eligible participants will undergo an initial cognitive assessment to document their baseline cognitive status using cognitive tests…
- Trial name
- 0150-24 SOR (NCT07596186)
- Where
- Israel
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Prostate Cancer
The i4i PRODICT® Study: Evaluation of the i4i PRODICT® Test in Different Ethnic Groups (The i4i PRODICT® Study).
The i4i PRODICT® study has been developed to investigate the uptake and acceptability of the i4i PRODICT® test which combines both common and rare genetic changes (genetic variants) into one saliva-based DNA test to estimate a…
- Trial name
- NCT06636526
- Testing
- The i4i PRODICT® test., Prostate cancer screening, MRI Scan
- Where
- 3 sites in United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Institute of Cancer Research, United Kingdom
Colorectal Cancer Screening
FLU-FIT Program at Kaiser Permanente Northern California
The investigators overall goal is to develop, implement, test, and disseminate an intervention to increase colorectal cancer screening rates at Kaiser Permanente (KP) by providing home fecal immunochemical test kits (FIT) to…
- Trial name
- NCT01210235
- Testing
- FLU-FIT Program
- Where
- United States
- Volunteers
- 7,465 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Anxiety, Prostate Cancer
proState Cancer Health Education to pRomote Early sreENing Uptake (SCREEN): A Pilot Randomised Control Trial
Prostate cancer is an issue of significant public health concern. Yet in low- and middle-income countries like Nigeria, men are adversely affected due to factors including poor early prostate cancer screening uptake.
- Conditions
- Anxiety, Prostate Cancer, Health Education, Screening and Brief Interventions
- Trial name
- SCREEN (NCT07800390)
- Testing
- proState Cancer awareness education to pRomote Early screENing uptake, Control group
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Teesside University
Malnutrition
Comparing Performance of Simplified Mid-Upper Arm Circumference Devices ("Click-MUACs") to Detect Acute Malnutrition
The Click-Mid-Upper Arm Circumference study aims to describe and compare the performance of a set of three simplified mid-upper arm circumference classification devices ("Click-MUAC") for use by mothers and caregivers to screen…
- Trial name
- NCT02833740
- Testing
- Click-MUAC prototype & regular MUAC tape
- Where
- Kenya
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- Action Contre la Faim
Pulmonary Disease
DECAMP-2: Screening of Patients With Early Stage Lung Cancer or at High Risk for Developing Lung Cancer
The goal of this project is to improve lung cancer screening in high-risk individuals by identifying biomarkers of preclinical disease and disease risk that are measured in minimally invasive and non-invasive biospecimens.
- Trial name
- DECAMP-2 (NCT02504697)
- Testing
- Biosamples from airway and blood
- Where
- 15 sites in United States
- Volunteers
- 665 people, healthy volunteers welcome
- Sponsor
- Boston University
Breast Cancer
Assessment of Automated Breast Ultrasound
The investigators are interested in assessing the value of and comparing the use of automated breast ultrasound (ABUS) (either as a primary screening approach or as a supplementary procedure) with digital breast tomosynthesis…
- Trial name
- NCT02386176
- Where
- United States
- Volunteers
- 598 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cervical Cancer, Cervical Intraepithelial Neoplasia
HPV Integration Testing for Cervical Cancer Screening
The primary objective is to determine the sensitivity and specificity of the HPV Integration-based cervical screening for detection of high-grade cervical intraepithelial neoplasia (CIN), using colposcopic inspection as the…
- Trial name
- NCT02576158
- Testing
- TCT，HPV，colposcopic inspection
- Where
- China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Cancer
Pan-canceR Early DetectIon projeCT (PREDICT)
PREDICT is a prospective, multicenter study for the early detection of pan-cancer through cell-free DNA (cfDNA) methylation-based model, in which approximately 14,000 participants will be enrolled.
- Trial name
- NCT04817306
- Testing
- Multi-cancer early detection test
- Where
- 3 sites in China
- Volunteers
- 14,026 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Ovarian Cancer, BRCA Mutation
Polygenic Risk Scores and Multi-cancer Early Detection for Ovarian Cancer
The overall goal of the Polygenic Risk Scores and Multi-cancer Early Detection for Ovarian Cancer (PROMISE) study is to better understand how women may incorporate both polygenic risk score (PRS) and novel early detection…
- Trial name
- PROMISE (NCT06436248)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Neoplasms, Cancer
PRediction Of Five Usual Tumors Using Blood Test for Risk Assessment and Early Detection
Liquid biopsy technology based on cell-free nucleic acids and protein characteristics has unique advantages and significant application prospects in cancer early detection.
- Trial name
- PROFUTURE (NCT05874648)
- Testing
- Multi-cancer early detection test
- Where
- China
- Volunteers
- 3,830 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Breast Cancer, Metastatic, Breast Cancer Invasive
Evaluation of Circulating Tumor Cells (CTC) Relevance in Breast Cancer Follow-up Using the ScreenCell Device
Liquid biopsy is a noninvasive method for detecting and quantifying circulating tumor cells (CTCs). Thanks to ScreenCell technology, this study aims to evaluate the evolution of the number of CTCs during breast cancer follow-up.
- Conditions
- Breast Cancer, Metastatic, Breast Cancer Invasive, Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Trial name
- PROBE-CTC (NCT06807502)
- Testing
- The DM/DIV ScreenCell is the experimental product studied during this research
- Where
- France
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- ScreenCell
Down Syndrome, Chromosome Abnormalities
Down Syndrome - Comparison of Screening Methods in the 1st and 2nd Trimesters
Too much or too little genetic information (chromosome material) can cause abnormal development of the fetus or death. Each year approximately 2.5 million pregnant women are screened for Down Syndrome using invasive screening…
- Trial name
- NCT00006445
- Testing
- Ultrasound, Serum screen
- Where
- 10 sites in United States
- Volunteers
- 38,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Colorectal Cancer, Colorectal Carcinoma
Combining Risk Factors and Faecal Immunochemical Testing in Colorectal Cancer Screening: a Randomized Controlled Trial
Colorectal Carcinoma (CRC) is the third most frequent diagnosed cancer worldwide, with 1.4 million new cases every year. In an attempt to reduce this number many countries have implemented a nationwide screening programme…
- Conditions
- Colorectal Cancer, Colorectal Carcinoma, Colorectal Neoplasms, Colorectal Adenoma
- Trial name
- NCT04490551
- Testing
- Risk-based logistic regression model, FIT
- Where
- Netherlands
- Volunteers
- 6,753 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
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