Clinical trials: Early Cancer Detection, open to volunteers
Breast Neoplasms, Early Detection of Cancer
Breast Ultrasound Screening in Elderly Women: A Multicenter Cluster Randomized Trial
This multicenter, cluster randomized trial will evaluate whether community-based breast ultrasound screening improves the early detection of breast cancer in women aged 65 to 80 years, compared with routine health management.
- Trial name
- NCT07698366
- Testing
- Standardized Breast Ultrasound Screening
- Where
- 2 sites in China
- Volunteers
- 80,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cancer
Occupational Cancer Screening in Firefighters: A Pilot Study Within the Inova Health System
The purpose of this study is to further understand the clinical impact and follow-up steps that may be required based on using whole-body Magnetic Resonance Imaging (MRI) or whole-body ultrasound and blood tests to detect…
- Trial name
- NCT06931561
- Testing
- Whole Body MRI, Whole Body Ultrasound, MCD Assay
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Inova Health Care Services
Breast Cancer Screening, Artificial Intelligence (AI)
Screening Mammography: Single Reading by One Radiologist With AI vs. Double Reading by Two Radiologists (AI-BCSQ)
A randomized prospective study comparing the evaluation of mammography images in a breast cancer screening programme by a single radiologist with AI support versus standard double reading by two radiologists without AI support.
- Conditions
- Breast Cancer Screening, Artificial Intelligence (AI), Breast Cancer Screening and Diagnosis
- Trial name
- AI-BCSQ (NCT07075679)
- Testing
- Group with AI iCAD version 3, Group without AI
- Where
- Czechia
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Olomouc
Colorectal Cancer, Significant Bowel Pathology
Optimising Colorectal Cancer Patient Pathways
Bowel cancer (colorectal cancer) is the 4th most common cancer in Scotland. Approximately 4,000 cases are diagnosed annually. Cancer-related deaths in Scotland are higher than other UK nations.
- Trial name
- NCT07430540
- Testing
- Additional FIT testing
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University of Edinburgh
Colorectal Neoplasms, Breast Neoplasms
Increasing Breast and Colorectal Cancer Screening in the Community
The goal of the proposed study is to conduct a pilot randomized controlled trial (RCT) of Chi gung, a community-based intervention using peer education and tailored navigation to simultaneously improve colorectal (CRC) and breast…
- Trial name
- NCT07748377
- Testing
- Chi gung: Stay Well, Live Well
- Where
- 7 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Head and Neck Squamous Cell Carcinoma, Anal Cancer
Blood Biomarkers Based Screening for HPV-driven OPC
The objective of our study is to demonstrate that it is possible to detect and treat human papilloma virus (HPV)-related oropharyngeal cancers (OPC) early using simple blood tests.
- Conditions
- Head and Neck Squamous Cell Carcinoma, Anal Cancer, Human Papilloma Virus
- Trial name
- SCREEN-HPV (NCT06528353)
- Testing
- HPV16-E6 serology and HPV ctDNA
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- UNICANCER
Cancer, Occupational Therapy
Validation of the Screen of Cancer Survivorship - Occupational Therapy Services (SOCS-OTS) Tool for Use in a Physical Medicine Rehabilitation Clinic
To compare the results of the SOCS-OTS to another standardized screening measure that is currently being used by rehabilitation services at MD Anderson Cancer Center and to ensure that the SOCS-OTS correctly identifies those…
- Trial name
- NCT06329531
- Testing
- Screen of Cancer Survivorship - Occupational Therapy Services (SOCS-OTS)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer (CRC) Screening, CRC Screening
Improving Colorectal Cancer Screening Uptake Through Education and Stool-Based Testing Outreach
This is a mixed-methods implementation pilot combining an educational intervention with a mailed stool-based testing outreach feasibility study within a resident primary care clinic.
- Conditions
- Colorectal Cancer (CRC) Screening, CRC Screening, Rectal Cancer, Colon Cancer
- Trial name
- NCT07781774
- Testing
- Colorectal Cancer Education Materials, Cologuard test kit, Fecal immunochemical test kit
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Type 1 Diabetes
Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-age Families
This R01 is in response to RFA-DK-19-021, Treating Diabetes Distress to Improve Glycemic Outcomes in Type 1 Diabetes. The objective is to test the feasibility and acceptability of a novel, practical, and potentially scalable…
- Trial name
- R2D2 (NCT05268250)
- Testing
- R2D2 mHealth intervention
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Nemours Children's Clinic
Hepatocellular Carcinoma, Liver Cirrhosis
Prospective Evaluation of Hepatocellular Carcinoma Surveillance in At-Risk Patients (Screening HCC)
This prospective multicenter observational study evaluates the performance of a structured hepatocellular carcinoma (HCC) surveillance program in patients at increased risk of developing liver cancer.
- Conditions
- Hepatocellular Carcinoma, Liver Cirrhosis, Chronic Hepatitis B, Metabolic Dysfunction-Associated Steatotic Liver Disease
- Trial name
- Screening HCC (NCT07764835)
- Volunteers
- 300 people
- Sponsor
- D'Or Institute for Research and Education
HR-HPV Testing
Expanding Access to Cervical Cancer Screening Through Primary HR-HPV Testing and Self-sampling: a Multicomponent Intervention for Safety Net Health Systems
To learn about the attitudes toward implementing self-collection among healthcare providers and staff, participants, and other stakeholders; and to inform the development of patient education and provider training materials to…
- Trial name
- NCT06843720
- Testing
- HR-HPV Testing
- Where
- United States
- Volunteers
- 7,100 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Cervical Cancer Screening, Cervical Cancer
Culturally Adapted Materials to Increase Cervical Cancer Screening Among Polish Women in Iceland
This study tests whether sending Polish women residing in Iceland a culturally adapted invitation letter - tailored in language and messaging to the target group - increases participation in cervical cancer screening compared…
- Conditions
- Cervical Cancer Screening, Cervical Cancer, Cervical Cancer (Early Detection)
- Trial name
- NCT07856862
- Testing
- Culturally adapted cervical cancer screening invitation letter, Standard cervical cancer screening invitation letter
- Where
- Iceland
- Volunteers
- 2,000 people
- Sponsor
- The Primary Health Care in the Capital Area
Pancreatic Cancer, Pancreatic Neoplasms
Pancreatic Cancer Screening Using the Enzeavour Assay in Japan
This nationwide, multicenter, prospective, single-arm interventional feasibility study evaluates the Enzeavour Pancreatic Cancer assay in routine health checkups and cancer screening in Japan.
- Trial name
- ENZEAVOUR FS (NCT07605819)
- Testing
- Enzeavour Pancreatic Cancer Assay
- Where
- 69 sites in Japan
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Cosomil, Inc.
Persons With Visual Disabilities, Breast Neoplasms
Breast and Cervical Cancer Awareness Training in Visually Impaired Women
This quasi-experimental study aims to determine whether a breast and cervical cancer awareness training program can increase participation in cancer screening among women with visual impairments.
- Conditions
- Persons With Visual Disabilities, Breast Neoplasms, Uterine Cervical Neoplasms, Awareness
- Trial name
- GORSEM (NCT07541859)
- Testing
- Cancer Screening Awareness Education for Visually Impaired Women
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Marmara University
Breast Carcinoma
Mobile Health Patient Navigation for the Improvement of Screening and the Early Detection of Breast Cancer in Women Accessing Primary Care Clinics in Kenya
This clinical trial develops and studies how well mobile health (m-Health) patient navigation (PN) strategies work to improve screening and the early detection of breast cancer in women accessing primary care clinics in Kenya.
- Trial name
- NCT07764796
- Testing
- Best Practice, Discussion, Interview - Stakeholder
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Emory University
Monoclonal Gammopathy, Monoclonal Gammopathy of Undetermined Significance (MGUS)
Early Detection of Amyloidosis in Monoclonal Gammopathy Using Nuclear Medicine Imaging
The goal of this clinical trial is to evaluate whether ¹⁸F-florbetaben PET/MR can detect systemic amyloid deposits early and noninvasively in patients with monoclonal gammopathy.
- Conditions
- Monoclonal Gammopathy, Monoclonal Gammopathy of Undetermined Significance (MGUS), Multiple Myeloma, AL Amyloidosis
- Trial name
- MGUS-PET (NCT07624760)
- Testing
- ¹⁸F-florbetaben
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Heavy Smokers, Lung Cancer Screening
Akershus Cardiac Examination (ACE) 5 Study
Individuals with extensive smoking history have 2- to 3-fold increased risk of dying prematurely compared to age- and gender-matched peers.
- Conditions
- Heavy Smokers, Lung Cancer Screening, Cardiovascular Risk Profile, Cardiovascular Disease Prevention
- Trial name
- ACE5 (NCT07301489)
- Testing
- Lung Cancer Screening Plus Program, Standard of Care
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Akershus
Cervical Cancer, Cervical Intraepithelial Neoplasia
Study on Novel Strategies for Cervical Cancer Screening Using Photoelectric Detection and Epigenetic Procotol
A national multicenter, open randomized controlled study was conducted. It is planned to invite 30 multi-center units across the country to compete for enrollment, and each multi-center will enroll 140 patients meeting…
- Trial name
- CC-AZ (NCT06866392)
- Testing
- photoelectric detection
- Volunteers
- 4,200 people
- Sponsor
- Peking Union Medical College Hospital
Pain, Postoperative
Screen Addiction and Postoperative Pain
Excessive or problematic smartphone use has become increasingly common and has been associated with various psychological and physical health consequences, including anxiety, depressive symptoms, reduced sleep quality…
- Trial name
- NCT07242872
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Cirrhosis, Hepatocellular Carcinoma
Project OASIS: Optimizing Approaches to Select Implementation Strategies
Barriers that prevent healthcare methods supported by science from being adopted in the real world have led to low-quality, inequitable medical care.
- Trial name
- OASIS (NCT06061328)
- Testing
- OASIS DA training, Current DA Tool training
- Where
- United States
- Volunteers
- 8,020 people
- Sponsor
- VA Office of Research and Development