Clinical trials: Early Childhood
Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders
Arabic NODA Validation Study for Autism Diagnosis in Saudi Arabia
This study aims to validate the Arabic adaptation of the Naturalistic Observation Diagnostic Assessment (NODA), a telehealth tool designed to help diagnose Autism Spectrum Disorder (ASD) in young children.
- Conditions
- Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders, Child Development Disorders, Pervasive
- Trial name
- NODA-ARSA (NCT07089108)
- Testing
- Arabic NODA Video-Based Diagnostic Assessment
- Where
- Saudi Arabia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Prince Sultan Military Medical City
Anxiety
Feasibility and Preliminary Outcomes of the Brave Elephant Program: A Single-Arm Pretest-Posttest Study
Anxiety disorders are highly prevalent in childhood and have increased following the COVID-19 pandemic. Behavioral inhibition in early childhood is a well-established risk factor for later anxiety.
- Trial name
- Brave_Elephant (NCT07567820)
- Testing
- Brave Elephant Program
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ISPA - Instituto Universitario de Ciencias Psicologicas, Sociais e da Vida
Caries, Dental, Health Behavior
Interactive Parent-Targeted Text Messaging in Pediatric Clinics to Reduce Caries Among Urban Children
This is a randomized clinical trial to test the efficacy of a parent-targeted text message-based intervention program on caries incidence and oral health behaviors (child and parent).
- Trial name
- iSmile (NCT03294590)
- Testing
- OHT Parent targeted text messages, CWT Parent targeted text messages
- Where
- United States
- Volunteers
- 754 people, healthy volunteers welcome
- Sponsor
- Boston University
Dyslipidemias, Children, Only
The Effect of Childhood Dyslipidemia on Endothelial and Renal Function
The aim of the study is to assess if abnormal lipid levels in childhood could cause early damage of the inner layer of the vessels, the endothelium.
- Conditions
- Dyslipidemias, Children, Only, Endothelial Dysfunction, Renal Dysfunction
- Trial name
- NCT03856476
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Ioannina
Down Syndrome
Promoting Health Through Parent Empowerment and the Activation of Routines (PrO-PEAR)
This study will examine the feasibility of the Promoting Health through Parent Empowerment and the Activation of Routines (Pro-PEAR) intervention using a open case-series for intervention optimization followed by a pilot RCT in…
- Trial name
- Pro-PEAR (NCT05020366)
- Testing
- Promoting Health through Parent Empowerment and the Activation of Routines, Enhanced Usual Care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh
Child Development, Attachment Disorder
Experimental Evaluation of Semillas de Apego
The current trial focuses on the effectiveness evaluation of Semillas de Apego in Tumaco, a municipality in Colombia heavily affected by violence and poverty.
- Conditions
- Child Development, Attachment Disorder, Exposure to Violent Event, Parenting
- Trial name
- NCT03502252
- Testing
- Semillas de Apego
- Where
- Colombia
- Volunteers
- 1,280 people
- Sponsor
- University of Los Andes, Columbia
Physical Activity
Sustainability Via Active Garden Education
The goal of SAGE is to determine if a garden-based curriculum can increase physical activity and improve nutrition in young children at early care and education centers (ECEC) throughout Phoenix
- Trial name
- SAGE (NCT03261492)
- Testing
- Physical Activity, Child Safety Attention Comparison
- Where
- United States
- Volunteers
- 712 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Glomerulonephritis
US Time-Harmonic Elastography for the Early Detection of Childhood Glomerulonephritis
US Time-Harmonic Elastography for the Early Detection of Childhood Glomerulonephritis
- Trial name
- NCT04582890
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Obesity, Childhood, Child Development
El Sendero: Pathways to Health Study
This project will continue to follow two birth cohorts of mother-infant Latino dyads through a series of new assessments at age 6y, with an emphasis on examining the the role early nutritional exposures, exposures to…
- Trial name
- NCT05551650
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Major Depressive Disorder (MDD), History of Childhood Sexual Abuse (CSA)
An Investigation of Early Life Stress and Depression
The purpose of this study is to investigate brain pathways within adult females (with a history of CSA that occurred between the ages of 5-14) with and without a current diagnosis of major depressive disorder (MDD).
- Trial name
- NCT01701258
- Testing
- Amisulpride
- Where
- 2 sites in United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Child Development, Developmental Disabilities
Testing the Effectiveness of Telephone-based Early Childhood Developmental Screening
The purpose of this research study is to test the effectiveness of telephone-based early childhood developmental screening and care coordination, compared to usual care in a primary care pediatrics clinic.
- Conditions
- Child Development, Developmental Disabilities, Ambulatory Care, Screening
- Trial name
- NCT02495025
- Testing
- Telephone-based developmental screening and care coordination
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Attention Deficit and Disruptive Behavior Disorders, Child Behavior Disorders
Study of Children at Risk for Disruptive Behavior Disorders
A conduct disorder is characterized by repetitive and persistent patterns of behavior where the basic rights of others and rules are violated.
- Conditions
- Attention Deficit and Disruptive Behavior Disorders, Child Behavior Disorders, Passive-Aggressive Personality Disorder
- Trial name
- NCT00001233
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Stress, Early Life Stress
How Does the Opioid System Shape Stress and Social Behaviour in Men and Women and What Role Does Childhood Unpredictability Play?
The study aims to investigate sex differences in the effect of mu-opioid receptor (MOR) activation on stress response and social behaviour modulated by early life stress.
- Conditions
- Stress, Early Life Stress, Sex Differences, Opioid
- Trial name
- MOR-SAFE (NCT07778511)
- Testing
- Morphine
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sara L. Kroll
Obesity, Childhood
Parent Mentor Interventions for Early Childhood Obesity
The purpose of this clinical trial is to identify the most effective strategy for intervention to change behaviors and affect weight status in obese children 2-5 years of age within the context of early childhood education…
- Trial name
- NCT03330743
- Testing
- Parent Mentor with Standard Education, Parent Mentor with Positive Deviance
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Early Childhood Caries
Effectiveness of Nano-silver Fluoride and Silver Diamine Fluoride for Arresting Early Childhood Caries
Aim of the study: To evaluate and compare the clinical cariostatic efficacy of NSF with 38% SDF solution after sex and twelve months in arresting ECC lesions.
- Trial name
- NCT05255913
- Testing
- Nanosilver, Silver diamine fluoride
- Where
- Egypt
- Volunteers
- 360 people
- Sponsor
- Alexandria University
Childhood Obesity
Genetic Determinants and Clinical Consequences of Early-onset Severe Obesity
The aim of the present study is to identify new obesity-related genetic defects and determine their association with clinical manifestations in families with childhood-onset severe obesity.
- Trial name
- PeLi (NCT02645422)
- Volunteers
- 400 people
- Sponsor
- Helsinki University Central Hospital
Early Childhood Caries
Silver Diamine Fluoride(SDF) Versus SDF Combined With Sodium Fluoride Varnish in the Arrest of Early Childhood Caries
Early childhood caries (ECC) is the most common chronic childhood disease worldwide. Early restorative intervention may treat the disease but this is often difficult especially with uncooperative children so it may be left…
- Trial name
- NCT05642494
- Testing
- SDF, NaF
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Alexandria University
Wheeze
Treating Wheezing in Children With Hypertonic Saline (TWICS)
Hypothesis: substitution of nebulized 3% NaCl (HS) for the standard normal saline (NS) used in bronchodilator therapy for acute viral wheezing in all children under age 6 years will provide superior symptom relief leading to…
- Trial name
- TWICS (NCT01868932)
- Testing
- hypertonic saline, saline
- Sponsor
- Dr. Michael Flavin
Parent-Child Relations, Parenting
CenteringParenting Clinical Intervention on Kindergarten Readiness in Early Childhood
Disparities in health begin in early childhood. Early life experiences influence brain development and have significant implications on future health and developmental outcomes.
- Conditions
- Parent-Child Relations, Parenting, Child Development, Child Behavior
- Trial name
- NCT03641092
- Testing
- CenteringParenting Intervention, Routine Well Child Care
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Obesity
Delta Healthy Sprouts: Intervention to Promote Maternal Weight Control and Reduce Childhood Obesity in the MS Delta
The Delta Healthy Sprouts Project is a randomized, controlled trial evaluating the enhancement of an existing Mother, Infant, and Early Childhood Home Visiting Program in 150 African American women in their early second trimester…
- Trial name
- NCT01746394
- Testing
- Parents as Teachers Enhanced, Parents as Teachers
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- USDA, Delta Human Nutrition Research Program