Clinical trials: Early Childhood Caries
Dental Caries
Preventing Caries with Silver Diamine Fluoride
Background: Early childhood caries (tooth decay, ECC) affected 55% 5-year-old Hong Kong children, and 70% of these children had gross destruction of the upper anterior teeth with negative long-term impacts on health and quality…
- Trial name
- NCT04399369
- Testing
- SDF, NaF
- Where
- Hong Kong
- Volunteers
- 688 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Early Childhood Caries
The Anticariogenic Effect of Silver Diamine Fluoride and Sodium Fluoride Varnish
Sodium Fluoride (NAF) varnish was considered as the treatment of Early Childhood Caries (ECC). However, the emergence of Silver Diamine Fluoride (SDF) has become more popular to tackle dental caries among children.
- Trial name
- NCT06316323
- Testing
- Silver diamine fluoride, Sodium fluoride
- Where
- Malaysia
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Universiti Teknologi Mara
Early Childhood Caries
Arresting Early Childhood Caries With a Silver Diamine Fluoride Gel
The objective is to determine whether the efficacy of a 38% silver diamine fluoride (SDF) gel is non-inferior to a 38% SDF solution for arresting carious lesions in preschool children when applied at half-yearly intervals over a…
- Trial name
- NCT06241261
- Testing
- Silver diamine fluoride gel, Silver diamine fluoride solution
- Where
- China
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Early Childhood Caries
Salivary Interleukin-32, Interleukin-10, Interleukin-6 and Tumor Necrosis Factor-alpha Levels in Children
This study aimed to evaluate the levels of interleukin 10, interleukin 6, interleukin 32 and tumor necrosis factor-alpha (TNF-α) in saliva of children with early childhood caries.
- Trial name
- NCT04958005
- Testing
- ELISA
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Aydin Adnan Menderes University
Dental Caries, Obesity Risk
Mothers' Action Project for Child Health
This randomized controlled trial will recruit Bangladeshi mothers and their young children into a 12 month intervention that provides child health and oral health education and seeks to build social networks among mothers.
- Trial name
- MAP-CH (NCT06753669)
- Testing
- health education and social network building, dental referral and educational materials
- Where
- United States
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Dental Caries Tooth Demineralization, Early Childhood Caries (ECC)
Effects of Calcium-Containing Oral Sprays on Fluorescence-Detectable Plaque Area in Children
This exploratory randomized clinical trial aimed to evaluate the effects of calcium-containing oral sprays on the primary clinical outcome, fluorescence-detectable plaque-associated area measured by quantitative light-induced…
- Trial name
- NCT07269730
- Testing
- oral spray
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Early Childhood Caries (ECC)
Analysis of Salivary Proteins in Young Children as an Device to Improve Caries Risk Assessment
The goal of this observational study is to learn if the composition of salivary proteins in 3-year-old children, from communities with documented varying caries risks, can be used to identify future diagnostic predictors for…
- Trial name
- DecodECC (NCT06957509)
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Early Childhood Caries
Povidone Iodine Efficacy Study
This is a single center, randomized, double-blind, placebo-controlled Phase II clinical trial (RCT) to evaluate the efficacy of topical 10% Polyvinylpyrrolidone-Iodine (PVPI) to prevent new caries lesions when applied to the…
- Trial name
- PIES (NCT05272254)
- Testing
- 10% povidone iodine + FV
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Early Childhood Caries
Parental Acceptance and Perception of Silver Diamine FlouridApplication Among A Sample of Egyptian Children.
Dental caries can be prevented or arrested . Moreover, preventive measures for dental caries are more cost effective than emergency room visits or restorative treatments when the illness has been established .
- Trial name
- NCT04218955
- Testing
- Silver Diamine Flouride
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Cairo University
Severe Early Childhood Caries
Thiol/Disulfide and Oxidative Stress
The aim of this study was to evaluate the role of thiol/disulfide homeostasis and oxidative stress in the saliva of children with severe early childhood caries
- Trial name
- NCT04655859
- Testing
- saliva cotton swab
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Early Childhood Caries (ECC), Oral Health Behavior Change
Oral Health Awareness Among Egyptian Population
The objective of this research is to investigate the effect of digital tele-dentistry application using AI-generated content on the awareness and performance among a sample of Egyptian children and their caregivers in both…
- Trial name
- NCT07248800
- Where
- Egypt
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Cairo University
Caries
Oral Health Care Early Intervention Project
This pilot project consists of co-locating dental hygienist services in medical primary care offices. Dental hygienists will work in close collaboration with the primary care offices, providing preventive dental care to young…
- Trial name
- NCT00793507
- Testing
- Oral Health Care Early Intervention Project
- Where
- 5 sites in United States
- Volunteers
- 1,178 people
- Sponsor
- University of Colorado, Denver
Oral Health in Pregnancy and Early Childhood, Early Childhood Caries (ECC)
Midwives' Perspectives on Oral Health in Pregnancy and Early Childhood: A Cross-Sectional Online Survey
This study aims to explore how midwives in Germany perceive their professional role in the context of oral health of pregnant women and young children.
- Conditions
- Oral Health in Pregnancy and Early Childhood, Early Childhood Caries (ECC), Health Promotion by Midwives
- Trial name
- NCT07572799
- Volunteers
- 200 people
- Sponsor
- University Medical Center Goettingen
Early Childhood Caries
Silver Diamine Fluoride(SDF) Versus SDF Combined With Sodium Fluoride Varnish in the Arrest of Early Childhood Caries
Early childhood caries (ECC) is the most common chronic childhood disease worldwide. Early restorative intervention may treat the disease but this is often difficult especially with uncooperative children so it may be left…
- Trial name
- NCT05642494
- Testing
- SDF, NaF
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Alexandria University
Oral Health, Dental Caries
WhatsApp Messages to Improve Mothers' Oral Health Knowledge and Children's Toothbrushing
Tooth decay is one of the most common health problems in young children in Saudi Arabia. Brushing twice a day with fluoride toothpaste is one of the most effective ways to prevent it, but preschool children cannot do this…
- Conditions
- Oral Health, Dental Caries, Health Behavior, Oral Hygiene
- Trial name
- NCT07765654
- Testing
- Standardized Face-to-Face Oral Health Education, WhatsApp-Based Oral Health Messages
- Volunteers
- 106 people
- Sponsor
- King Abdulaziz University
Early Childhood Caries (ECC), Dental Caries Prevention
Evaluating the Effect of Xylitol Wipes on Cariogenic Bacteria in Infants and Toddlers
This clinical study evaluates whether cleaning infants' and toddlers' teeth and gums with xylitol-containing wipes can help reduce oral bacteria associated with early childhood caries.
- Conditions
- Early Childhood Caries (ECC), Dental Caries Prevention, Oral Bacterial Colonization, Pediatric Oral Health
- Trial name
- NCT07245433
- Testing
- Xylitol Dental Wipes
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Early Childhood Caries
Study of Obstacles and Barriers to Changing Risky Eating Behaviors in Families of Children With Severe Early Childhood Caries (QUALIKIDS).
Dental caries is the most common chronic disease in children, and its early form-Early Childhood Caries (ECC)-which particularly affects children under the age of six, represents a major public health problem worldwide.
- Trial name
- QUALIKIDS (NCT07377240)
- Testing
- Interview
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Early Childhood Caries
A Clinical Trial of Silver Diamine Fluoride to Arrest Early Childhood Caries in Young Children
Silver diamine fluoride (SDF) is an antibiotic liquid that has the potential to arrest Early Childhood Caries in young children and delay treatment until children can be seen in outpatient settings.
- Trial name
- NCT04054635
- Testing
- Silver diamine fluoride
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- University of Manitoba
Early Childhood Caries (ECC)
Preventing Early Childhood Caries With a Silver Diamine Fluoride Gel
The objective is to compare the efficacy of SDF gel with that of NaF varnish in preventing carious lesions in preschool children when applied at half-yearly intervals over a 24-month period.
- Trial name
- NCT07455604
- Testing
- Silver diamine fluoride gel, Sodium Fluoride varnish
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Early Childhood Caries, Dental Caries
Vertical Dimension Changes After Bioflx vs Stainless Steel Crowns in Primary Molars
this randomized controlled trial will compare Bioflx crowns and stainless-steel crowns in children with pulp-treated primary molars.
- Conditions
- Early Childhood Caries, Dental Caries, Pulp-Treated Primary Molars
- Trial name
- BIOFLX-SSC-RCT (NCT07523776)
- Testing
- Bioflx Crown, Stainless Steel Crown
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Cairo University