Clinical trials: Early Intervention, open to volunteers
Smoking Reduction, Asthma in Children
Early Life Intervention in Pediatrics Supported by E-health - SMOKE
Unrestricted parental smoking habits are lifestyle risk behaviors associated with chronic, systemic inflammation, which promotes the pathogenesis of non-communicable diseases (NCDs).
- Conditions
- Smoking Reduction, Asthma in Children, Wheezing, Non-Communicable Disease
- Trial name
- ELIPSE-II (NCT06311162)
- Testing
- Life-Style app
- Where
- Switzerland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Socioemotional Development, Cognitive Ability
Early Institutionalization Intervention Impact Project
The purpose of this study is to determine the effects of early intervention (placement into foster care, and a caregiving training) on physical, cognitive, social and brain development and psychiatric symptomatology in children…
- Conditions
- Socioemotional Development, Cognitive Ability, Behavioral and Neural Patterns of Attention, Brain Function
- Trial name
- EI-3 (NCT04165746)
- Testing
- Foster Care, Caregiving Intervention
- Where
- Brazil
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Heart Failure (HF)
Early Detection and IntervenTion in Heart Failure
Heart failure (HF) occurs when the heart is no longer able to pump blood effectively throughout the body. This leads to symptoms that gradually worsen over time and are often mistaken for normal signs of aging.
- Trial name
- EDIT-HF (NCT07731490)
- Testing
- Intervention bundle comprising increased awareness, early diagnostics, and early treatment to improve HF prognosis.
- Where
- 21 sites in Austria, Bulgaria and 7 more
- Volunteers
- 18,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Alzheimer's Disease
Acupressure as Long-term Intervention to Slow the Progression of Early/Mild Alzheimer's Disease
This is an assessor-blinded, randomized controlled trial. A total of 188 older adults aged 60-85 years with early/mild Alzheimer's disease (AD) will be recruited from care and attention homes for the elderly and elderly activity…
- Trial name
- NCT07779863
- Testing
- Comfy Acupressure for the Elderly, Least acupressure control
- Where
- Hong Kong
- Volunteers
- 188 people
- Sponsor
- The University of Hong Kong
Cancer, Early Detection of Cancer
Multi-canceR Early-detection Test in Asymptomatic Individuals (PREVENT)
PREVENT is a prospective, multicenter, interventional study evaluating the performance of the OverC multi-cancer detection blood test in asymptomatic individuals with cancer risk.
- Conditions
- Cancer, Early Detection of Cancer, Circulating Cell-free DNA
- Trial name
- PREVENT (NCT05227534)
- Testing
- OverC multi-cancer detection blood test
- Where
- China
- Volunteers
- 12,500 people, healthy volunteers welcome
- Sponsor
- Guangzhou Burning Rock Dx Co., Ltd.
Sleep Onset Latency
Circadian Light Exposure Adjustment for Restfulness
Many young children are exposed to light int he evening hours before bedtime. Children's biological clocks are highly sensitive to evening light exposure, which can delay the timing of the clock and make it harder to fall asleep.
- Trial name
- CLEAR (NCT07391852)
- Testing
- Amber Tinted Glasses, Clear Glasses, Smart Lightbulbs
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Arizona
Post Intensive Care Syndrome (PICS), Critical Illness
"PROTECT-ICU: Impact of an Educational Intervention
Brief Summary The goal of this study is to learn if a structured training program for intensive care unit (ICU) staff can reduce health problems after a stay in the ICU in adults.
- Trial name
- PROTECT-ICU (NCT07542613)
- Testing
- Standardized Training on the ABCDEF Care Bundle (A-F), Standardized training on the expanded ABCDEF care bundle (A-Z)
- Where
- 2 sites in Spain
- Volunteers
- 900 people
- Sponsor
- Carola Giménez-Esparza Vich
Alzheimer Disease, Mild Cognitive Impairment (MCI)
Biomarker-based Trial of NPC-1 for Alzheimer's Pathology
This early phase, open label, single arm clinical trial will determine the intraindividual safety, tolerability and effects of NPC1 (parthenolide and ipriflavone) on blood-based biomarkers of Alzheimer's disease (AD) pathology…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
- Trial name
- NPC1-AD (NCT07236190)
- Testing
- natural product combination-1 (NPC1)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Flexible Flatfoot
Early Warning and Intervention Mechanism of Foot Health Risk in Children and Adolescents
This clinical study was a prospective intervention study. The growth and development parameters and kinematic parameters of 120 children were planned to be collected for an observational study, and then the sensors were used to…
- Trial name
- NCT06581978
- Testing
- Whole-Body Vibration Intervention, Exercise Intervention Group
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Melanoma
Feasibility of an Enhanced Symptom Monitoring and Expedited Subspecialty Care Referral Intervention to Improve Side Effect Management for Patients With Melanoma Receiving an Immune Checkpoint Inhibitor
This clinical trial tests the feasibility of patient reported outcomes monitoring with early, rapid immunotherapy toxicity subspecialty care to improve side effect management for patients with melanoma receiving an immune…
- Trial name
- NCT07660666
- Testing
- Electronic Health Record Review, Internet-Based Intervention, Patient Navigation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Communication Disorder, Childhood, Autism
Evaluating Georgia Part C Implementation Outcomes
This study aims to answer the question: What is the best way to help Early Intervention (EI) providers deliver high-quality services to children with communication delays for autism? The primary goal of this project is to examine…
- Trial name
- NCT07148258
- Testing
- Project ImPACT Training As Usual, Project ImPACT Training Plus Co-Production, Routine Project ImPACT
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Emory University
Triple Negative Breast Cancer (TNBC), Early Setting
LifEStyle Intervention to Enhance Efficacy of Neoadjuvant Therapy in Patients With Triple Negative Breast Cancer
LESLIE is a multicentric randomized controlled trial in patients with triple negative breast cancer receiving neoadjuvant chemo/immunotherapy (NAT).
- Trial name
- LESLIE (NCT06831955)
- Testing
- Exercise Therapy, Fasting-Mimicking Diet, SOC
- Where
- 10 sites in Belgium
- Volunteers
- 356 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Food Allergy in Children
Evaluation of The Food Allergy Mastery Program
The proposed research project will evaluate a novel behavioral intervention that promotes early adolescent food allergy self-management and adjustment through 1) food allergy education, 2) problem-solving, communication…
- Trial name
- NCT06034678
- Testing
- Food Allergy Mastery Program
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Children's National Research Institute
Vascular Access
Early Feasibility Study to Assess the Safety and Effectiveness of the OnePoint Dialysis CannulaTM as a Single-Site Vascular Access Device for Hemodialysis Procedures
This is an early feasibility, pre-market, prospective, interventional, single-arm, non-randomized / open-label study intended to support a future pivotal IDE study for eventual FDA clearance of the study device based on the…
- Trial name
- ONEPOINT-01 (NCT07599085)
- Testing
- OnePoint Dialysis Cannula
- Volunteers
- 20 people
- Sponsor
- Evolve Medicus, Inc.
Prematurity
Study of the Interprofessional Reproducibility of a Clinical Observation Scale for the Development of Very Premature Infants
The research concerns the study of the interprofessional reproducibility of a grid for observing the development of premature infants from 1 to 6 months corrected age.
- Trial name
- SPIN-NA (NCT07169110)
- Testing
- SPIN-NA Developmental Observation Grid Assessment via Home-Based Standardized Video Recording
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Toulouse
Mother-Child Relations, Substance Use
Optimizing Mental Health for Infants Exposed to Early Adversity: A Comparison of Breaking the Cycle and Maxxine Wright
The goal of this clinical trial is to compare the effectiveness of the Breaking the Cycle (BTC) and Maxxine Wright (MW) programs in substance-involved mothers and their children.
- Trial name
- NCT05768815
- Testing
- Breaking the Cycle Program, Maxxine Wright Program
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University of Ottawa
Age-Related Macular Degeneration
Feasibility Study of a Remote Behavioral Dietary Intervention in Patients With Early to Intermediate AMD: Glucose Lowering for Vision Extension
The primary goal of the study is to test dietary intervention at glycemic control and carotenoid levels in participants with intermediate age-related macular degeneration.
- Trial name
- GLOVE (NCT07605468)
- Testing
- Low glycemic Mediterranean diet behavioral modification
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Stanford University
Typical Development
Promoting Motor Development in Infants and Toddlers Through Education and Early Detection
The "Little Movers" study promotes healthy motor development in early childhood by providing education to caregivers and professionals in the child's environment and by implementing early detection strategies for motor delays.
- Trial name
- Little-Movers (NCT07091474)
- Testing
- Educational Workshops for Parents and Early Educators, Motor Development Assessment in Children 0-36 Months
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Microbiota, Gut Microbiome
Flourish: Exploring the Early Infant Gut Microbiome
The goal of this clinical trial is to learn whether microbiome analysis, education, and personalized recommendations can improve gut health and reduce early markers of immune-related conditions in infants aged 0-3 months…
- Conditions
- Microbiota, Gut Microbiome, Eczema, Microbiome
- Trial name
- NCT07333482
- Testing
- Tailored Recommendations, Consult Call, Educational Email Series
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Seeding Inc
Lung Cancer Screening, Lung Neoplasms
Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)
Lung cancer screening (LCS) with low-dose computed tomography (LDCT) can reduce the risk of dying from lung cancer, but many people who are eligible for screening do not receive it.
- Conditions
- Lung Cancer Screening, Lung Neoplasms, Smoking ( Cigarette), Early Detection of Cancer
- Trial name
- Empower LCS+ (NCT07711691)
- Testing
- Empower LCS, Call+ Telephone Navigation, Usual Care
- Where
- 57 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Irvine