Clinical trials: Early Interventions
Diabetes Mellitus, Type 1
Early Dietary Intervention and Later Signs of Beta-Cell Autoimmunity
The proposed mechanistic formula feeding study sets out to identify the mechanism(s) by which an extensively hydrolyzed casein formula is able to protect children at risk for type 1 diabetes (T1D) from beta-cell autoimmunity.
- Trial name
- EDIA (NCT01735123)
- Testing
- dietary intervention
- Where
- Finland
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Vascular Cognitive Impairment
Study on Early Brain Injury Mechanism and Comprehensive Intervention of VCI
Alzheimer's disease (AD) and vascular dementia (VaD) are the most common forms of senile dementia. Although the animal research of dementia has made remarkable progress, clinical trials of drugs for AD pathology have failed in…
- Trial name
- NCT04999813
- Testing
- Comprehensive intensive intervention
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Alzheimer Disease, Early Onset, Parkinsons Disease with Dementia
Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease
The goal of this Multicenter observational pilot study is to Compare the specifics of musical engagement (behaviors related to music in everyday life) in subjects aged over 60 with Alzheimer s disease, Parkinson s disease and…
- Conditions
- Alzheimer Disease, Early Onset, Parkinsons Disease with Dementia, Non Pharmacological Intervention
- Trial name
- MUSENGAGE (NCT06688968)
- Testing
- neuropsychologist interview, questionnaire
- Where
- 3 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Media Effects on Literacy Gains in Young Children
Literacy Instruction Through Media for Everyone
The goal of this study is to determine whether an intervention to support caregivers in engaging with their children while using educational media together can improve children's early literacy skills, compared to an aligned…
- Trial name
- LIME (NCT06796790)
- Testing
- Media instruction, Storybook intervention
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Sleep Problem, Behavior, Child
Parents Advancing Toddler Health
Although early interventions can improve health equity in young children living in poverty, this promise often is not realized because of barriers to family engagement.
- Trial name
- PATH (NCT04824989)
- Testing
- Sleep Health in Preschoolers (SHIP), Family Check-Up (FCU), Oral Health, Child Safety, and Environmental Health Intervention (Active Control)
- Where
- 2 sites in United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Overweight, Childhood, Obesity Prevention
High Five! - School-based Prevention of Overweight and Obesity Among 6 to 9 Year Olds
The goal of this interventional study is to assess the effectiveness of the school-based "High Five!" program in reducing overweight, obesity and high blood pressure in children aged 7-9 years old.
- Conditions
- Overweight, Childhood, Obesity Prevention, Blood Pressure
- Trial name
- DINO-PL (NCT07357857)
- Testing
- High Five
- Where
- Poland
- Volunteers
- 659 people, healthy volunteers welcome
- Sponsor
- Institute of Mother and Child, Warsaw, Poland
Acne Vulgaris, Medical Education
AI-Generated Acne Vulgaris Learning Material Study
This comparative educational intervention study evaluated the educational effectiveness of artificial intelligence-generated patient information material on acne vulgaris among early-year medical students.
- Trial name
- NCT07652112
- Testing
- Artificial Intelligence-Generated Acne Vulgaris Educational Material, Turkish Dermatology Association Acne Vulgaris Educational Material
- Where
- Turkey (Türkiye)
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Hasan Durmuş
Early Intervention
The Effect of Sensory Motor Training in Preschool Children
When looking at the literature, sensory-motor skills, self-regulation, executive functions, cognitive styles, and school readiness are strongly related concepts.
- Trial name
- NCT05880238
- Testing
- Intervention group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Biruni University
Child Development
Early Literacy Promotion Intervention
This study is testing the effects of early literacy promotion compared to standard literacy promotion at The Children's Hospital of Philadelphia.
- Trial name
- ELPI (NCT02713659)
- Testing
- Early Literacy Promotion, Standard Literacy Promotion
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Early Detection of Cancer
The Effect of Face-to-face and Online Health Education on Women's Cervical Cancer Knowledge, Health Beliefs and Screening
Aim: The aim of this study is to determine the effect of health education given by two different methods on women's knowledge about HPV, cervical cancer health belief and screening test.
- Trial name
- NCT06021496
- Testing
- face to face health education, online health education
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Cardiovascular Risk Factor
Random Assignment of Intervention Messages for Developing Personalized Decision Rules to Promote Physical Activity
Our goal is to develop personalized decision rules for selecting the frequency, timing, and content of messages to promote physical activity.
- Trial name
- RandomAIM (NCT03907683)
- Testing
- Short Message with Text and Optional Image
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Penn State University
Health Behavior, Childhood Obesity
Healthy Environments Study (HEROs)
Obesity is a multi-dimensional problem that has roots in infancy and tracks into adulthood. Obesity is represented disproportionately among children and families from low socioeconomic and minority backgrounds, particularly in…
- Trial name
- NCT04743531
- Testing
- HEROs
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Colorado State University
HIV
Efficacy of SMS to Improve Early Retention in HIV Care for PLWH in Lima
Randomized controlled study that will evaluate the effect of a text message-based strategy to improve retention in HIV care.
- Trial name
- NCT03862196
- Testing
- Tailored text messages to improve retention in HIV care
- Where
- Peru
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- NGO Via Libre
Anterior Crossbite, Class III Malocclusion in Growing Patients
Comparison Between Protraction Facemask and Upper Braces for Underbite Correction in Growing Children
The goal of this clinical trial is to compare the effectiveness of a protraction facemask and upper partial fixed appliance in correcting anterior crossbite in growing children with class III malocclusion.
- Trial name
- NCT06759896
- Testing
- Protraction facemask, Upper partial fixed appliance
- Where
- Malaysia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Anxiety
Happy Mother - Healthy Baby: Supplement Study on Biological Processes Underlying Anxiety During Pregnancy
As a supplement to the ongoing randomized evaluation of the Cognitive Behavioral Therapy (CBT) anxiety prevention intervention in Pakistan (R01-MH111859), the investigators propose to explore potential biological mechanisms…
- Trial name
- HMHB-Bio (NCT04566861)
- Testing
- Cognitive Behavioral Therapy (CBT) for anxiety during pregnancy
- Where
- Pakistan
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Child Development, Child Development Disorder
Every Newborn-Reach Up Early Education Intervention for All Children- a Parent Group Intervention for School Readiness in Bangladesh, Nepal, and Tanzania
The goal of this clinical trial is to test the effect of a pre-primary education parent group intervention in children with and without disability in Nepal Bangladesh and Tanzania.
- Trial name
- EN-REACH (NCT06334627)
- Testing
- Pre-Primary Intervention
- Where
- 3 sites in Bangladesh, Nepal and 1 more
- Volunteers
- 1,651 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Posttraumatic Stress Disorder, Burns
Early Intervention to Prevent Development of PTSD in Burn Survivors and Their Caregivers
The purpose of this clinical trial is to adapt and test a brief patient-caregiver early intervention designed to reduce posttraumatic stress symptoms in hospitalized burn patients and their caregivers.
- Conditions
- Posttraumatic Stress Disorder, Burns, Traumatic Injury, Acute Stress Disorder
- Trial name
- NCT07656545
- Testing
- Promotion of Emotional Disclosure for Burns (PoED-B), minimally Enhanced Usual Care control (mEUC)
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Cardiovascular Diseases
Early Intervention to Promote Cardiovascular Health of Mothers and Children
The goal of this clinical trial is to examine whether a multi-component intervention delivered during pregnancy and after delivery can improve the cardiovascular health of pregnant individuals enrolled in home visiting programs…
- Trial name
- ENRICH (NCT05856162)
- Testing
- ENRICH pilot intervention (full intervention), ENRICH pilot intervention (partial intervention: only diet and physical activity)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Child Obesity
Preventing and Addressing At-obesity-Risk Early Years INtervention with Home Visits in Toronto (PARENT): a Pragmatic RCT
The PARENT Trial aims to determine if the Parents Together program consisting of parent workshops, home visits and coaching calls, will result in better health outcomes for children.
- Trial name
- PARENT (NCT03219697)
- Testing
- Parenting education program
- Where
- 2 sites in Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Psychological Adaptation
Problem-solving: A Stroke Caregiver Early Intervention
Intervention studies for stroke caregivers (CG's) during early caregiving are few and have met with limited success. The Post-Stroke Rehabilitation Clinical Practice Guidelines (1995) recommend sensitivity to the adverse effects…
- Trial name
- CPSI (NCT01141738)
- Testing
- Caregiver Problem-Solving Intervention, Wait List Control
- Where
- 4 sites in United States
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Northwestern University