Clinical trials: Early Life Adversity
Stress, Mindfulness
Remote Mindfulness Training Following Early Life Adversity
This study will test the feasibility of delivering smartphone-based mindfulness and coping interventions to a sample of emerging/young adults with a history of early life adversity (ELA).
- Conditions
- Stress, Mindfulness, Early Life Adversity
- Trial name
- ReMind (NCT05516108)
- Testing
- Mindfulness, Coping
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Early Life Adversity, Trauma
Study of Cannabidiol and Neuroimaging on Stress
Dysregulation in stress responsivity is a growing psychiatry-transdiagnostic fundamental phenomenon, with limited therapeutic strategies.
- Conditions
- Early Life Adversity, Trauma, Stress
- Trial name
- SCANS (NCT07278505)
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Early Life Adversity, Chronic Stress
Health Experiences & Early Life Disadvantages
Growing up in a low-income household has been shown to increase risk for, and susceptibility to many illnesses.The purpose of the study is to test an affective intervention for reversing biological risk factors, as related to…
- Trial name
- HEELD (NCT02400593)
- Testing
- Meditation Workshop
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Depression
Positive Affect Treatment for Adolescents With Early Life Adversity
Youth exposed to early life adversity (ELA) are known to be at greater risk for depression and suicidality and account for almost half of the youth suffering from psychiatric diseases today.
- Trial name
- PAT4ELA (NCT06273137)
- Testing
- Positive affect treatment, Supportive psychotherapy (SUP)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Stress, Psychological Stress
Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity
The aim of the Everyday Moments of Mindfulness (EMMI) study is to test whether brief mindfulness-based practices will improve daily psychological stress responses in women (age 30-60) who report a history of early life adversity.
- Conditions
- Stress, Psychological Stress, Child Maltreatment, Depressive Symptoms
- Trial name
- EMMI (NCT04606199)
- Testing
- Mindfulness-based intervention, up to 5 minutes 0-3 times/day
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Stress, Mindfulness
Remote Mindfulness Training Following Early Life Adversity 2
This pilot study aims to evaluate the effects of a 10-week online Mindfulness-Based Stress Reduction (MBSR) intervention on stress and inflammatory outcomes in a sample of emerging adults with a history of early life adversity.
- Conditions
- Stress, Mindfulness, Early Life Adversity
- Trial name
- ReMind 2 (NCT07085052)
- Testing
- Mindfulness-Based Stress Reduction (MBSR)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Emotional Dysfunction, Early Life Stress
Dyadic Neurofeedback for Emotion Regulation in Youth With Maternal Adversity
This study will examine the effect of a real-time functional magnetic resonance imaging (fMRI) dyadic neurofeedback protocol with mothers and their adolescent daughters.
- Trial name
- NCT04964726
- Testing
- Real-time fMRI dyadic neurofeedback
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University Center for Health Sciences
Early Life Adversity, Caregiver Stress
Collaborative Approach to Examining Adversity and Building Resilience Study
To examine the behavioral, psychosocial, and biologic impact of resilience-promoting interventions associated with primary care.
- Trial name
- CARE (NCT05259436)
- Testing
- Caregiver-child Intervention, Enhanced Primary Care
- Where
- 4 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Adolescents With Early Life Stress
Augmented Mindfulness Training for Resilience in Early Life
This project aims to determine whether neurofeedback augmented mindfulness intervention increases the plasticity in brain areas affected by exposure to early life adversity in youth.
- Trial name
- A-MindREaL (NCT04053582)
- Testing
- AMT
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Adverse Childhood Experience, Endothelial Function (FMD)
Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity
Adverse childhood experiences (ACEs) represent highly stressful events in the first 18 years of life that include abuse, neglect, and household and community-level dysfunction.
- Conditions
- Adverse Childhood Experience, Endothelial Function (FMD), Endothelial Injury, Mitochondrial Function
- Trial name
- PROMISE (NCT07244809)
- Testing
- Mitoquinone mesylate (MitoQ)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Early Life Adversity, Caregiver Stress
The Resilience Clinic Evaluation
Early life adversity can affect children's physical and mental health. The Resilience Clinic is a support program for young children and their caregivers who have been exposed to significant adversity, aiming to prevent the…
- Trial name
- NCT05690256
- Testing
- Resilience Clinic, Enhanced primary care
- Where
- 4 sites in United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco