Clinical trials: Early Stages of Cognitive Decline
Mild Cognitive Impairment, Alzheimer Disease
INTERCEPTOR Project: From MCI to Dementia
In the next years a number of phase 2-3 trials which utilize experimental drugs possibly disease modifying for Alzheimer Dementia will reach their conclusion.
- Trial name
- INTERCEPTOR (NCT03834402)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Catholic University of the Sacred Heart
Mild Cognitive Impairment (MCI), Early Stages of Cognitive Decline
Mild Cognitive Impairment Community Screening and Early Intervention Via Stem Cell Therapy and Wearable Brain Computer Interface Device.
This study aims to evaluate the efficacy of community-based early detection and targeted interventions, including stem cell therapy and wearable non-invasive brain-computer interface (BCI) devices, for Mild Cognitive Impairment…
- Conditions
- Mild Cognitive Impairment (MCI), Early Stages of Cognitive Decline, Alzheimer's Disease Dementia, Alzheimer's Disease Diagnosis
- Trial name
- MCITestCare (NCT07214974)
- Testing
- Structured wellness care, Wearable brain-computer interface devices, Stem Cell Therapy - Experimental
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Noah Tech, Corp.
Mild Cognitive Impairment, Dementia, Mild
Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment
The goal of this clinical trial is to compare a precision medicine approach to the standard-of-care for people with mild cognitive impairment or early-stage dementia.
- Trial name
- EVANTHEA (NCT05894954)
- Testing
- Precision Medicine Approach, Hormones and Medications tailored to lab tests, combined with devices that support stress management and brain exercises, Standard-of-Care
- Where
- 6 sites in United States
- Volunteers
- 73 people
- Sponsor
- Alzheimer's Prevention and Reversal Project, Inc.
Mild Cognitive Impairment, Dementia
A 3 Year Study to Evaluate the Safety and Efficacy of Low Dose Ladostigil in Patients With Mild Cognitive Impairment
The purpose of this study is to determine whether treatment with the investigational drug ladostigil will delay the onset of Alzheimer's disease(AD) in patients with Mild Cognitive Impairment (MCI).
- Trial name
- NCT01429623
- Testing
- ladostigil hemitartrate
- Where
- 12 sites in Austria, Germany and 1 more
- Volunteers
- 210 people
- Sponsor
- Avraham Pharmaceuticals Ltd
Postoperative Neurocognitive Dysfunction, Cognitive Dysfunction
Perioperative IL-33 is Associated with the Early Stage of Postoperative Neurocognitive Dysfunction After Major Abdominal Surgery
Perioperative neurocognitive dysfunction(PND) are common complications of major surgery among patients, could be a long-term disease, which sometimes lasts for several years, and it is meaningful to find a biomarker of PND at the…
- Conditions
- Postoperative Neurocognitive Dysfunction, Cognitive Dysfunction, Postoperative Complications, Neuropsychological Tests
- Trial name
- NCT06704451
- Where
- China
- Volunteers
- 150 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Parkinson Disease, Alzheimer Disease
Effectiveness of Probiotic K10 in Managing Health Outcomes in Parkinson and Alzheimer Disease
Evaluation of the effects of the K10 probiotic mix in patients with degenerative neurological diseases (Parkinson and Alzheimer's) with a focus on cognitive, motor and psychiatric neurological evaluation.
- Trial name
- Probiótico (NCT06019117)
- Testing
- Probiotic K10
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- Deivis de Oliveira guimaraes
Cognitive Impairment
Home-based Cognitive Treatment and Cognitive Impairment
The prevalence of neurodegenerative diseases is expected to increase over the next years, in parallel with the aging of the world population.
- Trial name
- NCT04889560
- Testing
- Experimental group, Control group
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Alzheimer Disease, Preclinical Alzheimer's Disease
Amyloid Prediction in Early Stage Alzheimer's Disease From Acoustic and Linguistic Patterns of Speech - FUTURE Extension
The primary objective of the study is to evaluate whether a set of algorithms analysing acoustic and linguistic patterns of speech, can predict change in PACC5 between baseline and +12 month follow up across all four Arms, as…
- Conditions
- Alzheimer Disease, Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease, Alzheimer's Disease (Incl Subtypes)
- Trial name
- AMYPRED-FUTURE (NCT04846426)
- Where
- 4 sites in United Kingdom
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Novoic Limited
Alzheimer Disease, Preclinical Alzheimer's Disease
Amyloid Prediction in Early Stage Alzheimer's Disease From Acoustic and Linguistic Patterns of Speech
The primary objective of the study is to evaluate whether a set of algorithms analysing acoustic and linguistic patterns of speech can detect amyloid-specific cognitive impairment in early stage Alzheimer's disease, as measured…
- Conditions
- Alzheimer Disease, Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease, Alzheimer's Disease (Incl Subtypes)
- Trial name
- AMYPRED (NCT04828122)
- Where
- 4 sites in United Kingdom
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Novoic Limited
Mild Cognitive Impairment, Dementia, Mild
Effects of Multimodal Cognitive Enhancement Therapy (MCET) for Ealy Dementia
This study evaluates the effects of Multimodal Cognitive Enhancement Therapy (MCET) for people with mild cognitive impairment and early stage dementia by a randomized, controlled (mock-therapy), double-blind, cross-over trial
- Trial name
- NCT02350738
- Testing
- Period I MCET (8 wks), Washout (4 wks), Period II MCET (8 wks)
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Ki Woong Kim
Alzheimers' Disease
Cognitive Behavioural Therapy for Persons With MCI or Mild Dementia
A total of 200 home dwelling participants, who fulfil the inclusion criteria, Alzheimer's disease, will be recruited from three hospitals in Norway.
- Trial name
- NCT02013518
- Testing
- Cognitive Behavioural Therapy
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Mindfulness for Cognition in Early-stage Alzheimer's Disease
The goal of this clinical trial is to learn if mindfulness meditation can improve outcomes in older adults with and without cognitive impairment. The main questions it aims to answer are: 1.
- Conditions
- Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, TBI (Traumatic Brain Injury), Aging
- Trial name
- NCT06792877
- Testing
- Mindfulness Intervention, Waitlist then mindfulness
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- VA Boston Healthcare System
Geriatric Depression, Cognitive Impairment
Electronic Training of Elderly Depression With Cognitive Impairment
late-life depression (LLD) is the most common mental illness in the elderly. Due to the increasing prevalence of population aging, it has become one of the important factors affecting the quality of life of the elderly.
- Trial name
- NCT05588102
- Testing
- Selective Serotonin Reuptake Inhibitor（SSRIs，Fluoxetine, paroxetine, fluvoxamine, sertraline, citalopram, escitalopram）
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Capital Medical University
Mild Cognitive Impairment, Ischemic Stroke
Clinical Trial of Efficacy and Safety of MMH-MAP in the Treatment of Mild Cognitive Impairment in Early Recovery Stage After Ischemic Stroke
The purpose of this study is: to evaluate efficacy of MMH-MAP in the treatment of mild cognitive impairment in subjects in early rehabilitation period of ischemic stroke to evaluate safety of MMH-MAP in the treatment of mild…
- Trial name
- NCT03815292
- Testing
- MMH-MAP
- Where
- 28 sites in Russia
- Volunteers
- 276 people
- Sponsor
- Materia Medica Holding
MCI, MCI-AD, Early Stage Alzheimer's Disease
Efficacy and Safety of Dimethyl Fumarate Among Patients with Mild Cognitive Impairment and Dementia Due to Alzheimer's Disease
The goal of this clinical trial is to assess the degree of improvement in cognitive functions, including memory, attention, thinking, executive and language functions in diagnosed patients MCI and AD taking dimethyl fumarate 480…
- Conditions
- MCI, MCI-AD, Early Stage Alzheimer's Disease, Alzheimer's Disease
- Trial name
- NCT06850597
- Testing
- dimethyl fumarate
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Alzheimer Type Dementia, Alzheimer's Disease (AD)
Impact of Ketoflex 12/3 Diet on Early-to-Mid Stage Alzheimer's Progression
This study investigates the effects of the Ketoflex 12/3 diet on the clinical progression of early-to-mid stage Alzheimer's disease.
- Trial name
- NCT06898424
- Testing
- Ketoflex 12/3 Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Prof. Lutfu Hanoglu, MD
Cognitive Impairment
Non-Pharmacological Treatments and Cognitive Impairment (NPT-CI2019)
The prevalence of neurodegenerative diseases is expected to increase over the next years, in parallel with the aging of the world population.
- Trial name
- NPT-CI2019 (NCT04118686)
- Testing
- CoRe software training plus non-invasive brain stimulation techniques (anodical tDCS / rTMS)
- Where
- Italy
- Volunteers
- 19 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Subjective Cognitive Impairment, Mild Cognitive Impairment
Molecular Mediators of Physical Exercise and Carnosine Induced Effects in Patients With Preclinical and Early Stage Neurodegenerative Disease
The purpose of this study is to investigate the beneficial effects of regular exercise and the impact of food supplement carnosine on cognitive, motoric and metabolic functions as well as on specific biologically active…
- Conditions
- Subjective Cognitive Impairment, Mild Cognitive Impairment, Parkinson Disease, Healthy Volunteers
- Trial name
- NCT03330470
- Testing
- exercise, carnosine supplementation, stretching
- Where
- 3 sites in Slovakia, Taiwan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Dementia Mild, Mild Cognitive Impairment
An Advance Care Planning Programme for Persons With Early Stage Dementia in the Community
Advance care planning (ACP) has been widely advocated for persons with early stage dementia (PWEDs) and persons with mild cognitive impairment (MCI).
- Trial name
- NCT04491578
- Testing
- ACP programme "Have a Say"
- Where
- 10 sites in Hong Kong
- Volunteers
- 100 people
- Sponsor
- Hong Kong Metropolitan University
MCI-AD, Early Stage Alzheimer's Disease, Alzheimer s Disease
Home-Based Closed-Loop Auditory Stimulation to Enhance Slow-Wave Activity in MCI Due to Alzheimer's Disease: A Proof-of-Concept Study
This proof-of-concept study explores whether long-term home-based closed-loop auditory stimulation during sleep enhances slow-wave activity (SWA) and yields preliminary efficacy signals in patients with amnestic mild cognitive…
- Conditions
- MCI-AD, Early Stage Alzheimer's Disease, Alzheimer s Disease, Mild Cognitive Impairment (MCI) Amnestic, AD
- Trial name
- Nana-Home (NCT07672977)
- Testing
- Closed-Loop Auditory Stimulation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Bitbrain