Clinical trials: Early Waking
Spinal Fusion, Pain, Postoperative
The Effect of Foot Massage on Pain, Sleep Quality and Early Discharge in Patients Undergoing Spinal Surgery
In recent years, it is known that the use of complementary approaches, which are accepted as a safe and effective method for maintaining health and well-being, providing relaxation/relaxation, and reducing the effects of illness…
- Trial name
- NCT05354830
- Testing
- Foot Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Istanbul Medeniyet University
REM Sleep Behavior Disorder, Pre-motor Parkinson's Disease
Terazosin Effect on Cardiac Changes in Early Parkinson's Disease
Parkinson's disease (PD) is characterized by many non-motor symptoms that occur several years before the diagnosis, in particular idiopathic REM behavior disorder (iRBD), which is associated with autonomic impairment.
- Conditions
- REM Sleep Behavior Disorder, Pre-motor Parkinson's Disease, Symptomatic Parkinson Disease
- Trial name
- NCT04386317
- Testing
- Terazosin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Cedars-Sinai Medical Center
Obstructive Sleep Apnoea Syndrome
Identification of Biomarkers for Obstructive Sleep Apnoea Syndrome
Untreated Obstructive Sleep Apnea Syndrome (OSAS) has long-term complications, namely metabolic imbalances (obesity, dislipidemia, type 2 diabetes mellitus).
- Trial name
- NCT02043483
- Where
- Portugal
- Volunteers
- 120 people
- Sponsor
- Universidade Nova de Lisboa
Sleep Disturbance
Effect of Intraoperative Dexamethasone on Early Postoperative Sleep Quality in Patients Undergoing Nasal Surgery
This study aims to evaluate the effect of intraoperative dexamethasone on early postoperative sleep quality in adult patients undergoing nasal surgery under general anesthesia.
- Trial name
- NCT07550803
- Testing
- Dexamethasone, Normal Saline
- Volunteers
- 102 people
- Sponsor
- Seoul National University Hospital
Psychotic Disorders, Psychosis
CBT to Reduce Insomnia and Improve Social Recovery in Early Psychosis
Sleep disturbances and cognitive dysfunction are consistently reported as extremely troublesome aspects of psychotic illnesses. While sleep disturbances are not included in definitions of psychosis they are associated with poor…
- Conditions
- Psychotic Disorders, Psychosis, Sleep
- Trial name
- CRISP (NCT04180709)
- Testing
- Sleepio
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Cambridge
Insomnia, Cognitive Disorder
Study on Cognitive Impairment of Insomnia Based on MRI
Insomnia is a common sleep disorder. In recent years, the incidence of insomnia is increasing worldwide. Studies point out that insomnia plays an important role in the pathogenesis of cognitive impairment.
- Conditions
- Insomnia, Cognitive Disorder, MRI
- Trial name
- NCT05659511
- Testing
- MRI
- Where
- China
- Volunteers
- 684 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Atopic Dermatitis, Sleep Disturbance
Assessing SleeP IN Infants With Atopic Dermatitis by Longitudinal Evaluation
The SPINDLE study will examine sleep in infants with atopic dermatitis by serial assessment over the first year of life, in comparison to infants without atopic dermatitis.
- Trial name
- SPINDLE (NCT05031754)
- Where
- Ireland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University College Cork
Post Traumatic Stress Disorder, Obstructive Sleep Apnea
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone.
- Conditions
- Post Traumatic Stress Disorder, Obstructive Sleep Apnea, Substance Use Disorder, Residential Treatment Program
- Trial name
- NCT05156112
- Testing
- Positive Airway Pressure Device
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- VA Office of Research and Development
REM Sleep Behavior Disorder
Gut Microbiota Across Early Stages of Synucleinopathy: From High-risk Relatives, REM Sleep Behavior Disorder to Early Parkinson's Disease
With the global ageing population, neurodegenerative disorders including synucleinopathy are major burdens to patients, carers and society.
- Trial name
- NCT03645226
- Testing
- Colonoscopy
- Where
- 2 sites in Hong Kong
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Post Traumatic Stress Disorder, Rape Sexual Assault
Early Psychological Intervention After Rape
Rape is a common cause of post-traumatic stress disorder (PTSD) among women, as around 30-50% will develop PTSD in the aftermath of rape.
- Conditions
- Post Traumatic Stress Disorder, Rape Sexual Assault, Sexual Dysfunctions, Psychological, Pelvic Floor Myalgia
- Trial name
- EIR (NCT05489133)
- Testing
- Modified prolonged exposure
- Where
- 4 sites in Norway
- Volunteers
- 166 people
- Sponsor
- St. Olavs Hospital
Valve Heart Disease, Awakening Early
Prospective Evaluation of Volatile Sedation After Heart Valve Surgery
Cardiac surgery is a complex operative procedure with a substantial risk of postoperative complications, so that patients undergoing valve surgery are usually transferred to the intensive care unit postoperatively.
- Trial name
- NCT04958668
- Testing
- Post-operative intensive care using volatile sedation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Goethe University
Sleep Initiation and Maintenance Disorders, Insomnia
Efficacy and Safety of Eplivanserin Treatment for Sleep Maintenance Insomnia Followed by Optional Extension up to 1 Year
The purpose of the study is to assess efficacy and safety of eplivanserin in the population of patients complaining of sleep maintenance insomnia.
- Trial name
- EPLILONG (NCT00253903)
- Testing
- eplivanserin (SR46349)
- Where
- 14 sites in United States, Argentina and 12 more
- Volunteers
- 1,155 people
- Sponsor
- Sanofi
OSA, Heart Failure
Impact of Early Diagnosis and Treatment of OSA on Hospital Readmission in Hospitalized Cardiac Patients
The purpose of this study is to determine whether early diagnosis of obstructive sleep apnea and initiation of and adherence to CPAP therapy in hospitalized cardiac patients would impact 30-day hospital readmission rates.
- Conditions
- OSA, Heart Failure, Myocardial Infarction, Arrhythmia, Cardiac
- Trial name
- CV Readmit (NCT03647891)
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Sleep Apnea Syndrome
Effect of Early Education on the Observance of CPAP Treatment
Sleep apnea (SA) affects more than 4% from general population and is largely underdiagnosed. SA can increase the occurrence of cardiovascular, endocrine and metabolic events (particularly stroke, diabetes \& obesity).
- Trial name
- CoachSAS (NCT02657304)
- Testing
- Coaching group, Control group
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Diabetes, Depression
e-Pharmacovigilance II - Surveillance for Safety and Effectiveness - Calling for Earlier Detection of Adverse Reactions
Specific Aim 1: To develop a patient-reported, EHR-integrated system to actively monitor the safety and effectiveness of treatment for patients taking FDA-approved medications for one of four common chronic conditions (diabetes…
- Conditions
- Diabetes, Depression, Insomnia, Hypertension
- Trial name
- CEDAR (NCT02087293)
- Testing
- Intervention arm - automated call and phone-based pharmacist counseling
- Where
- United States
- Volunteers
- 38,400 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Benefit of Cheyne-Stokes Respiration Remote Monitoring in CPAP-treated Patients With Obstructive Sleep Apnea to Detect Early Events of Heart Failure.
Obstructive sleep apnea (OSA) syndrome affects 40-60% of patients presenting with cardiovascular diseases. Cheyne-Stokes respiration is a type of central apnea characterised by the presence of at least three consecutive episodes…
- Trial name
- NCT03592108
- Testing
- CSR remote monitoring
- Where
- France
- Volunteers
- 555 people
- Sponsor
- Groupe Medical de Pneumologie, Polyclinique Saint-Laurent
Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
Early Warning System
The study will begin in 2013 whereby patients having an early warning system (EWS) alert will be randomized to be seen by the rapid response team (RRT) for triage versus usual care.
- Conditions
- Congestive Heart Failure, Chronic Obstructive Pulmonary Disease, Cancer, Diabetes Mellitus
- Trial name
- NCT01741480
- Testing
- Early warning system monitoring., routine care
- Where
- United States
- Volunteers
- 571 people
- Sponsor
- Washington University School of Medicine
Disease Bowel, Crohn Disease
Evaluation of Sleep Changes in Inflammatory Bowel Diseases (IBD) Patients.
Inflammatory Bowel Diseases (IBD) go through two phases: flare and remission. Prediction of flares and identification of patients in remission but at high risk of flare are a major issue when taking care of IBD patients.
- Conditions
- Disease Bowel, Crohn Disease, Ulcerative Colitis
- Trial name
- RECIDREAM (NCT05835973)
- Testing
- Sleep activity, Questionnaires
- Where
- 4 sites in France
- Volunteers
- 216 people
- Sponsor
- Hospices Civils de Lyon
Substance-Related Disorders, Substance Use Disorder
Sleep Architecture, Cognitive Function, and Quality of Life During Early Recovery From Substance Use Disorder
This prospective cohort study investigates how sleep disturbances affect cognitive recovery and quality of life during early recovery from substance use disorder (SUD).
- Conditions
- Substance-Related Disorders, Substance Use Disorder, Sleep Wake Disorders, Cognitive Dysfunction
- Trial name
- NCT07852052
- Volunteers
- 34 people
- Sponsor
- Assiut University
Lung Cancer
Early Diagnosis and Treatment of Sleep Disordered Breathing in Lung Cancer
Sleep-disordered breathing at night is a common medical problem. It leads to daytime fatigue, impairment in concentration and daily activities, and a higher risk of cardiovascular disease and life-threatening events.
- Trial name
- NCT03443908
- Testing
- CPAP
- Where
- United States
- Sponsor
- Mark M. Fuster, MD