Clinical trials: Early-stage Breast Cancer
Breast Cancer
A Study of Pertuzumab in Combination With Herceptin and Chemotherapy in Participants With HER2-Positive Breast Cancer
This 3 arm study will assess the tolerability, safety and efficacy of 3 neoadjuvant treatment regimens in participants with locally advanced, inflammatory or early stage human epidermal growth factor receptor 2 (HER2)-positive…
- Trial name
- NCT00976989
- Testing
- Pertuzumab, Trastuzumab, FEC
- Where
- 55 sites in Bosnia and Herzegovina, Brazil and 18 more
- Volunteers
- 225 people
- Sponsor
- Hoffmann-La Roche
Breast Cancer
Adjuvant Trastuzumab, Pertuzumab Plus Docetaxel in the Treatment of Early HER2-positive Breast Cancer
This randomized clinical trial compares two systemic treatments for HER2-positive breast cancer. The treatments are given either prior to breast surgery (as neoadjuvant treatment) or after breast surgery (as adjuvant treatment).
- Trial name
- BOLD-1 (NCT02625441)
- Testing
- Pertuzumab, Trastuzumab
- Where
- Finland
- Volunteers
- 516 people
- Sponsor
- Helsinki University Central Hospital
Metastatic Breast Cancer
Corrected QT Interval Effects of Trastuzumab Emtansine (T-DM1) in Patients With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Locally Advanced or Metastatic Breast Cancer and the Safety and Tolerability of Combined T-DM1 and Pertuzumab in Patients With Early Disease Progression
This is a multicenter, open-label, single-arm Phase II study designed to evaluate the effect of T-DM1 on the duration of corrected QT (QTc) interval in patients with HER2-positive locally advanced or metastatic breast cancer and…
- Trial name
- NCT00943670
- Testing
- pertuzumab, Trastuzumab emtansine [Kadcyla]
- Volunteers
- 51 people
- Sponsor
- Genentech, Inc.
Breast Cancer Female, Breast Cancer
Robotic vs. Open NSM for Early Stage Breast Cancer
This study evaluates the safety and effectiveness of the da Vinci SP Surgical System compared to Open NSM in Nipple Sparing Mastectomy procedures.
- Conditions
- Breast Cancer Female, Breast Cancer, Breast Cancer, Early-Onset, Breast Disease
- Trial name
- SP NSM (NCT05720039)
- Testing
- Robotic NSM, Open NSM
- Where
- 15 sites in United States
- Volunteers
- 204 people
- Sponsor
- Intuitive Surgical
Early-Stage Breast Carcinoma, HER-2 Positive Breast Cancer
Neoadjuvant Response-guided Treatment of HER2 Positive Breast Cancer
The purpose of this trial is to evaluate efficacy and toxicity of either the combination of docetaxel, trastuzumab sc and pertuzumab (arm A) or trastuzumab emtansin (arm B).
- Trial name
- PREDIX HER2 (NCT02568839)
- Testing
- docetaxel + trastuzumab sc + pertuzumab, trastuzumab emtansin
- Where
- 7 sites in Sweden
- Volunteers
- 202 people
- Sponsor
- Thomas Hatschek
Early-Stage Breast Cancer
Proton Therapy for Early Stage Breast Cancer
The purpose of this study is to determine if partial breast proton therapy is effective treatment for early stage breast cancer following lumpectomy.
- Trial name
- NCT00614172
- Testing
- Proton radiation therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Loma Linda University
Cancer
Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients
RATIONALE: Palliative care may help patients with advanced cancer live more comfortably. PURPOSE: This randomized clinical trial is studying an early intervention palliative care program to see how well it works compared to a…
- Trial name
- NCT00253383
- Testing
- counseling intervention, educational intervention, psychosocial assessment and care
- Where
- 2 sites in United States
- Volunteers
- 329 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Cancer, Early-stage Breast Cancer
Cardiometabolic Screening Program
This research study is being done to implement a screening program for prediabetes, diabetes, dyslipidemia and/or hyperlipidemia, and higher risk of cardiovascular disease in breast cancer survivors.
- Trial name
- NCT05386719
- Testing
- Prescreening, Screening and Enrollment, Baseline
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Early Stage Breast Cancer
Percent Weight Change in the Medical Supplement Group of Early Breast Cancer
The goal of this RCT is to compare percent weight change in early breast cancer who takes medical supplement or not, during treatment with chemotherapy (standard AC regimen).
- Trial name
- NCT06311357
- Testing
- Ensure
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Breast Cancer
Internal Mammary Sentinel Lymph Node Biopsy in Early Breast Cancer Patients With Clinically Axillary Node -Negative
In addition to the axillary lymph node, the internal mammary lymph node (IMLN) chain is also the first-echelon nodal drainage site for metastasis and provides important prognostic information in breast cancer patients.
- Trial name
- IMSLNB-EBCP (NCT01642511)
- Testing
- 99mTc-labeled Sulfur Colloid, Axillary Sentinel Lymph Node Biopsy, Methylthioninium
- Where
- China
- Volunteers
- 407 people
- Sponsor
- Shandong Cancer Hospital and Institute
Her-2 Negative Breast Cancer, HRR Gene Mutation
Neoadjuvant Camrelizumab and Fluzoparib and Nab-paclitaxel in Early Breast Cancer With HRR Gene Mutation
This study is to evaluate the efficacy and safety of combination of Camrelizumab (Immunotherapy, PD-1 inhibitor), Fluzoparib (PARP inhibitor) and Nab-paclitaxel in neoadjuvant therapy of Her-2 negative breast cancer patients with…
- Trial name
- IMPARP (NCT05761470)
- Testing
- Camrelizumab, Fluzoparib, Nab-paclitaxel
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Ying Lin
Breast Neoplasms
Trial of Tomotherapy in Breast Cancer
Tomotherapy is a new radiation therapy system that uses an integrated CT scanner during delivery of radiation treatment to improve the accuracy of the treatment.
- Trial name
- TomoBreast (NCT00459628)
- Testing
- Conventional radiotherapy, Tomotherapy
- Where
- Belgium
- Volunteers
- 118 people
- Sponsor
- Vrije Universiteit Brussel
Early-Stage Breast Cancer
Trial to Evaluate Genomic Expression Profiles to Direct Preoperative Chemotherapy in Early Stage Breast Cancer
This multi-center randomized Phase II study assigned HER2-negative early-stage breast cancer patients to receive preoperative systemic chemotherapy in either a "genomic-guided" arm or a "non-guided arm." The "genomic-guided"…
- Trial name
- NCT00636441
- Testing
- Doxorubicin/Cyclophosphamide (AC) or Docetaxel/Cyclophosphamide (TC)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Duke University
Colorectal Cancer, Breast Cancer
A Research Study to Collect Patient Reported Outcomes Using Electronic Surveys
A single-centre, randomized, 2-arm clinical trial comparing follow-up consisting of tumour-specific Electronic Patient-Reported Outcomes (ePROs) with targeted symptom management versus standard of care follow-up during…
- Trial name
- NCT04990895
- Testing
- Electronic Tumour-Specific Patient-Reported Outcomes (ePRO) questionnaires
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- AHS Cancer Control Alberta
Early Stage Breast Cancer
A Randomized, Controlled Trial to Determine the Effects of an Exercise Intervention on Physical Activity During Chemotherapy for Patients With Early Stage Breast Cancer
This study is designed to randomly assign breast cancer patients requiring and agreeing to chemotherapy into two groups. One group will be receive an exercise prescription aimed at increasing physical activity by a minimum of 10…
- Trial name
- NCT02159157
- Testing
- Exercise prescription
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Cancer, Metastatic, Artifical Intelligence
Artificial Intelligence Model-Assisted Accurate Diagnosis of Early-Stage Breast Cancer
Retrospectively collect the clinical data, breast MRI images, breast ultrasound images and reports, laboratory indicators (such as CA199, CA153, CA125, CEA/AFP), pathological diagnosis results, HE staining images, and existing…
- Trial name
- NCT07063667
- Testing
- bulid primary AI model, verdict model and develop its function
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Breast Cancer
Accelerated Partial Breast Irradiation Using Intensity Modulated Radiotherapy Versus Whole Breast Irradiation
The aim of this Phase 3 randomised trial is to compare the efficacy and safety of whole breast radiotherapy to accelerated partial breast irradiation using intensity-modulated radiotherapy technique in selected early breast…
- Trial name
- NCT02104895
- Testing
- Accelerated partial breast irradiation (APBI), Whole breast irradiation (WBI)
- Volunteers
- 520 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Early Stage Breast Cancer (Stage 0-III)
Breast Cancer Patients: A Breast Cancer Rehabilitation and Exercise Laboratory
The proposed study compares the outcomes of a physical activity intervention begun at diagnosis, continuing through active cancer treatment and into six months of survivorship compared to the outcomes of a control group receiving…
- Trial name
- NCT01157130
- Testing
- Exercise Regimen
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nevada Cancer Institute
Breast Neoplasm
Evaluation of Drug Activity in Women With Breast Cancer and no Previous Herceptin Treatment
To compare the activity of AZD8931 against placebo on the cell markers in cancer tumours
- Trial name
- CHIVE (NCT01596530)
- Testing
- Drug-AZD8931
- Where
- 7 sites in Germany, South Korea and 1 more
- Volunteers
- 3 people
- Sponsor
- AstraZeneca
Early-stage Breast Cancer
Sentinel Lymph Node Identification in Patients With Breast Cancer Using SPECT/CT
Role of SPECT/CT in detection of sentinel lymph node in patients with breast cancer that is in early stage with small mass with no nodal or distant metastasis using radioactive material nannocolloid that can change surgical…
- Trial name
- NCT03468374
- Testing
- lymphoscintigraphy, Single Photon Emission Tomography
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Assiut University