Clinical trials: Eclampsia
Pregnancy Related
Longitudinal Study of Gene Expression in the Human Placenta During First-trimester and Full-term Pregnancy at the Single Cell Level
The single nucleus RNA-seq approach allows the placental transcriptome to be analyzed from nuclei, thus preserving the integrity of placental syncytium.
- Trial name
- VilliRNAseq (NCT06427408)
- Testing
- Non applicable
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preeclampsia, IUGR
Prediction of Preeclampsia & Other Obstetric Complications by Serum Homocysteine & Doppler
Second trimester homocysteine \& uterine artery doppler will be assessed\& the cases will be followed up till delivery for development of preeclampsia, IUGR(intra-uterine growth retardation) \& other obstetric complications.
- Trial name
- NCT02541110
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Severe Pre-eclampsia, Eclampsia
Comparison of Loading Dose Magnesium Sulphate With Prichard Regimen in the Management of Severe Preeclampsia and Eclampsia.
Preeclampsia/eclampsia is part of a spectrum of multi-systemic pregnancy disorder that contributes substantially to maternal and perinatal morbidity and mortality, especially in low resource setting.
- Trial name
- NCT06126068
- Testing
- Use of magnesium sulfate to prevent and stop fits in pre-eclampsia and Eclampsia
- Where
- Nigeria
- Volunteers
- 120 people
- Sponsor
- Federal Teaching Hospital Abakaliki
Preeclampsia, Gestational Hypertension
Serum Vasohibin, Cardiotrophin, Endocan & Perinatal Outcomes
Investigation of the relationship between maternal serum vasohibin-1, vasohibin-2, cardiotrophin -1 and endocan concentrations at the 11th and 14th weeks of gestation and adverse perinatal outcomes.
- Conditions
- Preeclampsia, Gestational Hypertension, Gestational Diabetes, Preterm Birth
- Trial name
- NCT06416995
- Testing
- first trimester serum diagnostic test
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Umraniye Education and Research Hospital
Preeclampsia
Exosome Cargo From Preeclampsia Patients
Although extensively studied, the cause of preeclampsia remains uncertain other than it is thought that the placenta plays a critical role in the development of preeclampsia.
- Trial name
- NCT04154332
- Testing
- Sample collection
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Preeclampsia Postpartum
Guideline-directed Management and Therapy (GDMT) for the Prevention of Postpartum Cardiac Dysfunction in Preeclamptic African American Women
This is a single-center, open-label pilot study looking at how Guideline-directed management and therapy (GDMP) in post-partum women with preeclampsia can improve Global Longitudinal Strain (GLS).
- Trial name
- GDMT For PE (NCT05534932)
- Testing
- Remote Patient Monitoring
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Preeclampsia
Haptoglobin and Preeclampsia
The purpose of this study is to show that a certain protein called haptoglobin protects against preeclampsia which is a common pregnancy complication.
- Trial name
- NCT01027130
- Where
- Israel
- Sponsor
- Bnai Zion Medical Center
Pre-Eclampsia, Pregnancy Complications
ASA Patterns for Prevention of Preeclampsia in SLE Pregnancies
Preeclampsia is a serious maternal condition affecting up to 5% of pregnancies from the general population and up to 30% of lupus pregnancies.
- Conditions
- Pre-Eclampsia, Pregnancy Complications, Systemic Lupus
- Trial name
- NCT03749044
- Testing
- Patient Educational Tool
- Where
- Canada
- Volunteers
- 73 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Recurrent Pregnancy Losses, Preeclampsia
Study of the Role of Tissular Maternofetal Alloimmunization in Placentation Pathologies
Justification: We have recently demonstrated that maternofetal alloimmunization was not limited to blood cells: maternal alloimmunization against a glomerular podocyte antigen expressed by the placenta can induce neonatal…
- Conditions
- Recurrent Pregnancy Losses, Preeclampsia, Intervillositis
- Trial name
- NCT00456118
- Where
- 7 sites in France
- Volunteers
- 83 people
- Sponsor
- University Hospital, Limoges
Preeclampsia, Maternal Deaths
The Project of Gestational Hypertension and Preeclampsia Screening and Prevention Center
Preeclampsia is the main cause of illness and death in pregnant women and fetuses. Currently, there is no effective treatment for preeclampsia in clinical practice, and the fundamental treatment is still termination of pregnancy…
- Trial name
- NCT06383858
- Testing
- Screening method
- Where
- China
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated Hospital of Guangzhou Medical University
Preeclampsia (PE) Risk, Oocyte Donation
Preeclampsia and Defective Placentation in Oocyte Donation: Importance of HLA-C and KIR
The IMMUN-OR study aims to study HLA-C/KIR combinations when looking at the risk of development of preeclampsia (PE) in pregnancies after oocyte donation.
- Trial name
- IMMUN-OR (NCT07178652)
- Volunteers
- 2,325 people
- Sponsor
- Universitair Ziekenhuis Brussel
Pre-eclampsia
Phenylephrine Versus Ephedrine in Pre-eclampsia
Phenylephrine administration is associated with reductions in CO and SctO2 compared with ephedrine when used for blood pressure management in women with pre-eclampsia undergoing cesarean delivery under spinal anesthesia.
- Trial name
- NCT02025426
- Testing
- Phenylephrine, Ephedrine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Duke University
Preeclampsia, Pregnancy
MitoQ to Improve Vascular Funciton in Preeclampsia
Preeclampsia is a leading cause of maternal and neonatal morbidity and mortality. There is a lack of effective therapeutics for prevention or treatment.
- Trial name
- MAVEN (NCT07229261)
- Testing
- Mitoquinol Mesylate
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Medical College of Wisconsin
Cesarean Section
Number of Previous Cesarean Sections on the Results of Angiogenic Factors.
Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries.
- Trial name
- NCT06166303
- Testing
- sFlt-1/PGIF
- Where
- Panama
- Volunteers
- 540 people
- Sponsor
- Saint Thomas Hospital, Panama
Brain Health, Gestational Hypertension
Brain Health in Midlife
The purpose of this study is to learn if hypertensive disorders during pregnancy affects brain health in midlife.
- Conditions
- Brain Health, Gestational Hypertension, Alzheimer Disease, Dementia
- Trial name
- ADORE BRAIN (NCT06640842)
- Testing
- A combination of various tests and biomarkers will be completed to understand the effect of hypertensive disorders of pregnancy on brain health in midlife.
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Severe Preeclampsia
Algorithm-Based Timing of Delivery Using the sFlt-1/PlGF Ratio in Early-Onset Severe Preeclampsia. (MAP 2 Study : Management Based on Angiogenic Markers in Preeclampsia 2 Study )
Preeclampsia is a serious pregnancy complication caused by abnormal placental development and function. It can lead to high blood pressure and damage to organs such as the liver, kidneys, brain, or cardiovascular system.
- Trial name
- MAP 2 (NCT07665112)
- Testing
- sFlt-1/PlGF ratio-guided management algorithm, Usual Care
- Where
- Spain
- Volunteers
- 386 people
- Sponsor
- Hospital Clinic of Barcelona
Pre-Eclampsia, Effects of; Anesthesia, Spinal and Epidural, in Pregnancy
Electroencephalographic Effects of Spinal Anaesthesia During Caesarean Delivery in Preeclampsia
Neuraxial anesthesia has been associated with delayed brainstem conduction and decreasing afferent sensory transmission, thereby modifying reticulo-thalamo-cortical mechanisms regulating arousal.
- Trial name
- NCT03917342
- Testing
- EEG measure
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pulmonary Artery Doppler
Pulmonary Artery Doppler in Preeclamptic Mothers
Evaluation of Pulmonary artery Doppler parameters in fetuses of mothers with severe preeclampsia
- Trial name
- NCT06755073
- Testing
- Pulmonary artery Doppler ultrasound
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Assiut University
Pre-Eclampsia, Pre-Term
Vascular Inflammation and Anti-inflammatory Supplements After Adverse Pregnancy Outcomes
Women who had an adverse pregnancy outcome (APO), such as preeclampsia, preterm birth, or gestational diabetes, have a higher risk for heart disease.
- Conditions
- Pre-Eclampsia, Pre-Term, Intrauterine Growth Restriction, Hypertension in Pregnancy
- Trial name
- VIA (NCT04633551)
- Testing
- Anti-inflammatory supplement
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Preeclampsia
Assessing the Usability and Clinical Utility of the Congo Red Dot Test: A Case-control Study
A case-control study will evaluate the clinical utility of the Congo Red test GV-005 in following women with a clinical diagnosis of preeclampsia and clinically healthy women in the postpartum period
- Trial name
- NCT02610972
- Testing
- Congo Red test GV-005
- Where
- 2 sites in Bangladesh, Mexico
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects