Clinical trials: Edema
Macular Degeneration, Diabetic Macular Edema
Single-center Study Measuring OSDI Dry Eye Score in Patients Undergoing an Anti-VEGF Induction Protocol
The purpose of this study is to assess the sensation of ocular dry eye symptom after an intravitreal injection of anti-VEGF.
- Conditions
- Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- PISO (NCT06262737)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Diabetic Macular Edema, DME
A Phase 2a Study to Evaluate the Safety, Tolerability, and Efficacy of SNP318 in DME Patients
The objective of this study is to assess the safety, efficacy, and tolerability of SNP318 in patients with DME.
- Trial name
- NCT07199777
- Testing
- SNP318
- Volunteers
- 60 people
- Sponsor
- SciNeuro
Diabetic Retinopathy, Diabetes Complications
Study Evaluating Efficacy and Safety of PF-04523655 Versus Laser in Subjects With Diabetic Macular Edema
To evaluate the effectiveness of study drug in improving visual acuity compared to laser treatment in the patients with diabetic macular edema
- Trial name
- DEGAS (NCT00701181)
- Testing
- Laser Treatment, PF-04523655 high, PF-04523655 middle
- Where
- 53 sites in United States, Denmark and 6 more
- Volunteers
- 184 people
- Sponsor
- Quark Pharmaceuticals
Uveitis, Cystoid Macular Edema
The Comparison Between the Therapeutic Affect of Intravitreal Diclophenac and Triamcinolone in Persistent Uveitic Cystoids Macular Edema
Cystoids macular edema (CME) is one of the most common causes of low vision due to uveitis. The treatment for reducing the intra-ocular inflammation can decrease the macular edema.
- Trial name
- NCT00893854
- Testing
- Diclophenac, Triamcinolone
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Heart Failure, Heart Failure Acute
Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial
Nearly 80% of acute heart failure (AHF) patients admitted to the hospital are initially treated in the emergency department (ED). Once admitted, within 30 days post-discharge, 27% of patients are re-hospitalized or die.
- Conditions
- Heart Failure, Heart Failure Acute, Acute Cardiac Failure, Acute Cardiac Pulmonary Edema
- Trial name
- N-FURIOUS (NCT03259165)
- Testing
- Nitrates, Loop Diuretics
- Where
- 3 sites in United States
- Volunteers
- 52 people
- Sponsor
- Indiana University
Hypertension
Fluid Overload Management and Vascular Stiffness in Chronic Kidney Disease Patients With Hypertension
This study aims to reduce fluid overload in order to control blood pressure of hypertensive CKD patients using bio-impedance assessment of fluid status and using a diuretic therapy algorithm.
- Trial name
- NCT05378750
- Testing
- Diuretic algorithm
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Alberta
Bone Marrow Edema
Subchondroplasty for Treatment of Bone Marrow Edema in the Foot and Ankle
The subchondroplasty procedure has been used to treat bone marrow edema mostly located in the periarticular region of the knee. In the past few years, it has expanded its use in the foot and ankle.
- Trial name
- NCT03921489
- Testing
- Subchondroplasty
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ellianne M. Nasser
Diabetic Retinopathy, Macular Edema
A Study to Evaluate the Safety and Efficacy of THR-317 for the Treatment of Diabetic Macular Oedema (DME)
This study is conducted to evaluate the safety of THR-317 when administered intravitreally and to assess the compound's efficacy in improving best-corrected visual acuity (BCVA) and reducing central subfield thickness (CST) in…
- Trial name
- NCT03071068
- Testing
- Anti-PlGF recombinant monoclonal antibody, 4mg dose, Anti-PlGF recombinant monoclonal antibody, 8mg dose
- Where
- 13 sites in Czechia, Hungary and 1 more
- Volunteers
- 49 people
- Sponsor
- ThromboGenics
Diabetic Macular Edema
Dose Ranging Study of an Ocular Sirolimus (Rapamycin) Formulation in Patients With Diabetic Macular Edema
The purpose of this study is to determine the safety and efficacy of an ocular sirolimus (rapamycin) formulation at various doses in patients with diabetic macular edema.
- Trial name
- NCT00656643
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- Santen Inc.
Refractory Diabetic Macular Edema
The Effect of Intravitreal Erythropoietin Injection for Refractive Diabetic Macular Edema
after advent of RD photoreceptor degeneration Occurred. This process appears as a incredible and progressive event that will not stop till reattachment of RPE and neurosensory retina happened .
- Trial name
- NCT03821168
- Testing
- injection of bevacizumab and erythropoietin, injection of bevacizumab
- Where
- Iran
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Meniere's Disease, Ménière's Vertigo
Study of Lamotrigine to Treat Ménière's Disease
This double-blinded study evaluates the frequency of vertigo attacks and the quality of life of patients diagnosed with Ménière's disease after being randomly assigned to take a placebo or lamotrigine.
- Conditions
- Meniere's Disease, Ménière's Vertigo, Vertigo, Intermittent, Vertigo, Aural
- Trial name
- NCT02158585
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Dent Neuroscience Research Center
Pulmonary Edema, Respiratory Distress Syndrome
Performance Evaluation of Clinical Ultrasound in Management of Acute Pulmonary Edema in Elderly Patient
The main objective is to assess the validation of the diagnosis early acute pulmonary edema in elderly patients with acute respiratory distress, admitted in a host of vital emergency services by lung ultrasound associated with…
- Trial name
- ECHOP (NCT02638350)
- Testing
- Strategy with lung ultrasound
- Where
- France
- Volunteers
- 123 people
- Sponsor
- University Hospital, Toulouse
Hypervolemic Hyponatremia
International, Multicenter, Open-Label and Randomized Withdrawal Study of Oral Lixivaptan in Heart Failure Patients With Chronic Hyponatremia
To demonstrate that after 12 weeks of open-label lixivaptan treatment, serum sodium is maintained in hyponatremic patients continuing to receive lixivaptan compared to placebo during the 4 week double blind treatment period.
- Trial name
- NCT00876876
- Testing
- Lixivaptan
- Volunteers
- 300 people
- Sponsor
- CardioKine Inc.
Pulmonary Edema, Dyspnea
Continuous Positive Airway Pressure for Acute Pulmonary Edema
The investigators hypothesise that CPAP + pharmaceutical treatment, compared to pharmaceutical treatment alone, improves the respiratory and hemodynamic status of the patients before H2 after the inclusion time and decreases the…
- Conditions
- Pulmonary Edema, Dyspnea, Paroxysmal, Congestive Heart Failure
- Trial name
- CPAP (NCT00554580)
- Testing
- Continuous Positive Airway Pressure (CPAP), usual care of acute pulmonary oedema
- Where
- France
- Volunteers
- 208 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Branch Retinal Vein Occlusion
Study to Assess the Clinical Efficacy and Safety of Intravitreal Aflibercept Injection (IAI;EYLEA®;BAY86-5321) in Patients With Branch Retinal Vein Occlusion (BRVO)
This is a phase III, double-masked, randomized, active-controlled, parallel-group, 52-week study to assess the efficacy and safety of Intravitreal Aflibercept Injection (IAI;EYLEA®;BAY86-5321) compared to laser treatment in…
- Trial name
- VIBRANT (NCT01521559)
- Testing
- Macular Laser Photocoagulation, Intravitreal Aflibercept Injection (IAI;EYLEA®;BAY86-5321)
- Where
- 56 sites in United States, Canada and 1 more
- Volunteers
- 183 people
- Sponsor
- Regeneron Pharmaceuticals
Cystoid Macular Edema, Fuchs Dystrophy
Descemet Membrane Endothelial Keratoplasty vs. Descemet's Stripping With Endothelial Keratoplasty vs. Descemet Stripping Only
This study aims to evaluate and compare incidence of post-operative cystoid macular edema (CME) after Descemet Membrane Endothelial Keratoplasty (DMEK), Descemet's Stripping Automated endothelial Keratoplasty (DSEK) and Descemet…
- Trial name
- NCT04527523
- Testing
- Optical Coherence Tomography
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Wake Forest University Health Sciences
Cosmetic Surgery
Effectiveness Study of MIST Therapy After Cosmetic Surgery Procedures of the Face and Body
A clinical trial to evaluate the effect of MIST Therapy on outcomes after cosmetic procedures(including facelifts, blepharoplasties, breast augmentations and reductions, mastopexies, and abdominoplasties) traditionally associated…
- Trial name
- NCT01206855
- Testing
- MIST Therapy, Standard Postoperative Incision Care
- Where
- United States
- Volunteers
- 3,440 people
- Sponsor
- Celleration, Inc.
Diabetic Retinopathy, Diabetic Macular Edema
Intravitreal Triamcinolone Acetonide for Diabetic Macular Edema
Efficacy duration of triamcinolone acetonide (steroid) for treatment of diabetic macular edema. Furthermore, dosage dependency of triamcinolone acetonide comparing a high dosage versus a low dosage.
- Trial name
- NCT00476918
- Testing
- Intravitreal injection (triamcinolone acetonide)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heidelberg University
Meniere Disease
Phase 3 Study of OTO-104 in Subjects With Unilateral Meniere's Disease
The purpose of this study is to evaluate the effectiveness of OTO-104 for the treatment of Meniere's disease.
- Trial name
- NCT03664674
- Testing
- OTO-104
- Where
- 65 sites in United States, Belgium and 6 more
- Volunteers
- 148 people
- Sponsor
- Otonomy, Inc.
Diffuse Diabetic Macular Edema
Intravitreal Diclofenac Versus Avastin as Primary Treatment of Diffuse Diabetic Macular Edema
Diffuse Macular Edema is the main cause of visual disorders in diabetic patients. Diclofenac is a cheap drug available in most of treatment centers.in animal studies the safe dosage is identified that can be used in diffuse…
- Trial name
- NCT00999791
- Testing
- Bevacizumab, Diclofenac
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences