Clinical trials: Edema
Retinal Vein Occlusion, Diabetic Macular Edema
Peripheral and Macular Retinal Vascular Perfusion and Leakage in DME and RVO
This interventional study will evaluate the retinal vascular dynamics associated with Intravitreal Aflibercept Injection (IAI) therapy in eyes with diabetic macular edema (DME) or macular edema secondary to retinal vein occlusion…
- Conditions
- Retinal Vein Occlusion, Diabetic Macular Edema, Branch Retinal Vein Occlusion, Central Retinal Vein Occlusion
- Trial name
- PERMEATE (NCT02503540)
- Testing
- Aflibercept
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Justis Ehlers
Diabetic Macular Edema
Ozurdex in Suboptimal Diabetic Macular Edema Patients
The primary focus of this study is to understand the anatomic and visual outcomes of patients with refractory and suboptimal treatment response diabetic macular edema (DME) using anti-vascular endothelial growth factor (VEGF) to…
- Trial name
- DME (NCT04856397)
- Testing
- Intravitreal Implant in Applicator, Eylea
- Volunteers
- 200 people
- Sponsor
- Uptown Eye Specialists
Cystoid Macular Edema, Diabetes Mellitus
Assessing Diabetes Mellitus on Cytokine Analysis and Macular Edema Following FLACS
The purpose of this study is to assess the effects of diabetes mellitus (DM) on anterior chamber cytokine production and postoperative macular edema in patients undergoing femtosecond laser-assisted cataract surgery (FLACS).
- Conditions
- Cystoid Macular Edema, Diabetes Mellitus, Cataract
- Trial name
- NCT04856670
- Testing
- Cataract surgery
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Uptown Eye Specialists
Brain Edema, Metabolic Disturbance
Effect of Mannitol 20% Versus Hypertonic Saline 7.5% in Brain Metabolism and Oxygenation
Usage of osmotic agents is a standard practice in neuroanesthesia since cerebral edema is a very common situation for patients with pathology in the brain.
- Conditions
- Brain Edema, Metabolic Disturbance, Electrolyte and Fluid Balance Conditions
- Trial name
- NCT03573999
- Testing
- Mannitol, NaCl 7.5%
- Where
- 2 sites in Greece
- Volunteers
- 54 people
- Sponsor
- Aristotle University Of Thessaloniki
Age Related Macular Degeneration, Diabetic Macular Edema
Cytokine and Visual Outcome Variations in Eyes Receiving Aflibercept
Objective: To determine the association between baseline aqueous cytokine levels and treatment intervals for patients under a variable dosing regimen with intravitreal aflibercept in patients with neovascular age-related macular…
- Conditions
- Age Related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Macular Edema
- Trial name
- COVARIANT (NCT03056079)
- Testing
- Intravitreal aflibercept
- Where
- 2 sites in Canada
- Volunteers
- 168 people
- Sponsor
- Unity Health Toronto
Age Related Macular Degeneration, Diabetic Macular Edema
Cytokine and Visual Outcome Variations in Eyes Receiving Ranibizumab
Objective: To determine the association between baseline aqueous cytokine levels and treatment intervals for patients under a variable dosing regimen with intravitreal ranibizumab in patients with neovascular age-related macular…
- Conditions
- Age Related Macular Degeneration, Diabetic Macular Edema, Macular Edema, Retinal Vein Occlusion
- Trial name
- COVERT (NCT03056092)
- Testing
- Intravitreal ranibizumab
- Where
- 2 sites in Canada
- Volunteers
- 168 people
- Sponsor
- Unity Health Toronto
Glioblastoma, Cerebral Edema
Antisecretory Factor in Primary Glioblastoma 1
This is a non-randomised, open-label, single center-centre, Phase I-II study in patients with newly diagnosed glioblastoma. 5 patients with newly diagnosed glioblastoma are enrolled in the study and will receive an egg powder…
- Conditions
- Glioblastoma, Cerebral Edema, Chemotherapy Effect
- Trial name
- AFGBM1 (NCT04116138)
- Testing
- Salovum
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Peter Siesjö
Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
Time Efficiency Comparison of Two IntraVitreal Injection Techniques
Prospective, single-center, randomized, clinical trial (RCT) comparing the time efficiency and safety of a single-use intravitreal injection (IVI) guide versus a traditional technique using a dual blade speculum among patients…
- Conditions
- Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion With Macular Edema, Uveitic Macular Edema
- Trial name
- TIVI (NCT04455399)
- Testing
- Intravitreal injection guide (Malosa), Dual Blade Eyelid Speculum
- Where
- Philippines
- Volunteers
- 200 people
- Sponsor
- Peregrine Eye and Laser Institute
Macular Edema, Retinal Vein Occlusion
Suprachoroidal Injection of Triamcinolone Acetonide With IVT Anti-VEGF in Subjects With Macular Edema Following RVO
This Phase 3, multicenter, randomized, masked, controlled, parallel group study is designed to demonstrate that suprachoroidal (SC) CLS-TA administered with intravitreal (IVT) anti-VEGF agent in subjects with treatment naive RVO…
- Trial name
- TOPAZ (NCT03203447)
- Testing
- suprachoroidal CLS-TA, Lucentis or Avastin
- Where
- 92 sites in United States, Australia and 3 more
- Volunteers
- 325 people
- Sponsor
- Clearside Biomedical, Inc.
Erythema, Edema
Human Repeat Insult Patch Test to Evaluate Personal Lubricants
The purpose of this test is to evaluate the sensitizing potential of a personal lubricant, as a result of repeated occlusive patch.
- Trial name
- HRIPT (NCT02737631)
- Testing
- "Chameleon" Personal Lubricant
- Where
- United States
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Macular Edema, Retinal Vein Occlusion
Suprachoroidal Injection of Triamcinolone Acetonide With IVT Aflibercept in Subjects With Macular Edema Following RVO
This is a Phase 3, multicenter, randomized, masked, controlled, parallel group study of 12 months duration in treatment naïve subjects with RVO.
- Trial name
- SAPPHIRE (NCT02980874)
- Testing
- suprachoroidal CLS-TA, IVT aflibercept
- Where
- 110 sites in United States, Australia and 14 more
- Volunteers
- 460 people
- Sponsor
- Clearside Biomedical, Inc.
Edema Leg, Compression; Vein
Safety and Efficacy of the ElastiMed's SACS 2.0 - Smart Active Compression Stocking for the Treatment of Venous Edema
Device Efficacy: The primary efficacy assessment will be defined as successful if the edema volume will be reduced over time after using the SACS 2.0 device.
- Trial name
- NCT04837560
- Testing
- ElastiMed's SACS 2.0
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- ElastiMed ltd
Cardiogenic Pulmonary Edema, Ventilator-Induced Lung Injury
Ultra Protective Ventilation During Venoarterial Extracorporeal Membrane Oxygenation (UPV-ECMO)
Mechanical ventilation, in spite of being a life-saving technique, can also induce lung injury (VILI) mediated by an inflammatory response, thus having a profound impact in the course of critically ill patients.
- Conditions
- Cardiogenic Pulmonary Edema, Ventilator-Induced Lung Injury, Extracorporeal Circulation; Complications
- Trial name
- UPV-ECMO (NCT03041428)
- Testing
- Ultraprotective ventilation
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias
Diabetic Macular Edema, Non-proliferative Diabetic Retinopathy
Ozurdex for Treatment of Recalcitrant Diabetic Macular Edema
The purpose of this study is to test the efficacy of an 0.7 mg intravitreal dexamethasone implant (Ozurdex®) on macular leakage and visual acuity for patients with recalcitrant diabetic macular edema.
- Conditions
- Diabetic Macular Edema, Non-proliferative Diabetic Retinopathy, Proliferative Diabetic Retinopathy
- Trial name
- NCT01571232
- Testing
- dexamethasone intravitreal implant, intravitreal bevacizumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Retina Macula Institute
Diabetes Retinopathy, Diabetes Macular Edema
Uptake of Telemedicine System Trial in Rual Canton
To evaluate the impact of telemedicine system in rural hospitals for diagnosis and treatment of Diabetes retinopathy and Diabetes macular edema.
- Trial name
- NCT01832077
- Testing
- 90 D, fundus camera and grader
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Sun Yat-sen University
Carcinomatous Edema
A Multicenter, Open-label, Dose-finding Trial of OPC-41061 to Investigate Efficacy, Pharmacokinetics, Pharmacodynamics, and Safety in Patients With Carcinomatous Edema (Phase 2)
OPC-41061 will be administered to patients with volume overload associated with cancer, first by dose-escalation and subsequently for 6 consecutive days at the fixed dose at which urine volume is increased to investigate…
- Trial name
- NCT01684202
- Testing
- OPC-41061
- Where
- Japan
- Volunteers
- 43 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Diabetic Macular Edema
Comparison of VA Guided Versus OCT Guided TER Using Aflibercept for Diabetic Macular Edema (AVOCT Study)
This study will evaluate the effectiveness of aflibercept (Eylea®) using two different treatment protocols in patients with vision loss from diabetic macular edema.
- Trial name
- AVOCT (NCT03394573)
- Testing
- OCT guided treatment arm, VA guided treatment arm
- Where
- Switzerland
- Volunteers
- 110 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetic Macula Edema
Efficacy and Safety of Brolucizumab vs. Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema
The purpose of this study is to evaluate the efficacy and safety of brolucizumab in treatment of patients with visual impairment due to diabetic macular edema (DME).
- Trial name
- BUZZARD (NCT04079231)
- Testing
- Brolucizumab, Aflibercept
- Sponsor
- Novartis Pharmaceuticals
Ventilator Weaning
Interaction Diaphragm and Cardiac Function During Ventilator Weaning
Weaning failure is associated with prolonged duration of mechanical ventilation that itself can worsen patient's prognosis. Therefore, identification of the causes and mechanisms leading to weaning failure is important in daily…
- Trial name
- I-DISCO (NCT03486249)
- Testing
- Repetition of medical examinations performed as part of the care
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cataract, Macula Edema
Intraoperative Berger Space Imaging (IBSI)
The investigational device is an approved femtosecond laser (FSL) device with an integrated imaging system to perform certain steps of the cataract procedure.
- Trial name
- IBSI (NCT04775849)
- Testing
- Femtosecond Laser
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Medical University of Vienna