Clinical trials: Edema
Meniere's Disease
Famvir for Treatment of Hearing in Unilateral Meniere's Disease
The specific aim of this study is to determine the efficacy of treatment with famciclovir in unilateral Meniere's Disease patients, specifically whether hearing can be improved.
- Trial name
- Famvir (NCT01526408)
- Testing
- Famciclovir
- Volunteers
- 11 people
- Sponsor
- House Research Institute
Macular Edema, Branch Retinal Vein Occlusion
REtinal Vein OccLUsion Treatment With Scatter Laser Guided by UWFA in combiNAtion With Ranibizumab Study
Branch retinal vein occlusion is a leading cause of vision loss. Treatment with ranibizumab (vascular endothelial growth factor (VEGF) inhibitor) on a monthly basis has been associated with improved vision results.
- Trial name
- Revolution (NCT01247220)
- Testing
- Ranibizumab, Peripheral Laser
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Retina Associates of Florida, P.A.
Glioblastoma, Cerebral Metastases
Impact of Salovum® and SPC® Flakes on Brain Tumor Induced Edema
The objective of this clinical trial is to explore the effects of Salovum®, an egg yolk powder enriched with the endogenous protein antisecretory factor, and SPC® flakes , hydrothermically processed oats, on cerebral edema with…
- Conditions
- Glioblastoma, Cerebral Metastases, Meningioma
- Trial name
- AFBTEdema (NCT06710249)
- Testing
- Salovum/SPC flakes
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Peter Siesjö
Hypovolemia, Diuretic Toxicity
Diagnosis Accuracy of Abdominal Compression and Hemoconcentration to Detect Diuretic Induced Fluid Removal Intolerance.
Fluid overload increases morbidity and mortality of pediatrics patients in intensive care unit (ICU). It could be interesting to predict the decrease in stroke volume when diuretics are prescribed.
- Conditions
- Hypovolemia, Diuretic Toxicity, Fluid Overload
- Trial name
- NCT03145935
- Testing
- Abdominal compression (AC), blood sample
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hopital Louis Pradel
Edema Leg, Venous Insufficiency of Leg
Discovering the Effect of Venous Insufficiency on Nocturia (DEVINe)
Nocturia, or waking during the night to pass urine, is a multifactorial disease. An important cause of nocturia are peripheral edema due to accumulation of fluid in the lower limbs.
- Conditions
- Edema Leg, Venous Insufficiency of Leg, Nocturia, Bio-Impedance Measurements
- Trial name
- DEVINe Pilot (NCT03928197)
- Testing
- Tilt Test, Inbody S10, Tape measurements
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Diabetic Retinopathy, Diabetic Macular Edema
Treatment of Diabetic Macular Edema: Triamcinolone Injections Vs. Laser Photocoagulation
This study will compare the side effects of two treatments for diabetic macular edema, in which blood vessels in the retina (tissue that lines the back of the eye) become leaky and the retina and macula (the center part of the…
- Conditions
- Diabetic Retinopathy, Diabetic Macular Edema, DME
- Trial name
- NCT00105404
- Testing
- Triamcinolone Acetonide
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Macular Edema, Pars Plana Vitrectomy
Microinvasive Pars Plana Vitrectomy Combined ILM Peeling Versus Anti-VEGF Intravitreal Injection for Treatment-naïve Diabetic Macular Edema
Diabetic macular edema (DME) is the main cause of vision loss in patients with diabetes. At present, anti-vascular endothelial growth factor (VEGF) intravitreal injection is the first-line therapy for DME, nevertheless, some…
- Conditions
- Diabetic Macular Edema, Pars Plana Vitrectomy, Conbercept
- Trial name
- NCT05728476
- Testing
- Vitrectomy combined with ILM peeling, Conbercept intravitreal injection
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Tianjin Medical University Eye Hospital
Tongue Edema, Tongue Enlarged
Tongue Edema Caused by Intubation Tube in Intensive Care Unit Patients
Tongue edema (TE) is an enlargement of the tongue that can be noticed with the naked eye and protrudes from the mouth. Endotracheal intubation tube, which can exert high pressure on the tongue for a long time, may cause TE.
- Conditions
- Tongue Edema, Tongue Enlarged, Mechanical Ventilation Complication, Intubation Complication
- Trial name
- NCT05249738
- Testing
- Measuring tongue cross-sectional area by submental ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Selcuk University
Diabetic Retinopathy, Diabetic Macular Edema
Evaluation of Single Nucleotide Polymorphisms (SNPs) in Patients With and Without Diabetic Macular Edema
Background: Diabetic macular edema (DME) is a common condition in people with diabetes. DME occurs when blood vessels in the eye leak fluid, resulting in swelling inside the back of the eye and progressive vision loss.
- Trial name
- NCT01168258
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Retinopathy, Macular Edema
A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004)
Researchers are looking for new ways to treat diabetic macular edema (DME). In this trial, researchers want to learn if a trial medicine called MK-8748 can treat DME.
- Trial name
- NCT07705555
- Testing
- MK-8748, Aflibercept
- Where
- 33 sites in United States, Argentina and 2 more
- Volunteers
- 960 people
- Sponsor
- Merck Sharp & Dohme LLC
Intracerebral Hemorrhage
Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH)
This first-in-patient phase 2a pilot study will assess the safety and tolerability of MW01-6-189WH (hereafter called MW189) in patients with Intracerebral Hemorrhage (ICH).
- Trial name
- BEACH (NCT05020535)
- Testing
- MW189, Saline
- Where
- 11 sites in United States
- Volunteers
- 120 people
- Sponsor
- Johns Hopkins University
Diabetic Macular Edema
IVI Aflibercept Before and After Phaco in DME.
To study whether or not cataract surgery should be deferred until treating the co-existing diabetic macular edema (DME) using intravitreal (IVI) anti-vascular endothelial growth factor (anti-VEGF).
- Trial name
- NCT05731089
- Testing
- Phacoemulsification with IVI of aflibercept
- Where
- Kuwait
- Volunteers
- 40 people
- Sponsor
- Al Hadi Hospital
Postoperative Pain, Postoperative Edema
Patient Satisfaction and Recovery Outcomes Associated With Perioperative ELIXIR MD Use
The goal of this observational registry study is to characterize postoperative recovery outcomes in adult patients receiving standard-of-care perioperative light therapy using an FDA-cleared photobiomodulation device as part of…
- Conditions
- Postoperative Pain, Postoperative Edema, Postoperative Ecchymosis, Surgical Wound Healing
- Trial name
- NCT07311889
- Testing
- Perioperative photobiomodulation light therapy
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Elixir MD Inc
Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
Safety, Tolerability and PK of Subcutaneous D-4517.2 in Subjects With Wet AMD or DME
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of D-4517.2 After Subcutaneous Administration in subjects with Neovascular (wet) Age-Related Macular Degeneration (AMD) or subjects with Diabetic Macular Edema…
- Trial name
- Tejas (NCT05387837)
- Testing
- D-4517.2
- Where
- 16 sites in United States
- Volunteers
- 50 people
- Sponsor
- Ashvattha Therapeutics, Inc.
Brain Edema, Craniocerebral Trauma
A Comparison Between Two Techniques for Performing Decompressive Craniectomy
The purpose of this study is to compare two surgical techniques for a neurosurgical procedure used to treat cerebral edema (decompressive craniectomy): with watertight duraplasty vs.
- Conditions
- Brain Edema, Craniocerebral Trauma, Infarction, Middle Cerebral Artery
- Trial name
- NCT02594137
- Testing
- Without watertight duraplasty
- Volunteers
- 58 people
- Sponsor
- Hospital of the Restoration, Recife
Macular Edema, Epiretinal Membrane
Intravitreal Dexamethasone Implant for Persistent Macular Thickening and Edema After Vitrectomy for Epiretinal Membrane
This study seeks to evaluate the effect of the intravitreal 0.7mg dexamethasone implant on central macular thickness and visual acuity in those patients with persistent macular edema after pars plana vitrectomy for epiretinal…
- Conditions
- Macular Edema, Epiretinal Membrane, Vitrectomy
- Trial name
- DEMO (NCT02995746)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Maxillofacial Deformity, Maxillofacial Abnormalities
a Comparative Analysis of Subspinal and Conventional Le Fort I Osteotomy on Nasolabial Soft Tissues
Following surgical operations, patients have aesthetic expectations as well as functional ones. To minimize undesirable aesthetic results after surgery and to increase the effectiveness of the surgery, the surgical method used…
- Conditions
- Maxillofacial Deformity, Maxillofacial Abnormalities, Maxillo-facial Surgery
- Trial name
- NCT07549659
- Testing
- conventional le fort I osteotomy type, subspinal le fort I osteotomy type
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Diabetic Macular Edema
Safety and Effect of Intravitreal Injection of a Derivative of Nucleoside Reverse Transcriptase Inhibitor in Subjects with Diabetic Macular Edema
This study is designed to assess the safety and initial evidence of efficacy of the novel compound SOM-401 (K8), a derivative of a nucleoside reverse transcriptase inhibitor, in subjects with untreated, clinically significant…
- Trial name
- NCT05699759
- Testing
- K8
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Michelle Abou-Jaoude
Pneumonia, Pulmonary Edema
Chest U/S in Differentiating Lung Congestion & Pneumonia in Adult Critically-ill Patients and Its Prognostic Impact
This study aim will be to assess the effectiveness of chest ultrasound as a diagnostic and differentiating modality in cases of pneumonia and lung congestion .
- Trial name
- NCT05636631
- Testing
- Chest ultrasound
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Respiratory Failure
Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients
The COSMIC trial will be a multicentred, national, parallel-group, pragmatic vanguard pilot trial.
- Trial name
- COSMIC (NCT05456542)
- Testing
- Cuff Leak Test, Dexamethasone 4mg
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 100 people
- Sponsor
- St. Joseph's Healthcare Hamilton
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