Clinical trials: Edema Brain
Cerebral Edema, Brain Metastases
Glyburide vs Placebo as Prophylaxis Against Cerebral Edema in Patients Receiving Radiosurgery for Brain Metastases (RAD 1502/UAB 1593)
Primary Objectives: Pilot Portion: To determine the feasibility and safety of administering oral glyburide to non-diabetic patients receiving stereotactic radiosurgery (SRS) for newly diagnosed brain metastases.
- Trial name
- NCT02460874
- Testing
- Glyburide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Alabama at Birmingham
Acute Ischemic Stroke, Mechanical Thrombectomy
Rapid Local Ischemic Postconditioning in Acute Ischemic Stroke
The objective of this clinical trial is to determine whether rapid local ischemic postconditioning (RL-IPostC) is effective in preventing brain edema and safe in acute ischemic stroke (AIS) patients treated with mechanical…
- Conditions
- Acute Ischemic Stroke, Mechanical Thrombectomy, Ischemic Postconditioning, Brain Edema
- Trial name
- RAPID-SAVE (NCT06307743)
- Testing
- rapid local ischemic postconditioning
- Volunteers
- 135 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Endovascular Therapy, Brain Edema
Early Identification of Malignant Brain Edema in laRge Artery oCclusive Stroke After Endovascular Therapy (EMBRACE Study)
To design and validate a predictive model for malignant brain edema after endovascular thrombectomy.
- Conditions
- Endovascular Therapy, Brain Edema, Prediction Model, Ischemic Stroke
- Trial name
- EMBRACE (NCT06451887)
- Where
- China
- Volunteers
- 1,950 people
- Sponsor
- Zhejiang Provincial People's Hospital
Stroke, Intracranial Hypotension
Safety & Tolerability of Hypertonic Saline Administration Via Intraosseous Access
Hypertonic saline is used to treat elevated intracranial pressure. Intraosseous vascular access has been used to administer fluids and medications. This study combines these to administer 3% hypertonic saline via IO.
- Conditions
- Stroke, Intracranial Hypotension, Cerebral Edema
- Trial name
- NCT03276494
- Testing
- Intraosseous, Hypertonic saline
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Ohio State University
Intracerebral Hemorrhage
Retrospective Cohort Study of Intracerebral Hemorrhage
The investigators design a retrospective, observational cohort study to provide contemporary information on the prevalence, characteristics, risk stratification，cost-effective, treatments and prognosis of Chinese hospitalized…
- Trial name
- REST (NCT04803292)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Meniere's Disease
Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Patients With Meniere's Disease
This prospective study aims to better characterize inner ear's perilymphatic structures with Magnetic Resonance Imaging using contrast media and delayed injection in patient's with Meniere's disease.
- Trial name
- PROSPER (NCT02530931)
- Testing
- Gadolinium
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Grenoble
Stroke, Acute, Brain Edema
Automatic PredICtion of Edema After Stroke
To use machine learning for early detection of malignant brain edema in patients with MCA ischemia
- Trial name
- APICES (NCT04057690)
- Where
- 19 sites in Austria, Germany and 1 more
- Volunteers
- 1,687 people
- Sponsor
- University Hospital Tuebingen
Stroke
Robot-assisted Rehabilitation of Hand by Paralysis of the Upper Limb After Stroke
The investigators evaluate the effectiveness of the application of continuous passive motion device for hand rehabilitation in two classes of patients: with a residual active motion and without a residual active motion.
- Trial name
- NCT01936298
- Testing
- A-ROM Continuous Passive Rehabilitation, P-ROM Continuous Passive Rehabilitation
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Chiara Mulé
Aneurysmal Subarachnoid Hemorrhage
Decompressive Craniectomy After Aneurysmal Subarachnoid Hemorrhage (DECIDE-SAH)
DECIDE-SAH is an international, multicenter, retrospective, observational, non-interventional secondary-use cohort study of adults with aneurysmal subarachnoid hemorrhage (aSAH).
- Trial name
- DECIDE-SAH (NCT07872774)
- Testing
- Decompressive craniectomy
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Essen
Traumatic Brain Injury, Cerebral Edema
Trial of Dexamethasone for Traumatic Brain Injured Patients With Brain Contusions and Pericontusional Edema
The DEXCON-TBI trial is a multicenter, pragmatic, randomized, triple-blind, placebo controlled trial to quantify the effects of the administration of dexamethasone on the prognosis of TBI patients with brain contusions and…
- Conditions
- Traumatic Brain Injury, Cerebral Edema, Head Injury Trauma
- Trial name
- DEXCON-TBI (NCT04303065)
- Testing
- Dexamethasone Oral
- Where
- Spain
- Volunteers
- 600 people
- Sponsor
- Jon Pérez Bárcena
Hemodynamic Instability, Water on the Brain
Multi-parameters'Change Process During Dehydration Therapy on Brain Edema Patients.
This study aims to investigate the inner mechanism during different dehydration therapies such as mannitol injection and hypertonic saline.
- Conditions
- Hemodynamic Instability, Water on the Brain, Intracranial Pressure Increase
- Trial name
- NCT03828032
- Testing
- Mannitol injection, Hypertonic saline injection
- Volunteers
- 80 people
- Sponsor
- Ting Li
Retinitis Pigmentosa, Maculopathy, Age Related
Bimodal and Coaxial High Resolution Ophtalmic Imaging
The knowledge of the pathogenesis of retinal affections, a major cause of blindness, has greatly benefited from recent advances in retinal imaging.
- Conditions
- Retinitis Pigmentosa, Maculopathy, Age Related, Macular Dystrophy, Macular Edema
- Trial name
- AOSLO-OCT (NCT04620876)
- Testing
- Bimodal high resolution imaging of the retina
- Where
- France
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Cerebral Edema
Evaluation of the Cerebral Edema in Children Having Diabetic Ketoacidosis
The purpose of this study is to determine cerebral edema with evaluation of measurement of diameter of optic nerve sheath.
- Trial name
- NCT02937441
- Testing
- Ultrasonic Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Cukurova University
Fluid Therapy, Brain Edema
Effects of Intraoperative GDFT on the Postoperative Brain Edema
Whether a fluid protocol aiming for protecting vital organ perfusion or fluid restriction is favorable to post-craniotomy outcomes such as brain edema remains uncertain.
- Conditions
- Fluid Therapy, Brain Edema, Brain Tumor
- Trial name
- NCT03323580
- Testing
- GDFT, traditional fluid therapy
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Beijing Tiantan Hospital
Traumatic Brain Injury, Head Injury
Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery
This study has two main goals: 1) to refine and enhance the R2R-TBI intervention; and 2) to examine the efficacy of the R2R-TBI intervention in a randomized control trial.
- Conditions
- Traumatic Brain Injury, Head Injury, Head Injuries, Closed, Brain Hemorrhage, Traumatic
- Trial name
- NCT05622461
- Testing
- Road-to-recovery
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Glioblastoma, Malignant Glioma
Dexamethasone and Azeliragon for Management of Post-Resection Cerebral Edema in Patients with Glioblastoma
This phase I trial tests the safety, side effects, and best dose of dexamethasone when given with azeliragon in managing cerebral edema after surgery (post-resection) in patients with glioblastoma.
- Trial name
- NCT05773664
- Testing
- Azeliragon, Biospecimen Collection, Computed Tomography
- Sponsor
- City of Hope Medical Center
Intracerebral Hemorrhage
Systemic Normothermia in Intracerebral Hemorrhage (ICH)
Patients with a supratentorial intracerebral hemorrhage will be randomly assigned to either the experimental group which will keep them at a normal body temperature or the standard of care group.
- Trial name
- SNICH (NCT02078037)
- Testing
- Arctic Sun cooling device, Standard of Care
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The Cleveland Clinic
Brain Edema, Brain Edema Caused by Drugs
A Pharmacovigilance Study of Brain Oedema
Literature reports the development of brain oedema following the use of certain drugs. Therefore, this study aims to present a comprehensive disproportionality analysis of brain oedema cases reported to the Food and Drug…
- Trial name
- NCT04311359
- Testing
- Drugs, Generic
- Where
- Pakistan
- Volunteers
- 9,524 people
- Sponsor
- University of Peshawar
Brain Death, Organ Donor
The Effect of Nebulized Albuterol on Donor Oxygenation
The purpose of this study is to test the effectiveness of albuterol versus placebo with the following specific aims: a) Treatment of brain dead organ donors with albuterol will reduce pulmonary edema, improve donor oxygenation…
- Conditions
- Brain Death, Organ Donor, Pulmonary Edema
- Trial name
- NCT00310401
- Testing
- Albuterol, Saline
- Where
- United States
- Volunteers
- 506 people
- Sponsor
- Vanderbilt University Medical Center
Cerebral Edema, Saline Solution, Hypertonic
Small-Volume, Patient-Specific, Balanced Hypertonic Fluid Protocol Validation
Many patients with traumatic brain injuries (including strokes, blood clots, or other brain injuries) are given concentrated salt water solutions (hypertonic saline) in order to treat brain swelling (cerebral edema).
- Trial name
- NCT03330704
- Testing
- 3% Sodium Chloride, 23.4% Sodium Chloride, 8.4% Sodium Bicarbonate
- Where
- United States
- Sponsor
- Stanford University